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INTRODUCTION

HEPTADIL LIQUID is a combination of Cyproheptadine and Tricholine Citrate, which belong to the groups of medicines called antihistamines and bile acid-binding agents, respectively. It is used to treat loss of appetite, weight loss and anorexia nervosa (an eating disorder). It is also used to treat weight gain in anti-tubercular and antiretroviral regimens.

In children, it is used for gaining weight, having an inadequate dietary intake or loss of appetite or suffering from anaemia, liver disease or digestive disorders. It is also used to treat allergic rhinitis and conjunctivitis, migraine, asthma and hepatic disorders. Appetite loss is a state in which an individual has no desire to eat food, which leads to a deficiency of essential and non-essential nutrients that are required for the proper metabolism and growth of the body.

HEPTADIL LIQUID is not recommended for use in patients who have or had angle-closure glaucoma, stenosing peptic ulcer, symptomatic prostatic hypertrophy, bladder neck obstruction or pyloroduodenal obstruction. Alcohol should be avoided during HEPTADIL LIQUID treatment because it may increase the HEPTADIL LIQUID's action.

Before taking this medicine, tell your physician if you have a history of bronchial asthma, increased intraocular pressure, hyperthyroidism, cardiovascular disease, liver problems, kidney problems or hypertension. HEPTADIL LIQUID is not recommended for use by pregnant or breastfeeding women. It should be recommended for use in children and adolescents (below 18 years of age).

The most common side effects of taking this medicine are drowsiness, dizziness, insomnia, blurred vision, loss of coordination, skin rash, gastrointestinal upset, nausea or vomiting. Contact your physician if the symptoms worsen.

USES OF HEPTADIL LIQUID

HEPTADIL LIQUID is used to treat the following:

  • Loss of appetite
  • weight loss
  • Anorexia nervosa
  • As an adjunct to anti-tubercular and antiretroviral regimens to gain weight
  • In children to gain weight due to inadequate dietary intake or loss of appetite and also in children suffering from anemia, liver or digestive disorder
  • Allergic rhinitis and conjunctivitis
  • Migraine
  • Asthma
  • Hepatic disorders

HOW HEPTADIL LIQUID WORKS

HEPTADIL LIQUID contain Cyproheptadine and Tricholine Citrate, where Cyproheptadine prevents weight loss by reducing the effect of serotonin (a chemical messenger) in the hypothalamus that helps in regulating appetite and Tricholine Citrate is a bile acid-binding agent that works by removing the bile acids from the body, which results in the liver using cholesterol, leading to more production of bile acids, which causes a decreased cholesterol level in the body, resulting in weight gain.

DIRECTIONS FOR USE

Take HEPTADIL LIQUID as advised by your physician. Shake well before use. Your physician will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF HEPTADIL LIQUID

COMMON

  • drowsiness
  • dizziness
  • sleeplessness
  • blurred vision
  • loss of coordination
  • skin rash
  • signs of gastrointestinal upset such as body chills, burning sensation, cramps, discomfort and diarrhea
  • nausea
  • vomiting
  • constipation
  • dry mouth

RARE

Stop taking HEPTADIL LIQUID and contact your physician immediately if you experience any of the following side effects:

  • experience any other side effects or persistent problem

HOW TO MANAGE SIDE EFFECTS

Dizziness:

Try to rest and get enough sleep. Try to avoid driving or operating any tools or machines while you feel dizzy. Limit your consumption of alcohol, as it can aggravate dizziness. Consult and inform your doctor if the symptom worsens.

Nausea or vomiting:

Take this medicine with meals or just after meals. Stick to simple meals. Avoid eating rich or spicy foods.

Constipation:

Try to eat high-fiber foods such as vegetables, cereals and fresh fruit and drink plenty of water. Engage in regular exercise (going for a daily walk or run) and if this does not help, consult and inform your doctor about receiving alternate treatments for constipation.

Dry mouth:

Try to drink plenty of cold water and sip on cold unsweetened drinks and use lip balm if your lips are dry. Brush your teeth twice a day and try to use mouthwash. Consult and inform your doctor if the symptom worsens.

WARNING & PRECAUTIONS

PREGNANCY

HEPTADIL LIQUID is not recommended for use in pregnant women. Consult your physician for advice.

BREASTFEEDING

HEPTADIL LIQUID is not recommended for use in breastfeeding women. Consult your physician for advice.

DRIVING AND USING MACHINES

Do not drive or operate any machines if you feel dizziness or drowsiness after taking HEPTADIL LIQUID.

ALCOHOL

Avoid consumption of alcohol while taking HEPTADIL LIQUID since it may increase the risk of stomach problems.

KIDNEY

HEPTADIL LIQUID should be used with caution if you have any kidney disease such as renal failure. Consult your physician for advice.

LIVER

HEPTADIL LIQUID should be used with caution in patients with liver problems such as liver impairment. If you have any liver problems. Consult your physician for advice.

ALLERGY

Talk to your physician if you are allergic to Cyproheptadine, Tricholine citrate or any of the other ingredients in this medicine.

LUNGS

HEPTADIL LIQUID should be used with caution in patients with a history of bronchial asthma. Consult your doctor before taking HEPTADIL LIQUID.

HEART DISEASE

HEPTADIL LIQUID should be used with caution in patients with cardiovascular disease. Consult your physician for advice.

OTHERS

HEPTADIL LIQUID is not recommended for use if you:

  • have or had angle-closure glaucoma (an eye disorder)
  • have stenosing peptic ulcer
  • have symptomatic prostatic hypertrophy (enlarged prostate gland)
  • have bladder neck obstruction
  • have signs of pyloroduodenal obstruction (gastric outlet obstruction) such as vomiting
  • have high blood pressure

Before taking HEPTADIL LIQUID, inform your doctor if you:

  • have increased intraocular pressure (pressure in the eye)
  • have signs of hyperthyroidism (overactive thyroid) such as unintentional weight loss, rapid heartbeat, irregular heartbeat
  • have high blood pressure

Use in Pediatrics:

HEPTADIL LIQUID is recommended for use in children and adolescents (below 18 years of age). Consult your physician before taking it.

Use in Geriatrics:

HEPTADIL LIQUID is generally not recommended for use in elderly patients unless it is indicated necessary for use. Consult your physician before taking.

INTERACTIONS

A. Drug-Drug interactions:

Before taking HEPTADIL LIQUID, inform your doctor, if you are taking any of the following medicine:

  • medicine used to treat depression (Ex. monoamine oxidase inhibitors (MAO))
  • other antidepressants such as hypnotics (Ex. quazepam), sedatives (Ex. barbiturates), tranquilizers (Ex. diazepam)
  • antianxiety agents (medicines used to treat anxiety) such as alprazolam and chlordiazepoxide

Overdosage:

If you or anyone else accidentally took too much of this medicine, consult your physician immediately. The symptoms of overdosage are hallucinations, depression and fits.

SYNOPSIS

Drug :   Cyproheptadine, Tricholine Citrate
Pharmacological Category :   Antihistamine, Bile acid-binding agent
Therapeutic Indication :  

Loss of appetite, weight loss, anorexia nervosa, adjunct to anti-tubercular and antiretroviral regimens for weight gain, allergic rhinitis and conjunctivitis, migraine, asthma and hepatic disorders, in children suffering from anemia, liver or digestive disorder

Dosage Forms :   Drops, Syrup, Liquid

MORE INFORMATION

  • Keep out of reach from children
  • Store at a room temperature

FAQs ABOUT HEPTADIL LIQUID

Is it safe to consume alcohol along with HEPTADIL LIQUID?

Avoid consuming alcohol while taking HEPTADIL LIQUID as it has additive effects and may increase the risk of stomach problems. Consult your physician before taking it.

Does HEPTADIL LIQUID cause dry mouth?

The most common side effect of HEPTADIL LIQUID is dry mouth. When dry mouth occurs, try to manage it by drinking plenty of cold water, sipping on cold unsweetened drinks and using lip balm if lips are dry. Brush your teeth twice a day and try to use mouthwash. If the symptoms do not improve or get worse, consult your doctor immediately.

Can I use HEPTADIL LIQUID with children?

HEPTADIL LIQUID can be given to children and adolescents (below 18 years of age) if prescribed by the physician. The dose may vary depending on the child’s age, body weight and disease condition.

Can I take HEPTADIL LIQUID along with antidepressants?

No, HEPTADIL LIQUID should not be taken along with antidepressants, especially monoamine oxidase inhibitors (MAOI), as it may prolong and increase the effects of HEPTADIL LIQUID. Consult your physician before taking HEPTADIL LIQUID with other medicines to avoid unpleasant side effects.

Can I drive after taking HEPTADIL LIQUID?

Avoid driving and do not operate any machine after taking HEPTADIL LIQUID because HEPTADIL LIQUID may cause drowsiness and dizziness. Patients should be warned about engaging in activities requiring mental alertness and motor coordination. So, please consult your physician before taking HEPTADIL LIQUID.

REFERENCES

1. KD Tripathi. 5-Hydroxytryptamine, its Antagonists and Drug Therapy of Migraine. Essentials of medical pharmacology. 7th edition. 2013. Page – 174.

2. Randal A. Skidgel. Histamine, Bradykinin and Their Antagonists. Goodman & Gilman’s The Pharmacological basics of Therapeutics. 13th Edition. New York McGraw Hill Medical 2018. Page – 711-726.

3. Mayuresh Dilip Kiran, Shaheen Naseem Sheikh, Lalit Jeevan Pawaskar. Safety and Efficacy of a Combination of Cyproheptadine and Tricholine Citrate: Phase IV Study. Annals of International Medical and Dental Research. December 2017. [Accessed on 17th June 2022] https://www.readcube.com/articles/10.21276%2Faimdr.2018.4.2.pe1

4. Khadijehsadat Najib, MD, Mozhgan Moghtaderi, MD, Zohreh Karamizadeh, MD and Ebrahim Fallahzadeh, MD.  Beneficial Effect of Cyproheptadine on Body Mass Index in Undernourished Children: A Randomized Controlled Trial. Iranian Journal of Pediatrics. December 2014. [Accessed on 17th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442838/

5. Centaur Pharmaceutical Pvt. Ltd. Oraxin syrup and drop. [Revised on January 2021] [Accessed on 17th June 2022] https://www.centaurpharma.com/downloads/2021/pediatrics/nutritional-and-vitamins/Oraxin%20syrup%20and%20drop.pdf

6. Alaina Pharma. Cyproheptadine and Tricholine citrate syrup. [Accessed on 17th June 2022] http://alainapharma.com/Cyproheptadine%20and%20Tricholine%20Citrate%20Syrup.html

USEFUL DIAGNOSTIC TESTS

  • Upper gastrointestinal (GI) endoscopy and biopsy
  • Complete Blood Count Test

AUTHOR DETAILS

Written By Dr. Dhivakaran R, BDS
Last updated on 10 Dec 2022 | 02:51 PM(IST)

PRODUCT DETAILS
    Net Qty
    1 N
    Shelf Life
    720
    Item Weight
    215 g
    Ingredient
    Cyproheptadine 2 mg+Tricholine 275 mg
    Hsn Code
    30049099
DISCLAIMER

The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.