INVISTA 100mg Tablet 10's

INTRODUCTION

INVISTA 100MG TABLET contains Dasatinib which belongs to the group of medicines called Tyrosine Kinase Inhibitor. It is used to treat cancers of blood and bone marrow (such as chronic myeloid leukaemia (CML) or Philadelphia chromosome positive (Ph+) acute lymphoblastic leukaemia) in adults, adolescents and in children (aged 1 year or above).

It is primarily used in patients when treatment with conventional therapies is not suitable or fails to provide adequate response.

Leukaemia is the cancer of blood cells. It is caused due to abnormal growth and multiplication of blood cells within the bone marrow. It is characterized by severe tiredness, breathlessness, increased bleeding tendency, tiredness, anemia, night sweats, fever, chills, frequent infections and weight loss.

During treatment with INVISTA 100MG TABLET your doctor will closely monitor your health condition through several blood tests to avoid the risk of unwanted side effects. Avoid eating grapefruit or drinking grapefruit juice while taking INVISTA 100MG TABLET as it may increase the risk of side effects.

Before taking INVISTA 100MG TABLET inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have or at risk of developing hepatitis C infection as a precaution.

Avoid concomitant use of antacids or any stomach medicines along with INVISTA 100MG TABLET. Leave a time gap of at least 2 hours between the medicines. INVISTA 100MG TABLET is not recommended for use in pregnant or breastfeeding women.

Men and women taking INVISTA 100MG TABLET must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with INVISTA 100MG TABLET.

The most common side effects of taking INVISTA 100MG TABLET are increased bleeding tendency, increased infections, feeling tired or weak, nausea, vomiting, hair loss, mouth ulcers, changes in taste, inflammation of the food pipe or stomach, muscle pain or spasm, skin rashes, headache, dizziness and weight loss. Contact your doctor if any of these side effect worsens.

USES OF INVISTA 100MG TABLET

It is used in adults, adolescents and in children (aged 1 year or above) to treat:

• Cancers of blood and Bone marrow (such as chronic myeloid leukaemia or (Ph+) acute lymphoblastic leukaemia)

HOW INVISTA 100MG TABLET WORKS

INVISTA 100MG TABLET is an anti-cancer medicine. It works by blocking the actions of certain proteins (such as BCR-ABL, Src kinase, etc.) in the body that triggers cancer formation. As a result, it reduces abnormal growth and multiplication of cancer cells in the body.

DIRECTIONS FOR USE

Take INVISTA 100MG TABLET as advised by your physician. It can be taken with or without meals. Swallow the medicine with a glass of water. Do not crush or chew the medicine.

Try to take INVISTA 100MG TABLET at the same time each day. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition. Do not stop taking INVISTA 100MG TABLET unless advised by your doctor.

SIDE EFFECTS OF INVISTA 100MG TABLET

HOW TO MANAGE SIDE EFFECTS

Skin rash:

Avoid hot showers because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. Consult your doctor if your skin rash worsens.

Headache:

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Consult your doctor if your headache worsens.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Consult your doctor if your dizziness worsens.

Nausea and Vomiting:

Stick to simple meals. Avoid eating oil rich or spicy foods. If your nausea worsens, consult your doctor for advice.

Mouth ulcers:

Avoid eating spicy foods. Drink plenty of water. Apply a pain-relieving gel on the affected areas of the mouth if required. Consult your doctor if the symptom did not improve.

Diarrhoea:

Drink lots of fluids, such as water to keep yourself hydrated. Try to avoid taking any medicine on your own to treat diarrhoea and consult your doctor if the symptom gets worse.

Constipation:

Try to eat more high-fibre foods such as fresh fruit, vegetables, cereals and drink plenty of water. Try doing exercise regularly (going for a daily walk or run). If this does not help, inform your doctor for receiving alternate treatments for constipation.

WARNING & PRECAUTIONS

PREGNANCY

INVISTA 100MG TABLET is not recommended for use in pregnant women unless considered necessary by the physician. Therefore, inform your doctor before taking INVISTA 100MG TABLET if you are pregnant or think you may be pregnant. Women of childbearing potential must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with INVISTA 100MG TABLET.

BREASTFEEDING

INVISTA 100MG TABLET is not recommended for use in breastfeeding women as it may pass through the breast milk. Therefore, consult your doctor taking it.

DRIVING AND USING MACHINES

Do not drive or operate any heavy tools or machines if you feel dizzy after taking INVISTA 100MG TABLET.

ALCOHOL

Avoid consumption of alcohol while taking INVISTA 100MG TABLET as it could make you feel dizzier.

KIDNEY

INVISTA 100MG TABLET should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it.

LIVER

INVISTA 100MG TABLET should be used with caution in patients with liver problems. Therefore, consult your doctor before taking it.

ALLERGY

Do not take INVISTA 100MG TABLET if you are allergic to Dasatinib.

HEART DISEASE

INVISTA 100MG TABLET should be used with caution in patients with heart problems. Therefore, consult your doctor before taking it.

INTERACTIONS

A. Drug-Drug Interactions:

Before taking INVISTA 100MG TABLET, inform your doctor, if you are taking any of the following medicines such as:

• medicines used for blood thinning (Ex. warfarin)
• ketoconazole, itraconazole (used to treat fungal infection)
• medicines used to treat bacterial infection (such as erythromycin, clarithromycin, telithromycin)
• ritonavir (a medicine used to treat HIV infection)
• medicines used to treat epilepsy (Ex. phenytoin, carbamazepine, phenobarbital)
• rifampicin (a medicine used to treat tuberculosis)
• medicines used to treat stomach ulcers (such as famotidine, omeprazole)
• St. John’s wort (an herbal preparation used to treat depression)
• antacids (used to neutralize stomach acids) Ex. aluminium hydroxide or magnesium hydroxide

B. Drug-Food Interactions:

Avoid eating grapefruit or drinking grapefruit juice while taking INVISTA 100MG TABLET as it may increase the risk of side effects.

Overdosage:

If you or anyone else accidentally took more INVISTA 100MG TABLET, consult your doctor immediately or visit the nearby hospital.

SYNOPSIS

MORE INFORMATION

• Keep INVISTA 100MG TABLET out of reach of children
• Store INVISTA 100MG TABLET at room temperature

FAQs ABOUT INVISTA 100MG TABLET

What INVISTA 100MG TABLET is used for?

INVISTA 100MG TABLET is used to treat cancers of blood and bone marrow (such as chronic myeloid leukaemia (CML) or Philadelphia chromosome positive (Ph+) acute lymphoblastic leukaemia) in adults, adolescents and in children (aged 1 year or above). It is primarily used in patients when treatment with conventional therapies is not suitable or fails to provide adequate response.

How INVISTA 100MG TABLET works on my body?

INVISTA 100MG TABLET is an anti-cancer medicine. It works by blocking the actions of certain proteins (such as BCR-ABL, Src kinase, etc.) in the body that triggers cancer formation. As a result, it reduces abnormal growth and multiplication of cancer cells in the body.

Can INVISTA 100MG TABLET cure cancer?

The cure rate of cancer depends upon the severity of the disease. However, INVISTA 100MG TABLET acts by preventing the abnormal growth and multiplication of cancer cells in the body, which may help in curing cancer completely.

Can the use of INVISTA 100MG TABLET cause hair loss?

Hair loss is one of the common side effects of taking INVISTA 100MG TABLET. If it bothers you, consult your doctor for advice.

Can the use of INVISTA 100MG TABLET cause mouth ulcers?

Mouth ulcers are one of the common side effects of taking INVISTA 100MG TABLET. Avoid eating spicy foods. Drink plenty of water. Apply a pain-relieving gel on the affected areas of the mouth if required. Consult your doctor if the symptom did not improve.

Can INVISTA 100MG TABLET be used in children?

INVISTA 100MG TABLET can be used in children and adolescents (aged 1 year or above) if prescribed by the physician. It should not be used in children aged below 1 year due to increased risk of side effects.

Is INVISTA 100MG TABLET a chemo drug?

Yes. INVISTA 100MG TABLET contains a medicine called Dasatinib which is a chemotherapeutic agent. It stops abnormal growth and multiplication of cancer cells in the body.

What happens if I forgot to take a dose of INVISTA 100MG TABLET?

If you forgot to take a dose of INVISTA 100MG TABLET, take it as soon as you remember. However, if it is time for the next dose of INVISTA 100MG TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of INVISTA 100MG TABLET to compensate the missed ones.

What precautions must be followed while taking INVISTA 100MG TABLET?

Before taking INVISTA 100MG TABLET inform your doctor if you have any liver, kidney or heart problems or if you have or at risk of developing hepatitis C infection as a precaution. Avoid eating grapefruit or drinking grapefruit juice while taking INVISTA 100MG TABLET. Leave a time gap of at least 2 hours between INVISTA 100MG TABLET and stomach medicines. Inform your doctor before taking INVISTA 100MG TABLET if you are pregnant or breastfeeding women. Men and women taking INVISTA 100MG TABLET must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with INVISTA 100MG TABLET.

Will taking a higher dose of INVISTA 100MG TABLET be more effective?

No, taking a higher dose of INVISTA 100MG TABLET will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.

What happens if I stop taking INVISTA 100MG TABLET?

No. Do not stop taking INVISTA 100MG TABLET without consulting your doctor as it may make your symptoms reappear. Therefore, take INVISTA 100MG TABLET as advised by your doctor for the stipulated duration.

Can INVISTA 100MG TABLET be used during pregnancy?

INVISTA 100MG TABLET is not recommended for use in pregnant women unless considered necessary by the physician. Therefore, inform your doctor before taking INVISTA 100MG TABLET if you are pregnant or think you may be pregnant.

Can the use of INVISTA 100MG TABLET make me feel tired?

Yes. INVISTA 100MG TABLET may make you feel tired easily. This is because, it reduces the levels of red blood cells in your blood and may make you anaemic. Consult your doctor if you experience tiredness after taking INVISTA 100MG TABLET. Tiredness can also occur if you have any pre-existing disease conditions such as liver or kidney impairment while taking this medicine.

Can I drive a car after taking INVISTA 100MG TABLET?

INVISTA 100MG TABLET may make you feel tired or dizzy. Therefore, do not drive or operate any heavy tools or machines if your ability is affected by INVISTA 100MG TABLET.

How to take INVISTA 100MG TABLET?

Take INVISTA 100MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. INVISTA 100MG TABLET can be taken with or without food.

How to control nausea caused due to INVISTA 100MG TABLET?

Generally, anticancer medicines are associated with uncontrollable nausea and vomiting. To avoid this, your doctor would prescribe a suitable medicine to control them along with INVISTA 100MG TABLET. If not, consult your doctor for a suitable anti-emetic medicine. Do not self-treat nausea.

What are the side effects of taking INVISTA 100MG TABLET?

The most common side effects of taking INVISTA 100MG TABLET are increased bleeding tendency, increased infections, feeling tired or weak, nausea, vomiting, hair loss, mouth ulcers, changes in taste, inflammation of the food pipe or stomach, muscle pain or spasm, skin rashes, headache, dizziness and weight loss. Contact your doctor if any of these side effect worsens.

Who should avoid taking INVISTA 100MG TABLET?

INVISTA 100MG TABLET is not recommended for use if you are allergic to dasatinib. It is also not recommended for use in pregnant or breastfeeding women and in children (aged below 1 year).

Is INVISTA 100MG TABLET safe to use in kidney disease?

INVISTA 100MG TABLET should be used with caution in patients with kidney problems. Your doctor will access your health condition and suggest a suitable dose for you.

Can the use of INVISTA 100MG TABLET affect the liver?

Yes. INVISTA 100MG TABLET may affect the way your liver work. It can elevate the levels of certain liver enzymes in your body. Therefore, it should be used with caution in patients with liver problems. Consult your doctor before taking it.

REFERENCES

1. Laurence Brunton. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies and Cytokines. Goodman and Gillman’s: The Pharmacological Basics of Therapeutics. Twelfth Edition. 2011. Page – 1732-1734.

2. Dilek Keskin, Sevil Sadri, Ahmet Emre Eskazan. Dasatinib for the treatment of chronic myeloid leukemia: patient selection and special considerations. NIH National Library of Medicine. National Centre for Biotechnology Information. PMC PubMed Central. October 2016. [Assessed on 10th November 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066856/

3. Zentiva Pharma UK Limited. Electronic Medicines Compendium (EMC). [Revised in May 2022]. [Accessed on 10th November 2022] https://www.medicines.org.uk/emc/files/pil.10921.pdf

4. Bristol-Myers Squibb Pharma EEIG. Electronic Medicines Compendium (EMC). [Revised in March 2022]. [Accessed on 10th November 2022] https://www.medicines.org.uk/emc/files/pil.3958.pdf

5. Bristol-Myers Squibb Canada. SPRYCEL. [Revised in November 2021] [Assessed on 10th November 2022] https://www.bms.com/assets/bms/ca/documents/productmonograph/SPRYCEL_EN_PM.pdf

AUTHOR DETAILS

Written By Srilekha. R, B.Pharm
Last updated on 12 Nov 2022 | 10:44 AM(IST)