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INTRODUCTION
IOBRIM contains Brimonidine which belongs to the group of medicines called Ophthalmic anti-glaucoma agents. It is used to treat ocular hypertension and glaucoma. Ocular hypertension refers to increased pressure within the eye without any significant damage to the optic nerve. Whereas glaucoma is a group of eye condition that causes significant damage to the optic nerve due to elevated pressure within the eye followed by vision loss if left untreated.
Both ocular hypertension and glaucoma are caused due to impaired secretion or drainage of fluids (aqueous humour) within the eyes. Brimonidine reduces the pressure within the eyes by decreasing the production of excessive eye fluids (aqueous humour) while simultaneously increasing their drainage. This reduces strain on the eyes and therefore decreases the elevated pressure within the eye.
Before using IOBRIM inform your doctor if you have any liver, kidney, or heart problems. You must also inform your doctor if you have depression or other types of mental illnesses.
Consult your doctor before using IOBRIM if you are pregnant or think you may be pregnant or breastfeeding. It is not recommended for use in children aged below 12 years due to lack of safety data.
If you wear soft contact lenses, remove the lens before applying IOBRIM and wait for at least 15 minutes before reinsertion. IOBRIM may make your vision blur, therefore be cautious while you drive or operate heavy tools.
The most common side-effect of using IOBRIM are eye redness, burning sensation, eye inflammation and itching, watery eyes, dry mouth, and blurred vision. Consult your doctor if any of these side effect worsens.
USES OF IOBRIM
- Treats ocular hypertension and glaucoma
HOW IOBRIM WORKS
IOBRIM effectively reduces the elevated pressure within the eye, where brimonidine acts by decreasing the production of excessive eye fluids (aqueous humour) while simultaneously increasing their drainage. This reduces strain on the eyes and therefore decreases the elevated pressure within the eye.
DIRECTIONS FOR USE
Use IOBRIM as advised by your doctor. It is for ophthalmic use only. Wash your hands before use. Instil few drops of IOBRIM into the affected eye. Close your eyes and press the corner of your eye with your finger for a minute.
Do not touch the tip of the dropper with your eye or other body surface to avoid contamination. Apply applying IOBRIM, leave a time gap of at least 5 minutes before applying other eye drops or ointment. If you wear soft contact lenses, remove the lens before applying IOBRIM and wait for at least 15 minutes before reinsertion.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop using IOBRIM without consulting your doctor, as the pressure within the eye may raise once again.
SIDE EFFECTS OF IOBRIM
COMMON
- eye redness, itching, burning or stinging sensation
- white spots on the whites of the eye
- blurred vision
- feeling of something in the eye
- headache
- tiredness, weakness
- drowsiness
- dry mouth
- erosion on eye surface, staining
- swollen or red eyelid, abnormal vision, sticky, watery eyes, sensitivity to light
- pain, irritation, whitening of the membrane covering the inside of the eyelid
- inflammation of the cornea (outer layer of the eye)
- nausea, vomiting
- stomach and digestion problems
- cold-like symptoms
- abnormal taste
UNCOMMON
- depression
- palpitations or changes in heart rate
- dry nose
- general allergic reactions
RARE
- shortness of breath
Stop using IOBRIM and contact your doctor immediately if you experience any of the following symptoms:
- severe allergic reaction symptoms of which are difficulty in breathing, swelling of tongue, lips, face, or throat
HOW TO MANAGE SIDE EFFECTS
Eye redness, itching or burning sensation:
Wash your eyes with plain cold water. Place an ice pack on your eye to ease the irritation. Avoid straining your eyes by looking at mobile phones, laptops, or television. Wear protective eyeglasses while going outdoors.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Blurred vision:
Close your eyes and relax. Do not strain your eyes by looking at mobile phones, laptops, or television. Avoid driving or operating any heavy tools or machines while your vision is blur. Consult your doctor if you experience blurred vision for a prolonged period.
WARNING & PRECAUTIONS
PREGNANCY
IOBRIM should be used with caution in pregnant women. Therefore, consult your doctor before using it.
BREASTFEEDING
IOBRIM is not recommended for use in breastfeeding women. Therefore, consult your doctor before using it.
DRIVING AND USING MACHINES
Do not drive or operate any heavy tools or machines if you experience blurred vision, drowsiness or tiredness after using IOBRIM.
ALCOHOL
Avoid the consumption of alcohol while using IOBRIM as it may increase the risk of side effects.
KIDNEY
IOBRIM should be used with caution in patients having kidney diseases.Therefore, consult your doctor before using it.
LIVER
IOBRIM should be used with caution in patients having liver diseases.Therefore, consult your doctor before using it.
ALLERGY
Do not use IOBRIM if you are allergic to Brimonidine.
HEART DISEASE
IOBRIM should be used with caution in patients with heart diseases.Therefore, consult your doctor before using it.
OTHERS
Before using IOBRIM, inform your doctor if you:
- have depression
- have light-headedness or dizziness while standing up
- have reduced blood supply to the brain or reduced mental capacity
- have poor blood circulation or problems in blood vessels supplying the limbs (Ex. deep vein thrombosis)
Use in pediatrics:
IOBRIM can be used in children and adolescents aged between 2-12 years if prescribed by a physician. It is not recommended for use in infants and children aged below 12 years due to lack of safety data. Therefore, consult your doctor before using it.
Use in geriatrics:
IOBRIM should be used with caution in elderly patients. Therefore, consult your doctor before using it.
INTERACTIONS
A. Drug-Drug Interaction:
Before using IOBRIM, inform your doctor if you are taking any of the following:
- medicines used to treat depression such as (Ex. citalopram, escitalopram, fluoxetine, sertraline, amitriptyline, nortriptyline)
- medicines used to induce sleep (Ex. alprazolam, midazolam, phenobarbital)
- medicines used to treat mental illness (Ex. chlorpromazine, methylphenidate, reserpine)
- pain killers (Ex. paracetamol, ibuprofen)
- medicines used to lower blood pressure (Ex. enalapril, ramipril)
- medicines that work similar to brimonidine (Ex. prazosin, isoprenaline)
- anaesthetics (used to induce numbness) Ex. lidocaine
Overdosage:
It is unlikely to have an overdosage of IOBRIM in adults. However, if overdosage occurs in children receiving IOBRIM as a part of their treatment contact your doctor immediately. Symptoms of overdosage might include sleepiness, floppiness, low temperature or breathing difficulties.
SYNOPSIS
| Drug | : | Brimonidine |
| Pharmacological Category | : | Alpha adrenergic receptor agonists |
| Therapeutic Indication | : | Glaucoma |
| Dosage Forms | : | Eye Drops, Ophthalmic Solution, Gel |
MORE INFORMATION
- Keep IOBRIM out of reach of children
- Store IOBRIM at room temperature
FAQs ABOUT IOBRIM
Are there any specific instructions I need to follow while using IOBRIM?
IOBRIM is only meant for ophthalmic use only. Do not touch the tip of the dropper with your eye or other body surface to avoid contamination. Apply applying IOBRIM, leave a time gap of at least 5 minutes before applying other eye drops or ointment. If you wear soft contact lenses, remove the lens before applying IOBRIM and wait for at least 15 minutes before reinsertion.
What if I miss a dose of IOBRIM?
If you missed a dose of IOBRIM, apply it as soon as you remember. However, if it is time for next dose, skip the missed dose and use the regular dose. Do not use a double dose of IOBRIM to compensate the missed dose.
Can IOBRIM cause blurred vision?
Yes. IOBRIM may cause blurred vision after application. If you experience blurred vision, close your eyes and relax. Do not strain your eyes by looking at mobile phones, laptops, or television. Avoid driving or operating any heavy tools or machines while your vision is blur. Consult your doctor if your condition did not improve.
What is the use of IOBRIM?
IOBRIM is used to treat ocular hypertension and glaucoma. It decreases the elevated pressure within the eye and reduces the risk of optic nerve damage and subsequent vision loss.
What type of drug is [GBNKEYWORD]?
IOBRIM contains Brimonidine which is an alpha-adrenergic receptor agonist. treat ocular hypertension and glaucoma. It decreases the elevated pressure within the eye and reduces the risk of optic nerve damage and subsequent vision loss.
Who should not take [GBNKEYWORD]?
Do not take IOBRIM if you are allergic to brimonidine. Inform your doctor if you are pregnant or breastfeeding before using IOBRIM. It is not suitable for use in children aged below 12 years. Patients taking antidepressants must consult their doctor before taking IOBRIM.
How long do you take IOBRIM?
Take IOBRIM as advised by your doctor. IOBRIM is usually taken as long-term therapy along with other medicines to treat glaucoma. Therefore, take it as long as prescribed by your doctor. Do not stop taking IOBRIM without consulting your doctor.
Can I stop using IOBRIM without consulting my doctor?
Do not stop using IOBRIM without consulting your doctor. If you think that you are feeling better or if you wish to stop using IOBRIM, contact your doctor for advice. Your doctor will check your condition and gradually withdraw the use of IOBRIM.
Can I use other eye medicines while using IOBRIM?
Yes. You can use other eye medicines while undergoing therapy with IOBRIM. But make sure to leave a time gap of at least 5 minutes before applying other eye drops or ointment.
Can I use IOBRIM while wearing contact lenses?
If you wear soft contact lenses, remove the lens before applying IOBRIM and wait for at least 15 minutes before reinsertion.
Is [GBNKEYWORD] a beta blocker?
No. IOBRIM is not a beta blocker. IOBRIM contains Brimonidine which belongs to the group of medicines called Alpha adrenergic receptor agonists. It is used to treat ocular hypertension and glaucoma.
Can we drink alcohol while using [GBNKEYWORD]?
No, you should not drink alcohol while using IOBRIM as it may increase the risk of side effects.
REFERENCES
1. KD. Tripathi. Anti-Adrenergic Drugs Acting on ANS. Essentials of medical pharmacology. Seventh edition. 2013. Page – 154.
2. Louis B Cantor. Brimonidine in the treatment of glaucoma and ocular hypertension. NIH. National Library of Medicine, National center for biotechnology information. Pubmed central. December 2006. [Accessed on 14th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1936355/
3. FDC International Ltd. Electronic Medicines Compendium (EMC). [Revised in October 2020]. [Accessed on 13th May 2022] https://www.medicines.org.uk/emc/files/pil.3426.pdf
4. Allergan, Inc. US Food and Drug Administration (USFDA). [Revised in May 2010]. [Accessed on 13th May 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021262s020,021770s004lbl.pdf
5. Allergan New Zealand Ltd. [Revised in Feb 2013]. [Accessed on 13th May 2022] https://allergan-web-cdn-prod.azureedge.net/allergan/allergannewzealand/media/allergannewzealand/products/alphagan-p-nz-ds.pdf
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