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Human Insulatard 40IU Injection 1X10ml
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INTRODUCTION
HUMAN INSULATARD 40IU INJECTION contains Isophane Insulin which belongs to the group of medicines called Antidiabetic agents. It is used to treat diabetes mellitus (both type I and type II).
Diabetes mellitus is a chronic disease characterized by abnormally high levels of glucose in the blood. It is caused either due to inadequate production of a hormone called insulin (produced by pancreas to metabolize glucose) in the body or due to inadequate sensitivity of body cells to the actions of insulin.
Talk to your doctor before starting therapy with HUMAN INSULATARD 40IU INJECTION if you have any liver, kidney or heart problems. You must also inform your doctor if you have a history of stroke, any infection in the recent days, perform intense exercise or planning to go abroad (as the mealtime and injection timings may vary) as a precaution.
Do not use this medicine if you have hypoglycemia (low blood sugar levels). Consult your doctor before using this medicine if you are pregnant or breastfeeding. Along with the treatment, carefully follow the instructions given by your doctor regarding the mealtime and exercise (such as how often and how much to do).
The most common side effects of receiving HUMAN INSULATARD 40IU INJECTION are low blood sugar levels, pain, redness, itching, swelling or thickening at the injection site, lump formation under the skin and swelling of body parts. Consult your doctor if any of these side effect troubles you.
USES OF HUMAN INSULATARD 40IU INJECTION
- Treats diabetes mellitus (both type I and type II)
HOW HUMAN INSULATARD 40IU INJECTION WORKS
HUMAN INSULATARD 40IU INJECTION helps your body to make utilise of the circulating blood glucose. It helps in the transport of glucose from the blood into the muscles and fat tissues. It also stops the production of glucose by the liver. As a result, it controls blood sugar levels and improve sugar control in patients with diabetes mellitus.
DIRECTIONS FOR USE
Always inject this medicine into your thighs, buttocks, upper arm, or abdomen (i.e., subcutaneously). Do not administer this medicine into the vein or muscle directly. It should be administered at least 30 minutes before meals. Eat a meal or snack containing carbohydrates within 30 minutes of the injection to avoid low blood sugar.
Before administration, roll the vial/cartridge between your hands until the liquid becomes uniformly white and cloudy. While injecting, keep the needle under the skin for at least 6 seconds to make sure that the entire dose is injected.
Prior to the administration, visualize the cartridge/vial for any visible particulate matter and discoloration. Discard the needle and syringe after use and do not share your needles with others to avoid the risk of transmission of infections.
Avoid repeatedly injecting the medicine at the same site to prevent skin damage. Instead, rotate the injection site. Make sure to consult your doctor before changing the injection site as a precaution.
HUMAN INSULATARD 40IU INJECTION should not be mixed with any other insulins before use. Do not stop therapy with HUMAN INSULATARD 40IU INJECTION without consulting your doctor. Your doctor will decide correct dose and frequency of administration depending upon your age, body weight and health condition.
SIDE EFFECTS OF HUMAN INSULATARD 40IU INJECTION
COMMON
- Injection site reactions (such as pain, redness, itching or swelling)
- Lipodystrophy (shrinkage of fat tissues beneath the skin)
- Lumps under the skin
- Edema (swelling of face, hands and legs)
- Low blood sugar levels (signs include tiredness, hunger, nausea, headache, nervousness, cold sweats, fast heartbeat)
RARE
Consult your doctor immediately if you experience any of the following side effects:
- signs of heart failure (such as shortness of breath, chest pain, swelling of body parts, sudden weight gain)
- serious allergic reaction (such as hives, swelling of the face, lips, tongue or throat causing difficulty in breathing or swallowing)
HOW TO MANAGE SIDE EFFECTS
Hypoglycemia
Have foods rich in sugars such as fruit juices, glucose drinks, candies, honey or biscuits. Check your blood sugar after 10 minutes. If not gained optimum level, take another sugary snack, or a drink and check the blood sugar again. Consult your doctor if there is no improvement in your condition.
Injection Site Reactions
Place an ice pack on the injected site. Do not move the affected area frequently. If the symptom worsens, consult your doctor. Do not inject this medicine at the same site. Always rotate injection sites within the same region from one injection to the next to reduce skin damage.
WARNING & PRECAUTIONS
PREGNANCY
Consult your doctorConsult your doctor before undergoing therapy with HUMAN INSULATARD 40IU INJECTION if you are pregnant, think you may be pregnant or planning to have a baby.
BREASTFEEDING
Consult your doctorConsult your doctor before undergoing therapy with HUMAN INSULATARD 40IU INJECTION if you are breastfeeding.
DRIVING AND USING MACHINES
Use with CautionDo not drive or operate any machines if your ability is affected by HUMAN INSULATARD 40IU INJECTION.
ALCOHOL
Consult your doctorAvoid consumption of alcohol while undergoing therapy with HUMAN INSULATARD 40IU INJECTION as it may make this medicine less effective.
KIDNEY
Use with CautionHUMAN INSULATARD 40IU INJECTION should be used with caution in patients with kidney problems. Therefore, consult your doctor before administration.
LIVER
Use with CautionHUMAN INSULATARD 40IU INJECTION should be used with caution in patients with liver problems. Therefore, consult your doctor before administration.
ALLERGY
ContraindicatedTalk to your doctor before receiving HUMAN INSULATARD 40IU INJECTION if you are allergic to Isophane Insulin or to any other insulin types.
HEART DISEASE
Use with CautionHUMAN INSULATARD 40IU INJECTION should be used with caution in patients with heart problems. Therefore, consult your doctor before administration.
USE IN PEDIATRICS
Monitoring requiredHUMAN INSULATARD 40IU INJECTION should be used in children and in adolescents (aged below 18 years) only if prescribed by the physician. Therefore, consult your doctor before administration.
USE IN GERIATRICS
Use with CautionHUMAN INSULATARD 40IU INJECTION should be used with caution among the elderly patients (aged 65 years or above). Therefore, consult your doctor before administration.
OTHERS
HUMAN INSULATARD 40IU INJECTION is not recommended for use if you:
- have or at risk of developing hypoglycaemia (low blood sugar levels)
Talk to your doctor before receiving HUMAN INSULATARD 40IU INJECTION if you:
- have diabetes that is well controlled by the current insulin therapy
- recently became ill or had any infections
- perform intense exercise or physical activity
- are planning to go abroad (as mealtime and injection timings may get changed)
- have a history of stroke
INTERACTIONS
A. Drug-Drug interactions:
Before HUMAN INSULATARD 40IU INJECTION is administered, inform your doctor if you are taking any of the following medicines such as:
- other medicines used to treat diabetes (Ex. glimepiride, glyburide, gliclazide, rosiglitazone, pioglitazone)
- medicines used to treat asthma (Ex. salbutamol or terbutaline)
- corticosteroids (used to treat pain and inflammation) Ex. hydrocortisone, prednisolone
- thyroid hormones (used to treat thyroid deficiency) such as thyroxine, levothyroxine
- thiazide diuretics (used to reduce edema and to treat hypertension) Ex. hydrochlorothiazide, chlorothiazide
- medicines used to treat pain and inflammation (such as aspirin)
- medicines used to treat high blood pressure (such as atenolol, propranolol, captopril, enalapril, ramipril, lisinopril, losartan, valsartan, olmesartan, telmisartan)
- growth hormone (used to increase growth)
- octreotide (used to treat diarrhea)
- lanreotide (a medicine used to treat abnormal body growth)
- danazol (a medicine used to treat uterine problems)
- beta-blockers (used to treat heart problems) such as atenolol propranolol, labetalol
- medicines used for depression (such as moclobemide, isocarboxazid, phenelzine, selegiline, tranylcypromine)
Overdosage:
If you or anyone else accidentally took more HUMAN INSULATARD 40IU INJECTION, consult your doctor immediately or visit the nearby hospital.
SYNOPSIS
| Drug | : | Isophane Insulin |
| Pharmacological Category | : | Insulin Preparations |
| Therapeutic Indication | : | Diabetes mellitus |
| Dosage Forms | : | Injection, Cartridge, Disposable pen |
MORE INFORMATION
- Keep HUMAN INSULATARD 40IU INJECTION out of the sight and reach of children
- Before use: Store HUMAN INSULATARD 40IU INJECTION in the refrigerator (between 2-8°C)
- In Use: Store at room temperature after opening for up to 28 days
FAQs ABOUT HUMAN INSULATARD 40IU INJECTION
Q: What is HUMAN INSULATARD 40IU INJECTION used for?
A: HUMAN INSULATARD 40IU INJECTION is used to treat diabetes mellitus (both type I and II).
Q: How HUMAN INSULATARD 40IU INJECTION should be administered?
A: HUMAN INSULATARD 40IU INJECTION should be administered beneath the skin. Do not inject this medicine direcrly into your vein or muscle directly.
Q: How long should I take HUMAN INSULATARD 40IU INJECTION?
A: You need to take HUMAN INSULATARD 40IU INJECTION as long as your doctor prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Q: What to do if I forgot to take a dose of HUMAN INSULATARD 40IU INJECTION?
A: If you forgot to take a dose of HUMAN INSULATARD 40IU INJECTION, take it as soon as you remember. However, if it is time for the next dose of HUMAN INSULATARD 40IU INJECTION, skip the missed dose and take the next one regularly. Do not take a double dose of HUMAN INSULATARD 40IU INJECTION to compensate the missed ones.
Q: What are the most common side effects of taking HUMAN INSULATARD 40IU INJECTION?
A: The most common side effects of receiving HUMAN INSULATARD 40IU INJECTION are low blood sugar levels, pain, redness, itching, swelling or thickening at the injection site, lump formation under the skin and swelling of body parts. Consult your doctor if any of these side effect troubles you.
Q: Can I stop therapy with HUMAN INSULATARD 40IU INJECTION without consulting your doctor?
A: No. You should not stop therapy with HUMAN INSULATARD 40IU INJECTION without consulting your doctor because it may lead to reversal of symptoms. If you feel better after using HUMAN INSULATARD 40IU INJECTION, consult your doctor for advice.
Q: Will taking a higher dose of HUMAN INSULATARD 40IU INJECTION be more effective?
A: No, taking a higher dose of HUMAN INSULATARD 40IU INJECTION will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
Q: Can I take medication for high blood pressure along with HUMAN INSULATARD 40IU INJECTION?
A: It is not advisable to take medicines to control blood pressure while taking HUMAN INSULATARD 40IU INJECTION without consulting your doctor. Therefore, consult your doctor before taking any antihypertensive medications along with HUMAN INSULATARD 40IU INJECTION as they have known interactions with HUMAN INSULATARD 40IU INJECTION.
Q: Can HUMAN INSULATARD 40IU INJECTION be used in pregnant women?
A: Consult your doctor before undergoing therapy with HUMAN INSULATARD 40IU INJECTION if you are pregnant, think you may be pregnant or planning to have a baby.
Q: How much HUMAN INSULATARD 40IU INJECTION should I take?
A: HUMAN INSULATARD 40IU INJECTION should be used only under medical supervision. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body condition and severity of the disease condition.
REFERENCES
1. KD. Tripathi. Insulin, Oral hypoglycaemic drugs and glucagon. Essentials of Medical Pharmacology. 7th Edition. 2013. Page – 264.
2. Fatima Saleem; Ashish Sharma. NPH Insulin. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. June 2022. [Accessed on 21st February 2023] https://www.ncbi.nlm.nih.gov/books/NBK549860/
3. Eli Lilly and Company Limited. HUMULIN® I (Isophane) KwikPen® 100 IU/ml suspension for injection. Electronic Medicines Compendium (EMC). [Revised in January 2021] [Accessed on 21st February 2023] https://www.medicines.org.uk/emc/files/pil.8194.pdf
4. Insuman Rapid 40IU/100IU. European Medical Agency. [Revised in January 2021] [Accessed on 21st February 2023] https://www.ema.europa.eu/en/documents/product-information/insuman-epar-product-information_en.pdf
USEFUL DIAGNOSTIC TESTS
- Glucose-Fasting Blood
- Glucose-Postprandial Blood
- Glycosylated Haemoglobin
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