INTRODUCTION

IVABLES 5MG contain Ivabradine which belongs to a group of medicine called hyperpolarization-activated cyclic nucleotide-gated channel blockers. It is used to treat Symptomatic stable angina pectoris and chronic heart failure. Stable angina is a heart disease occurs when there is lack of oxygen supply to the heart. It usually occurs in people between 40 and 50 years of age and is more likely to happen when the heart beats faster in situations such as exercise, emotion, exposure to the cold or after eating which increases heart rate and can cause chest pain.

Chronic heart failure is a heart disease which happens when your heart cannot pump enough blood to the rest of your body. The most common symptoms of heart failure are breathlessness, fatigue, tiredness, and ankle swelling. Before taking this medicine consult your doctor if you have any kidney or liver problems. This medicine is not recommended for use in children and adolescents under 18 years.

USES OF IVABLES 5MG

• Treat symptomatic stable angina pectoris
• Treat chronic heart failure

HOW IVABLES 5MG WORKS

It works by reducing the heart rate by a few beats per minute. This lowers the heart need for oxygen especially in the situations when an angina attack is more likely to happen. In this way this medicine helps to control and reduce the number of angina attacks. This specific heart rate lowering action of this medicine also helps to improve heart functioning and vital prognosis in patients with chronic heart failure.

DIRECTIONS FOR USE

Take IVABLES 5MG according to the dose and frequency as instructed by your doctor. This medicine must be taken with food. It should be swallowed whole with water. Do not crush or chew the medicine.

SIDE EFFECTS OF IVABLES 5MG

HOW TO MANAGE SIDE EFFECTS

Headache:

Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.

Dizziness:

Lying down and closing the eyes. drink plenty of water and keep hydrated. Take plenty of sleep.

WARNING & PRECAUTIONS

INTERACTIONS

Talk to your doctor, if you are taking,

• quinidine, disopyramide, sotalol, ibutilide, amiodarone (used to treat heart rhythm disorders)
• other medicines to treat angina pectoris
• pimozide, ziprasidone, sertindole (used to treat anxiety and schizophrenia)
• mefloquine or halofantrine (used to treat malaria)
• pentamidine (used to treat parasitic disease)
• cisapride (against the gastro-oesophageal reflux)
• intravenous erythromycin, rifampicin (used to treat infection)
• fluconazole (used to treat fungal disease)
• barbiturates, phenytoin (used to treat difficult sleeping or epilepsy)
• hypericum perforatum or St John’s Wort (used to treat depression)
• furosemide, hydrochlorothiazide, indapamide (used to treat oedema and high blood pressure)

SYNOPSIS

MORE INFORMATION

Store at room temperature and keep out of reach of children.

FAQs ABOUT IVABLES 5MG

Is IVABLES 5MG a beta-blocker?

No, it is not a beta-blocker. It lowers the heart rate by selectively blocking the sodium channel present in heart pacemaker cells responsible for the increase in the heart rate.

Can I take IVABLES 5MG during kidney disease?

It should be used with caution in patients suffering from active kidney diseases.

Does IVABLES 5MG affect vision?

It may cause temporary brightness in the field of vision (luminous visual phenomena). This usually disappears with continuous use of this medicine. If this happens to you, be careful when driving or using machine at time when there could be sudden changes in light intensity especially when driving at night.

REFERENCES

1. KD Tripathi. Antianginal and Other Anti-ischaemic Drugs. Essentials of Medical Pharmacology. Seventh Edition,2013. Page-554.

2. Bertram G. Katzung, Agents Used in Cardiac Arrhythmias, Basic & Clinical Pharmacology, Fourteenth Edition, 2015. Page – 247.

3. Rahul Chaudhary 1, Jalaj Garg 2, Parasuram Krishnamoorthy 3, Neeraj Shah 4, Gregg Lanier 5, Mathew W Martinez 4, Ronald Freudenberger 4. Ivabradine: Heart Failure and Beyond. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov.Jul 2016. [Accessed 17 Nov 2020] https://pubmed.ncbi.nlm.nih.gov/26721645/

4. Balkanpharma - Dupnitsa AD; Electronic Medicines Compendium (EMC); [Revised on Jun 2019] [Accessed 17 Nov 2020] https://www.medicines.org.uk/emc/files/pil.9084.pdf