INTRODUCTION

GOGLIP 20 contains Teneligliptin which belongs to the group of medicines called Anti-diabetic drugs. It is used as an adjunct to diet and exercise to control elevated blood sugar levels in adult patients with type II diabetes mellitus.

Type II diabetes mellitus is a chronic disease associated with abnormally high levels of glucose in the blood due to inadequate production of a hormone called insulin (produced by pancreas to metabolize glucose) or due to inadequate sensitivity of body cells to the actions of insulin.

Teneligliptin is a dipeptidyl peptidase (DPP)-4 inhibitor. It lowers blood glucose levels by blocking the actions of an enzyme called dipeptidyl peptidase (DPP)-4 that regulates the secretion of insulin in the body. As a result, it improves insulin production and helps in the digestion of circulating blood glucose. It can also regulate blood sugar post meal by controlling glucagon secretion.

During therapy with GOGLIP 20, your doctor might ask you to make certain lifestyle changes such as following a healthy diet, regular physical exercise, and quitting alcohol consumption.

Before taking GOGLIP 20, inform your doctor if you have any liver or heart problems. You must also inform your doctor if you have hormonal problems, stomach problems (surgery in the gut) or if you are malnourished, starved, on an irregular diet.

GOGLIP 20 is not suitable for use in patients with type I diabetes mellitus. Consult your doctor before taking GOGLIP 20 if you are pregnant or planning to become pregnant.

One of the most common side effects of taking GOGLIP 20 is hypoglycemia (low blood sugar levels) which can be identified by symptoms such as increased hunger, sweating, shakiness, weakness, or an irregular heartbeat. To avoid this, your doctor will periodically monitor your blood sugar levels and adjust the dose of GOGLIP 20 accordingly.

You can also carry a sugary snack (such as biscuits, glucose drinks or sweet candies) along with you as a precaution and have them immediately if you experience any signs of hypoglycemia (low blood sugar levels). However, consult your doctor if there is no improvement in your condition. Other common side effects of taking GOGLIP 20 are headache, dizziness, and constipation.

USES OF GOGLIP 20

• Used in adults to treat type II diabetes mellitus along with diet and exercise

HOW GOGLIP 20 WORKS

GOGLIP 20 effectively controls blood glucose levels in patients with type II diabetes mellitus. It contains teneligliptin which is a dipeptidyl peptidase (DPP)-4 inhibitor. It lowers blood glucose levels by blocking the actions of an enzyme called dipeptidyl peptidase (DPP)-4 that regulates the secretion of insulin in the body. As a result, it improves insulin production and helps in the digestion of circulating blood glucose. It can also regulate blood sugar post meal by controlling glucagon secretion.

DIRECTIONS FOR USE

Take GOGLIP 20 as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. GOGLIP 20 should be taken preferably after meals. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF GOGLIP 20

HOW TO MANAGE SIDE EFFECTS

Headache:  

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.

Diarrhea:

Hydrate yourself by drinking plenty of fluids, such as water or fruit juices. Consuming ORS can also be beneficial. Do not self-treat diarrhea on your own. Consult your doctor if your diarrhea becomes uncontrollable.

Constipation:

Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.

Low blood sugar:

Have foods rich in sugars such as fruit juices, glucose drinks, candies, honey, or biscuits. Check your blood sugar after 10 minutes. If not gained optimum level, take another sugary snack, or a drink, and check the blood sugar again. Consult your doctor if there is no improvement in your condition.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug Interaction:

Before taking GOGLIP 20, inform your doctor if you are taking any of the following medicines such as:

• other medicines used to treat diabetes (such as glimepiride, exenatide, acarbose, metformin, pioglitazone, repaglinide, empagliflozin or insulin)
• beta blockers (medicines used to treat high blood pressure) Ex. atenolol, propranolol
• salicylic acid (a medicine used to treat skin problems like acne)
• medicines used to treat depression (Ex. phenelzine, selegiline)
• adrenaline (a medicine used to treat shock caused by allergic reactions or collapse)
• thyroid hormones (used to treat thyroid deficiency) Ex. levothyroxine, liothyronine
• medicines used to treat irregular heartbeats (Ex. quinidine, procainamide, amiodarone, sotalol, etc.)

Overdosage:

If you or anyone else accidentally took more GOGLIP 20, consult your doctor immediately or visit the nearby hospital.

SYNOPSIS

MORE INFORMATION

• Keep GOGLIP 20 out of reach of children
• Store GOGLIP 20 at room temperature

FAQs ABOUT GOGLIP 20

What is GOGLIP 20 used for?

GOGLIP 20 contains Teneligliptin which is used to treat type II diabetes (high blood sugar levels) in adults, that cannot be controlled by diet and exercise alone. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

Is GOGLIP 20 safe to use in pregnancy?

GOGLIP 20 should be used in pregnant women only if prescribed by the physician. Your doctor may prescribe GOGLIP 20 for you after evaluating the risks and benefit ratio. Therefore, consult your doctor before taking it.

What precautions do I need to follow while taking GOGLIP 20?

Before taking GOGLIP 20, inform your doctor if you have any liver or heart problems. You must also inform your doctor if you have any hormonal problems, stomach problems (surgery in the gut) or if you are malnourished. GOGLIP 20 is not suitable for use in patients with type I diabetes mellitus. Consult your doctor before taking GOGLIP 20 if you are pregnant or planning to become pregnant. During therapy with GOGLIP 20, follow the diet and lifestyle changes instructed by your doctor. Always carry a sugary snack (such as biscuits, glucose drinks or sweet candies) along with you as a precaution and have them immediately if you experience any signs of hypoglycemia (low blood sugar levels).

Can I take medication for high blood pressure along with GOGLIP 20?

It is not advisable to take medicines to control blood pressure while taking GOGLIP 20 without consulting your doctor. Therefore, consult your doctor before taking any antihypertensive such as beta blockers (Ex. atenolol, propranolol) along with GOGLIP 20 as they have known interactions with GOGLIP 20.

What should I do if I experience low blood sugar after taking GOGLIP 20?

Low blood sugar is a common side effect of taking GOGLIP 20. Try to have sugar rich food items such as fruit juice, glucose tablets or gel, soft drinks, honey, or sugary candy. If there is no improvement in your condition or if your condition worsens, consult your doctor immediately.

Can GOGLIP 20 cause dizziness?

Yes. Dizziness is a common side effect of using GOGLIP 20. In case you experience dizziness, lie down until it passes, then get up slowly and carefully. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, and alcohol. Do not drive or use machinery to avoid accidents. Consult your doctor if you experience dizziness continuousy for a long time after taking GOGLIP 20.

Can GOGLIP 20 be taken with insulin?

Co-administration of GOGLIP 20 with insulin is considered risky as they are increased chances of hypoglycemia (low blood sugar levels). Consult your doctor before taking it.

How to take GOGLIP 20?

You must take GOGLIP 20 as advised by your physician. Try to take this medicine preferably after meals and swallow it with a glass of water. Do not crush or chew the medicine.

How much GOGLIP 20 should I take?

GOGLIP 20 should be used only under medical supervision. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body condition and severity of the disease condition.

Can GOGLIP 20 cause constipation?

Yes. Constipation is a common side effect of using GOGLIP 20. Eat plenty of fiber rich foods such as fresh fruits, vegetables, cereals as well as drink plenty of water and exercise more regularly when taking this medicine. Contact your doctor if you experience constipation for a long time.

REFERENCES

1. Joseph T. DiPiro, Robert L. Talbert, Gary C. Yee, Gary R. Matzke, Barbara G. Wells, L. Michael Posey. Diabetes Mellitus. Pharmacotherapy- A Pathophysiologic Approach. Eighth edition. Page- 1263, 1264.

2. Mitra, A., & Ray, S. Evaluation of the Safety and Efficacy of Teneligliptin at a Higher Dose in Indian Type 2 Diabetes Patients: A Retrospective Analysis. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. January 2020. [Accessed on 19th April 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047936/

3. Torrent Pharmaceutical Ltd. Teneligliptin. [Revised in April 2021] [Accessed on 19th April 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2991.pdf

4. Mitsubishi Tanabe Pharma Factory Ltd. Teneligliptin. [Revised in April 2020] [Accessed on 19th April 2022] http://ndi.fda.moph.go.th/uploads/drug_detail_corporation/doc/word/1163/2f4b9cbb0657cbd755ecd3d5f00d6b99-a1.pdf

USEFUL DIAGNOSTIC TESTS

• Glucose - Fasting Blood
• Glucose - Postprandial Blood
• Glycosylated Hemoglobin
• Liver Function Test (LFT)
• Kidney Function Test (KFT)
• Complete Blood Count (CBC)
• Serum ketone test