INTRODUCTION

HINDER contains Eflornithine which belongs to a group of medicines called Ornithine Decarboxylase Inhibitors. It works by blocking the enzyme ornithine decarboxylase (ODC) that stimulates facial hair growth. It slows down the growth of the hair on the face through its effect on an enzyme (a protein in the body involved in the production of the hair). It is used to reduce the growth of excessive hair (Hirsutism) on the face of women older than 18 years of age.

Always use HINDER as directed by physician. It is not recommended for the use in children and adolescents under 18 years. Do not use this medicine, if you suffer from polycystic ovary syndrome (PCOS) or specific hormone producing tumors. Do not use this medicine if you are pregnant or breastfeeding women. Consult your doctor before using this medicine. Tell your doctor, if you are using or might use any other medicines. The most common side effects include acne, dry skin, hair loss, inflammation around the hair shaft, itching, rash, redness, skin irritation and bumps caused by shaving, skin irritation and stinging, tingling or burning feeling on the skin.

USES OF HINDER

• Used to reduce the growth of excessive hair (Hirsutism) on the face of women older than 18 years of age

HOW HINDER WORKS

HINDER works by blocking the enzyme ornithine decarboxylase (ODC) that stimulates hair growth.

DIRECTIONS FOR USE

Apply twice a day, at least 8 hours apart or as directed by physician. Clean and dry the areas of your skin where you going to be use. Apply a thin layer of this medicine and rub it thoroughly until no visual residual product remains on the treated areas. It is for external use only.

SIDE EFFECTS OF HINDER

HOW TO MANAGE SIDE EFFECTS

Skin itching:

Avoid bath in hot water because hot water can irritate the skin. Moisturizers can be used regular basis to soothe and hydrate the affected area.

WARNING & PRECAUTIONS

INTERACTIONS

Talk to your doctor if you need to use other medicines on the areas of skin where you are using the medicine.

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT HINDER

Can HINDER be used in pregnant women?

No. It is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.

What are the possible side effects of HINDER?

It may cause temporary redness, stinging, burning, tingling or rash on areas of the skin where it is applied.

REFERENCES

1. Amit Kumar, Youssef W. Naguib, Yan-chun Shi and Zhengrong Cui; A method to improve the efficacy of topical eflornithine hydrochloride cream; [Revised on Sep 2014] [Accessed 29 Dec 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348346/

2. Goodman and Gilman’s: The Pharmacological Basis of Therapeutics. Chapter – 50 – Chemotherapy of protozoal infections; 12th ed. New York, New York: McGraw-Hill Medical, 2011. Page – 1424.

3. Almirall Hermal GmbH, Electronic Medicines Compendium (EMC); [Revised on Apr 2017] [Accessed 29 Dec 2020] https://www.medicines.org.uk/emc/files/pil.6398.pdf

4. Bristol-Myers Squibb Company; U.S. Food and drug administration; [Revised on July 2000] [Accessed 29 Dec 2020] https://www.accessdata.fda.gov/drugsatfda_docs/label/2000/21145lbl.pdf

5. Vanessa Ngan; Dermnet; [Revised on July 2000] [Accessed 29 Dec 2020] https://dermnetnz.org/topics/eflornithine-hydrochloride/