INSTAFLEX D contains Diclofenac which belongs to a group of medicines known as non-steroidal anti-inflammatory drugs (NSAIDs). It is indicated for treatment of mild to moderate acute pain in adults. Diclofenac is a NSAID which exhibits anti-inflammatory analgesic and antipyretic activities. It involves inhibition of cyclooxygenase (COX-1 and COX-2) and it is a potent inhibitor of prostaglandin synthesis in vitro. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain and mediators of inflammation. Diclofenac is an inhibitor of prostaglandin synthesis, its mode of action may be due to a decrease of prostaglandins in peripheral tissues.
Always take INSTAFLEX D exactly as directed by your doctor. Before taking this medicine, tell your doctor if you have liver, kidney or heart problems, are pregnant or breastfeeding. The common side effects are edema, nausea, headache, vomiting and constipation.
INSTAFLEX D works by blocking the action of enzyme cyclooxygenase, which is required for the biosynthesis of prostaglandins.
Always take INSTAFLEX D exactly as your doctor has told you. Swallow this medicine with a glass of water and do not crush or chew. It can be taken with or without food.
Nausea:
Stick to simple normal meals and do not eat rich or spicy foods.
Headache:
Rest and drink plenty of fluids. Apply a cold, wet cloth or ice pack to your forehead. Rest in a quiet, comfortable, dark room.
Dizziness:
Get up and move around to feel awake, take small naps to edge off the sleepiness. Give your eyes a break to avoid fatigue and eat a healthy food to boost energy.
Vomiting:
Drink clear or ice-cold drinks. Eat light, bland foods and avoid fried, greasy, or sweet foods.
Constipation:
Add fruits, vegetables whole grains and other high-fiber foods to your normal diet.
INSTAFLEX D is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.
INSTAFLEX D is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.
INSTAFLEX D is not recommended in patients with severe kidney failure or any active kidney diseases. Discuss the risks and benefits with your doctor.
INSTAFLEX D is not recommended in patients with liver failure or any other active liver diseases. Discuss the risks and benefits with your doctor.
Tell your doctor if you are allergic (hypersensitive) to Diclofenac.
INSTAFLEX D is not recommended in patients with severe heart failure, cerebrovascular disease or any other active heart diseases. Discuss the risks and benefits with your doctor.
Inform your doctor if you have or had,
Inform your doctor if you are using or have recently taken any other medicines, including medicines obtained without a prescription or the following,
Drug | : | Diclofenac |
Pharmacological Category | : | Analgesic, Nonopioid, Nonsteroidal Anti-inflammatory Drug (NSAID) |
Therapeutic Indication | : | Osteoarthritis, Rheumatoid arthritis, Ankylosing spondylitis, |
Dosage Forms | : | Capsule, Tablet, Injection, Oral solution |
Store below 20-25°C and keep out of reach of children.
Can INSTAFLEX D be used during pregnancy?
It is not recommended during pregnancy and may be prescribed in pregnant women only if the benefits outweigh the risks involved with its use in pregnant women.
Is INSTAFLEX D safe?
Yes, it is safe if administered by your doctor. However, tell your doctor if you have any heart diseases, because it may raise the risk of heart and blood vessel problems.
What if I miss a dose of INSTAFLEX D?
Always take your missed dose as soon as you remember, unless it’s almost time for your next one. Do not take double doses to make up for it.
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2. Grosser T, Smyth E, FitzGerald GA. Anti-Inflammatory, Antipyretic, and Analgesic Agents; Pharmacotherapy of Gout. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. Page: 986-987.
3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page: 295-297.
4. R. Andrew Moore and Sheena Derry. Diclofenac Potassium in Acute Postoperative Pain and Dysmenorrhoea: Results from Comprehensive Clinical Trial Reports. Jan 17, 2018; [Accessed on Jan 21, 2021]
5. Iroko Pharmaceuticals, LLC 1988, U.S. Food & Drug Administration; [Revised on Oct, 2013] [Accessed on Jan 21, 2021] https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/204592s000lbl.pdf
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