INTRODUCTION

HYAL ORAL contains Sodium hyaluronate which belongs to the group of medicine called viscoelastic supplements. It is used in the treatment of osteoarthritis in patients who have failed to respond adequately to simple analgesics and conservative non-pharmacologic therapy. Osteoarthritis is a degenerative bone disease characterized by severe chronic pain in joints of the hands, neck, lower back, knees or hips. It is caused due to gradual wearing down of cartilage (protective tissue at the ends of bones) and the underlying bone.

Sodium hyaluronate reduces inflammation caused by wearing of bones and cartilages in osteoarthritic joints. It also lubricates the joints and induces the growth of new cartilage and bone tissue in the affected area. People taking HYAL ORAL or any other visco-supplementation should be advised to avoid any prolonged (for more than an hour) or strenuous activities (like lifting heavy weights, running, jumping).

HYAL ORAL is generally safe and does not cause any side effects. However, if you experience any unusual side effects after taking this medicine, inform your doctor. This medicine is not recommended for use in pregnant or breastfeeding women and children under 18 years of age. Consult your doctor before taking. Before taking this medicine, inform your doctor if you have any liver, kidney or heart disease.

USES OF HYAL ORAL

• Treat osteoarthritis

HOW HYAL ORAL WORKS

Sodium hyaluronate is available as a salt form of hyaluronic acid. Oral administration of hyaluronic acid binds to an intestinal receptor called Toll-like receptor-4 (TLR-4) and suppresses the gene expression of pleiotrophin and other proinflammatory cytokines leading to anti-inflammation of arthritis. It also helps in the growth and development of new bones and cartilages by enhancing the growth of new cells and tissues. It can also lubricate and cushion your joint which provides relief from joint friction and pain.

DIRECTIONS FOR USE

Take HYAL ORAL as directed by your physician. Swallow the medicine as whole with a sip of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and health condition. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.

SIDE EFFECTS OF HYAL ORAL

It is generally safe and does not cause any side effects. However, if you experience any unusual side effects after taking this medicine, inform your doctor.

WARNING & PRECAUTIONS

INTERACTIONS

Tell your doctor about all the medicines you use, including non-prescription and prescription medicines, and herbal supplements.

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT HYAL ORAL

What shall I do if I forgot to take HYAL ORAL?

If you forgot to take a dose, take it as soon as you remember. However, if it is time for your next dose, skip the missed dose and take it as usual. At any cause, do not take a double dose to make up the missed one.

Can I stop taking HYAL ORAL without consulting a doctor?

No. Do not stop taking this medicine suddenly without consulting your doctor, as it may become less beneficial. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.

I’m pregnant, can I take HYAL ORAL?

No. This medicine is not recommended for use in pregnant women due to lack of safety data. Consult your doctor for advice before taking.

REFERENCES

1. Harsh Mohan. The Musculoskeletal system. Joints. Textbook of Pathology. 6th Edition. 2010. Page – 850- 851.

2. Daiichi Sankyo, Inc. The Efficacy Study of Sodium Hyaluronate to Treat Symptomatic Hip Osteoarthritis. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on January 2008] [Accessed 21st December 2020] https://clinicaltrials.gov/ct2/show/NCT00330135

3. China Medical University Hospital. Effectiveness of Oral Hyaluronic Acid in Knee Osteoarthritis. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on April 2020] [Accessed 21st December 2020] https://clinicaltrials.gov/ct2/show/NCT04352322

4. Mariko Oe, Toshiyuki Tashiro, Hideto Yoshida, Hiroshi Nishiyama, Yasunobu Masuda, Koh Maruyama, Takashi Koikeda, Reiko Maruya and Naoshi Fukui. Oral hyaluronan relieves knee pain: a review. NCBI; PMC US National Library of Medicine, National Institute of Health. January 2016. [Accessed 21st December 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729158/

USEFUL DIAGNOSTIC TESTS

• Blood calcium levels
• Rheumatoid Factor IgG Antibody
• Rheumatoid Factor IgM Antibody