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INTRODUCTION
GLICLA DM 40MG TABLET contains Gliclazide which belongs to the group of medicines called Antidiabetic agents. It is used in adults in the management of type II diabetes mellitus when diet, exercise and lifestyle changes alone does not result in adequate response.
Type II diabetes mellitus is a chronic disease associated with abnormally high levels of glucose in the blood. It is caused either due to inadequate production of a hormone called insulin (produced by pancreas to metabolize glucose) or due to inadequate sensitivity of body cells to the actions of insulin.
During therapy with GLICLA DM 40MG TABLET, your doctor might ask you to make certain lifestyle changes such as following a healthy diet, regular physical exercise and quitting alcohol consumption.
Before taking GLICLA DM 40MG TABLET, inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have any hormonal problems, genetic disorders (such as G6PD deficiency) or if you are malnourished, starved, on an irregular diet.
GLICLA DM 40MG TABLET is not suitable for use in patients with type I diabetes mellitus. Consult your doctor before taking GLICLA DM 40MG TABLET if you are pregnant or planning to become pregnant or breastfeeding.
One of the most common side effects of taking GLICLA DM 40MG TABLET is hypoglycemia (low blood sugar levels) which can be identified through symptoms such as increased hunger, sweating, shakiness, weakness, or an irregular heartbeat. To avoid this, your doctor will periodically monitor your blood sugar levels and adjust the dose of GLICLA DM 40MG TABLET accordingly.
You can also carry a sugary snack (such as biscuits, glucose drinks or sweet candies) along with you as a precaution and have them immediately if you experience any signs of hypoglycemia. However, consult your doctor if there is no improvement in your condition. Other common side effects of taking GLICLA DM 40MG TABLET are headache, dizziness, and constipation.
USES OF GLICLA DM 40MG TABLET
- Management of type II diabetes mellitus in adults
HOW GLICLA DM 40MG TABLET WORKS
GLICLA DM 40MG TABLET effectively controls blood sugar levels, where gliclazide makes the pancreas secrete more insulin to digest the circulating sugars (glucose) in the blood. It also makes the body more sensitive to insulin which helps in utilizing the circulating blood glucose (sugars) leading to decrease in blood glucose levels.
DIRECTIONS FOR USE
Take GLICLA DM 40MG TABLET before meals or as advised by your physician. Swallow the medicine with a glass of water. Do not cursh or chew the medicine.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Continue to take GLICLA DM 40MG TABLET for the duration recommended by your doctor to achieve better control over blood sugar levels.
SIDE EFFECTS OF GLICLA DM 40MG TABLET
COMMON
- hypoglycemia (low blood sugar levels)
- dizziness
- headache
UNCOMMON
- stomach pain
- nausea or vomiting
- indigestion, diarrhoea, or constipation
RARE
- low RBC and platelet count (causing pale skin, tiredness, headache, prolonged bleeding or bruising, shortness of breath or dizziness)
- skin rash and itching
- changes in vision
Stop taking GLICLA DM 40MG TABLET and contact your doctor immediately if you experience any of the following side effects:
- severe allergic reaction (such as skin rash, swelling of the face, eyelids, lips, tongue, or throat which causes difficulty in breathing or swallowing)
- severe skin reactions (such as DRESS characterized by fever or flu-like symptoms along with skin rashes with widespread blistering or peeling of skin)
- signs of liver problems (such as fever, yellowing of skin and whites of the eyes, weakness, fatigue, weight loss and loss of appetite)
- signs of severe decrease in blood sugar level (such as confusion, headache, excessive sweating, clammy skin, trembling, weakness, double vision, excessive hunger, nausea, vomiting, problems in sleeping, feeling agitated, unable to concentrate, drowsiness, loss of consciousness, slowed reactions, depression, trouble seeing or speaking, paralysis, numbness, dizziness, hallucinations, difficulty in breathing, slowed or faster heartbeat with chest pain)
HOW TO MANAGE SIDE EFFECTS
Constipation
Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.
Diarrhea
Hydrate yourself by drinking plenty of fluids, such as water or fruit juices. Consuming ORS can also be beneficial. Do not self-treat diarrhea on your own. Consult your doctor if your diarrhea becomes uncontrollable.
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Headache
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Hypoglycemia
Have foods rich in sugars such as fruit juices, glucose drinks, candies, honey, or biscuits. Check your blood sugar after 10 minutes. If not gained optimum level, take another sugary snack, or a drink, and check the blood sugar again. consult your doctor if there is no improvement in your condition.
WARNING & PRECAUTIONS
PREGNANCY
ContraindicatedGLICLA DM 40MG TABLET is generally not recommended for use in pregnant women. Therefore, consult your doctor before taking it.
BREASTFEEDING
ContraindicatedGLICLA DM 40MG TABLET is generally not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.
DRIVING AND USING MACHINES
Use with CautionDo not drive or operate any machines if you feel dizzy or experience blurred vision after taking GLICLA DM 40MG TABLET.
ALCOHOL
Consult your doctorAvoid alcohol consumption while taking GLICLA DM 40MG TABLET as it could aggravate your exisiting condition.
KIDNEY
Consult your doctorGLICLA DM 40MG TABLET is not recommended for use in patients with severe kidney disease. It should be used with caution in patients with decreased kidney functions. Therefore, consult your doctor before taking it.
LIVER
Consult your doctorGLICLA DM 40MG TABLET is not recommended for use in patients with severe liver disease. It should be used with caution in patients with decreased liver functions. Therefore, consult your doctor before taking it.
ALLERGY
ContraindicatedDo not take GLICLA DM 40MG TABLET if you are allergic to Gliclazide or to any other medicines that belongs to sulphonylureas (such as glibenclamide, glipizide).
USE IN PEDIATRICS
ContraindicatedGLICLA DM 40MG TABLET is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before administration.
USE IN GERIATRICS
Use with CautionGLICLA DM 40MG TABLET should be used with caution in elderly patients especially in those who take medicines such as CNS depressants or beta-blockers. Therefore, consult your doctor before taking it.
OTHERS
GLICLA DM 40MG TABLET is not recommended for use if you:
- have type I diabetes (or insulin-dependent diabetes)
- have diabetic ketoacidosis (increased levels of sugar and ketone bodies in the blood)
- have diabetic coma or pre-coma
- have serious traumatic injury
- have G6PD deficiency (an inherited blood disorder)
- have prophyria (an inherited blood disorder)
Before taking GLICLA DM 40MG TABLET inform your doctor if you:
- are malnourished, starved, on an irregular diet, or feeling weak
- perform extreme physical exercises
- have hormonal problems (Ex. disorders of pituitary gland, adrenal cortex or thyroid gland)
INTERACTIONS
A. Drug-Drug interactions:
Before taking GLICLA DM 40MG TABLET, inform your doctor if you are taking any of the following medicines such as:
- other antidiabetic medications such as metformin, insulin, glipizide, glibenclamide, dapaglifozin, teneligliptin etc.
- antifungal medicines (used to treat fungal infections) such as miconazole or fluconazole
- St. John’s Wort (a herbal preparations used to treat depression)
- antibiotics (used to treat bacterial infections) such as fluorquinolones (Ex. ciprofloxacin, moxifloxacin), clarithromycin, co-trimoxazole, rifampicin, chlormaphenicol, tetracyclines or sulphonamides (Ex. sulphasalazine)
- medicines used to treat high blood pressure or heart failure such as beta blockers (Ex. atenolo, propranolol), ACE-inhibitors (Ex. captopril or enalapril)
- medicines used to treat stomach ulcers such as ranitidine, famotidine
- medicines used to treat depression (such as moclobemide, isocarboxazid, phenelzine and tranylcypromine)
- medicines used for pain relief (Ex. aspirin, phenylbutazone, ibuprofen, phenylbutazone, azapropazone)
- medicines containing alcohol such as cough preparations
- medicines to treat mental illness (such as chlorpromazine, prochlorperazine, lithium)
- corticosteroids (used to treat pain and inflammation) Ex. prednisolone, cotisone, betamethasone
- medicines used to treat asthma (Ex. salbutamol, terbutaline)
- ritodrine (a medicine used to stop pre-mature labour)
- danazol (a medicine used to treat breast disorders, heavy menstrual bleeding and endometriosis)
- medicines used for blood thinning (Ex. warfarin).
- diuretics (used to increase urine ouptut and to reduce edema) such as bendroflumethiazide, hydrochlorothiazide, furosemide
- oral contraceptives (birth control pills) Ex. drospirenone, ethinylestradiol
- sulfinpyrazone (a medicine used to treat gout)
- aminoglutethimide (a medicine used to treat breast cancer or prostate cancer)
- thyroid hormones such as thyroxine (used to treat thyroid deficiency)
- octreotide (a medicine used to treat bleeding in the gut)
- testosterone (a hormonal medicine used to treat delayed puberty in men)
- cimetidine (a medicine used to treat stomach ulcers)
- clofibrate (a medicine used to treat high blood cholesterol levels)
- disopyramide (a medicine used for irregular heartbeats)
- laxatives (used to treat constipation) Ex. lactulose, ispagula
Overdosage:
If you or anyone else accidentally took more of GLICLA DM 40MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose might include signs of low blood glucose levels such as weakness, sweating, trembling, fast heartbeat, confusion, and double vision.
SYNOPSIS
| Drug | : | Gliclazide |
| Pharmacological Category | : | Sulfonylureas |
| Therapeutic Indication | : | Type II Diabetes Mellitus |
| Dosage Forms | : | Tablet, Capsule |
MORE INFORMATION
- Keep GLICLA DM 40MG TABLET out of reach of children
- Store GLICLA DM 40MG TABLET at room temperature
FAQs ABOUT GLICLA DM 40MG TABLET
Q: What is GLICLA DM 40MG TABLET used for?
A: GLICLA DM 40MG TABLET is an antidiabetic medicine used in the management of type II diabetes mellitus when diet, exercise and lifestyle changes alone does not result in adequate response.
Q: How and when to take GLICLA DM 40MG TABLET?
A: Take GLICLA DM 40MG TABLET before meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Q: How long should I take GLICLA DM 40MG TABLET?
A: You need to take GLICLA DM 40MG TABLET as long as your doctor or physician prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Q: Can I stop taking GLICLA DM 40MG TABLET without consulting your doctor?
A: No. You should not stop taking GLICLA DM 40MG TABLET without consulting your doctor because it may lead to reversal of symptoms. If you feel better after using GLICLA DM 40MG TABLET, consult your doctor for advice. Your doctor might would reduce the dose gradually before discontinuation of therapy.
Q: Will taking a higher dose of GLICLA DM 40MG TABLET be more effective?
A: No, taking a higher dose of GLICLA DM 40MG TABLET will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
Q: What to do if I forget to take a dose of GLICLA DM 40MG TABLET?
A: If you forget to take a dose of GLICLA DM 40MG TABLET, take it as soon as you remember. However, if it is time to take the next dose, skip the missed dose and take the next one at regular times. Do not take a double dose of GLICLA DM 40MG TABLET to compensate a missed dose, as it could lead to toxicity.
Q: What precautions do I need to follow while taking GLICLA DM 40MG TABLET?
A: Before taking GLICLA DM 40MG TABLET, inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have hormonal problems, genetic problems (surgery in the gut) or if you are malnourished. GLICLA DM 40MG TABLET is not suitable for use in patients with type I diabetes mellitus. Consult your doctor before taking GLICLA DM 40MG TABLET if you are pregnant or planning to become pregnant. During therapy with GLICLA DM 40MG TABLET, follow the diet and lifestyle changes instructed by your doctor. Always carry a sugary snack (such as biscuits, glucose drinks or sweet candies) along with you as a precaution and have them immediately if you experience any signs of hypoglycemia.
Q: Can I take medication for high blood pressure along with GLICLA DM 40MG TABLET?
A: No. It is not advisable to take medicines to control blood pressure while taking GLICLA DM 40MG TABLET without consulting your doctor. Therefore, consult your doctor before taking any antihypertensive such as beta blockers (Ex. atenolol, propranolol) along with GLICLA DM 40MG TABLET as they have known interactions with GLICLA DM 40MG TABLET.
Q: What should I do if I experience low blood sugar after taking GLICLA DM 40MG TABLET?
A: Low blood sugar is a common side effect of taking GLICLA DM 40MG TABLET. Try to have sugar rich food items such as fruit juice, glucose tablets or gel, soft drinks, honey, or sugary candy. Check your blood sugar after 10 minutes. If not gained optimum level, take another sugary snack, or drink, and check the blood sugar again. In case of persistent low blood sugar levels, consult your doctor immediately.
Q: Can GLICLA DM 40MG TABLET cause dizziness?
A: Yes. Dizziness is a common side effect of using GLICLA DM 40MG TABLET. In case you experience dizziness, lie down until it passes, then get up slowly and carefully. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, and alcohol. Do not drive or use machinery to avoid accidents. Consult your doctor if you experience dizziness continuously for a long time after taking GLICLA DM 40MG TABLET.
Q: Can GLICLA DM 40MG TABLET be taken with insulin?
A: Co-administration of GLICLA DM 40MG TABLET with insulin is considered risky as they are increased chances of hypoglycemia (decreased blood sugar levels). Consult your doctor before taking it.
Q: Can GLICLA DM 40MG TABLET be used in pregnant women?
No. GLICLA DM 40MG TABLET is not recommended for use in pregnant women. Therefore, consult your doctor for advice before taking.
REFERENCES
1. K.D. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 270-272.
2. Shinnya Miwa, Hirotaka Watada, Ohmura chie and Yasushi Tanaka. Efficacy and Safety of Once Daily Gliclazide (20 mg/day) Compared with Nateglinide. ScienceDirect.com. August 2004. [Accessed on 2nd September 2022] https://www.researchgate.net/publication/8361650_Efficacy_and_Safety_of_Once_Daily_Gliclazide_20_mgday_Compared_with_Nateglinide
3. Les Laboratoires Servier. Electronic Medicines Compendium (EMC). [Revised in July 2022] [Accessed on 2nd September 2022] https://www.medicines.org.uk/emc/files/pil.1321.pdf
4. Accord. Electronic Medicines Compendium (EMC). [Revised in March 2021] [Accessed on 2nd September 2022] https://www.medicines.org.uk/emc/product/5883/pil#gref
5. Accord. Electronic Medicines Compendium (EMC). [Revised in March 2021] [Accessed on 2nd September 2022] https://www.medicines.org.uk/emc/files/pil.2044.pdf
6. Balkanpharma-Dupnitsa AD. Electronic Medicines Compendium (EMC). [Revised in January 2021] [Accessed on 2nd September 2022] https://www.medicines.org.uk/emc/files/pil.4991.pdf
7. Zentiva Pharma UK Limited. Electronic Medicines Compendium (EMC). [Revised in June 2021] [Accessed on 2nd September 2022] https://www.medicines.org.uk/emc/files/pil.13829.pdf
USEFUL DIAGNOSTIC TESTS
- Glucose-Fasting Blood
- Glucose-Postprandial Blood
- Glycosylated Haemoglobin
AUTHOR DETAILS
Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 18 Oct 2023 | 05:00 PM(IST)
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