INTRODUCTION

INSTADEC contains Nandrolone decanoate which belongs to the group of medicines known as anabolic steroids. It is indicated to treat osteoporosis (loss of bone tissue), certain types of anaemia, breast cancer (in women) and patients on long term corticosteroids. It helps to rebuild tissues that have become weak because of continuing illness or serious injury and used to increase lean body mass in the case of negative nitrogen balance. It can also be used to increase bone mass and stimulate the formation of red blood cells in the bone marrow.  

Nandrolone is an anabolic steroid occurs in the human body, which increases production and urinary excretion of erythropoietin, also have a direct action on bone marrow. It binds to the androgen receptor to a greater degree than testosterone, but due to its inability to act on the muscle in ways unmediated by the receptor, has less overall effect on muscle growth. Nandrolone is an androgen receptor agonist which bounds to the receptor complexes that allows it to enter the nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA. 

Before receiving this medicine, tell your doctor if you have liver, kidney or heart problems, are pregnant or breastfeeding. This medicine is not recommended for children below 3 years of age. The common side effects are pain at the injection site, nausea, rash and itching.

USES OF INSTADEC

Treats,

• osteoporosis (loss of bone tissue)
• certain types of anaemia
• breast cancer (in women)
• patients on long term corticosteroids

HOW INSTADEC WORKS

INSTADEC is an androgen receptor agonist that bounds to the receptor complexes which allows it to enter the nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA.

DIRECTIONS FOR USE

INSTADEC should only be given by your doctor or a nurse. It will be administered deeply into a muscle (in the buttock, upper leg or upper arm).

SIDE EFFECTS OF INSTADEC

HOW TO MANAGE SIDE EFFECTS

Nausea:

Stick to simple normal meals and do not eat rich or spicy foods.

WARNING & PRECAUTIONS

INTERACTIONS

Inform your doctor if you are using or have recently taken any other medicines, including medicines obtained without a prescription or the following,

• insulin (used to control blood sugar levels)
• erythropoietin (used to reduce anemia)
• anti-coagulants (used to treat blood clot)
• hormone ACTH or corticosteroids (used to treat conditions such as rheumatism, arthritis, allergic conditions and asthma)

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT INSTADEC

Is INSTADEC safe?

It is safe if used as directed by your doctor.

Can INSTADEC administer for children?

This medicine is not recommended for use in children under 3 years of age.

Can INSTADEC be used during pregnancy?

 It is not recommended if you are trying to pregnant or pregnant. Consult your doctor for advice.

REFERENCES

1. KD Tripathi MD. Hormones and related drugs. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page – 300.

2. Francesco P. Busardò, Paola Frati, Mariantonia Di Sanzo, Simona Napoletano, Enrica Pinchi, Simona Zaami and Vittorio Fineschi. The Impact of Nandrolone Decanoate on the Central Nervous System. Current Neuropharmacology. Jan 2015; [Accessed on Jan 22, 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462037/  

3. Merck Sharp & Dohme Ltd.  July 2013; [Accessed on Jan 22, 2021] https://www.nps.org.au/assets/medicines/7776844b-1932-4292-8886-a53300fee6aa-reduced.pdf

4. Aspen Pharma Trading Limited, Electronic Medicines Compendium (EMC); [Revised April 2019] [Accessed on Jan 22, 2021] https://www.medicines.org.uk/emc/files/pil.5374.pdf

USEFUL DIAGNOSTIC TESTS

• Calcium