INTRODUCTION

HEP 5 contains Heparin which belongs to a group of medicines called anticoagulants which helps to stop blood clotting. It is used to treat and prevent blood clots in veins, lung, unstable angina pectoris, acute peripheral arterial occlusion and mural thrombosis. This medicine is also used during heart and lung operations and during kidney dialysis.

Heparin is an anticoagulant which acts indirectly by activating plasma antithrombin III (AT III, a serine proteinase inhibitor). This heparin-AT III complex then binds to clotting factors of the intrinsic and common pathways and inactivates them but not factor VIIa operative in the extrinsic pathway. Then it is exerted mainly by inhibition of factor Xa as well as thrombin (IIa) mediated conversion of fibrinogen to fibrin.

Before receiving HEP 5, tell your physician if you have liver, kidney or heart problems, are pregnant or breastfeeding. The common side effects are bleeding and red lumps or itchy patches like eczema. It must be avoided for premature and newborn babies.

USES OF HEP 5

Treats and prevents,

• blood clots in veins and lungs
• unstable angina pectoris
• acute peripheral arterial occlusion
• mural thrombosis

HOW HEP 5 WORKS

Heparin belongs to class of medications called anticoagulants which works by decreasing the clotting ability of the blood.

DIRECTIONS FOR USE

HEP 5 will be administered by your doctor or nurse into vein (intravenously) either all at once or over a longer period of time (via a drip) or injected underneath your skin.

SIDE EFFECTS OF HEP 5

WARNING & PRECAUTIONS

INTERACTIONS

Tell your doctor if you are taking,

• aspirin, ketorolac, diclofenac, ibuprofen (treats pain)
• dextran solutions (used to treat shock)
• dipyridamole, epoprostenol, clopidogrel and streptokinase
• cephalosporins, gentamicin, amikacin, neomycin or tobramycin (treats infections)
• captopril, enalapril, lisinopril, ramipril, losartan or valsartan (treats high blood pressure or heart problems)
• amiloride, triamterene, eplerenone or spironolactone (increase the potassium level in your blood)
• glyceryl trinitrate (for coronary heart disease)
• probenecid (treats gout)

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT HEP 5

Can HEP 5 be used during pregnancy?

It is not suitable for use during pregnancy. Consult your doctor for advice.

Can I take HEP 5 if I have liver problems?

It is not recommended if you have liver disease. Consult your doctor for advice.

When is HEP 5 given?

It is usually given after surgery, which remains hospitalized for several days to prevent blood clots.

REFERENCES

1. KD Tripathi MD. Drugs affecting coagulation, bleeding and thrombosis. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page – 617.

2. Weitz JI. Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. Page - 853-859.

3. Zehnder JL. Drugs Used in Disorders of Coagulation. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. Page - 591-593.

4. Fox KA, White HD, Gersh BJ, et al. Antithrombotic Agents: Platelet Inhibitors, Acute Anticoagulants, Fibrinolytics, and Chronic Anticoagulants. In: Opie LH, Gersh BJ, editors. Drugs for the Heart. 8th ed. Philadelphia, Pennsylvania: Elsevier Saunders; 2013. Page - 367-373.

5. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 652-653.

6. Clive Page. Heparin and Related Drugs: Beyond Anticoagulant Activity. July 30, 2013. ] [Accessed on June 19, 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747464/

7. Wockhardt UK Ltd. Electronic Medicines Compendium (EMC); [Revised on June, 2018] [Accessed on June 19, 2021] https://www.medicines.org.uk/emc/files/pil.1678.pdf