Best Price* ₹ 127.20 MRP ₹ 159.00
(Inclusive of all taxes) *10 Tablet(s) in a Strip * Mkt: Medigenesis Pharma Pvt Ltd * Country of Origin: India * Delivery charges if applicable will be applied at checkout


ISTAFOL TABLET is a combination of L-Methylfolate, Methylcobalamin, and Pyridoxal Phosphate which belongs to the group of medicines called Vitamins. It is used to treat endothelial dysfunction (large blood vessels on the heart's surface narrow instead of widening) or hyperhomocysteinemia (high levels of an amino acid called homocysteine) in patients who present with lower extremity ulceration.

ISTAFOL TABLET can also be used to promote optimum health and protect nerve cells in diabetic peripheral neuropathy. Diabetic neuropathy is nerve damage that occurs over time because of high sugar and fat levels in the blood due to diabetes. Symptoms depend on the type of neuropathy, such as pain and numbness in your feet or problems with organ functions like those of your heart and bladder.

Avoid smoking and drinking during treatment with ISTAFOL TABLET. ISTAFOL TABLET has not been proven safe or effective in children, so consult your doctor before using it. Before taking ISTAFOL TABLET, inform your doctor if you have any other conditions or if you are taking any medicines. In pregnant and breastfeeding women, ISTAFOL TABLET should be used with caution. Consult your doctor if you experience any side effects or if your symptoms worsen.


  • Treats endothelial dysfunction or hyperhomocysteinemia
  • Promotes optimum health
  • Promotes nerve cells in diabetic peripheral neuropathy


ISTAFOL TABLET helps protect nerve cells where L-methyl folate is a form of folate that increases levels of nitric oxide vasodilator, thus increasing blood flow to the peripheral nerves, methylcobalamin participates in many processes like the production of red and white blood cells, and regeneration of RNA and DNA, synthesis of proteins, nerve cell and sheath maintenance and maintenance of bone marrow, and pyridoxal-5-phosphate takes part in a wide range of biochemical reactions like the metabolism of amino acids and glycogen, the synthesis of nucleic acids, haemoglobin, and certain neurotransmitters.


Take ISTAFOL TABLET as advised by your physician. Swallow with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of ISTAFOL TABLET for you according to your age, body weight and disease condition.



  • allergic reactions
  • acne, skin reactions, light sensitivity
  • nausea, vomiting, abdominal pain, loss of appetite, mild diarrhoea
  • increased levels of liver enzymes
  • tingling or pricking sensation
  • sleepiness
  • headaches
  • polycythemia vera (a type of blood cancer)
  • itching, temporary skin rash accompanied by fever
  • swelling of the entire body


Loss Of Appetite

Eat when you are hungry. Eat smaller meals more often than usual. Snack only when you're hungry. Eat a nutritious snack rich in calories and protein, such as dried fruit and nuts. If your appetite does not improve, contact your doctor.


Drink lots of fluids, like water or fruit juice to keep yourself hydrated. Ask your doctor before taking any medicine for diarrhoea. If diarrhoea does not improve, contact your doctor.

Nausea And Vomiting

Take ISTAFOL TABLET with, or just after meals. Stick to simple meals. Avoid eating oily or spicy foods. If nausea does not improve, contact your doctor.

Skin Rash Or Itching

Avoid hot showers because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. Consult your doctor if your skin rash worsens.


Drink an ample amount of water. Get adequate rest. Try to be relaxed and stress-free. Ask your doctor before taking any medicine for headaches. If the headache does not improve, contact your doctor.


Use with Caution

ISTAFOL TABLET should be used with caution in pregnant women. Consult your doctor before taking it.

Consult your doctor

There is no information available about the distribution of ISTAFOL TABLET in breast milk. Consult your doctor before taking it.

Use with Caution

Do not drive or use any machines if you feel disturbed mental alertness and motor coordination after taking ISTAFOL TABLET.

Consult your doctor

Avoid consumption of alcohol while taking ISTAFOL TABLET.

Consult your doctor

There is no information available about the use of ISTAFOL TABLET in patients with kidney failure. Consult your doctor before taking it.

Consult your doctor

There is no information available about the use of ISTAFOL TABLET in patients with liver impairment. Consult your doctor before taking it.


Do not take ISTAFOL TABLET if you are allergic to L-Methylfolate, Methylcobalamin, Pyridoxal Phosphate, or any of the other ingredients of this medicine.

Consult your doctor

The safety and effectiveness of ISTAFOL TABLET in children have not been established. Consult your doctor before taking it.

Consult your doctor

The safety and effectiveness of ISTAFOL TABLET in elderly patients have not been established. Consult your doctor before taking it.


A. Drug-Drug interactions:

Before taking ISTAFOL TABLET, inform your doctor if you are taking any of the following medicines:

  • pyrimethamine, pentamidine (used to treat parasitic infection)
  • medicines used to treat fits (Ex. carbamazepine, fosphenytoin, phenytoin, phenobarbital, primidone, valproic acid, valproate, lamotrigine)
  • levodopa (used for Parkinson’s disease)
  • medicines used to treat bacterial infections (Ex erythromycin, cefixime)
  • cholestyramine, colestipol (used to control blood cholesterol levels)
  • colchicine (used to treat gout)
  • metformin (used to treat diabetes)
  • potassium chloride (used to prevent potassium deficiency)
  • nitrous oxide (used as general anaesthesia)
  • methotrexate (used in certain types of cancer)
  • sulfasalazine (used to treat inflammatory diseases like Crohn’s)
  • pancreatic enzymes (pancrelipase, pancreatin)
  • triamterene (used to treat fluid retention)
  • trimethoprim (used to treat bacterial infections)
  • warfarin (used to thin blood)


If you or anyone else accidentally took too much of ISTAFOL TABLET, contact your doctor immediately.


Drug :   L-Methylfolate, Methylcobalamin, and Pyridoxal Phosphate
Pharmacological Category :   Vitamins
Therapeutic Indication :   Endothelial dysfunction, Hyperhomocysteinemia, Optimize health, Diabetic peripheral neuropathy
Dosage Forms :   Tablet, Capsule


  • Keep ISTAFOL TABLET out of reach from children
  • Store in a cool place


Q: Can I take other medicines with ISTAFOL TABLET?

A: Before taking ISTAFOL TABLET, inform your doctor if you are taking, have taken, or might take any other medicine, including prescription, non-prescription, or any herbal medicine, as these might interact with each other and cause serious side effects. The influence that Silymarin (one of the ingredients in this medicine) has on liver function should be considered when other medicines are given concomitantly.

Q: Can I drive a car after taking ISTAFOL TABLET?

A: Activities like driving a car or operating machinery should be done cautiously after taking ISTAFOL TABLET as they require complete mental alertness and motor coordination. Your doctor will tell you about these activities after assessing your response to the medicine.

Q: Does ISTAFOL TABLET cause vomiting?

A: Vomiting is a possible side effect of ISTAFOL TABLET. ISTAFOL TABLET. In such a case, get adequate rest and drink lots of fluids, especially water. Have small sips if you feel sick. Eat when you feel like it; you do not need to eat or avoid any specific foods. Do not take any medicine for vomiting without asking your doctor. Tell your doctor if you have continuous vomiting.

Q: Can ISTAFOL TABLET be given to children?

A: The safety and efficacy of ISTAFOL TABLET in children have yet to be determined. Your doctor will determine the correct dose or select a suitable alternative treatment for your child.

Q: What if I forget to take a dose of ISTAFOL TABLET?

A: If you forget to take a dose of ISTAFOL TABLET, take it as soon as you remember. However, omit the missed dose if it is almost time for the next one. Do not take the medicine twice to make up for the forgotten dose.

Q: Can ISTAFOL TABLET be stopped?

A: Continue taking ISTAFOL TABLET until your doctor tells you to stop, unless you experience any unwanted effects, a worsening of your condition, or any new symptoms. Contact your doctor in such a case.

Q: Can ISTAFOL TABLET be crushed?


1. KD Tripathi. Drugs Affecting Blood and Blood Formation. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 608.

2. Trippe BS, Barrentine LW, Curole MV, Tipa E. Nutritional management of patients with diabetic peripheral neuropathy with L-methyl folate-methylcobalamin-pyridoxal-5-phosphate: results of a real-world patient experience trial. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. 2016. [Accessed on 28th July May 2022] https://pubmed.ncbi.nlm.nih.gov/26439233/

3. Pure and Cure Healthcare Pvt. Ltd. L-Methylfolate + Methylcobalamin + Pyridoxal phosphate. [Revised in January 2022] [Accessed on 28th July 2022] https://www.centaurpharma.com/downloads/2022/neurology/NURING%20ACTIVE.pdf

4. DM Pharma. L-Methylfolate + Methylcobalamin + Pyridoxal phosphate + Vitamin D3. [Accessed on 28th July 2022] http://dmpharma.co.in/Methylcobalamin,%20L-Methylfolate,%20Pyridoxal-5-phosphate,%20Vitamin%20D3%20Tablet.html


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