INTRODUCTION

KETOCIP contains Ketoconazole belongs to the class of drugs called azole antifungals. It is used to treat fungal infections including blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis. It gets bound to proteins such as albumin in the circulating blood and is widely distributed in body tissues. This medicine works by binding to the fungal p450 enzymes and stops the cells making ergosterol of the cell wall which is necessary for them to grow.

Always take this medicine as directed by physician. Your doctor will decide the dose and duration of therapy depending upon your age, weight and condition. Swallow the medicine with a glass of water. It is recommended for the use in children and adolescents. Do not take this medicine, if you have adrenal insufficiency. It is not recommended for use in pregnant or breastfeeding women. Consult your doctor before taking this medicine. Tell your doctor, if you are taking or taken or might take any other medicines. The most common side effects include diarrhea, nausea, headache, stomach pain and abnormal liver function test.

USES OF KETOCIP

• Treat fungal infections in the body

HOW KETOCIP WORKS

KETOCIP binds to the fungal p450 enzymes and stops the cells making ergosterol of the cell wall which is necessary for them to grow.

DIRECTIONS FOR USE

Always take KETOCIP exactly as prescribed by your doctor. Swallow the medicine whole with plenty of water. If you take more this medicine than you should, talk to your doctor.

SIDE EFFECTS OF KETOCIP

HOW TO MANAGE SIDE EFFECTS

Skin rash:

Avoid bath in hot water because hot water can irritate the skin. Moisturizers can be used regular basis to soothe and hydrate the affected area.

Nausea and vomiting:

Keep try taking this medicine with, or just after, a meal or snack and stick to simple meals and do not eat rich or spicy food.

Diarrhea:

Drink lot of fluid, such as water or squash, to avoid dehydration. Do not take any other medicine without consulting your doctor.

WARNING & PRECAUTIONS

INTERACTIONS

Talk to your doctor, if you are taking:

• medicines for lowering blood cholesterol such as simvastatin, atorvastatin, lovastatin
• heart medicines such as epleronone, dronedarone, disopyramide, felodipine, nisoldipine
• medicines used for the treatment of the paludism such as quinidine, halofantrine
• medicines used for severe mental health disorders and severe depression such as pimozide, sertindole, lurasidone, quetiapine
• medicines used for the allergies such as mizolastine
• dabigatran
• medicine used to prevent the formation of blood clots
• medicines to help to sleep and for anxiety such as triazolam, alprazolam, midazolam (taken by mouth)
• medicines used for migraine attacks such as dihydroergotamine, ergometrine (ergonovine)
• medicines used in cancers such as irinotecan, everolimus
• sirolimus such as used to prevent your body from rejecting a kidney transplant

SYNOPSIS

MORE INFORMATION

Store at room temperature 15-25°C and keep out of reach of children.

FAQs ABOUT KETOCIP

Can KETOCIP be used in pregnant women?

No. It is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.

How does KETOCIP kill fungus?

It kills fungi by binding to the fungal p450 enzymes and stops the cells making ergosterol of the cell wall.

REFERENCES

1. Hadeer Sinawe; Damian Casadesus, Ketoconazole, [Revised on Jun 2020] [Accessed 11 Dec 2020] https://www.ncbi.nlm.nih.gov/books/NBK559221/

2. Jan van cutsem; The antifungal activity of ketoconazole; [Revised on Jan 1983] [Accessed 11 Dec 2020] https://www.amjmed.com/article/0002-9343(83)90508-9/fulltext

3. K.D.Tripathi, Essentials of medical pharmacology, Antimicrobial drugs, Chapter 57 – Antifungal drugs, 7th edition 2013, Page – 792.

4. Glenmark Pharmaceuticals s.r.o., U.S. Food and Drug Administration; [Revised on July 2013] [Accessed 11 Dec 2020] https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/018533s040lbl.pdf