INTRODUCTION
INVEGA SUSTENNA 75MG contain paliperidone which belongs to a group of medicine called antipsychotics. It is used as a maintenance treatment for the symptoms of schizophrenia in adult patients. Schizophrenia is a disorder characterised by symptoms such as hearing, seeing or sensing thing that are not present, unusual suspiciousness, becoming withdrawn, incoherent speech, and behaviour and emotional changes. People with this disorder can also feel depressed, anxious, guilty, or tensed. It works by affecting the levels of chemical messengers (dopamine and serotonin) to improve mood, thoughts and behaviour.
INVEGA SUSTENNA 75MG will be administered by a doctor or nurse. It will be given as an injection into upper arm or buttocks. It is not recommended for use in children and adolescents under 18 years. Do not drive or operate any machine while taking this medicine since it may cause dizziness, extreme tiredness, and vision problems. Before taking this medicine tell your doctor if you have ever had kidney disease, heart disease, liver problems. Pregnant and breastfeeding women should consult their doctor before taking this medicine. The most common side effects are dizziness, sleepiness, tremor, injection site reactions (including itching, pain or swelling).
USES OF INVEGA SUSTENNA 75MG
- Used as a maintenance treatment for the symptoms of schizophrenia in adult patients
HOW INVEGA SUSTENNA 75MG WORKS
INVEGA SUSTENNA 75MG works by affecting the levels of chemical messengers (dopamine and serotonin) to improve mood, thoughts and behavior.
DIRECTIONS FOR USE
INVEGA SUSTENNA 75MG will be administered by a doctor or nurse. It will be given as an injection into upper arm or buttocks. Your doctor will decide the dose and frequency depending on your condition.
SIDE EFFECTS OF INVEGA SUSTENNA 75MG
SERIOUS
- blood clots in the veins, especially in the legs
- dementia
- muscle stiffness, sweating or a lowered level of consciousness (Neuroleptic Malignant Syndrome)
- prolonged or painful erection(priapism)
- involuntary rhythmic movements of the tongue, mouth, and face
- severe allergic reaction (fever, swollen mouth, face, lip or tongue, shortness of breath, itching, skin rash and sometimes drop in blood pressure)
- are planning to have an operation on your eye
- low number of a certain type of white blood cell
COMMON
- difficulty falling or staying asleep
- common cold symptoms, urinary tract infection
- high prolactin (symptoms includes breast swelling, difficulty in getting or maintaining erections, or other sexual dysfunction (in women) breast discomfort, leakage of milk from the breasts, missed menstrual periods, or other problems with your cycle)
- high blood sugar, weight gain, weight loss, decreased appetite
- irritability, depression, anxiety
- parkinsonism
- restlessness, sleepiness, or less alert
- dystonia
- dizziness
- dyskinesia
- tremor, headache
- rapid heart rate, high blood pressure
- cough, stuffy nose
- abdominal pain, vomiting, nausea, constipation, diarrhoea, indigestion, toothache
- increased liver transaminases in your blood
- bone or muscle ache, back pain, joint pain
- loss of menstrual periods
- fever, weakness, fatigue (tiredness)
- injection site reactions (including itching, pain or swelling)
RARE
- eye infection
- skin inflammation
- increase in eosinophils in your blood
- inappropriate secretion of a hormone
- sugar in the urine
- uncontrolled diabetes
- low blood sugar
- excessive drinking of water
- confusion
- sleep walking
- lack of emotion
- inability to reach orgasm
- blood vessel problems in the brain, including sudden loss of blood supply to brain (stroke or mini stroke), unresponsive to stimuli, loss of consciousness, low level of consciousness, convulsion (fits), balance disorder
- abnormal coordination
HOW TO MANAGE SIDE EFFECTS
Dizziness:
Get up and move around to feel awake, take small naps to edge off the sleepiness. Give your eyes a break to avoid fatigue and eat a healthy food to boost energy.
Headache:
Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.
Abdominal pain:
Try to rest and relax. Eat and drink slowly or have smaller and frequent meals. Applying heat pad or covered hot water bottle on your stomach may also help. If still pain persists, speak to your doctor.
Nausea and vomiting:
Try taking this medicine with, or just after, a meal or snack and stick to simple meals and do not eat rich or spicy food.
Constipation:
Take fibre rich foods such as fresh fruit, vegetables and cereals, and drink plenty of water. Exercise more regularly.
Diarrhoea:
Drink lot of fluid such as water or squash, to avoid dehydration. Do not take any other medicines without talking to a doctor.
WARNING & PRECAUTIONS
PREGNANCY
INVEGA SUSTENNA 75MG is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.
BREASTFEEDING
INVEGA SUSTENNA 75MG is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.
DRIVING AND USING MACHINES
Do not drive or operate any machine while taking this medicine since it may cause dizziness, extreme tiredness, and vision problems.
ALCOHOL
Consumption of alcohol is not recommended during treatment with INVEGA SUSTENNA 75MG.
KIDNEY
INVEGA SUSTENNA 75MG should be used with caution in patients suffering from active kidney diseases. Consult your doctor for advice.
LIVER
INVEGA SUSTENNA 75MG should be used with caution in patients suffering from liver function impairment or active liver diseases. Consult your doctor for advice.
ALLERGY
Do not take INVEGA SUSTENNA 75MG if you are allergic (hypersensitive) to paliperidone or any other ingredients in this medicine.
HEART DISEASE
INVEGA SUSTENNA 75MG should be used with caution in patients suffering from active heart diseases. Consult your doctor for advice.
OTHERS
Tell your doctor if you have or had a condition such as,
- parkinson’s disease
- high temperature and muscle stiffness (Neuroleptic Malignant Syndrome)
- abnormal movements of the tongue or face (Tardive dyskinesia)
- low levels of white blood cells in the past
- breast cancer or a tumour in the pituitary gland in your brain
- epilepsy
- prolonged and/or painful erection
- problems with controlling core body temperature or overheating
- an abnormally high level of the hormone prolactin in your blood or have a possible prolactin-dependent tumour
- family history of blood clots
INTERACTIONS
Talk to your doctor if you are taking,
- anti-epileptic and mood stabiliser such as carbamazepine
- psychiatric medications, opioids, antihistamines, and sleep medication
- medicines used to treat lower blood pressure
- levodopa (used to treat parkinson’s disease and restless legs)
- medicines used to treat the rhythm of the heart or to treat infection
- medicines used to treat depression
- psychostimulants such as methylphenidate (increase the activity of the central nervous system)
SYNOPSIS
| Drug | : | Paliperidone |
| Pharmacological Category | : | Second Generation (Atypical) Antipsychotic agent |
| Therapeutic Indication | : | Schizophrenia |
| Dosage Forms | : | Tablet, Injection |
MORE INFORMATION
Store below 20-25°C and keep out of reach of children.
FAQs ABOUT INVEGA SUSTENNA 75MG
Does INVEGA SUSTENNA 75MG cause weight gain?
Yes, this medicine is known to cause weight gain.
Does INVEGA SUSTENNA 75MG cause erectile dysfunction?
It may cause priapism (prolonged and/or painful erection) which may contribute to erectile dysfunction. Please follow your doctor's advice regarding its use.
Can INVEGA SUSTENNA 75MG cause Constipation?
Yes, this medicine may cause constipation in some individuals. Take fibre rich foods such as fresh fruit, vegetables and cereals, and drink plenty of water. Exercise more regularly.
REFERENCES
1. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page – 2940-2943.
2. Joshua Kantrowitz1 and Leslie Citrome1,2. Paliperidone: the evidence of its therapeutic value in schizophrenia. US National Library of Medicines, National Institutes of Health. 31 Jul 2008. [Accessed 03 Dec 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012441/
3. Janssen Pharmaceutica NV; Electronic Medicines Compendium (EMC); [Revised on Sep 2018] [Accessed 03 Dec 2020] https://www.medicines.org.uk/emc/files/pil.7652.pdf
PRODUCT DETAILS
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