Imat 400mg Tablet 10'S

Cancer/Oncology Rx required
OUT OF STOCK

Best Price*  ₹ 1,479.24
MRP ₹1,849.05
(Inclusive of all taxes) *10 Tablet(s) in a Strip * Mkt: Biochem Pharmaceutical Industries Ltd * Country of Origin: India * Delivery charges if applicable will be applied at checkout



INTRODUCTION

IMAT contains Imatinib mesylate which belongs to a group of medicines called corticosteroids which reduces infl­ammation. It is indicated to treat chronic myeloid leukaemia and Philadelphia chromosome positive acute lymphoblastic leukaemia in adults and children.

Leukaemia is a cancer of white blood cells, the cells usually help the body to fight infection. IMAT also used to treat myelodysplastic/myeloproliferative diseases, hypereosinophilic syndrome (HES) and/or chronic eosinophilic leukaemia, gastrointestinal stromal tumours and dermatofibrosarcoma protuberans in adults. Tyrosine kinases are proteins which act as chemical messengers that are used by the cancer cells to signal to each other for their growth. This medicine works by blocking this enzyme and stops the cancer cells from growing.

Take this medicine according to the dose and frequency as advised by your doctor. Swallow whole with a large glass of water. It can be taken with food. The common side effects are fluid retention, weight gain. Before taking this medicine tell your doctor if you have kidney, liver or heart problems. It is not recommended during pregnancy and breastfeeding.

USES OF IMAT

  • Chronic myeloid leukaemia
  • Philadelphia chromosome positive acute lymphoblastic leukaemia
  • Myelodysplastic/myeloproliferative diseases
  • Hypereosinophilic syndrome (HES) and/or chronic eosinophilic leukaemia
  • Gastrointestinal stromal tumours
  • Dermatofibrosarcoma protuberans

HOW IMAT WORKS

IMAT is a protein-tyrosine kinase inhibitor. Tyrosine kinases are proteins which act as chemical messengers that are used by the cancer cells to signal to each other for their growth. Imatinib mesylate by blocking this enzyme stops the cancer cells from growing.

DIRECTIONS FOR USE

Take this medicine according to the dose and frequency as advised by your doctor. Swallow whole with a large glass of water. It can be taken with food.

SIDE EFFECTS OF IMAT

COMMON

  • rapid weight gain (severe fluid retention)
  • fever, severe chills
  • sore throat
  • mouth ulcers
  • unexpected bleeding or bruising

WARNING & PRECAUTIONS

PREGNANCY

IMAT is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.

BREASTFEEDING

IMAT is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.

DRIVING AND USING MACHINES

Do not drive or operate machinery while taking this medicine, since it may cause dizziness, drowsiness or blurred vision.

KIDNEY

IMAT should be used with caution in patients suffering from active kidney diseases. Consult your doctor for advice.

LIVER

IMAT should be used with caution in patients suffering from liver function impairment or active liver diseases. Consult your doctor for advice.

ALLERGY

Do not take if you are allergic (hypersensitive) to Imatinib.

HEART DISEASE

IMAT should be used with caution in patients suffering from active heart diseases. Consult your doctor for advice.

OTHERS

Inform your doctor if you have,

  • hepatitis B infection

INTERACTIONS

Inform your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or the following,

  • levothyroxine
  • paracetamol
  • herbal medicines (St. John’s Wort)
  • medicines used to prevent the formation of blood clots

SYNOPSIS

Drug :   Imatinib
Pharmacological Category :   Antineoplastic Agent, BCR-ABL Tyrosine Kinase Inhibitor
Therapeutic Indication :   Leukemia, Gastrointestinal stromal tumors
Dosage Forms :   Tablet

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT IMAT

Can use IMAT during pregnancy?

This medicine is not recommended during pregnancy, or if you are planning to get pregnant.

Does IMAT safe while driving?

Do not drive or operate any machines since it may cause dizziness, drowsiness or blurred vision

What causes chronic myeloid leukaemia?

It is caused by a genetic change in the stem cells produced by the bone marrow which causes the stem cells to produce too many underdeveloped white blood cells.

REFERENCES

1. KD Tripathi MD. Chemotherapy of neoplastic diseases: Anticancer Drugs. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page – 869.

2. Chabner BA, Barnes J, Neal. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. Page: 1732-1734.

3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page: 692-694.

4. Nida Iqbal & Naveed Iqbal. Imatinib: A Breakthrough of Targeted Therapy in Cancer; May 19, 2014 [Accessed Nov 6 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055302/

5. Novartis Limited, 7 Nov 2001; [Revised 7 Nov 2006] [Accessed Nov 6, 2020] https://www.ema.europa.eu/en/documents/product-information/glivec-epar-product-information_en.pdf

6. Novartis Pharmaceuticals Corporation; U.S. Food & Drug Administration [Accessed Nov 6, 2020] https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/021588s009lbl.pdf

USEFUL DIAGNOSTIC TESTS

  • Bcr-Abl Gene Translocation  
  • Bcr-Abl Gene Translocation  
  • Complete Blood Count
  • Peripheral Smear Examination

PRODUCT DETAILS

    Net Qty
    1
    Item Weight
    17.5
    Ingredient
    IMATINIB MESYLATE 400MG
    Hsn Code
    30049039
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