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Kexone 1gm Injection 1's
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INTRODUCTION
KEXONE 1GM INJECTION contains Ceftriaxone which belongs to the group of medicines called Antibiotics. It is used to treat bacterial infections such as urinary tract infections, lower respiratory tract infections, bacteremia, septicaemia, meningitis, abdominal infections and infections caused by pseudomonas species. KEXONE 1GM INJECTION is also used to prevent infections, before and after surgery.
Tell your doctor before receiving KEXONE 1GM INJECTION if you have or had a history of kidney or liver diseases, fungal diseases, gastrointestinal disease or diarrhoea. If you are pregnant or breastfeeding, inform your doctor before receiving KEXONE 1GM INJECTION.
Inform your doctor if you are allergic (hypersensitive) to cephalosporins, penicillin or any antibiotics before receiving the medicine.
Your doctor will administer the right dose depends on your child’s age, body weight and disease condition. KEXONE 1GM INJECTION should be used with caution in elderly patients, consult your doctor before receiving the medicine.
The most common side effect of receiving this medicine are pain, tenderness, hardness, or at injection site and diarrhoea. Consult your doctor immediately if any of the above symptoms worsen.
USES OF KEXONE 1GM INJECTION
Used to treat:
- urinary tract infections
- lower respiratory tract infections
- bacteremia
- septicaemia
- meningitis
- abdominal infections and
- infections caused by pseudomonas species
HOW KEXONE 1GM INJECTION WORKS
KEXONE 1GM INJECTION contains ceftriaxone which is a second-generation cephalosporin that interferes with the synthesis of the bacterial cell wall by binding to specific binding proteins located inside the bacterial cell wall. This leads to breaking down the cell wall of the bacteria and reducing its stability, thus causing cell damage, and eventually causing bacterial elimination.
DIRECTIONS FOR USE
KEXONE 1GM INJECTION will be given to you intravenously or intramuscularly only by a doctor or a nurse. Your doctor will administer the right dose depends on your age, body weight and severity of the infection.
SIDE EFFECTS OF KEXONE 1GM INJECTION
COMMON
- abnormalities with white blood cells (such as a decrease of leucocytes and an increase of eosinophils) and platelets
- diarrhea
- thrombocytosis
- leukopenia
- headache
- dizziness
- changes in liver function
UNCOMMON
- anaemia
- nausea and vomiting
- pruritis (itching sensation)
- increased blood creatinine levels
- fungal infections
- decrease in white blood cells (granulocytopenia)
- blood clots (pain and swelling of your joints)
- pain or a burning feeling along the vein
- fever
RARE
- bronchospasm (breathing difficulty)
- haematuria (blood in urine)
- glycosuria (glucose in urine)
- chills
- inflammation of colon. signs include diarrhoea, usually with blood and mucus
- lumpy rash (hives), feeling itchy and swelling
- oedema (fluid build-up)
Contact your doctor if you experience any of the following side effects:
- sudden swelling of the face, throat, lips, or mouth. this can make it difficult to breathe or swallow
- severe rash that develops quickly, with blisters or peeling of the skin and possibly blisters in the mouth
- widespread rash, high body temperature, liver enzyme
- elevations, blood abnormalities (eosinophilia)
- enlarged lymph nodes and other body organs involvement
- jarisch-Herxheimer reaction which causes fever, chills, headache, muscle pain, and skin rash
HOW TO MANAGE SIDE EFFECTS
Diarrhoea:
Drink lots of fluids, such as water or fresh juice to keep yourself hydrated. Do not take any medicine on your own for treating diarrhoea. Consult your doctor if the symptom did not improve.
Headache:
Apply a pain-relieving balm on their head if required. Consult your doctor if the symptom did not improve.
WARNING & PRECAUTIONS
PREGNANCY
KEXONE 1GM INJECTION should be used during pregnancy only if clearly needed. Consult your doctor before receiving this medicine.
BREASTFEEDING
KEXONE 1GM INJECTION should be used with caution during breastfeeding as it may pass into the breast milk. Consult your doctor before receiving this medicine.
DRIVING AND USING MACHINES
Do not drive or handle any heavy machines if you experience dizziness or light headedness while receiving KEXONE 1GM INJECTION.
KIDNEY
KEXONE 1GM INJECTION should be used with caution in patients with kidney disease. Consult your doctor before receiving this medicine.
LIVER
KEXONE 1GM INJECTION should be used with caution in patients with liver diseases. Consult your doctor before receiving this medicine.
ALLERGY
Do not receive KEXONE 1GM INJECTION if you are allergic (hypersensitive) to Ceftriaxone or to any other ingredients of this medicine.
OTHERS
KEXONE 1GM INJECTION is not recommended for use if you have:
- gastrointestinal disease (colitis)
Before receiving KEXONE 1GM INJECTION inform your doctor if you:
- have haemolytic anaemia (a reduction in your red blood cells that may make your skin pale yellow and cause weakness or breathlessness)
- are on a low sodium diet
Use in pediatrics:
Your doctor will administer the right dose depends on your child’s age, body weight and severity of the infection. Consult your doctor before receiving KEXONE 1GM INJECTION.
Use in geriatrics:
KEXONE 1GM INJECTION should be used with caution in elderly patients. Consult your doctor before receiving this medicine.
INTERACTIONS
A. Drug-Drug interactions:
Before receiving KEXONE 1GM INJECTION, inform your doctor if you are receiving any of the following medicine:
- aminoglycoside (treats infections)
- chloramphenicol (used to treat infections, particularly of the eyes
Overdosage:
It is unlikely to receive overdose since it will be administered by the doctor or nurse. If you experience any unusual side effects, consult your doctor immediately.
SYNOPSIS
| Drug | : | Ceftriaxone |
| Pharmacological Category | : | Cephalosporin Antibiotics |
| Therapeutic Indication | : | Treats Bacterial infections |
| Dosage Forms | : | Injection |
MORE INFORMATION
- Keep out of reach of children
- Store at room temperature
FAQs ABOUT KEXONE 1GM INJECTION
What is KEXONE 1GM INJECTION used for?
It is used to treat bacterial infections such as urinary tract infections, lower respiratory tract infections, bacteremia, septicaemia, meningitis, abdominal infections and infections caused by pseudomonas species. KEXONE 1GM INJECTION is also used to prevent infections, before and after surgery.
Can KEXONE 1GM INJECTION be given to breastfeeding mothers?
KEXONE 1GM INJECTION should be used with caution as it may pass into the breast milk. Consult your doctor before receiving. It should only be given if the expected benefits outweigh any potential risk to the baby.
Can KEXONE 1GM INJECTION cause diarrhoea?
Yes, KEXONE 1GM INJECTION may cause diarrhea during or after use. Usually, discontinuation of medicine can subside diarrhea. However, if diarrhea persists or if there is blood in the stool then immediately consult your doctor.
In what condition KEXONE 1GM INJECTION should be avoided?
Before receiving KEXONE 1GM INJECTION tell your doctor if you have a history of kidney, liver, heart disease or allergic to ceftriaxone or to any other cephalosporin antibiotics.
REFERENCES
1. KD. Tripathi. Nonsteroidal Antimicrobials. Essentials of medical pharmacology. Seventh edition. 2013. Page – 728.
2. D M Richards, R C Heel, R N Brogden, T M Speight, G S Avery. Ceftriaxone. A review of its antibacterial activity, pharmacological properties, and therapeutic use. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. Jun 1984. [Accessed on Feb 21, 2022] https://pubmed.ncbi.nlm.nih.gov/6329638
3. ACS DOBFAR S.p.A. Electronic Medicines Compendium (EMC) [Revised in August 2021] [Accessed on Feb 21, 2022] https://www.medicines.org.uk/emc/files/pil.1362.pdf
4. Hospira, Inc [Revised in Oct 2017] [Accessed on Feb 21, 2022] https://labeling.pfizer.com/ShowLabeling.aspx?id=4387#section-15
PRODUCT DETAILS
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