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INTRODUCTION
JUVOBIN contains Darbepoetin alfa which belongs to a class of medications called erythropoiesis-stimulating agents (ESAs). It is used to treat anemia. Anemia is a condition where your blood does not contain enough red blood cells and symptoms may be fatigue, weakness and shortness of breath. It works in the same way as erythropoietin, the natural hormone which is produced in your kidneys and encourages your bone marrow to produce more red blood cells.
Always use JUVOBIN as your doctor has told you. It is not recommended for the use in children and adolescents under 18 years. Do not take this medicine, if you have suffered from sickle cell anemia, epileptic fits (seizures) and convulsions (fits or seizures). It should be used with caution in pregnant or breastfeeding women. Consult your doctor before taking this medicine. Tell your doctor, if you are taking or taken or might take any other medicines. The most common side effects include stroke, pain around the area injected, rash and/or redness of the skin, allergic reactions, high blood pressure, blood clots (thrombosis) and fluid retention (oedema).
USES OF JUVOBIN
- Treat Anemia
HOW JUVOBIN WORKS
It works by causing bone marrow (soft tissue inside the bones where blood is made) to make more red blood cells.
DIRECTIONS FOR USE
Always use JUVOBIN as your doctor has told you. Your injection to be given under the skin (subcutaneous).
SIDE EFFECTS OF JUVOBIN
COMMON
- stroke
- pain around the area injected
- rash and/or redness of the skin
- allergic reactions
- high blood pressure
- blood clots (thrombosis)
- fluid retention (oedema)
HOW TO MANAGE SIDE EFFECTS
Skin rash:
Avoid bath in hot water because hot water can irritate the skin. Moisturizers can be used regular basis to soothe and hydrate the affected area.
WARNING & PRECAUTIONS
PREGNANCY
JUVOBIN should be used with caution in pregnant women. Consult your doctor before taking this medicine.
BREASTFEEDING
JUVOBIN is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.
ALCOHOL
Consumption of alcohol is not recommended during treatment with JUVOBIN.
KIDNEY
JUVOBIN should be taken with caution in patients with severe kidney disease. Consult your doctor for advice.
LIVER
JUVOBIN should be taken with caution in patients with severe liver disease. Consult your doctor for advice.
ALLERGY
Do not take if you are allergic to the medicine.
HEART DISEASE
If you have any heart related problems, consult your doctor for advice before taking this medicine.
OTHERS
Do not take this medicine, if you have suffered from sickle cell anemia, epileptic fits (seizures) and convulsions (fits or seizures).
INTERACTIONS
Talk to your doctor if you are using, have recently used or might use any other medicines.
SYNOPSIS
| Drug | : | Darbepoetin alfa |
| Pharmacological Category | : | Erythropoiesis-stimulating agents |
| Therapeutic Indication | : | Anemia |
| Dosage Forms | : | Injection |
MORE INFORMATION
Store in a refrigerator (2-8°C). Do not freeze. Keep out of reach of children.
FAQs ABOUT JUVOBIN
Can JUVOBIN be used in pregnant women?
No. It should be used with caution in pregnant women. Consult your doctor before taking this medicine.
Is JUVOBIN a chemo drug?
It does not treat cancer. It is a support medication in treating anaemia associated with chronic kidney disease (CKD) caused by chemotherapy cancer treatment.
REFERENCES
1. Aleix Cases; Darbepoetin alfa: a novel erythropoiesis-stimulating protein; [Revised on Jul 2003] [Accessed 07 Jan 2021] https://pubmed.ncbi.nlm.nih.gov/12973399/
2. K.D.Tripathi, Essentials of medical pharmacology, DRUGS AFFECTING BLOOD AND BLOOD FORMATION, Chapter 43 – HAEMATINICS AND ERYTHROPOIETIN, 7th edition 2013, Page – 611.
3. Glenmark Pharmaceuticals s.r.o., Amgen; [Revised on Apr 2016] [Accessed 07 Jan 2021] https://www.pi.amgen.com/~/media/amgen/repositorysites/pi-amgen-com/aranesp/ckd/aranesp_pi_hcp_english.pdf
4. Amgen Europe B.V.; Electronic Medicines Compendium (EMC); [Revised on Nov 2019] [Accessed 07 Jan 2021] https://www.medicines.org.uk/emc/files/pil.6958.pdf
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