INTRODUCTION

IOBRIM contains Brimonidine which are Antiglaucoma agents. These are sterile, preserved, aqueous solution works by reducing pressure within the eyeball. It is used to treat the conditions of glaucoma or ocular hypertension (pressure in the eye). Glaucoma is a condition which damages the optic nerve, the health of which is vital for good vision. It is often caused by an abnormally high pressure in your eye. Ocular hypertension is a condition where the pressure inside the eye is higher than normal. In this condition the front of the eye does not drain aqueous humor (fluid in the eye) properly which causes eye pressure to build up.

Brimonidine has an effective ocular hypotensive effect which occurs at two hours post instillation. It works by reducing aqueous humor (fluid in the eye) production and increasing outflow of aqueous humor (uveoscleral outflow) and thus lowers the eye pressure. This medicine can be used alone or in conjunction with another eye drop that reduces pressure in the eye. It is for external use only. Tell your doctor if you wear contact lenses, before using the medication. It is not recommended for children between the ages of 2 and 12 years of age. The common side effects are allergic reactions, eye irritation and blurred or abnormal vision.

USES OF IOBRIM

• Treats glaucoma and ocular hypertension

HOW IOBRIM WORKS

IOBRIM works by reducing pressure within the eyeball by decreasing the production of aqueous humour (fluid in the eye), thereby lowering the increased eye pressure.

DIRECTIONS FOR USE

Always use as instructed by your doctor. Check the label for directions before use.

SIDE EFFECTS OF IOBRIM

HOW TO MANAGE SIDE EFFECTS

Dizziness or drowsiness:

Get up and move around to feel awake, take small naps to edge off the sleepiness. Give your eyes a break to avoid fatigue and eat a healthy food to boost energy.

Feeling sick (nausea) or indigestion:

Stick to simple normal meals and do not eat rich or spicy foods.

Dry mouth:

Chew sugar free candies to stimulate the flow of saliva. Limit your caffeine intake.

WARNING & PRECAUTIONS

INTERACTIONS

Tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or the following:

• monoamine oxidase (MAO) inhibitors
• tricyclic antidepressants
• sedative, barbiturate, opiates or hypnotic medicines
• chlorpromazine, methylphenidate or reserpine  
• pain killers
• medicines to treat heart condition or for lowering blood pressure
• prazosin and isoprenaline

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT IOBRIM

Does IOBRIM cause pupil dilation?

No, it does not cause pupil dilation. If you experience night vision difficulty, halos and glare. Contact your doctor if you experience these symptoms.

Does IOBRIM cause drowsiness?

Yes, it may cause drowsiness and fatigue which may impair the ability to drive or use machinery. It may also cause blurred or abnormal vision especially at night or in dim light.

How IOBRIM works?

It works by reducing pressure within the eyeball by decreasing the production of aqueous humor (fluid in the eye), thereby lowering the increased eye pressure.

REFERENCES

1. KD Tripathi MD. Drugs acting on ANS. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page - 154.

2. Westfall TC, WestfallIn DP. Adrenergic Agonists and Antagonists. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. Page - 297.

3. Biaggioni I, Robertson D. Adrenoreceptor Agonists & Sympathomimetic Drugs. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. Page - 144.

4. Louis B Cantor. Brimonidine in the treatment of glaucoma and ocular hypertension: Therapeutics and clinical risk management. Dec 2006; [Accessed Dec 3, 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1936355/

5. McLaurin, Eugene, Cavet, Megan E, Gomes, Paul J, Ciolino, Joseph B. Brimonidine Ophthalmic Solution 0.025% for Reduction of Ocular Redness: A Randomized Clinical Trial: OVS optometry and vision sciences. March 2018, Vol – 95, Issue -3 [Accessed Dec 3, 2020] https://journals.lww.com/optvissci/fulltext/2018/03000/brimonidine_ophthalmic_solution_0_025__for.13.aspx

6. FDC International Ltd, Electronic Medicines Compendium (EMC); [Revised Oct 2020] [Accessed Dec 3, 2020] https://www.medicines.org.uk/emc/files/pil.3426.pdf

7. Allergan, 1996; U.S. Food & Drug Administration; [Accessed Dec 3, 2020] https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/020613s031lbl.pdf