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INTRODUCTION
JANUVIA 25MG contain sitagliptin which belongs to a group of medicine called DPP-4 inhibitors (dipeptidyl peptidase-4 inhibitors) which is used for lowering blood sugar levels in adult patients with type 2 diabetes mellitus. This medicine helps to treat high blood sugar along with diet and exercise. Type 2 diabetes mellitus is a condition in which your body does not make enough insulin, or the insulin produced by your body does not work as well. When this happens, sugar builds up in the blood which can lead to serious medical problems like heart and kidney disease. It helps to increase the levels of insulin produced after a meal and decreases the amount of sugar made by the body.
JANUVIA 25MG can be used alone or in combination with certain other medicine (insulin, metformin, sulphonylureas, or glitazones) that lower blood sugar which you may already be taking for your diabetes together with a food and exercise plan. This medicine is strictly not recommended for use in children and adolescents under 18 years. Before taking this medicine tell your doctor if you have ever had kidney disease, heart disease, or pancreas problems. Pregnant and breastfeeding women should consult their doctor before taking this medicine.
USES OF JANUVIA 25MG
- Treat type 2 diabetes mellitus in adults
HOW JANUVIA 25MG WORKS
JANUVIA 25MG works by increasing the release of insulin from the pancreas. It also reduces the amount of glucagon, a hormone produces by pancreas which causes liver to produce more sugar. So by reducing the amount of glucagon in your body, this medicine helps to reduce the levels of glucose in your blood.
DIRECTIONS FOR USE
Always take JANUVIA 25MG exactly as your doctor has told you. This medicine must be taken with or without food. It should be swallowed whole with water. Do not crush or chew the medicine.
SIDE EFFECTS OF JANUVIA 25MG
SERIOUS
- severe and persistent pain in the abdomen which might reach through to your back with or without nausea and vomiting as these could be signs of an inflamed pancreas (pancreatitis)
- serious allergic reactions (including rash, hives, blisters on the skin/peeling skin and swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing)
- kidney problems
COMMON
- low blood sugar
- headache
- upper respiratory infection, stuffy or runny nose
- sore throat
- osteoarthritis
- arm or leg pain
RARE
- reduced number of platelets
HOW TO MANAGE SIDE EFFECTS
Headache:
Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.
Leg pain:
Rest as much as possible. Elevate your leg. Apply ice for up to 15 minutes. Gently stretch and massage cramping muscles.
Nausea and vomiting:
Keep try taking this medicine with, or just after, a meal or snack and stick to simple meals and do not eat rich or spicy food.
WARNING & PRECAUTIONS
PREGNANCY
JANUVIA 25MG is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.
BREASTFEEDING
JANUVIA 25MG is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.
DRIVING AND USING MACHINES
Do not drive or operate machinery while taking this medicine, since it may cause dizziness and drowsiness.
ALCOHOL
Avoid alcohol consumption during treatment with JANUVIA 25MG.
KIDNEY
JANUVIA 25MG should be used with caution in patients suffering from active kidney diseases. Consult your doctor for advice.
LIVER
JANUVIA 25MG should be used with caution in patients suffering from liver function impairment or active liver diseases. Consult your doctor for advice.
ALLERGY
Do not take JANUVIA 25MG if you are allergic (hypersensitive) to sitagliptin or any other ingredients in this medicine.
OTHERS
Tell your doctor if you have or had a condition such as,
- pancreatic disease
- gallstones, alcohol dependence or very high levels of triglycerides in your blood
- type 1 diabetes
- diabetic ketoacidosis (a complication of diabetes with high blood sugar and rapid weight loss, nausea, or vomiting)
INTERACTIONS
Talk to your doctor if you are taking,
- digoxin (used to treat irregular heartbeat and other heart problems)
SYNOPSIS
| Drug | : | Sitagliptin |
| Pharmacological Category | : | Antidiabetic agent |
| Therapeutic Indication | : | Type 2 diabetes mellitus |
| Dosage Forms | : | Tablet |
MORE INFORMATION
Store at room temperature and keep out of reach of children.
FAQs ABOUT JANUVIA 25MG
How long do I need to take JANUVIA 25MG?
This medicine only helps to manage your blood sugar levels. but does not cure your diabetes. Keep taking this medicine as long as your doctor recommends it. You may have to take it lifelong. It is an important to keep your blood sugar levels under control as any fluctuations in your blood sugar levels may cause serious problems. Therefore, do not stop taking this medicine without talking to your doctor.
How does JANUVIA 25MG works?
It increases the release of insulin from the pancreas which reduces the fasting and post meal sugar levels.
Can I take JANUVIA 25MG during pregnancy?
This medicine is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.
REFERENCES
1. KD Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of Medical Pharmacology. seventh edition.2013. Page-274-275.
2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page 3546-3548.
3. Maria Lee 1, Mary K Rhee. Sitagliptin for Type 2 diabetes. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. June 2015. [Accessed 26 Oct 2020] https://pubmed.ncbi.nlm.nih.gov/26000559/
4. Merck Sharp & Dohme Ltd; Electronic Medicines Compendium (EMC) [Revised on May 2020] [Accessed 26 Oct 2020] https://www.medicines.org.uk/emc/files/pil.7887.pdf
5. Merck Sharp & Dohme (Italia) S.p.A 2006; U.S. Food & Drug Administration; [Accessed 26 Oct 2020] https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021995s019lbl.pdf
USEFUL DIAGNOSTIC TESTS
- Glucose - Fasting Blood
- Glucose - Postprandial Blood
- Glycosylated Hemoglobin
ALTERNATE SALTS
The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.
