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Gliogen 250mg Tablet 5'S
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INTRODUCTION
GLIOGEN 250MG TABLET contains Temozolomide which belongs to the group of medicines called Antineoplastic agents. GLIOGEN 250MG TABLET is used to treat specific forms of brain tumors in adults with newly diagnosed glioblastoma multiforme which is used first together with radiotherapy as a concomitant phase of therapy and then used alone as a monotherapy.
It is also used in children (above 3 years) and adults to treat malignant glioma, such as glioblastoma multiforme or anaplastic astrocytoma if they return or get worse after standard treatment.
Glioblastoma multiforme is an aggressive type of cancer that affects the brain or spinal cord which is generally characterized by symptoms such as headache, nausea, drowsiness, blurred vision, personality changes and seizures.
Along with this treatment, your doctor might advise you to take liver function tests to assess the hepatotoxicity (injury to liver due to exposure to drug) and function of your liver.
Before taking GLIOGEN 250MG TABLET, inform your doctor if you have or ever had hepatitis B infection (serious liver infection).
GLIOGEN 250MG TABLET is not recommended for use if you have certain kinds of blood cells which are severely reduced such as white blood cell and platelet count.
GLIOGEN 250MG TABLET should be used with caution during pregnancy only if it is clearly necessary and not recommended for use in breastfeeding women.
It is not recommended for use in children below 3 years of age and should be used with caution in children and adolescents (from 3 to 18 years of age). Consult your doctor before taking GLIOGEN 250MG TABLET.
The most common side effects of taking GLIOGEN 250MG TABLET are loss of appetite, difficulty while speaking, headache, vomiting, nausea, diarrhea, and constipation. Consult and inform your doctor if any of these symptoms gets worse.
USES OF GLIOGEN 250MG TABLET
It is used to treat:
- specific forms of brain tumors in with newly diagnosed glioblastoma multiforme (in adults)
- malignant glioma, such as glioblastoma multiforme or anaplastic astrocytoma (in adults and children)
HOW GLIOGEN 250MG TABLET WORKS
GLIOGEN 250MG TABLET works by damaging the genetic material (DNA and RNA) of the cancer cells inside the brain cells which results in preventing their cell growth and multiplication thereby preventing the spread of the cancer to other parts of the body.
DIRECTIONS FOR USE
Take GLIOGEN 250MG TABLET as advised by your physician. Swallow GLIOGEN 250MG TABLET with a glass of water and do not chew or crush the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF GLIOGEN 250MG TABLET
COMMON
- loss of appetite
- difficulty while speaking
- headache
- vomiting, nausea
- diarrhea
- constipation
- rash
- hair loss
- tiredness
- infections, oral infections
- feeling sick, extreme tiredness, loss of appetite (signs of neutropenia)
- fever, cough, runny nose (signs of lymphopenia)
- prolonged cuts, bleeding from gums, blood in urine (signs of thrombocytopenia)
- allergic reactions
- memory impairment
- depression, anxiety, confusion, sleeplessness
- difficulty concentrating
- dizziness
- visual disturbances
- deafness, ringing in the ears, earache
- blood clot in lung or legs
- high blood pressure
- shortness of breath
- bronchitis
- cough and cold
- inflammation of your sinuses
- stomach or abdominal pain
- dry skin, itching
- muscle damage, muscle aches and pain, muscle weakness
- joint and back pain
- frequent urination
- fever
- flu-like symptoms such as chills, cough, fever, muscle aches
- pain
- fluid retention
- weight gain or loss
- radiation injury such as weakness, hair loss, and bloody vomit
UNCOMMON
- new or reactivated cytomegalovirus infections such as chickenpox, herpes simplex
- signs of reactivated hepatitis b virus infections such as abdominal pain, dark urine, fever, and joint pain
- secondary cancers including leukemia (blood cancer)
- reduced blood cell counts such as pancytopenia
- red spots under the skin
- signs of diabetes insipidus
- piles
- dry mouth
- blisters on body or in mouth
- skin peeling, skin eruption, painful reddening of the skin, severe rash with skin swelling
- increased sensitivity to sunlight
- urticaria (red, itchy skin)
- increased sweating
- change in skin color
- vaginal bleeding or irritation
- absent or heavy menstrual periods
- breast pain
- sexual impotence
- shivering
RARE
Stop taking GLIOGEN 250MG TABLET and contact your doctor if you experience any of the following side effects:
- signs of a severe allergic (hypersensitive) reaction such as itchy red skin, wheezing or other breathing difficulty
- uncontrolled bleeding
- seizures (fits)
- fever and symptoms of infections such as cough, chills, sweat
- chills
- severe headache
HOW TO MANAGE SIDE EFFECTS
Constipation:
Try to eat high-fiber foods such as vegetables, cereals, fresh fruit, and drink plenty of water. Consult and inform your doctor for receiving alternate treatments for constipation.
Dizziness:
Try to rest and get enough sleep. Try to avoid driving or operating any tools or machines while you feel dizzy. Limit consumption of alcohol, as it can aggravate dizziness. Consult and inform your doctor if the symptom does not improve.
Headache:
If GLIOGEN 250MG TABLET causes headache, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of taking GLIOGEN 250MG TABLET. If headaches last more than a week or severe, consult and inform your doctor.
Nausea and Vomiting:
Try to take GLIOGEN 250MG TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if symptom gets worse.
Diarrhea:
Drink plenty of water and stay hydrated. Try to avoid taking any medicine on your own to treat diarrhea, consult and inform your doctor if the symptom gets worse.
WARNING & PRECAUTIONS
PREGNANCY
GLIOGEN 250MG TABLET should be used with caution in pregnant women only if it is clearly necessary. Women with childbearing potential should use effective contraceptive precautions which should be continued for at least 6 months following the completion of treatment. Consult your doctor before taking GLIOGEN 250MG TABLET.
BREASTFEEDING
GLIOGEN 250MG TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking GLIOGEN 250MG TABLET.
DRIVING AND USING MACHINES
GLIOGEN 250MG TABLET may cause tiredness or sleepiness. If you experience any such effects avoid driving and using machines. Consult your doctor before taking GLIOGEN 250MG TABLET.
KIDNEY
GLIOGEN 250MG TABLET should be used with caution in patients with kidney problems such as severe renal impairment. Consult your doctor for advice before taking GLIOGEN 250MG TABLET.
LIVER
GLIOGEN 250MG TABLET should be used in patients with mild, moderate, and severe hepatic impairment. Consult your doctor for advice before taking GLIOGEN 250MG TABLET.
ALLERGY
Do not take GLIOGEN 250MG TABLET is not recommended for use if you are allergic to Temozolomide or any of the other ingredients of this medicine.
LUNGS
GLIOGEN 250MG TABLET should be used with caution in patients with lung disease such as pneumocystis jirovecii pneumonia (serious fungal infection of lungs). Consult your doctor before taking GLIOGEN 250MG TABLET.
OTHERS
GLIOGEN 250MG TABLET is not recommended for use if you:
- have certain kinds of blood cells which are severely reduced such as white blood cell and platelet count
Before taking GLIOGEN 250MG TABLET, inform your doctor if you:
- have signs of anemia (low red blood cell count)
- have signs of low platelet count
- small risk of other changes in blood cells such as leukemia (blood cancer)
Use in pediatrics:
GLIOGEN 250MG TABLET is not recommended for use in children below 3 years of age. There is limited information in patients over 3 years of age who have taken GLIOGEN 250MG TABLET. Consult your doctor before taking GLIOGEN 250MG TABLET.
Use in geriatrics:
GLIOGEN 250MG TABLET should be used with caution in elderly patients (aged 70 years or above). Consult your doctor before taking GLIOGEN 250MG TABLET.
INTERACTIONS
A. Drug-Drug Interactions:
Before taking GLIOGEN 250MG TABLET, inform your doctor, if you are taking any of the following medicine:
- dacarbazine (used to treat cancer of the lymph system and malignant melanoma (a type of skin cancer)
Overdosage:
If you or anyone else accidentally takes too much of GLIOGEN 250MG TABLET, consult your doctor immediately or visit the nearby hospital.
SYNOPSIS
| Drug | : | Temozolomide |
| Pharmacological Category | : | Antineoplastic agents |
| Therapeutic Indication | : | Glioblastoma multiforme, Anaplastic astrocytoma |
| Dosage Forms | : | Capsule, Tablet, Injection |
MORE INFORMATION
- Keep the medicine out of reach in children
- Store GLIOGEN 250MG TABLET at room temperature
FAQs ABOUT GLIOGEN 250MG TABLET
What GLIOGEN 250MG TABLET is used for?
GLIOGEN 250MG TABLET is used to treat specific forms of brain tumors in adults with newly diagnosed glioblastoma multiforme which is used first together with radiotherapy as a concomitant phase of therapy and then used alone as a monotherapy.
How should GLIOGEN 250MG TABLET be taken?
Take GLIOGEN 250MG TABLET as advised by your physician. Swallow GLIOGEN 250MG TABLET with a glass of water and do not chew or crush the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
What are the side effects of GLIOGEN 250MG TABLET?
The most common symptoms of taking GLIOGEN 250MG TABLET are loss of appetite, difficulty while speaking, headache, vomiting, nausea, diarrhea, and constipation. Consult and inform your doctor if any of these symptoms gets worse.
What happens if you forget to take GLIOGEN 250MG TABLET?
If you forget to take GLIOGEN 250MG TABLET at the usual time, take your dose as soon as possible and then continue with your medication at the usual times. Avoid taking a double dose to make up for forgotten individual doses. Consult and inform your doctor before taking GLIOGEN 250MG TABLET if you have queries on the missed dose.
Is GLIOGEN 250MG TABLET safe to use in children?
GLIOGEN 250MG TABLET is not recommended for use in children below 3 years of age. There is limited information in patients over 3 years of age who have taken GLIOGEN 250MG TABLET. Consult your doctor before taking GLIOGEN 250MG TABLET.
REFERENCES
1. KD. Tripathi. Anticancer Drugs. Seventh edition. 2013. Page – 858.
2. J.R. Wesolowski, P. Rajdev, and S.K. Mukherji. Temozolomide (Temodar). NIH National Library of Medicine, National center for biotechnology information. PMC PubMed Central. September 2010 [Accessed on 15th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7966084/
3. SP Labo N.V. Electronic medicines compendium (EMC). [Revised in August 2021] [Accessed on 15th June 2022] https://www.medicines.org.uk/emc/files/pil.1463.pdf
4. Merck & Co., Inc. TEMODAR. [Revised in November 2019] [Accessed on 15th June 2022] https://www.merck.com/product/usa/pi_circulars/t/temodar_capsules/temodar_pi.pdf
USEFUL DIAGNOSTIC TESTS
- Liver function test
AUTHOR DETAILS
Written By Dr. Janet.C, Pharm.D
Last updated on 12 Nov 2022 | 06:22 PM(IST)
PRODUCT DETAILS
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