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Drug Information

What is Domperidone + Paracetamol combination used for?

Domperidone + Paracetamol combination suspension/syrup/tablet is used for the treatment of the following conditions:

  • Migraine
  • Heartburn
  • Dyspepsia
  • Epigastric pain
  • Fever associated with nausea and vomiting

Domperidone + Paracetamol combination may also be prescribed for other conditions as determined by the doctor.

How does Domperidone + Paracetamol combination work?

In Domperidone + Paracetamol combination, Domperidone belongs to the class of drugs called dopamine receptor antagonist (anti-emetic). The drug acts by blocking the activity of certain receptors in the brain that regulates nausea and vomiting. Thus, it helps in treating the condition.

Paracetamol belongs to the class of drugs called analgesics and anti-pyretic. The drug acts by improving the pain threshold and blocking the action of certain enzymes at heat-regulating centres. Thus, it reduces pain and elevated body temperature.

How to take Domperidone + Paracetamol combination?

The dosage and the drug form depend on the age, weight and medical condition of an individual. Take Domperidone + Paracetamol combination suspension/syrup/tablet as prescribed by your doctor.

  • Swallow the tablet Do not crush or chew the tablet. Take the drug with or without food. However, taking the drug with food prevents stomach upset.
  • Shake the suspension/syrup well before taking each dose so as to ensure the uniform mixing of the drug. Use a measuring cup while taking each dose.

If you miss a dose of Domperidone + Paracetamol combination, please take it as soon as you remember. However, if it is almost time for your next dose, then skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed dose.

What are the drugs that interact with Domperidone + Paracetamol combination?

Drugs that interact with Domperidone + Paracetamol combination include the following:

  • Afatinib
  • Aspirin
  • Bupropion
  • Caffeine
  • Carbamazepine
  • Diazepam
  • Leflunomide
  • Lidocaine
  • Lomitapide
  • Simethicone

This is not a comprehensive list of drug interactions. Consult your doctor to know more about other possible drug interactions.

What are the side effects of Domperidone + Paracetamol combination?

The following are the most common side effects of Domperidone + Paracetamol combination:

  • Constipation
  • Drowsiness
  • Decreased libido
  • Allergic reaction
  • Abdominal pain
  • Dry mouth

The following are the severe side effects and you may require immediate medical attention:

  • Gynaecomastia
  • Galactorrhoea
  • Involuntary movements
  • Convulsions
  • Blood dyscrasias

This is not a complete list of side effects and others may occur. Please consult your doctor to know more about other possible side effects.

What special precautions should be followed while taking Domperidone + Paracetamol combination?

  • Avoid taking the medicine if you are allergic to Domperidone + Paracetamol combination or similar drugs.
  • Avoid consumption of alcohol as it may alter the absorption of Domperidone + Paracetamol combination.
  • Do not drive or operate heavy machinery if Domperidone + Paracetamol combination causes dizziness or blurred vision.
  • Avoid Domperidone + Paracetamol combination during pregnancy or breastfeeding because the safe use of the drug is not yet established.
  • Do not stop taking the medication abruptly unless instructed by the doctor. Stopping the medication suddenly may cause the illness to return.
  • Do not exceed the dose prescribed by the doctor.

You are advised not to take Domperidone + Paracetamol combination if

  • it has passed the expiry date of the medicine printed on the pack.
  • the foil or packaging is torn or shows signs of tampering or there is discolouration.

What should you tell your doctor before taking Domperidone + Paracetamol combination?

  • Tell your doctor if you have any history of heart, liver or kidney diseases.
  • Inform the doctor if you are taking any other drugs, OTC medications, herbal products or nutritional supplements.

Frequently Asked Questions about Domperidone + Paracetamol combination

  1. Is it safe to take Domperidone + Paracetamol combination in individuals having vitamin K deficiency?
  2. No. It is advised not to take Domperidone + Paracetamol combination in individuals having vitamin K deficiency, as it worsens the condition.

  3. Can Domperidone + Paracetamol combination be used in the treatment of postoperative nausea and vomiting?
  4. No. Domperidone + Paracetamol combination is not recommended in the treatment of postoperative nausea and vomiting. However, please consult your doctor.

  5. What are the contraindications of Domperidone + Paracetamol combination?
  6. Domperidone + Paracetamol combination is contraindicated in gastro-intestinal haemorrhage, obstruction and perforation.

Disclaimer:

The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment.  Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

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