INTRODUCTION

GUDCEF PLUS TABLET is a combination of Cefpodoxime and Ofloxacin which belongs to the group of medicines called Antibiotics. GUDCEF PLUS TABLET is used to treat mild to moderate bacterial infections such as acute otitis media, pharyngitis, and sinusitis.

GUDCEF PLUS TABLET is not recommended for use in patients allergic to Cefpodoxime, Ofloxacin, and/other cephalosporin antibiotics (such as cephalexin). It is also not recommended for use in patients suffering from epilepsy.

Before taking GUDCEF PLUS TABLET, inform your doctor if you have stomach/intestinal disease, blood clotting disorders, diarrhoea, kidney disease, and/or liver disease.

GUDCEF PLUS TABLET is not recommended for use during pregnancy as it may cause harm to the foetus. It is also not recommended for use in breastfeeding women since it may pass through breast milk.

GUDCEF PLUS TABLET is not recommended for use in children and adolescents (aged below 18 years) and is advised to be used with caution in elderly patients (aged above 65 years) after consulting the doctor.

The most common side effects of taking GUDCEF PLUS TABLET are stomach pain, nausea, vomiting, diarrhea, dizziness, headache, and/or pain in neck, lower legs. Consult your doctor if any of these side effects worsens.

USES OF GUDCEF PLUS TABLET

It is used to treat mild to moderate bacterial infections such as:

• acute otitis media (middle ear infection)
• pharyngitis (sore throat)
• sinusitis (infection of sinus)

HOW GUDCEF PLUS TABLET WORKS

GUDCEF PLUS TABLET treats bacterial infections, where Cefpodoxime works by preventing the formation of the bacterial protective covering which is essential for the survival of the bacteria in the human body and Ofloxacin works by inhibiting DNA gyrase (enzyme responsible for replication, transcription and repair of the DNA) which results in destruction of bacteria thus treating and preventing the spread of bacterial infection in affected individuals.

DIRECTIONS FOR USE

Take GUDCEF PLUS TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF GUDCEF PLUS TABLET

HOW TO MANAGE SIDE EFFECTS

Nausea and Vomiting:

Take GUDCEF PLUS TABLET with or just after a meal. Stick to simple meals. Avoid eating oil rich or spicy foods, sugary snacks and drinks. Avoid drinking too much liquid along with your meals, drink slowly in between meals. Inform your doctor if the condition worsens.

Diarrhoea:

Drink plenty of water and stay hydrated. Try to avoid taking any medicine on your own to treat diarrhea. Consult and inform your doctor if the symptom worsens.

Dizziness:

Try to rest and get enough sleep. Try to avoid driving or operating any tools or machines while you feel dizzy. Limit consumption of alcohol, as it can aggravate dizziness. Consult and inform your doctor if the symptom worsens.

Headache:

If GUDCEF PLUS TABLET causes headache, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of taking GUDCEF PLUS TABLET. If it lasts more than a week or severe, inform your doctor.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Inform your doctor about all the medicines you use including prescription, non-prescription and herbal medicines.

B. Drug-Food interaction:

Avoid consuming milk and dairy products as it may alter the effect the medicine. Consult your doctor before taking GUDCEF PLUS TABLET.

Overdosage:

If you or anyone else accidentally take too much of GUDCEF PLUS TABLET, consult your doctor immediately or visit the nearby hospital.

SYNOPSIS

MORE INFORMATION

• Keep GUDCEF PLUS TABLET out of reach of children
• Store GUDCEF PLUS TABLET at room temperature

FAQs ABOUT GUDCEF PLUS TABLET

What is GUDCEF PLUS TABLET used for?

GUDCEF PLUS TABLET is a combination of Cefpodoxime and Ofloxacin which belongs to the group of medicines called Antibiotics. It is generally used to treat mild to moderate bacterial infections such as acute otitis media, pharyngitis, and sinusitis in affected individuals.

What are the side effects of GUDCEF PLUS TABLET?

The most common side effects of taking GUDCEF PLUS TABLET are stomach pain, nausea, vomiting, diarrhea, dizziness, headache, and/or pain in neck, lower legs. Consult your doctor if any of these side effects worsens.

How GUDCEF PLUS TABLET works?

GUDCEF PLUS TABLET treats bacterial infections, where Cefpodoxime works by preventing the formation of the bacterial protective covering which is essential for the survival of the bacteria in the human body and Ofloxacin works by inhibiting DNA gyrase (enzyme responsible for replication, transcription and repair of the DNA) which results in destruction of bacteria thus treating and preventing the spread of bacterial infection in affected individuals.

How to take GUDCEF PLUS TABLET?

Take GUDCEF PLUS TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Can GUDCEF PLUS TABLET be used in children?

No, GUDCEF PLUS TABLET is not recommended for use in children and adolescents (aged below 18 years). Consult your doctor before taking GUDCEF PLUS TABLET.

REFERENCES

1. K.D. Tripathi. Beta-lactam Antibiotics and Sulphonamides, Cotrimoxazole & Quinolones. Essentials of medical pharmacology. Seventh edition. 2013. Page- 728, 713.

2. M T Borin, J J Ferry, K K Forbes, G S Hughes. Pharmacokinetics of cefpodoxime proxetil in healthy young and elderly volunteers. NIH National Library of Medicine. National Center for Biotechnology Information. PubMed.gov. [Revised in July 1994] [Accessed on 11th June 2022] https://pubmed.ncbi.nlm.nih.gov/7929873/

3. P Veyssier, J B Fourtillan, J Modai, W Couet, M A Lefebvre, J P Darchis, M Vincent Du Laurier, A Bryskier. Pharmacokinetics of ofloxacin in the elderly (65-85 years) with normal renal function after a single oral dose of 200 mg. NIH National Library of Medicine. National Center for Biotechnology Information. PubMed.gov. [Revised in June 1986] [Accessed on 11th June 2022] https://pubmed.ncbi.nlm.nih.gov/3534750/

4. Saintroy Lifescience. Olipod-OF 100. [Accessed on 11th June 2022] https://m.saintroylifescience.com/cefpodoxime-and-ofloxacin-tablets-6873585.html

5. Integrated Laboratories Pvt Ltd. INTEDPOD - OF. [Accessed on 11th June 2022] https://integratedlaboratories.in/cefpodoxime-proxetil-ofloxacin-200-mg-tablets-intepod-of/

6. Vibcare Pharma Pvt. Ltd. ODOXICEF O / CEFDOFEC O. [Accessed on 11th June 2022] https://vibcare.co.in/cefpodoxime-ofloxacin/

7. Alpha Drugs. SYFEDOX-O. [Accessed on 11th June 2022] https://www.alphadrug.in/product/syfedox-o/

8. Zeelab Pharmacy. Zedoxy-O 200. [Accessed on 11th June 2022] https://zeelabpharmacy.com/product/zedoxy-o-200

9. Smotec Pharmaceuticals. SMOPOD-OF. [Accessed on 11th June 2022] https://www.smotecpharma.com/smopod-of

10. StayHappi Pharmacy. Cefpodoxime Proxetil & Ofloxacin Tablets. [Accessed on 11th June 2022] https://www.stayhappi.com/stayhappi-generics/cefpodoxime-proxetil-200-mg-ofloxacin-200-mg-tablet-10s-8665

11. Wellona Pharma. CEFPOWELL-OF. [Accessed on 11th June 2022] https://wellonapharma.com/product/finished/cefpodoxime-and-ofloxacin-tablets

12. Actiza Pharmaceutical Private Limited. Cefpodoxime and ofloxacin tablets. [Accessed on 11th June 2022] https://www.actizapharma.com/products/cefpodoxime-proxetil-ofloxacin/

13. Alpic Remedies Ltd. Cipalp-O. [Accessed on 11th June 2022] https://www.alpicremediesltd.com/cefpodoxime-proxetil-200-mg-ofloxacin-3348739.html

USEFUL DIAGNOSTIC TESTS

• Complete blood count