GLIPCRIN M 50/500mg Tablet 15's

INTRODUCTION

GLIPCRIN M 50/500MG TABLET is a combination of Metformin and Sitagliptin which belongs to the group of medicines called Antidiabetic agents. It is used to control blood sugar levels in patients with type II diabetes mellitus along with proper diet and exercise.    

Type II diabetes mellitus is a chronic disease characterized by abnormally high levels of glucose in the blood. It is caused due to inadequate production of a hormone called insulin (produced by pancreas to metabolize glucose) in the body or due to inadequate sensitivity of body cells to the actions of insulin.

Before taking GLIPCRIN M 50/500MG TABLET inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have high blood cholesterol levels, severe systemic infections or are severely dehydrated due to excessive vomiting or diarrhea recently.

During therapy with GLIPCRIN M 50/500MG TABLET, your doctor might regularly monitor your blood sugar levels and kidney functions to avoid the risk of unwanted side effects. He might also ask you to make certain lifestyle changes such as following a healthy diet, regular physical exercise and quitting alcohol consumption to achieve better results.  

GLIPCRIN M 50/500MG TABLET is not recommended for use in patients with severe uncontrollable diabetes. It is also not suitable for use in patients with alcoholism, shock or problems in breathing or blood circulation.  

Consult your doctor before taking GLIPCRIN M 50/500MG TABLET if you are pregnant or breastfeeding. The most common side effects of taking GLIPCRIN M 50/500MG TABLET are low blood sugar levels, stomach upset, constipation, flatulence, metallic taste in mouth, sore throat, stuffy nose and joint pain. Consult your doctor if they bother you.

USES OF GLIPCRIN M 50/500MG TABLET

• Manage type II diabetes mellitus

HOW GLIPCRIN M 50/500MG TABLET WORKS

GLIPCRIN M 50/500MG TABLET is an antidiabetic medicine. It contains two medicines namely metformin and sitagliptin. Metformin makes the body more sensitive to insulin (a hormone involved in glucose metabolism). This helps our body cells to utilize more amount of the circulating blood glucose. Additionally, it can stop glucose production by the liver and reduces its absoprtion in the body.

Teneligliptin controls blood sugar levels by blocking the actions of an enzyme called dipeptidyl peptidase (DPP)-4 that reduces insulin secretion in the body. Collectively, GLIPCRIN M 50/500MG TABLET controls blood sugar levels and improve glycemic control in patients with type II diabetes.

DIRECTIONS FOR USE

Take GLIPCRIN M 50/500MG TABLET preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.

Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop taking GLIPCRIN M 50/500MG TABLET unless your doctor advice you to stop.

SIDE EFFECTS OF GLIPCRIN M 50/500MG TABLET

HOW TO MANAGE SIDE EFFECTS

Constipation

Taking GLIPCRIN M 50/500MG TABLET with meals may reduce the chances of constipation. However, if you experience constipation, eat plenty of fiber rich foods such as fresh fruits, vegetables and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.

Dizziness Or Drowsiness

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.

Headache

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

Hypoglycemia

Have foods rich in sugars such as fruit juices, glucose drinks, candies, honey or biscuits. Check your blood sugar after 10 minutes. If not gained optimum level, take another sugary snack or a drink and check your blood sugar levels once again. Contact your doctor if there is no improvement in your condition.

WARNING & PRECAUTIONS

PREGNANCY

Contraindicated

GLIPCRIN M 50/500MG TABLET is not recommended for use in pregnant women. Therefore, inform your doctor before taking GLIPCRIN M 50/500MG TABLET if you are pregnant, think you may be pregnant or planning to have a baby.

BREASTFEEDING

Contraindicated

GLIPCRIN M 50/500MG TABLET is not recommended for use in breastfeeding women. However, consult your doctor before taking it.

DRIVING AND USING MACHINES

Use with Caution

Do not drive or operate any machines if you feel dizzy after taking GLIPCRIN M 50/500MG TABLET.

ALCOHOL

Consult your doctor

Avoid consumption of alcohol while taking GLIPCRIN M 50/500MG TABLET as it may increase the risk of unwanted side effects.

KIDNEY

Contraindicated

GLIPCRIN M 50/500MG TABLET is not recommended for use in patients with severely reduced kidney functions. Therefore, consult your doctor before taking it.

LIVER

Consult your doctor

GLIPCRIN M 50/500MG TABLET is not recommended for use in patients with severe liver problems. It should be used with caution in patients with gall stones. Therefore, consult your doctor before taking it.

ALLERGY

Contraindicated

Do not take GLIPCRIN M 50/500MG TABLET if you are allergic to Metformin or Sitagliptin.

HEART DISEASE

Contraindicated

GLIPCRIN M 50/500MG TABLET is not recommended for use in patients with severe heart problems (such as acute heart failure or a recent heart attack). Therefore, consult your doctor before taking it.

USE IN PEDIATRICS

Contraindicated

GLIPCRIN M 50/500MG TABLET is not recommended for use in children and adolescents (aged below 18 years). However, consult your doctor before taking it.

USE IN GERIATRICS

Use with Caution

GLIPCRIN M 50/500MG TABLET should be used with caution in elderly patients (aged above 65 years). Therefore, consult your doctor before taking it.

INTERACTIONS

A. Drug-Drug interactions:

Before taking GLIPCRIN M 50/500MG TABLET, inform your doctor if you are taking any of the following medicines such as:

• other medicines used to treat diabetes (Ex. glimepiride, glyburide, gliclazide, teneligliptin, rosiglitazone, pioglitazone)
• iodine contrast medium (used during X-rays)
• medicines used to treat asthma (Ex. salbutamol or terbutaline)
• corticosteroids (used to treat pain and inflammation) Ex. hydrocortisone, prednisolone
• diuretics (used to reduce edema and to treat hypertension) Ex. furosemide, hydrochlorothiazide
• medicines used to treat pain and inflammation (such as ibuprofen and celecoxib)
• medicines used to treat high blood pressure (such as atenolol, propranolol, captopril, enalapril, ramipril, lisinopril, losartan, valsartan, olmesartan, telmisartan)
• alcohol containing medicines (such as cough syrups)
• cimetidine (a medicine used to treat stomach ulcer)
• dolutegravir (a medicine used to treat HIV infection)
• ranolazine (a medicine used to treat chest pain)
• trimethoprim (a medicine used to treat bacterial infection)
• digoxin (a medicine used to treat irregular heartbeat)

Overdosage:

If you or anyone else accidentally took more GLIPCRIN M 50/500MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are feeling cold or uncomfortable, severe nausea or vomiting, stomach pain, unexplained weight loss, muscular cramps and fast breathing.

SYNOPSIS

MORE INFORMATION

• Keep GLIPCRIN M 50/500MG TABLET out of the sight and reach of children
• Store GLIPCRIN M 50/500MG TABLET below 30°C

FAQs ABOUT GLIPCRIN M 50/500MG TABLET

Q: What is GLIPCRIN M 50/500MG TABLET used for?

A: GLIPCRIN M 50/500MG TABLET is an antidiabetic medicine used as an adjunct to diet and exercise to control blood sugar levels in patients with type II diabetes mellitus.

Q: How and when to take GLIPCRIN M 50/500MG TABLET?

A: Take GLIPCRIN M 50/500MG TABLET preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not cursh or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

Q: How long should I take GLIPCRIN M 50/500MG TABLET?

A: You need to take GLIPCRIN M 50/500MG TABLET as long as your doctor or physician prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

Q: What is the best time to take GLIPCRIN M 50/500MG TABLET?

A: GLIPCRIN M 50/500MG TABLET must be taken with meals to avoid gastrointestinal side effects.

Q: What to do if I forgot to take a dose of GLIPCRIN M 50/500MG TABLET?

A: If you forgot to take a dose of GLIPCRIN M 50/500MG TABLET, take it as soon as you remember. However, if it is time for the next dose of GLIPCRIN M 50/500MG TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of GLIPCRIN M 50/500MG TABLET to compensate the missed ones.

Q: What are the most common side effects of taking GLIPCRIN M 50/500MG TABLET?

A: The most common side effects of taking GLIPCRIN M 50/500MG TABLET are low blood sugar levels, stomach upset, constipation, flatulence, metallic taste in mouth, sore throat, stuffy nose and joint pain. Consult your doctor if they bother you.

Q: Can I stop taking GLIPCRIN M 50/500MG TABLET without consulting your doctor?

A: No. You should not stop taking GLIPCRIN M 50/500MG TABLET without consulting your doctor because it may lead to reversal of symptoms. If you feel better after using GLIPCRIN M 50/500MG TABLET, consult your doctor for advice.

Q: Will taking a higher dose of GLIPCRIN M 50/500MG TABLET be more effective?

A: No, taking a higher dose of GLIPCRIN M 50/500MG TABLET will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.

Q: What precautions do I need to follow while taking GLIPCRIN M 50/500MG TABLET?

A: Before taking GLIPCRIN M 50/500MG TABLET inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have high blood cholesterol levels, severe systemic infections or are severely dehydrated due to excessive vomiting or diarrhea recently. Along with the therapy, follow the diet and lifestyle changes advised by your doctor to achieve better results. Consult your doctor before taking GLIPCRIN M 50/500MG TABLET if you are pregnant or breastfeeding.

Q: Can I take medication for high blood pressure along with GLIPCRIN M 50/500MG TABLET?

A: It is not advisable to take medicines to control blood pressure while taking GLIPCRIN M 50/500MG TABLET without consulting your doctor. Therefore, consult your doctor before taking any antihypertensive such as beta blockers (Ex. atenolol, propranolol) along with GLIPCRIN M 50/500MG TABLET as they have known interactions with GLIPCRIN M 50/500MG TABLET.

Q: What should I do if I experience low blood sugar after taking GLIPCRIN M 50/500MG TABLET?

A: Low blood sugar is a common side effect of taking GLIPCRIN M 50/500MG TABLET. If you experience any signs of low blood sugar levels (such as increased hunger, sweating, shakiness, weakness or an irregular heartbeat), consume a sugary snack or sugar drink immediately. Consult your doctor if the symptom did not improve.

Q: Can GLIPCRIN M 50/500MG TABLET be taken with insulin?

A: Co-administration of GLIPCRIN M 50/500MG TABLET with insulin is considered risky as they increase the chance of hypoglycemia (decreased blood sugar levels). Therefore, consult your doctor before taking it.

Q: Can GLIPCRIN M 50/500MG TABLET be used in pregnant women?

A: GLIPCRIN M 50/500MG TABLET is not recommended for use in pregnant women. Therefore, consult your doctor for advice.

Q: How to take GLIPCRIN M 50/500MG TABLET?

A: You must take GLIPCRIN M 50/500MG TABLET as advised by your physician. Try to take this medicine preferably after meals and swallow it with a glass of water. Do not crush or chew the medicine.

Q: How much GLIPCRIN M 50/500MG TABLET should I take?

A: GLIPCRIN M 50/500MG TABLET should be used only under medical supervision. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body condition and severity of the disease condition.

Q: Can GLIPCRIN M 50/500MG TABLET cause constipation?

A: Yes. Constipation is a common side effect of using GLIPCRIN M 50/500MG TABLET. Eat plenty of fiber rich foods such as fresh fruits, vegetables, cereals as well as drink plenty of water and exercise more regularly when taking this medicine. Contact your doctor if this side effect bothers you.

REFERENCES

1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 274 & 275.

2. Erin L. St. Onge, Shannon Miller and Elizabeth Clements. Sitagliptin/Metformin (Janumet) as Combination Therapy in the Treatment of Type-2 Diabetes Mellitus. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. December 2012. [Accessed on 21st October 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541863/

3. Chitrabhanu Ballav and Stephen C.L. Gough. Safety and Efficacy of Sitagliptin-Metformin in Fixed Combination for the Treatment of Type 2 Diabetes Mellitus. Libertas Academica. 2013. [Accessed on 21st October 2022] https://journals.sagepub.com/doi/pdf/10.4137/CMED.S7314

4. Merck Sharp & Dohme (UK) Limited. Electronic Medicines Compendium (EMC) [Revised in February 2022] [Accessed on 21st October 2022] https://www.medicines.org.uk/emc/files/pil.564.pdf

5. Merck & Co., Inc. JANUMET® (sitagliptin and metformin hydrochloride) tablets, for oral use. [Revised in July 2022] [Accessed on 21st October 2022] https://www.merck.com/product/usa/pi_circulars/j/janumet/janumet_pi.pdf

6. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in June 2020] [Accessed on 21st October 2022] https://www.medicines.org.uk/emc/files/pil.594.pdf

7. Rx Farma Limited. Electronic Medicines Compendium (EMC). [Revised in September 2019] [Accessed on 21st October 2022] https://www.medicines.org.uk/emc/files/pil.11951.pdf

8. Organon Pharma (UK) Limited. Electronic Medicines Compendium (EMC). [Revised in November 2021] [Accessed on 21st October 2022] https://www.medicines.org.uk/emc/files/pil.7887.pdf

USEFUL DIAGNOSTIC TESTS

• Glucose - Fasting Blood
• Glucose - Postprandial Blood
• Glycosylated Hemoglobin

AUTHOR DETAILS

Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 18 Oct 2023 | 05:05 PM(IST)