INTRODUCTION

JANUMET XR CP 100/1000MG TABLET is a combination of Metformin and Sitagliptin which belongs to the group of medicines called Antidiabetic agents. It is used to control blood sugar levels in patients with Type II diabetes mellitus along with proper diet and exercise.

Type II diabetes mellitus is a chronic disease characterized by abnormally high levels of glucose in the blood. It is caused due to inadequate production of a hormone called insulin (produced by pancreas to metabolize glucose) in the body or due to inadequate sensitivity of body cells to the actions of insulin.

Before taking JANUMET XR CP 100/1000MG TABLET inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have high blood cholesterol levels, severe systemic infections or are severely dehydrated due to excessive vomiting or diarrhea recently.

During therapy with JANUMET XR CP 100/1000MG TABLET, your doctor might regularly monitor your blood sugar levels and kidney functions to avoid the risk of unwanted side effects. He might also ask you to make certain lifestyle changes such as following a healthy diet, regular physical exercise and quitting alcohol consumption to achieve better results.

JANUMET XR CP 100/1000MG TABLET is not recommended for use in patients with severe uncontrollable diabetes. It is also not suitable for use in patients with alcoholism, shock or problems in breathing or blood circulation.

Consult your doctor before taking JANUMET XR CP 100/1000MG TABLET if you are pregnant or breastfeeding. The most common side effects of taking JANUMET XR CP 100/1000MG TABLET are low blood sugar levels, stomach upset, constipation, flatulence, metallic taste in mouth, sore throat, stuffy nose and joint pain. Consult your doctor if they bother you.

USES OF JANUMET XR CP 100/1000MG TABLET

• Treats Type II diabetes mellitus

HOW JANUMET XR CP 100/1000MG TABLET WORKS

JANUMET XR CP 100/1000MG TABLET is an antidiabetic medicine. It contains two medicines namely metformin and sitagliptin. Metformin makes the body more sensitive to insulin (a hormone involved in glucose metabolism). This helps our body cells to utilize more amount of the circulating blood glucose. Additionally, it can stop glucose production by the liver and reduces its absoprtion in the body.

Sitagliptin controls blood sugar levels by blocking the actions of an enzyme called dipeptidyl peptidase (DPP)-4 that reduces insulin secretion in the body. Collectively, JANUMET XR CP 100/1000MG TABLET controls blood sugar levels and improve glycemic control in patients with type II diabetes.

DIRECTIONS FOR USE

Take JANUMET XR CP 100/1000MG TABLET preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.

Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop taking JANUMET XR CP 100/1000MG TABLET unless your doctor advice you to stop.

SIDE EFFECTS OF JANUMET XR CP 100/1000MG TABLET

HOW TO MANAGE SIDE EFFECTS

Hypoglycemia (low blood sugar levels)

Have foods rich in sugars such as fruit juices, glucose drinks, candies, honey or biscuits. Check your blood sugar after 10 minutes. If not gained optimum level, take another sugary snack or a drink and check your blood sugar levels once again. Contact your doctor if there is no improvement in your condition.

Headache:

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.

Constipation:

Taking JANUMET XR CP 100/1000MG TABLET with meals may reduce the chances of constipation. However, if you experience constipation, eat plenty of fiber rich foods such as fresh fruits, vegetables and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.

WARNING & PRECAUTIONS

PREGNANCY

JANUMET XR CP 100/1000MG TABLET is not recommended for use in pregnant women. Therefore, inform your doctor before taking JANUMET XR CP 100/1000MG TABLET if you are pregnant, think you may be pregnant or planning to have a baby.

BREASTFEEDING

JANUMET XR CP 100/1000MG TABLET is not recommended for use in breastfeeding women. However, consult your doctor before taking it.

DRIVING AND USING MACHINES

Do not drive or operate any machines if you feel dizzy after taking JANUMET XR CP 100/1000MG TABLET.

ALCOHOL

Avoid consumption of alcohol while taking JANUMET XR CP 100/1000MG TABLET as it may increase the risk of unwanted side effects.

KIDNEY

JANUMET XR CP 100/1000MG TABLET is not recommended for use in patients with severely reduced kidney functions. Therefore, consult your doctor before taking it.

LIVER

JANUMET XR CP 100/1000MG TABLET is not recommended for use in patients with severe liver problems. It should be used with caution in patients with gall stones. Therefore, consult your doctor before taking it.

ALLERGY

Do not take JANUMET XR CP 100/1000MG TABLET if you are allergic to Metformin or Sitagliptin.

HEART DISEASE

JANUMET XR CP 100/1000MG TABLET is not recommended for use in patients with severe heart problems (such as acute heart failure or a recent heart attack). Therefore, consult your doctor before taking it.

INTERACTIONS

A. Drug - Drug interactions:

Before taking JANUMET XR CP 100/1000MG TABLET, inform your doctor if you are taking any of the following medicines such as:

• other medicines used to treat diabetes (Ex. glimepiride, glyburide, gliclazide, teneligliptin, rosiglitazone, pioglitazone)
• iodine contrast medium (used during X-rays)
• medicines used to treat asthma (Ex. salbutamol or terbutaline)
• corticosteroids (used to treat pain and inflammation) Ex. hydrocortisone, prednisolone
• diuretics (used to reduce edema and to treat hypertension) Ex. furosemide, hydrochlorothiazide
• medicines used to treat pain and inflammation (such as ibuprofen and celecoxib)
• medicines used to treat high blood pressure (such as atenolol, propranolol, captopril, enalapril, ramipril, lisinopril, losartan, valsartan, olmesartan, telmisartan)
• alcohol containing medicines (such as cough syrups)
• cimetidine (a medicine used to treat stomach ulcer)
• dolutegravir (a medicine used to treat HIV infection)
• ranolazine (a medicine used to treat chest pain)
• trimethoprim (a medicine used to treat bacterial infection)
• digoxin (a medicine used to treat irregular heartbeat)

Overdosage:

If you or anyone else accidentally took more JANUMET XR CP 100/1000MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are feeling cold or uncomfortable, severe nausea or vomiting, stomach pain, unexplained weight loss, muscular cramps and fast breathing.

SYNOPSIS

MORE INFORMATION

• Keep JANUMET XR CP 100/1000MG TABLET out of the sight and reach of children
• Store JANUMET XR CP 100/1000MG TABLET below 30°C

FAQs ABOUT JANUMET XR CP 100/1000MG TABLET

What is JANUMET XR CP 100/1000MG TABLET used for?

JANUMET XR CP 100/1000MG TABLET is an antidiabetic medicine used as an adjunct to diet and exercise to control blood sugar levels in patients with Type II diabetes mellitus.

How and when to take JANUMET XR CP 100/1000MG TABLET?

Take JANUMET XR CP 100/1000MG TABLET preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not cursh or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

How long should I take JANUMET XR CP 100/1000MG TABLET?

You need to take JANUMET XR CP 100/1000MG TABLET as long as your doctor or physician prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

What is the best time to take JANUMET XR CP 100/1000MG TABLET?

JANUMET XR CP 100/1000MG TABLET must be taken with meals to avoid gastrointestinal side effects.

What to do if I forgot to take a dose of JANUMET XR CP 100/1000MG TABLET?

If you forgot to take a dose of JANUMET XR CP 100/1000MG TABLET, take it as soon as you remember. However, if it is time for the next dose of JANUMET XR CP 100/1000MG TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of JANUMET XR CP 100/1000MG TABLET to compensate the missed ones.

What are the most common side effects of taking JANUMET XR CP 100/1000MG TABLET?

The most common side effects of taking JANUMET XR CP 100/1000MG TABLET are low blood sugar levels, stomach upset, constipation, flatulence, metallic taste in mouth, sore throat, stuffy nose and joint pain. Consult your doctor if they bother you.

Can I stop taking JANUMET XR CP 100/1000MG TABLET without consulting your doctor?

No. You should not stop taking JANUMET XR CP 100/1000MG TABLET without consulting your doctor because it may lead to reversal of symptoms. If you feel better after using JANUMET XR CP 100/1000MG TABLET, consult your doctor for advice.

Will taking a higher dose of JANUMET XR CP 100/1000MG TABLET be more effective?

No, taking a higher dose of JANUMET XR CP 100/1000MG TABLET will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.

What precautions do I need to follow while taking JANUMET XR CP 100/1000MG TABLET?

Before taking JANUMET XR CP 100/1000MG TABLET inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have high blood cholesterol levels, severe systemic infections or are severely dehydrated due to excessive vomiting or diarrhea recently. Along with the therapy, follow the diet and lifestyle changes advised by your doctor to achieve better results. Consult your doctor before taking JANUMET XR CP 100/1000MG TABLET if you are pregnant or breastfeeding.

Can I take medication for high blood pressure along with JANUMET XR CP 100/1000MG TABLET?

It is not advisable to take medicines to control blood pressure while taking JANUMET XR CP 100/1000MG TABLET without consulting your doctor. Therefore, consult your doctor before taking any antihypertensive such as beta blockers (Ex. atenolol, propranolol) along with JANUMET XR CP 100/1000MG TABLET as they have known interactions with JANUMET XR CP 100/1000MG TABLET.

What should I do if I experience low blood sugar after taking JANUMET XR CP 100/1000MG TABLET?

Low blood sugar is a common side effect of taking JANUMET XR CP 100/1000MG TABLET. If you experience any signs of low blood sugar levels (such as increased hunger, sweating, shakiness, weakness or an irregular heartbeat), consume a sugary snack or sugar drink immediately. Consult your doctor if the symptom did not improve.

Can JANUMET XR CP 100/1000MG TABLET be taken with insulin?

Co-administration of JANUMET XR CP 100/1000MG TABLET with insulin is considered risky as they are increased chances of hypoglycemia (decreased blood sugar levels). Therefore, consult your doctor before taking it.

Can JANUMET XR CP 100/1000MG TABLET be used in pregnant women?

JANUMET XR CP 100/1000MG TABLET is not recommended for use in pregnant women. Therefore, consult your doctor for advice.

How to take JANUMET XR CP 100/1000MG TABLET?

You must take JANUMET XR CP 100/1000MG TABLET as advised by your physician. Try to take this medicine preferably after meals and swallow it with a glass of water. Do not crush or chew the medicine.

How much JANUMET XR CP 100/1000MG TABLET should I take?

JANUMET XR CP 100/1000MG TABLET should be used only under medical supervision. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body condition and severity of the disease condition.

Can JANUMET XR CP 100/1000MG TABLET cause constipation?

Yes. Constipation is a common side effect of using JANUMET XR CP 100/1000MG TABLET. Eat plenty of fiber rich foods such as fresh fruits, vegetables, cereals as well as drink plenty of water and exercise more regularly when taking this medicine. Contact your doctor if this side effect bothers you.

REFERENCES

1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 274 & 275.

2. Erin L. St. Onge, Shannon Miller and Elizabeth Clements. Sitagliptin/Metformin (Janumet) as Combination Therapy in the Treatment of Type-2 Diabetes Mellitus. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. December 2012. [Accessed on 21st October 2022]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541863/

3. Chitrabhanu Ballav and Stephen C.L. Gough. Safety and Efficacy of Sitagliptin-Metformin in Fixed Combination for the Treatment of Type 2 Diabetes Mellitus. Libertas Academica. 2013. [Accessed on 21st October 2022]. https://journals.sagepub.com/doi/pdf/10.4137/CMED.S7314

4. Merck Sharp & Dohme (UK) Limited. Electronic Medicines Compendium (EMC) [Revised in February 2022] [Accessed on 21st October 2022]. https://www.medicines.org.uk/emc/files/pil.564.pdf

5. Merck & Co., Inc. JANUMET® (sitagliptin and metformin hydrochloride) tablets, for oral use. [Revised in July 2022] [Accessed on 21st October 2022]. https://www.merck.com/product/usa/pi_circulars/j/janumet/janumet_pi.pdf

6. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in June 2020] [Accessed on 21st October 2022]. https://www.medicines.org.uk/emc/files/pil.594.pdf

7. Rx Farma Limited. Electronic Medicines Compendium (EMC). [Revised in September 2019] [Accessed on 21st October 2022]. https://www.medicines.org.uk/emc/files/pil.11951.pdf

8. Organon Pharma (UK) Limited. Electronic Medicines Compendium (EMC). [Revised in November 2021] [Accessed on 21st October 2022]. https://www.medicines.org.uk/emc/files/pil.7887.pdf

USEFUL DIAGNOSTIC TESTS

• Glucose - Fasting Blood
• Glucose - Postprandial Blood
• Glycosylated Hemoglobin

AUTHOR DETAILS

Written By Srilekha. R, B.Pharm
Last updated on 28 Oct 2022 | 05:57 PM(IST)