Kabanat 60mg Injection 1.5ml

INTRODUCTION

KABANAT 60MG INJECTION contains Cabazitaxel, which belongs to the group of medicines called Anti-neoplastic agents. It is indicated in combination with prednisone for the management of patients with metastatic castration-resistant prostate cancer previously treated with a docetaxel-containing treatment regimen.

Castration-resistant prostate cancer (CRPC) is a form of advanced prostate cancer. With metastatic castration-resistant prostate cancer (mCRPC), the cancer stops responding to hormone treatment, and it is found in other parts of the body. It can spread to nearby lymph nodes, bones, the bladder, rectum, liver, lungs, and maybe the brain.

KABANAT 60MG INJECTION is not recommended to be received if you are allergic to Cabazitaxel or any other ingredient of this medicine. KABANAT 60MG INJECTION is not recommended if you are pregnant, nursing, or are diagnosed with severe impairment of liver function. It should be used with caution if you are diagnosed with any respiratory disorder, end-stage kidney disease, or liver dysfunction. Consult your doctor before receiving it.

The most common side effects associated with KABANAT 60MG INJECTION are decreased count of red blood cells (anemia), unusual bleeding or bruising due to decreased count of platelets, tiredness, nausea, pain in the stomach or abdomen, constipation, decreased appetite, change in taste, weakness, blood in the urine, pain in the back and joints, fever, shortness of breath, cough, loss of hair, sensation of numbness, tingling, or burning, and/or decreased sensation in your hands and feet. Consult your doctor immediately if any of the above side effects worsen.

USES OF KABANAT 60MG INJECTION

• It is used in combination with prednisone for the management of patients with metastatic castration-resistant prostate cancer, previously treated with a docetaxel-containing treatment regimen.

HOW KABANAT 60MG INJECTION WORKS

KABANAT 60MG INJECTION belongs to the microtubule inhibitor, which binds to tubulin and promotes its assembly into microtubules while simultaneously inhibiting disassembly. This leads to the stabilization of microtubules, which results in the inhibition of mitotic and interphase cellular functions.

DIRECTIONS FOR USE

KABANAT 60MG INJECTION will be administered to you only by a doctor or a nurse. Your doctor will decide the correct duration for you depending on your age, body weight, and disease condition.

SIDE EFFECTS OF KABANAT 60MG INJECTION

HOW TO MANAGE SIDE EFFECTS

Constipation

Eat healthy meals that are rich in fiber. Try to incorporate green leafy vegetables and whole grains into your diet. Take an adequate amount of water. Consult your doctor if it persists for a long time or worsens with time.

Nausea And Vomiting

Stick to simple meals. Avoid eating heavily rich or spicy food. Stay hydrated. Consult your doctor if it persists for a long time or worsens with time.

Stomach Discomfort

Stick to simple meals. Avoid eating rich or spicy food. Take adequate rest. Consult your doctor if it persists for a long time or worsens with time.

WARNING & PRECAUTIONS

PREGNANCY

Contraindicated

KABANAT 60MG INJECTION is not recommended for use in pregnant women. Consult your doctor before receiving the medicine.

BREASTFEEDING

Consult your doctor

There is no information available on the presence of KABANAT 60MG INJECTION in breast milk. Consult your doctor before receiving the medicine.

KIDNEY

Use with Caution

 

KABANAT 60MG INJECTION should be received with caution if you are diagnosed with end-stage renal disease. Consult a doctor before receiving it.

LIVER

Consult your doctor

It is not recommended to receive it if you are diagnosed with severe impairment of liver function. It should be used with caution while receiving KABANAT 60MG INJECTION if you are diagnosed with mild impairment of liver function. Consult a doctor before receiving it.

ALLERGY

Contraindicated

Do not receive KABANAT 60MG INJECTION if you are allergic to Cabazitaxel or any other ingredient of this medicine.

LUNGS

Consult your doctor

It is recommended to consult a doctor before receiving KABANAT 60MG INJECTION if you have any respiratory disorder as it’s administration may cause increased risk of developing lung or breathing problems.

USE IN PEDIATRICS

Consult your doctor

The safety and effectiveness of KABANAT 60MG INJECTION in pediatric patients have not been established. Consult your doctor.

USE IN GERIATRICS

Consult your doctor

KABANAT 60MG INJECTION should be used with caution in elderly patients above 65 years of age. Consult your doctor.

INTERACTIONS

A. Drug-Drug Interactions:

Before receiving KABANAT 60MG INJECTION, inform your doctor if you are taking any of the following medicines:

• medicines used to manage fungal infections (Ex. ketoconazole, itraconazole)
• medicines used to manage viral infections (Ex. atazanavir, indinavir)
• medicines used to manage bacterial infections (Ex. clarithromycin)

Overdosage:

It is unlikely to get an overdose since KABANAT 60MG INJECTION will be administered by your doctor or nurse. If you experience any unusual reactions, consult your doctor immediately or visit a nearby hospital.

SYNOPSIS

MORE INFORMATION

• Keep out of reach of children
• Store at room temperature

FAQs ABOUT KABANAT 60MG INJECTION

Q: What is KABANAT 60MG INJECTION used for?

A: KABANAT 60MG INJECTION contains cabazitaxel, which belongs to the group of medicines called anti-neoplastic agents. It is indicated in combination with prednisone for the management of patients with metastatic castration-resistant prostate cancer previously treated with a docetaxel-containing treatment regimen.

Q: Is it safe to use KABANAT 60MG INJECTION with children?

A: The safety and effectiveness of KABANAT 60MG INJECTION in pediatric patients have not been established. Consult your doctor.

Q: Is it safe to use KABANAT 60MG INJECTION in elderly patients?

A: KABANAT 60MG INJECTION should be used with caution in elderly patients over 65 years of age. Consult your doctor.

Q: What are the common side effects after receiving KABANAT 60MG INJECTION?

A: The common side effects experienced after receiving KABANAT 60MG INJECTION include decreased count of red blood cells (anemia), unusual bleeding or bruising due to decreased count of platelets, tiredness, nausea, pain in the stomach or abdomen, constipation, decreased appetite, change in taste, weakness, blood in the urine, pain in the back and joints, fever, shortness of breath, cough, loss of hair, sensation of numbness, tingling, or burning, and/or decreased sensation in your hands and feet. It is recommended to consult a doctor if the side effects do not improve or worsen with time.

Q: Can KABANAT 60MG INJECTION be received by pregnant women?

A: KABANAT 60MG INJECTION is not recommended for pregnant women and/or those planning pregnancy, as it may cause damage to the fetus. Consult your doctor before receiving KABANAT 60MG INJECTION.

Q: Can KABANAT 60MG INJECTION be received by nursing women?

A: There is no information available on the presence of KABANAT 60MG INJECTION in breast milk. Consult your doctor before receiving the medicine.

Q: What medicines cannot be taken while receiving treatment with KABANAT 60MG INJECTION?

A: It is recommended not to take medicines such as ketoconazole, clarithromycin, atazanavir, and indinavir.

REFERENCES

1. Tsao, C.K., Cutting, E., Martin, J. and Oh, W.K., 2014. The role of cabazitaxel in the treatment of metastatic castration-resistant prostate cancer. Therapeutic advances in urology. [Published in June 2014] [Accessed on 30th March 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003844/    
 

2. Sanofi-aventis. U.S. Food & Drug Administration. [Published in June 2010] [Accessed on 30th March 2023] https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/201023lbl.pdf   

3. JEVTANA. Sanofi-aventis. [Revised in February 2021] [Accessed on 30th March 2023] https://products.sanofi.us/jevtana/jevtana.pdf

USEFUL DIAGNOSTIC TESTS

• Complete Blood Count (CBC)

AUTHOR DETAILS

Written By Dr. N. Sai Swaroop, Pharm.D
Last updated on 02 Nov 2023 | 11:11 AM(IST)