INTRODUCTION

GXTEN 20 TABLET contains Teneligliptin which belongs to the group of medicines called Anti-diabetic drugs. It is used to treat type II diabetes mellitus in adults in addition to proper diet, exercise and lifestyle changes.

Type II diabetes mellitus is a chronic disease associated with abnormally high levels of glucose in the blood due to inadequate production of a hormone called insulin (produced by the pancreas to metabolize glucose) or due to inadequate sensitivity of body cells to the actions of insulin.

Before taking GXTEN 20 TABLET, inform your doctor if you have any liver or heart problems. You must also inform your doctor if you have hormonal problems, stomach problems (surgery in the gut) or if you are malnourished, starved, on an irregular diet. 

GXTEN 20 TABLET is not suitable for use in patients with type I diabetes mellitus. Consult your doctor before taking GXTEN 20 TABLET if you are pregnant or planning to become pregnant. 

One of the most common side effects of taking GXTEN 20 TABLET is hypoglycemia (low blood sugar levels) which can be identified by symptoms such as increased hunger, sweating, shakiness, weakness, or an irregular heartbeat. To avoid this, your doctor will periodically monitor your blood sugar levels and adjust the dose of GXTEN 20 TABLET accordingly.

You can also carry a sugary snack (such as biscuits, glucose drinks or sweet candies) along with you as a precaution and have them immediately if you experience any signs of low blood sugar levels. However, consult your doctor if there is no improvement in your condition. Other common side effects of taking GXTEN 20 TABLET are headache, dizziness, and constipation.

USES OF GXTEN 20 TABLET

• Treats type II diabetes mellitus in adults

HOW GXTEN 20 TABLET WORKS

GXTEN 20 TABLET lowers blood glucose levels by blocking the actions of an enzyme called dipeptidyl peptidase (DPP)-4 that regulates the secretion of insulin in the body. As a result, it improves insulin production and helps in the digestion of circulating blood glucose. It can also regulate blood sugar levels post-meal by controlling glucagon secretion.

DIRECTIONS FOR USE

Take GXTEN 20 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. GXTEN 20 TABLET should be taken preferably after meals.

Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight and disease condition. Do not stop taking this medicine without consulting your doctor.

SIDE EFFECTS OF GXTEN 20 TABLET

HOW TO MANAGE SIDE EFFECTS

Headache:  

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.

Diarrhoea:

Hydrate yourself by drinking plenty of fluids, such as water or fruit juices. Consuming ORS can also be beneficial. Do not self-treat diarrhoea on your own. Consult your doctor if your diarrhoea becomes uncontrollable.

Constipation:

Eat plenty of fiber-rich foods such as fresh fruits, vegetables, and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.

Low blood sugar:

Have foods rich in sugars such as fruit juices, glucose drinks, candies, honey, or biscuits. Check your blood sugar after 10 minutes. If not gained an optimum level, take another sugary snack, or a drink, and check the blood sugar again. consult your doctor if there is no improvement in your condition.

WARNING & PRECAUTIONS

PREGNANCY

GXTEN 20 TABLET should be used in pregnant women only if prescribed by the physician. Your doctor may prescribe GXTEN 20 TABLET for you after evaluating the risks and benefits ratio. Therefore, consult your doctor before taking it.

BREASTFEEDING

Breastfeeding should be stopped during treatment with GXTEN 20 TABLET. However, consult your doctor before taking it.

DRIVING AND USING MACHINES

Do not drive or operate any machines if you feel dizzy after taking GXTEN 20 TABLET.

ALCOHOL

Avoid consumption of alcohol while taking GXTEN 20 TABLET as it may increase the risks of side effects.

LIVER

GXTEN 20 TABLET should be used with caution in patients with severe liver diseases. Therefore, consult your doctor before taking it.

ALLERGY

Do not take GXTEN 20 TABLET if you are allergic to Teneligliptin.

HEART DISEASE

GXTEN 20 TABLET should be used with caution in patients with heart problems (like heart failure or slow heartbeat). Therefore, consult your doctor before taking it.

INTERACTIONS

A. Drug - Drug interactions:

Before taking GXTEN 20 TABLET, inform your doctor if you are taking any of the following medicines such as:

• other medicines used to treat diabetes (such as glimepiride, exenatide, acarbose, metformin, pioglitazone, repaglinide, empagliflozin or insulin)
• beta-blockers (medicines used to treat high blood pressure) Ex. atenolol, propranolol
• salicylic acid (a medicine used to treat skin problems like acne)
• medicines used to treat depression (Ex. phenelzine, selegiline)
• adrenaline (a medicine used to treat shock caused by allergic reactions or collapse)
• thyroid hormones (used to treat thyroid deficiency) Ex. levothyroxine, liothyronine
• medicines used to treat irregular heartbeats (Ex. quinidine, procainamide, amiodarone, sotalol, etc.)

Overdosage:

If you or anyone else accidentally took more GXTEN 20 TABLET, consult your doctor immediately or visit the nearby hospital.

SYNOPSIS

MORE INFORMATION

• Keep GXTEN 20 TABLET out of reach of children
• Store GXTEN 20 TABLET at room temperature

FAQs ABOUT GXTEN 20 TABLET

Q: What is GXTEN 20 TABLET used for?

A: GXTEN 20 TABLET contains Teneligliptin which is used to treat type II diabetes (high blood sugar levels) in adults, that cannot be controlled by diet and exercise alone.  Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

Q: Is GXTEN 20 TABLET safe to use in pregnancy?

A: GXTEN 20 TABLET should be used in pregnant women only if prescribed by the physician. Your doctor may prescribe GXTEN 20 TABLET for you after evaluating the risks and benefits ratio. Therefore, consult your doctor before taking it.

Q: What precautions do I need to follow while taking GXTEN 20 TABLET?

A: Before taking GXTEN 20 TABLET, inform your doctor if you have any liver or heart problems. You must also inform your doctor if you have hormonal problems, stomach problems (surgery in the gut) or if you are malnourished. GXTEN 20 TABLET is not suitable for use in patients with type I diabetes mellitus. Consult your doctor before taking GXTEN 20 TABLET if you are pregnant or planning to become pregnant. During therapy with GXTEN 20 TABLET, follow the diet and lifestyle changes instructed by your doctor. Always carry a sugary snack (such as biscuits, glucose drinks or sweet candies) along with you as a precaution and have them immediately if you experience any signs of hypoglycemia.

Q: Can I take medication for high blood pressure along with GXTEN 20 TABLET?

A: No. It is not advisable to take medicines to control blood pressure while taking GXTEN 20 TABLET without consulting your doctor. Therefore, consult your doctor before taking any antihypertensive such as beta-blockers (Ex. atenolol, propranolol) along with GXTEN 20 TABLET as they have known interactions with GXTEN 20 TABLET.

Q: What should I do if I experience low blood sugar after taking GXTEN 20 TABLET?

A: Low blood sugar is a common side effect of taking GXTEN 20 TABLET. Try to have sugar-rich food items such as fruit juice, glucose tablets or gel, soft drinks, honey, or sugary candy. Check your blood sugar after 10 minutes. If not gained an optimum level, take another sugary snack, or drink, and check the blood sugar again. In case of persistent low blood sugar levels, consult your doctor immediately.

Q: Can GXTEN 20 TABLET cause dizziness?

A: Yes. Dizziness is a common side effect of using GXTEN 20 TABLET. In case you experience dizziness, lie down until it passes, then get up slowly and carefully. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, and alcohol. Do not drive or use machinery to avoid accidents. Consult your doctor if you experience dizziness continuously for a long time after taking GXTEN 20 TABLET.

Q: Can GXTEN 20 TABLET be taken with insulin?

A: Co-administration of GXTEN 20 TABLET with insulin is considered risky as they have increased chances of hypoglycemia (decreased blood sugar levels). Consult your doctor before taking it.

Q: How to take GXTEN 20 TABLET?

A: You must take GXTEN 20 TABLET as advised by your physician. Try to take this medicine preferably after meals and swallow it with a glass of water. Do not crush or chew the medicine.

Q: How much GXTEN 20 TABLET should I take?

A: GXTEN 20 TABLET should be used only under medical supervision. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body condition and severity of the disease condition.

Q: Can GXTEN 20 TABLET cause constipation?

A: Yes. Constipation is a common side effect of using GXTEN 20 TABLET. Eat plenty of fiber-rich foods such as fresh fruits, vegetables, cereals as well as drink plenty of water and exercise more regularly when taking this medicine. Contact your doctor if you experience constipation for a long time.

REFERENCES

1. Joseph T. DiPiro, Robert L. Talbert, Gary C. Yee, Gary R. Matzke, Barbara G. Wells, L. Michael Posey. Diabetes Mellitus. Pharmacotherapy- A Pathophysiologic Approach. Eighth edition. Page- 1263, 1264.

2. Mitra, A., & Ray, S. Evaluation of the Safety and Efficacy of Teneligliptin at a Higher Dose in Indian Type 2 Diabetes Patients: A Retrospective Analysis. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. January 2020. [Accessed on 19th April 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047936/

3. Torrent Pharmaceutical Ltd. Teneligliptin. [Revised in April 2021] [Accessed on 19th April 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2991.pdf

4. Mitsubishi Tanabe Pharma Factory Ltd. Teneligliptin. [Revised in April 2020] [Accessed on 19th April 2022] http://ndi.fda.moph.go.th/uploads/drug_detail_corporation/doc/word/1163/2f4b9cbb0657cbd755ecd3d5f00d6b99-a1.pdf

USEFUL DIAGNOSTIC TESTS

• Glucose - Fasting Blood
• Glucose - Postprandial Blood
• Glycosylated Hemoglobin
• Liver Function Test (LFT)
• Kidney Function Test (KFT)
• Complete Blood Count (CBC)
• Serum ketone test

AUTHOR DETAILS

Written By Srilekha. R, B.Pharm
Last updated on 06 Jan 2023 | 02:24 PM(IST)