INTRODUCTION

GLIPSOV 20MG contains Teneligliptin which belongs to the group of medicines called Anti-diabetic drugs. It is used as an adjunct to diet and exercise to control elevated blood sugar levels in adult patients with type II diabetes mellitus.

Type II diabetes mellitus is a chronic disease associated with abnormally high levels of glucose in the blood due to inadequate production of a hormone called insulin (produced by pancreas to metabolize glucose) or due to inadequate sensitivity of body cells to the actions of insulin.

Teneligliptin is a dipeptidyl peptidase (DPP)-4 inhibitor. It lowers blood glucose levels by blocking the actions of an enzyme called dipeptidyl peptidase (DPP)-4 that regulates the secretion of insulin in the body. As a result, it improves insulin production and helps in the digestion of circulating blood glucose. It can also regulate blood sugar post meal by controlling glucagon secretion.

During therapy with GLIPSOV 20MG, your doctor might ask you to make certain lifestyle changes such as following a healthy diet, regular physical exercise, and quitting alcohol consumption.

Before taking GLIPSOV 20MG, inform your doctor if you have any liver or heart problems. You must also inform your doctor if you have hormonal problems, stomach problems (surgery in the gut) or if you are malnourished, starved, on an irregular diet.

GLIPSOV 20MG is not suitable for use in patients with type I diabetes mellitus. Consult your doctor before taking GLIPSOV 20MG if you are pregnant or planning to become pregnant.

One of the most common side effects of taking GLIPSOV 20MG is hypoglycemia (low blood sugar levels) which can be identified by symptoms such as increased hunger, sweating, shakiness, weakness, or an irregular heartbeat. To avoid this, your doctor will periodically monitor your blood sugar levels and adjust the dose of GLIPSOV 20MG accordingly.

You can also carry a sugary snack (such as biscuits, glucose drinks or sweet candies) along with you as a precaution and have them immediately if you experience any signs of hypoglycemia (low blood sugar levels). However, consult your doctor if there is no improvement in your condition. Other common side effects of taking GLIPSOV 20MG are headache, dizziness, and constipation.

USES OF GLIPSOV 20MG

• Used in adults to treat type II diabetes mellitus along with diet and exercise

HOW GLIPSOV 20MG WORKS

GLIPSOV 20MG effectively controls blood glucose levels in patients with type II diabetes mellitus. It contains teneligliptin which is a dipeptidyl peptidase (DPP)-4 inhibitor. It lowers blood glucose levels by blocking the actions of an enzyme called dipeptidyl peptidase (DPP)-4 that regulates the secretion of insulin in the body. As a result, it improves insulin production and helps in the digestion of circulating blood glucose. It can also regulate blood sugar post meal by controlling glucagon secretion.

DIRECTIONS FOR USE

Take GLIPSOV 20MG as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. GLIPSOV 20MG should be taken preferably after meals. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF GLIPSOV 20MG

HOW TO MANAGE SIDE EFFECTS

Headache:  

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.

Diarrhea:

Hydrate yourself by drinking plenty of fluids, such as water or fruit juices. Consuming ORS can also be beneficial. Do not self-treat diarrhea on your own. Consult your doctor if your diarrhea becomes uncontrollable.

Constipation:

Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.

Low blood sugar:

Have foods rich in sugars such as fruit juices, glucose drinks, candies, honey, or biscuits. Check your blood sugar after 10 minutes. If not gained optimum level, take another sugary snack, or a drink, and check the blood sugar again. Consult your doctor if there is no improvement in your condition.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug Interaction:

Before taking GLIPSOV 20MG, inform your doctor if you are taking any of the following medicines such as:

• other medicines used to treat diabetes (such as glimepiride, exenatide, acarbose, metformin, pioglitazone, repaglinide, empagliflozin or insulin)
• beta blockers (medicines used to treat high blood pressure) Ex. atenolol, propranolol
• salicylic acid (a medicine used to treat skin problems like acne)
• medicines used to treat depression (Ex. phenelzine, selegiline)
• adrenaline (a medicine used to treat shock caused by allergic reactions or collapse)
• thyroid hormones (used to treat thyroid deficiency) Ex. levothyroxine, liothyronine
• medicines used to treat irregular heartbeats (Ex. quinidine, procainamide, amiodarone, sotalol, etc.)

Overdosage:

If you or anyone else accidentally took more GLIPSOV 20MG, consult your doctor immediately or visit the nearby hospital.

SYNOPSIS

MORE INFORMATION

• Keep GLIPSOV 20MG out of reach of children
• Store GLIPSOV 20MG at room temperature

FAQs ABOUT GLIPSOV 20MG

What is GLIPSOV 20MG used for?

GLIPSOV 20MG contains Teneligliptin which is used to treat type II diabetes (high blood sugar levels) in adults, that cannot be controlled by diet and exercise alone. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

Is GLIPSOV 20MG safe to use in pregnancy?

GLIPSOV 20MG should be used in pregnant women only if prescribed by the physician. Your doctor may prescribe GLIPSOV 20MG for you after evaluating the risks and benefit ratio. Therefore, consult your doctor before taking it.

What precautions do I need to follow while taking GLIPSOV 20MG?

Before taking GLIPSOV 20MG, inform your doctor if you have any liver or heart problems. You must also inform your doctor if you have any hormonal problems, stomach problems (surgery in the gut) or if you are malnourished. GLIPSOV 20MG is not suitable for use in patients with type I diabetes mellitus. Consult your doctor before taking GLIPSOV 20MG if you are pregnant or planning to become pregnant. During therapy with GLIPSOV 20MG, follow the diet and lifestyle changes instructed by your doctor. Always carry a sugary snack (such as biscuits, glucose drinks or sweet candies) along with you as a precaution and have them immediately if you experience any signs of hypoglycemia (low blood sugar levels).

Can I take medication for high blood pressure along with GLIPSOV 20MG?

It is not advisable to take medicines to control blood pressure while taking GLIPSOV 20MG without consulting your doctor. Therefore, consult your doctor before taking any antihypertensive such as beta blockers (Ex. atenolol, propranolol) along with GLIPSOV 20MG as they have known interactions with GLIPSOV 20MG.

What should I do if I experience low blood sugar after taking GLIPSOV 20MG?

Low blood sugar is a common side effect of taking GLIPSOV 20MG. Try to have sugar rich food items such as fruit juice, glucose tablets or gel, soft drinks, honey, or sugary candy. If there is no improvement in your condition or if your condition worsens, consult your doctor immediately.

Can GLIPSOV 20MG cause dizziness?

Yes. Dizziness is a common side effect of using GLIPSOV 20MG. In case you experience dizziness, lie down until it passes, then get up slowly and carefully. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, and alcohol. Do not drive or use machinery to avoid accidents. Consult your doctor if you experience dizziness continuousy for a long time after taking GLIPSOV 20MG.

Can GLIPSOV 20MG be taken with insulin?

Co-administration of GLIPSOV 20MG with insulin is considered risky as they are increased chances of hypoglycemia (low blood sugar levels). Consult your doctor before taking it.

How to take GLIPSOV 20MG?

You must take GLIPSOV 20MG as advised by your physician. Try to take this medicine preferably after meals and swallow it with a glass of water. Do not crush or chew the medicine.

How much GLIPSOV 20MG should I take?

GLIPSOV 20MG should be used only under medical supervision. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body condition and severity of the disease condition.

Can GLIPSOV 20MG cause constipation?

Yes. Constipation is a common side effect of using GLIPSOV 20MG. Eat plenty of fiber rich foods such as fresh fruits, vegetables, cereals as well as drink plenty of water and exercise more regularly when taking this medicine. Contact your doctor if you experience constipation for a long time.

REFERENCES

1. Joseph T. DiPiro, Robert L. Talbert, Gary C. Yee, Gary R. Matzke, Barbara G. Wells, L. Michael Posey. Diabetes Mellitus. Pharmacotherapy- A Pathophysiologic Approach. Eighth edition. Page- 1263, 1264.

2. Mitra, A., & Ray, S. Evaluation of the Safety and Efficacy of Teneligliptin at a Higher Dose in Indian Type 2 Diabetes Patients: A Retrospective Analysis. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. January 2020. [Accessed on 19th April 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047936/

3. Torrent Pharmaceutical Ltd. Teneligliptin. [Revised in April 2021] [Accessed on 19th April 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2991.pdf

4. Mitsubishi Tanabe Pharma Factory Ltd. Teneligliptin. [Revised in April 2020] [Accessed on 19th April 2022] http://ndi.fda.moph.go.th/uploads/drug_detail_corporation/doc/word/1163/2f4b9cbb0657cbd755ecd3d5f00d6b99-a1.pdf

USEFUL DIAGNOSTIC TESTS

• Glucose - Fasting Blood
• Glucose - Postprandial Blood
• Glycosylated Hemoglobin
• Liver Function Test (LFT)
• Kidney Function Test (KFT)
• Complete Blood Count (CBC)
• Serum ketone test