INTRODUCTION
KAIRAB 20 INJECTION contains Rabeprazole which belongs to the group of medicines called Proton pump inhibitors. It is used to treat Gastro-oesophageal Reflux Disease (GERD) and peptic ulcer. It is used as an alternative to oral therapy when patients are not able to swallow rabeprazole orally.
GERD is a chronic digestive disease in which the stomach acid frequently flows into the oesophagus leading to the irritation of lining of the food pipe. Symptoms include heartburn, chest pain, nausea, sensation of lump in throat and stomach discomfort.
Peptic ulcers are painful sores that develop on the linings of the stomach, oesophagus and/or intestines. Symptoms include stomach pain, flatulence, indigestion, vomiting and fatigue.
KAIRAB 20 INJECTION will be administered to you only by a doctor or a nurse into the vein. Before starting the treatment with KAIRAB 20 INJECTION inform your doctor if you have any liver problems. You must also inform your doctor if you have vitamin B12 deficiency, osteoporosis or any tumours in your stomach.
Inform your doctor before receiving KAIRAB 20 INJECTION if you are pregnant or breastfeeding. The most common side effects of receiving KAIRAB 20 INJECTION are sore throat, cough, flu-like symptoms, constipation, indigestion, stomach pain, headache and dizziness. Consult your doctor if any of the side effect troubles you.
You must also inform your doctor immediately if you experience severe uncontrollable diarrhea with stomach pain or tenderness after receiving KAIRAB 20 INJECTION.
USES OF KAIRAB 20 INJECTION
- Treats Gastro-Oesophageal Reflux Disease
- Treats and Prevents Peptic ulcers
HOW KAIRAB 20 INJECTION WORKS
KAIRAB 20 INJECTION is a proton pump inhibitor. It reduces the amount of acid produced in the stomach by blocking the actions of an enzyme called H+ K+ ATPase (also known as proton pump) which is present in the lining of the stomach walls. As a result, it reduces the chances for acid reflux into the oesophagus, heals peptic ulcers and esophageal lesions and prevents its recurrence.
DIRECTIONS FOR USE
KAIRAB 20 INJECTION will be administered to you only by a doctor or a nurse into the vein (as intravenously). Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF KAIRAB 20 INJECTION
COMMON
- cough, sore throat, runny nose
- difficulty in sleeping
- weakness
- headache, dizziness
- stomach pain, diarrhoea, flatulence, nausea, vomiting or constipation
- aches or back pain
- polyps in the stomach
UNCOMMON
- painful and blocked sinuses
- dry mouth, indigestion
- skin rash or redness
- muscle, leg or joint pain
- fractures involving wrist, hip and spine
- urinary tract infection
- changes in liver function
RARE
Inform your doctor immediately if you experience any of the following side effects after receiving KAIRAB 20 INJECTION:
- allergic reactions (such as skin rash, itching, swelling of your face, difficulty in breathing and low blood pressure)
- skin rashes on sun exposed areas
- signs of frequent infections (such as chills, sore throat and fever)
- painful ulcers in the mouth or throat
- bruising or bleeding easily
- severe watery or bloody diarrhoea with fever, stomach pain or tenderness
- signs of vitamin B12 deficiency (such as pale skin, oral sores, disturbed vision, irritability, depression)
- signs of low magnesium levels (such as fits, tremor, muscle spasms, abnormal eye movements)
HOW TO MANAGE SIDE EFFECTS
Diarrhea
Drink plenty of fluids, such as water or fruit juice to keep yourself hydrated. Consuming ORS can also be beneficial. Do not consume any medicine on your own without consulting your doctor. If your diarrhea worsens, contact your doctor immediately.
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Nausea And Vomiting
Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.
Headache
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
WARNING & PRECAUTIONS
PREGNANCY
ContraindicatedKAIRAB 20 INJECTION is not recommended for use in pregnant women. Therefore, consult your doctor before receiving it.
BREASTFEEDING
ContraindicatedKAIRAB 20 INJECTION is not recommended for use in breastfeeding women. Therefore, consult your doctor before receiving it.
DRIVING AND USING MACHINES
Use with CautionDo not drive or operate any machines if you feel sleepy after receiving KAIRAB 20 INJECTION.
ALCOHOL
Consult your doctorAvoid consumption of alcohol before receiving KAIRAB 20 INJECTION.
LIVER
Use with CautionKAIRAB 20 INJECTION should be used with caution in patients with liver disease. Therefore, consult your doctor before receiving it.
ALLERGY
ContraindicatedTalk to your doctor before receiving KAIRAB 20 INJECTION if you are allergic to Rabeprazole.
USE IN PEDIATRICS
ContraindicatedKAIRAB 20 INJECTION is not recommended for use in children and adolescents (aged below 18 years). However, consult your doctor for advice before receiving it.
USE IN GERIATRICS
Use with CautionKAIRAB 20 INJECTION should be used with caution in elderly patients. Therefore, consult your doctor before receiving it.
OTHERS
Before receiving KAIRAB 20 INJECTION, inform your doctor if you:
- have a tumor in the stomach
- have risk factors for vitamin B12 deficiency
- had a skin reaction after treatment with a medicine similar to KAIRAB 20 INJECTION
- have osteoporosis
- are going to have a specific blood test (Chromogranin A)
INTERACTIONS
A. Drug – Drug Interactions:
Before receiving KAIRAB 20 INJECTION, inform your doctor if you are taking any of the following medicines such as:
- medicines used to treat fungal infections (Ex. ketoconazole or itraconazole)
- medicines used to treat HIV-infection (Ex. atazanavir)
- chemotherapy medicine used in high doses to treat cancer (Ex. methotrexate)
- corticosteroids (used to treat pain and inflammation) such as prednisolone
Overdosage:
KAIRAB 20 INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.
SYNOPSIS
| Drug | : | Rabeprazole |
| Pharmacological Category | : | Proton Pump Inhibitors |
| Therapeutic Indication | : | GERD, Peptic ulcer |
| Dosage Forms | : | Tablet, Capsule, Powder, Injection, Infusion |
MORE INFORMATION
- Keep KAIRAB 20 INJECTION out of reach of children
- Store KAIRAB 20 INJECTION at room temperature
FAQs ABOUT KAIRAB 20 INJECTION
Q. What are the uses of KAIRAB 20 INJECTION?
A. KAIRAB 20 INJECTION is used to treat Gastro-esophageal Reflux Disease (GERD) and peptic ulcer in patients who are not able to swallow rabeprazole orally.
Q. How KAIRAB 20 INJECTION works?
A. KAIRAB 20 INJECTION is a proton pump inhibitor. It reduces the amount of acid produced in the stomach by blocking the actions of an enzyme called H+ K+ ATPase (also known as proton pump) which is present in the lining of the stomach walls. As a result, it reduces the chances for acid reflux into the oesophagus, heals peptic ulcers and esophageal lesions and prevents its recurrence.
Q. How long will it take for KAIRAB 20 INJECTION to cure my disease?
A. The time taken for healing depends on the severity of the disease. You may notice improvement in your condition within 1-2 days of therapy with KAIRAB 20 INJECTION. However, it may take several weeks for KAIRAB 20 INJECTION to completely heal the ulcers.
Q. When should I take KAIRAB 20 INJECTION?
A. KAIRAB 20 INJECTION is not meant for self-administration. It will be administered to you only by a doctor or a nurse into the vein (as intravenously).
Q. What are the long-term side effects of KAIRAB 20 INJECTION?
A. Taking KAIRAB 20 INJECTION especially over the time of a year can slightly increase the risk of hip, wrist, or spine fracture. Inform your doctor if you suffer from osteoporosis or if you are taking corticosteroids which can increase the risk of osteoporosis. It may also cause vitamin B12 deficiency and low magnesium levels in the blood.
Q. Can I stop therapy with KAIRAB 20 INJECTION once my symptoms subside?
A. Do not stop therapy with KAIRAB 20 INJECTION without consulting your doctor even if you feel better during the midway of the therapy. Make sure to receive all the doses of KAIRAB 20 INJECTION for the stipulated duration recommended by your doctor to achieve complete healing of ulcers.
Q. What precautions should be followed while taking KAIRAB 20 INJECTION?
A. Before receiving KAIRAB 20 INJECTION inform your doctor if you have any liver problems. You must also inform your doctor if you have vitamin B12 deficiency, osteoporosis or any tumors in your stomach. Inform your doctor before receiving KAIRAB 20 INJECTION if you are pregnant or breastfeeding. Regularly visit your doctor and take all the necessary blood test recommended by your doctor without fail. You must also inform your doctor immediately if you experience severe uncontrollable diarrhea with stomach pain or tenderness after receiving KAIRAB 20 INJECTION.
Q. Can I take KAIRAB 20 INJECTION daily?
A. Your doctor will evaluate your health condition and suggest whether you need to take KAIRAB 20 INJECTION every day or not.
Q. Can the use of KAIRAB 20 INJECTION affect the liver?
A. Yes. KAIRAB 20 INJECTION may affect the way your liver work. Therefore, it should be used with caution in patients with liver problems. Consult your doctor before receiving it.
Q. Can KAIRAB 20 INJECTION be taken during pregnancy?
A. KAIRAB 20 INJECTION is not recommended for use in pregnant women. Therefore, consult your doctor before receiving it.
Q. How is KAIRAB 20 INJECTION given?
A. KAIRAB 20 INJECTION will be administered to you only by a doctor or a nurse into the vein (intravenously).
Q. Does KAIRAB 20 INJECTION cause insomnia?
A. Yes, KAIRAB 20 INJECTION may cause difficulty in falling asleep in some patients. If you are suffering from this, consult your doctor for advice. Do not take any medicine on your own without consulting your doctor.
Q. Is KAIRAB 20 INJECTION safe to use in children?
A. KAIRAB 20 INJECTION is not recommended for use in children due to lack of data on safety and effectiveness. However, consult your doctor for advice.
REFERENCES
1. KD. Tripathi. Drugs for Peptic Ulcer and GERD. Essentials of medical pharmacology. Seventh edition. 2013. Page – 653
2. Fabio Pace, Stefano Pallotta, Stefania Casalini, and Gabriele Bianchi Porro. A review of rabeprazole in the treatment of acid-related diseases. NIH National Library of Medicine, National Center for biotechnology information. June 2007. [Accessed on 3rd October 2022]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386363/
3. Seiichi Hayato, Setsuo Hasegawa, Seiichiro Hojo, Hiroki Okawa, Hiroaki Abe, Nobuyuki Sugisaki, Masahiro Munesue, Yukio Horai, Akihiro Ohnishi. Dose-response relationships of rabeprazole 5, 10, 20, and 40 mg once daily on suppression of gastric acid secretion through the night in healthy Japanese individuals with different CYP2C19 genotypes. NIH National Library of Medicine, National Center for biotechnology information. Pubmed.gov. May 2012. [Accessed on 3rd October 2022]. https://pubmed.ncbi.nlm.nih.gov/22108775/
4. Cipla Ltd. Ciplamed. [Revised in June 2020]. [Accessed on 3rd October 2022]. https://www.ciplamed.com/content/rabicip-iv-injection
USEFUL DIAGNOSTIC TESTS
- Ultrasound
- Endoscopy
- Liver Function Test
- Complete Blood Count
PRODUCT DETAILS
ALTERNATE BRANDS View All
The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.