ISMOTAG 5mg Tablet 10's

INTRODUCTION

ISMOTAG 5MG contains Isosorbide dinitrate which belongs to the group of medicines called Nitrate Vasodilators. It is used to prevent angina pectoris due to coronary artery disease and helps to control certain types of heart failure.

Angina pectoris is defined as a sudden, sharp, severe pain originating from the apex of heart and radiating to the left shoulder. The pain is severe and crushing, and it is characterized by feeling of pressure and suffocation, behind breastbone.

ISMOTAG 5MG is not recommended for use if you have anaemia, had a heart attack, bleeding in the brain, head injury, very low blood pressure, low blood volume (hypovolaemia). Before taking ISMOTAG 5MG, inform your doctor if you have any liver, kidney, heart, or thyroid problems, glaucoma, or extremely low body temperature. Avoid consumption of alcohol during treatment with ISMOTAG 5MG as it may increase the risk of low blood pressure.

If you are pregnant or think you might be pregnant or planning to have a baby ask your doctor for advice before taking this medicine. ISMOTAG 5MG should be used with caution in breastfeeding women. Consult your doctor before taking it. Along with the treatment, your doctor might advice you to make certain lifestyle changes such as quitting alcohol and smoking, improve your sleep at night, eating a healthy diet and manage weight.

The most common side effects of taking ISMOTAG 5MG are headache, low blood pressure, dizziness when standing up, rapid heartbeat, drowsiness, tiredness, and swelling of the hands, ankles, or feet. Contact your doctor if any of the symptoms get worse.

USES OF ISMOTAG 5MG

• Prevents angina pectoris
• Helps to control certain types of heart failure

HOW ISMOTAG 5MG WORKS

ISMOTAG 5MG works by relaxing the blood vessels of the heart and this reduces the strain on the heart making it easier to pump blood, thereby it provides relief from anginal symptoms.

DIRECTIONS FOR USE

Take ISMOTAG 5MG as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you based upon your age and disease condition. Do not stop taking ISMOTAG 5MG unless your doctor advises you to stop.

SIDE EFFECTS OF ISMOTAG 5MG

HOW TO MANAGE SIDE EFFECTS

Headache:

Take rest and drink plenty of water. Try to be relaxed and stress free. Apply pain relieving balm on the forehead if necessary. Consult your doctor if the symptom does not improve.

Dizziness:

Try to rest and relax and get enough sleep. Try to avoid driving or operating any tools or machines while you are feeling dizzy. Limit your consumption of alcohol, as it can aggravate your dizziness. Consult and inform your doctor if the symptom does not improve.

Nausea or vomiting:

Try to take ISMOTAG 5MG with or just after a meal or a snack. Stick to simple meals. Avoid eating oily or spicy foods. Consult your doctor if the symptom gets worse.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug - Drug interactions:

Before taking ISMOTAG 5MG, inform your doctor if you are taking any of the following medicines:

• betablockers (Ex. atenolol), calcium channel blockers (Ex. amlodipine), vasodilators (Ex. hydralazine), ACE inhibitors (Ex. enalapril) (used to treat high blood pressure)
• monoamine oxidase inhibitors such as phenelzine, selegiline and tricyclic antidepressants such as amitriptyline, amoxapine (used to treat depression)
• neuroleptics such as thioridazine, chlorpromazine (used to treat symptoms of schizophrenia)
• riociguat (used to treat pulmonary hypertension)
• phosphodiesterase inhibitors such as sildenafil, tadalafil, or vardenafil (used to treat male erectile dysfunction)
• ergotamine (used to treat migraine)
• sapropterin (used to lower phenylalanine levels in the blood)

Overdosage:

If you or anyone else accidentally takes too much of ISMOTAG 5MG, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are extremely low blood pressure, nausea or dizziness.

SYNOPSIS

MORE INFORMATION

• Keep ISMOTAG 5MG out of reach of children
• Store at room temperature

FAQs ABOUT ISMOTAG 5MG

Can I drink alcohol during treatment with ISMOTAG 5MG?

You will be advised not to drink alcohol with ISMOTAG 5MG. Drinking alcohol or taking medicines containing alcohol with this medicine may lower your blood pressure too much or affect you more than usual.

Can ISMOTAG 5MG be given to children?

No, ISMOTAG 5MG is not recommended for use in children. Your doctor will decide the correct dose or select a suitable alternative treatment for your child depending upon the specific disease condition

What if I forget to take a dose of ISMOTAG 5MG?

If you forget to take a dose of ISMOTAG 5MG, take it as soon as you remember. However, omit the missed dose if it is almost time for the next one. Do not double the dose to make up for the forgotten one

Can I take sildenafil while taking ISMOTAG 5MG?

No, you should not take sildenafil along with this medicine. Both these medicines when used together it lowers the blood pressure and it can cause fainting or even a heart attack. Your doctor may prescribe alternate drug or change the interval between the drugs to prevent drug interactions in order to treat specific condition.

Is ISMOTAG 5MG safe to use in patients with kidney disease?

ISMOTAG 5MG should be used with caution in patients with severe kidney problems. Your doctor may monitor your kidney function test regularly to prevent any risk of damage to kidneys or unusual effects. Consult your doctor before taking ISMOTAG 5MG.

REFERENCES

1. KD. Tripathi. Antianginal and Other Anti-ischaemic Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 544-545.

2. Thomas Michel and Brian B. Hoffman. Treatment of myocardial ischemia and hypertension. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 747-750 & 752.

3. Gerald G. Briggs and Roger K. Freeman. I. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 2099-2100.

4. Zheng Tan, Xiaoming Shang, Li li, Luobing tian, Yi ma, Yan peng and Lingxi gao. Clinical study of isosorbide mononitrate treatment for angina pectoris in coronary heart disease. NIH: National Library of Medicine, National Center for Biotechnology Information. February 2013. [Accessed on 1st August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628368/

5. Stanley F.Malamed. Daniel L.Orr. Isosorbide Dinitrate. Medical Emergencies in the Dental Office (Seventh Edition). Science Direct. 2015. [Accessed on 1st August 2022] https://www.sciencedirect.com/topics/medicine-and-dentistry/isosorbide-dinitrate

6. Accord. Electronic Medicines Compendium (EMC). [Revised in March 2022] [Accessed on 1st August 2022] https://www.medicines.org.uk/emc/files/pil.5795.pdf

7. Meda Manufacturing GmbH. U.S. Food & Drug Administration. [Revised in January 2015] [Accessed on 1st August 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/012093s052lbl.pdf

USEFUL DIAGNOSTIC TESTS

• Electrocardiogram (ECG)
• Chest x-ray
• Chest CT
• Coronary CT angiography
• Cardiac MRI
• Coronary angiography
• Echocardiogram