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INTRODUCTION
HISONE 100MG contains Hydrocortisone sodium succinate which belongs to the group of medicine called corticosteroids. It is indicated in the treatment of swollen, painful joints and tendons in conditions such as, tennis elbow and golfer’s elbow. Hydrocortisone Injection can also be used to treat conditions such as severe asthma, allergic reactions, severe shock due to injury or infection or failure of the adrenal glands. It can also be used to treat shock following surgery, injuries, hypersensitivity (anaphylactic) reactions or other stressful conditions.
Corticosteroids are the substance that are naturally produced in your body and helps to maintain your health and well-being. Supplementing your body with extra corticosteroids in the form of injection/infusion can help to treat various illnesses and inflammatory conditions. HISONE 100MG binds to the corticosteroid receptors of adrenal glands and mediates various physiological functions. It also blocks the production of various inflammatory mediators responsible for causing inflammation and allergies.
Do not reduce the dose or stop taking this medicine abruptly without informing your doctor. Your doctor will slowly reduce the dose to avoid withdrawal symptoms such as itching, fever, muscle/joint pain, runny nose, sticky eyes, sweating and weight loss. While taking this medicine, inform your doctor immediately if you experience any signs of mental problems such as depression or suicidal thoughts. Your doctor might reduce your dose or suggest an alternative therapy. Stay away from people having chickenpox, shingles or measles, because infections are easier to get and harder to spot while taking HISONE 100MG.
The most common side effects of this medicine are injection site itching, pain and burning sensation. However, contact your doctor if you experience any other unusual side effects after taking this medicine. Do not take this medicine if you have any bacterial, viral or fungal infections. Before taking this medicine inform your doctor if you have any liver, kidney, heart or stomach problems. Pregnant and breastfeeding women should inform their doctor before taking HISONE 100MG as a precaution.
USES OF HISONE 100MG
Treats the following conditions:
- swollen, painful joints and tendons
- severe asthma
- allergic reactions
- severe shock due to injury or infection or failure of the adrenal glands. Shock following surgery, injuries, hypersensitivity (anaphylactic) reactions or other stressful conditions
HOW HISONE 100MG WORKS
HISONE 100MG binds to the corticosteroid receptors of adrenal glands and mediates various physiological functions. It also blocks the production of various inflammatory mediators responsible for causing inflammation and allergies.
DIRECTIONS FOR USE
HISONE 100MG will be given to you only by a doctor or nurse into the vein (intravenously) or muscle (intramuscularly) as an injection/infusion. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.
SIDE EFFECTS OF HISONE 100MG
SERIOUS
- allergic reactions (such as skin rash, swelling of the face and difficulty in breathing)
- symptoms of acute pancreatitis (stomach pain spreading through your back, with vomiting, shock and loss of consciousness)
- symptoms of bleeding ulcers (severe stomach pain, back pain, bleeding from the anus, black or bloodstained stools and vomiting up of blood)
- fever or flu-like symptoms
- pulmonary embolus (blood clot in the lung), chest pain, breathlessness and coughing up blood
- symptoms of pseudo tumour cerebri in children (increased cranial pressure, headaches with vomiting, lack of energy and drowsiness)
- thrombophlebitis (blood clots in the veins with redness and swelling)
COMMON
- injection site itching, pain or irritation
- high blood pressure, palpitations
- muscle cramps or spasms
- nausea, vomiting, indigestion, bloating, hiccups
- blurred vision, glaucoma, eye inflammation
- central serous chorioretinopathy (visual impairment leading to retinal detachment)
- permanent slowing of growth in children
- bone fractures
- mental problems (such as depression, suicidal thoughts, mania, anxiety, confusion, difficulty in sleeping, loss of memory, or hallucinations)
- infections
HOW TO MANAGE SIDE EFFECTS
Nausea or vomiting:
Try taking this medicine with, or just after meals. Stick to simple meals. Do not eat rich or spicy food.
Bloating:
Eat smaller and frequent meals. Eat and drink slowly, and exercise regularly. If the symptoms get worse, contact your doctor immediately.
WARNING & PRECAUTIONS
PREGNANCY
HISONE 100MG should be used with caution in pregnant women. Your doctor will decide whether you should use this medicine or not.
BREASTFEEDING
HISONE 100MG should be used with caution in breastfeeding women. Consult your doctor before taking this medicine.
ALCOHOL
Do not drive or operate any tools or machines if your ability is affected by this medicine.
KIDNEY
HISONE 100MG should be taken with caution in patients with kidney disease. Consult your doctor for advice.
LIVER
HISONE 100MG should be taken with caution in patients with liver disease. Consult your doctor for advice.
ALLERGY
Do not take this medicine if you are allergic (hypersensitive) to hydrocortisone or any other corticosteroid medicine.
HEART DISEASE
HISONE 100MG should be taken with caution in patients suffering from congestive heart disease, a recent heart attack, high blood pressure or other heart problems. Consult your doctor for advice.
OTHERS
Before taking HISONE 100MG, inform your doctor if you have following conditions:
- stroke or traumatic brain injury
- chicken pox or shingles (viral infections)
- ocular herpes simplex (viral eye infection)
- severe depression or bipolar disorder
- epilepsy
- diabetes
- glaucoma (increased pressure in the eyes)
- muscle weakness following steroidal administration in the past
- myasthenia gravis (muscle weakness)
- hypothyroidism (decreased thyroid levels)
- Kaposi’s sarcoma (a type of cancer that causes purplish lesions on the skin)
- osteoporosis (thinning of bones)
- pheochromocytoma (a rare tumor in the tissues of adrenal glands)
- amoebic dysentery or and strongyloidiasis (an infestation of gut worm)
- tuberculosis in the past
- stomach ulcers or other intestinal problems
- thrombophlebitis (blood clot in veins with redness and swelling)
- tuberculosis in the past
- got vaccinated recently or going to receive any vaccinations
- going to have any surgery
INTERACTIONS
Talk to your doctor, if you are taking:
- acetazolamide (used to treat epilepsy and glaucoma)
- aminoglutethimide (used to treat cancer)
- anticoagulants (used for blood thinning) e.g. acenocoumarol, phenindione and warfarin
- anticholinesterases (used to treat myasthenia gravis) e.g. distigmine and neostigmine
- antibiotics (used to treat bacterial infection) e.g. erythromycin
- non-steroidal anti-inflammatory medicines (e.g. aspirin and ibuprofen)
- medicines used to treat epilepsy (e.g. phenytoin, phenobarbital, carbamazepine and primidone)
- medicines used to treat heartburn and acid indigestion (e.g. carbenoxolone and cimetidine)
- ciclosporin (used to treat psoriasis or prevent graft rejection)
- digoxin (used to treat arrhythmia or heart failure)
- mibefradil and diltiazem (used to treat high blood pressure and other heart problems)
- diuretics (used to increase urine output) e.g. furosemide
- itraconazole or ketoconazole (used to treat fungal infections)
- pancuronium (a neuromuscular blocking agent used in some surgical procedures)
- rifabutin and rifampicin (used to treat tuberculosis)
- live vaccines
SYNOPSIS
| Drug | : | Hydrocortisone acetate |
| Pharmacological Category | : | Corticosteroids |
| Therapeutic Indication | : | Allergic and inflammatory conditions |
| Dosage Forms | : | Cream, Lotion, Rectal Foam, Enema, Inhaler |
MORE INFORMATION
Store below 20-25°C and keep out of reach of children.
FAQs ABOUT HISONE 100MG
Is HISONE 100MG a steroid?
Yes. This medicine is a corticosteroid used to treat various allergic and inflammatory conditions and metabolic disorders.
Is HISONE 100MG safe during pregnancy?
Consult your doctor before taking any medicine if you are pregnant or think you may be pregnant. Your doctor will decide whether you should take this medicine or not depending upon the severity of the disease.
How HISONE 100MG will be administered?
This medicine is not meant for self-administration. It will be given to you only by a doctor or nurse into the vein (intravenously) or muscle (intramuscularly) as an injection/infusion. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition.
REFERENCES
1. KD. Tripathi. Corticosteroids. Essentials of medical pharmacology. Seventh edition. 2013. Page – 288 & 290-293.
2. Bernard P. Schimmer and John. W. Funder. ACTH, Adrenal steroids and Pharmacology of the Adrenal Cortex. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 1227-1233.
3. Gerald G. Briggs and Roger K. Freeman. H. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 1875-1886.
4. Diurnal Limited. An Investigational Study of Hydrocortisone. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on April 2017] [Accessed 6th January 2021] https://clinicaltrials.gov/ct2/show/NCT01960530.
5. Marius Henriksen, Robin Christensen, Louise Klokker, Cecilie Bartholdy, Elisabeth Bandak, Karen Ellegaard, Mikael P Boesen, Robert G Coumine Riis, Else M Bartels and Henning Bliddal. Evaluation of the benefit of corticosteroid injection before exercise therapy in patients with osteoarthritis of the knee: a randomized clinical trial. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. June 2015. [Accessed 6th January 2021] https://pubmed.ncbi.nlm.nih.gov/25822572/
6. Mohammad Ali Tahririan, Amir Moayednia, Amir Momeni, Arash Yousefi and Babak Vahdatpour. A randomized clinical trial on comparison of corticosteroid injection with or without splinting versus saline injection with or without splinting in patients with lateral epicondylitis. NCBI; PMC US National Library of Medicine, National Institute of Health. September 2014. [Accessed 6th January 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268187/
7. PANPHARMA. Electronic Medicines Compendium (EMC); [Revised on January 2018] [Accessed 6th January 2021]. https://www.medicines.org.uk/emc/files/pil.9377.pdf
8. Pfizer. U.S. Food & Drug Administration. [Revised on April 2010] [Accessed 6th January 2021] https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/009866s080lbl.pdf
USEFUL DIAGNOSTIC TESTS
- Absolute Eosinophil Count
- Peripheral Smear Examination
- Total IgE
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