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INTRODUCTION
GRANDCEF CV TABLET is a combination of Cefpodoxime and Clavulanic Acid which belongs to the group of medicines called Cephalosporins and Beta-lactamase inhibitors, respectively. GRANDCEF CV TABLET is used to treat mild to moderate infections caused by susceptible strains of microorganisms in conditions such as acute otitis media (middle ear infection), pharyngitis (sore throat)/tonsillitis (inflammation of tonsils), community-acquired pneumonia, chronic bronchitis (respiratory infection), and acute maxillary sinusitis (sinus infection) in affected individuals.
GRANDCEF CV TABLET is also used to treat uncomplicated skin structure infections, urethral and cervical gonorrhoea (sexually transmitted disease), anorectal (anal/rectal) infections, and urinary tract infections in affected individuals.
GRANDCEF CV TABLET is not recommended for use in patients allergic to Cefpodoxime, Clavulanic Acid, and/or other cephalosporin group of antibiotics. It is also not recommended for use in patients suffering from galactose intolerance, Lapp lactase deficiency (lactose intolerance), and glucose-galactose malabsorption (condition marked by body’s inability to absorb glucose and galactose sugars).
Before taking GRANDCEF CV TABLET, inform your doctor if you have previous history of hypersensitivity reactions to medicines such as cefpodoxime, other cephalosporins, penicillin, and/or have kidney problems (such as mild/moderate/severe renal impairment), and liver problems (such as hepatic insufficiency/impairment).
GRANDCEF CV TABLET should be used with caution in pregnant women only if it is clearly necessary. It is not recommended for use in breastfeeding women as it may pass through breastmilk.
GRANDCEF CV TABLET is indicated for use in children and adolescents (aged above 12 years). Consult your doctor before administering the medicine to infants (less than 2 years) as safety and efficacy of the medicine have not been established. The medicine should be used with caution in elderly patients (aged above 65 years) after consulting the doctor.
The most common side effects of taking GRANDCEF CV TABLET are diarrhoea, nausea, vomiting, abdominal pain, headache, vaginal fungal infections, and/or vulvovaginal infections. Consult your doctor if any of these symptoms worsens.
USES OF GRANDCEF CV TABLET
- Treats mild to moderate infections such as acute otitis media, pharyngitis/tonsillitis, community-acquired pneumonia, chronic bronchitis, and acute maxillary sinusitis in affected individuals
- Treats uncomplicated skin structure infections, urethral and cervical gonorrhoea (sexually transmitted disease), anorectal infections, and urinary tract infections in affected individuals
HOW GRANDCEF CV TABLET WORKS
GRANDCEF CV TABLET helps to treat mild to moderate infections, where Cefpodoxime works by preventing the formation of the protective covering of the bacteria which is essential for the survival of bacteria and Clavulanic Acid works by reducing the resistance and enhancing the activity of Cefpodoxime against bacteria thus preventing the occurrence of infections in affected individuals.
DIRECTIONS FOR USE
Tablet:
Take GRANDCEF CV TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Dispersible Tablet:
Take GRANDCEF CV TABLET as advised by your physician. Disperse GRANDCEF CV TABLET in the specified quantity of water as mentioned in the label. Consume the mixture immediately after reconstitution. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF GRANDCEF CV TABLET
COMMON
- diarrhoea, nausea, vomiting, abdominal pain
- headache
- vaginal fungal infections, vulvovaginal infections
UNCOMMON
- fungal/yeast infection, bacterial infections, parasitic infections
- inflammation of stomach, abdominal distention
- general discomfort, weakness, tiredness
- fever, chest pain, back pain, muscle pain, chills, gout, localized/generalized pain, abscess, allergic reaction, facial swelling
- congestive heart failure, racing heartbeats, vasodilation (widening of blood vessels), high/low blood pressure
- indigestion, anorexia (eating disorder), belch, decreased appetite, flatulence, constipation, mouth ulcers, gastrointestinal disorders, rectal disorders, dehydration, swelling in legs/arms, weight increased, liver damage.
- dry mouth, tongue disorders, increased thirst, oral lesions, dry throat, toothache, gastric pressure.
- anaemia
- dizziness, sleeplessness, excessive sleepiness, anxiety, shakiness, nervousness, change in dreams, impaired concentration, confusion, nightmares, tingling/prickling sensation, internal spinning sensation
- asthma, cough, bleeding from nose, stuffy nose, wheezing, shortness of breath, pleural effusion, pneumonia, sinusitis (sinus infection)
- red itchy welts, rash, itching at non-application site, fungal dermatitis, dry skin at non-application site, hair loss, sunburn, hypersensitivity mucocutaneous reaction
- taste alterations, eye irritation, taste loss, ringing in ears
- metrorrhagia (abnormal bleeding), pain while urinating, frequent urination at night, penile infection, vaginal pain
- anaphylactic reactions (life threatening allergic reaction), bronchospasm (tightening of airways), purpura (rash of purple spots) and angioedema (swelling underneath the skin)
RARE
Stop taking GRANDCEF CV TABLET and inform your doctor straight away if you experience any of the following side effects:
- signs of allergic reactions such as runny nose, sneezing, breathlessness, itchy skin, and/or raised rash
- seizures
HOW TO MANAGE SIDE EFFECTS
Diarrhea:
Drink plenty of water and stay hydrated. Try to avoid taking any medicine on your own to treat diarrhea. Consult your doctor and inform them if the symptom gets worse.
Nausea and vomiting:
Try to take GRANDCEF CV TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if symptom gets worse.
Headache:
If GRANDCEF CV TABLET causes headache, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of taking GRANDCEF CV TABLET. If it lasts more than a week or severe, inform your doctor.
WARNING & PRECAUTIONS
PREGNANCY
GRANDCEF CV TABLET should be used with caution in pregnant women only if it is clearly necessary. Consult your doctor before taking GRANDCEF CV TABLET.
BREASTFEEDING
GRANDCEF CV TABLET is not recommended for use in breastfeeding women as it may pass through breast milk. Consult your doctor before taking GRANDCEF CV TABLET.
DRIVING AND USING MACHINES
Do not drive or operate machines if you feel dizzy after taking GRANDCEF CV TABLET.
KIDNEY
GRANDCEF CV TABLET should be used with caution in patients with kidney problems such as mild, moderate, and severe renal impairment. Consult your doctor before taking GRANDCEF CV TABLET.
LIVER
GRANDCEF CV TABLET should be used with caution in patients with liver problems such as hepatic impairment/insufficiency. Consult your doctor before taking GRANDCEF CV TABLET.
ALLERGY
Do not take GRANDCEF CV TABLET if you are allergic to Cefpodoxime, Clavulanic Acid, other cephalosporin group of antibiotics, and/or any other ingredients of this medicine.
OTHERS
GRANDCEF CV TABLET is not recommended for use if you:
- galactose intolerance, Lapp lactase deficiency (lactose intolerance), glucose-galactose malabsorption (condition marked by inability of the body to absorb glucose and galactose sugars).
Before taking GRANDCEF CV TABLET inform your doctor if you have:
- previous hypersensitivity reactions to cefpodoxime, other cephalosporins, penicillin, and/or other medicines.
Use in Paediatrics:
GRANDCEF CV TABLET is recommended for use in children and adolescents (aged above 12 years). Consult your doctor before administering the medicine to infants (less than 2 years) as safety and efficacy of the medicine have not been established.
Use in Geriatrics:
GRANDCEF CV TABLET should be used with caution in elderly patients (aged above 65 years). Consult your doctor before taking GRANDCEF CV TABLET.
INTERACTIONS
A. Drug-Drug Interactions:
Before taking GRANDCEF CV TABLET, inform your doctor, if you are taking any of the following medicine:
- antacids (medicines used to relieve indigestion and heartburn) Ex. sodium bicarbonate, aluminium hydroxide
- probenecid (used to treat gout)
- nephrotoxic drugs (medicines that can damage kidney via various mechanisms) Ex. aminoglycosides, amphotericin B.
Overdosage:
If you or anyone else accidentally take too much of GRANDCEF CV TABLET, consult your doctor immediately or visit the nearby hospital. The symptoms of overdosage of GRANDCEF CV TABLET may include nausea, vomiting, epigastric distress, and/or diarrhoea.
SYNOPSIS
| Drug | : | Cefpodoxime, Clavulanic Acid |
| Pharmacological Category | : | Cephalosporin, Beta-lactamase inhibitors |
| Therapeutic Indication | : | Mild to moderate infections (caused by susceptible strains of microorganisms) |
| Dosage Forms | : | Tablet, Dispersible Tablet, Dry Syrup, Dry Suspension, Oral Suspension, Suspension, Syrup |
MORE INFORMATION
- Keep GRANDCEF CV TABLET out of reach of children
- Store at room temperature in a cool and dry place
FAQs ABOUT GRANDCEF CV TABLET
What is GRANDCEF CV TABLET and why is it prescribed?
GRANDCEF CV TABLET is a combination of Cefpodoxime and Clavulanic Acid which belongs to the group of medicines called Cephalosporins and Beta-lactamase inhibitors, respectively. It is used to treat mild to moderate infections caused by susceptible strains of microorganisms in conditions such as acute otitis media (middle ear infection), pharyngitis (sore throat)/tonsillitis (inflammation of tonsils), and community-acquired pneumonia. It is also used to treat uncomplicated skin structure infections, urethral and cervical gonorrhoea (sexually transmitted disease), anorectal (anal/rectal) infections, and urinary tract infections in affected individuals.
How GRANDCEF CV TABLET works?
GRANDCEF CV TABLET helps to treat mild to moderate infections, where Cefpodoxime works by preventing the formation of the protective covering of the bacteria which is essential for the survival of bacteria and Clavulanic acid works by reducing the resistance and enhancing the activity of Cefpodoxime against bacteria thus preventing the occurrence of infections in affected individuals.
What are the most common side effects of taking GRANDCEF CV TABLET?
The most common side effects of taking GRANDCEF CV TABLET are diarrhoea, nausea, vomiting, abdominal pain, headache, vaginal fungal infections, and/or vulvovaginal infections. Consult your doctor if any of these symptoms worsens.
Can GRANDCEF CV TABLET cause diarrhoea?
Yes, GRANDCEF CV TABLET causes diarrhoea as it is the most common side effect associated with the use of medicine. If such side effects experienced, then drink plenty of water and stay hydrated. Avoid taking any medicine on your own to treat diarrhea. Consult and inform your doctor if the symptom gets worse.
Can GRANDCEF CV TABLET be used in pregnant and breastfeeding women?
Yes, GRANDCEF CV TABLET can be used but with caution in pregnant women only if clearly necessary. It is not recommended for use in breastfeeding women since it passes through breast milk. Consult your doctor before taking GRANDCEF CV TABLET.
REFERENCES
1. K.D. Tripathi. Beta-Lactam Antibiotics. Essentials of medical pharmacology. Seventh edition. 2013. Page – 724 & 728.
2. Angela Giarratano, Samantha EL Green, and David P Nicolau. Review of antimicrobial use and considerations in the elderly population. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. [Revised in May 2017] [Accessed on 7th July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909780/
3. CiplaMed. CEFOPROX CV Tablets. [Revised in October 2018] [Accessed on 7th July 2022] https://ciplamed.com/content/cefoprox-cv-tablets-suspension
4. Incepta Pharmaceuticals Ltd. Duo-5 LS. [Accessed on 7th July 2022] http://www.inceptapharma.com/product-details.php?pid=506
5. Macleods Pharmaceuticals Ltd. ZEDOCEF CV 50 DT. [Accessed on 7th July 2022] https://www.macleodspharma.com/products/
USEFUL DIAGNOSTIC TESTS
- Complete Blood Count
- Bacterial culture test
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