Glibetic 5mg Tablet 10'S

INTRODUCTION

GLIBETIC 5MG TABLET contains Glipizide which belongs to the group of medicines called Antidiabetic agents. It is used in adults in the management of type II diabetes mellitus when diet, exercise and lifestyle changes alone does not result in adequate response.

Type II diabetes mellitus is a chronic disease associated with abnormally high levels of glucose in the blood. It is caused either due to inadequate production of a hormone called insulin (produced by pancreas to metabolize glucose) or due to inadequate sensitivity of body cells to the actions of insulin.

Before taking GLIBETIC 5MG TABLET, inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have any hormonal problems, genetic disorders (such as G6PD deficiency) or if you are malnourished, starved, on an irregular diet.

GLIBETIC 5MG TABLET is not suitable for use in patients with type I diabetes mellitus. Consult your doctor before taking GLIBETIC 5MG TABLET if you are pregnant or planning to become pregnant or breastfeeding.

One of the most common side effects of taking GLIBETIC 5MG TABLET is hypoglycemia (low blood sugar levels) which can be identified through symptoms such as increased hunger, dizziness, sweating, shakiness, headache, confusion and visual disturbances. To avoid this, your doctor will periodically monitor your blood sugar levels and adjust the dose of GLIBETIC 5MG TABLET accordingly.

You can also carry a sugary snack (such as biscuits, glucose drinks or sweet candies) along with you as a precaution and have them immediately if you experience any signs of hypoglycemia. However, consult your doctor if there is no improvement in your condition. Other common side effects of taking GLIBETIC 5MG TABLET are nausea, diarrhea and stomach pain. Consult your doctor if they trouble you.

USES OF GLIBETIC 5MG TABLET

• Management of type II diabetes mellitus

HOW GLIBETIC 5MG TABLET WORKS

GLIBETIC 5MG TABLET effectively controls blood sugar levels, where glipizide makes the pancreas secrete more insulin to digest the circulating sugars (glucose) in the blood. It also helps the body cells to use insulin effectively, thereby reducing blood glucose levels.

DIRECTIONS FOR USE

Take GLIBETIC 5MG TABLET before meals or as advised by your physician. Swallow the medicine with a glass of water. Do not cursh or chew the medicine.

Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Continue to take GLIBETIC 5MG TABLET for the duration recommended by your doctor to achieve better control over blood sugar levels.

SIDE EFFECTS OF GLIBETIC 5MG TABLET

HOW TO MANAGE SIDE EFFECTS

Diarrhea

Hydrate yourself by drinking plenty of fluids, such as water or fruit juices. Consuming ORS can also be beneficial. Do not self-treat diarrhea on your own. Consult your doctor if your diarrhea becomes uncontrollable.

Dizziness Or Drowsiness

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.

Hypoglycemia

Have foods rich in sugars such as fruit juices, glucose drinks, candies, honey, or biscuits. Check your blood sugar after 10 minutes. If not gained optimum level, take another sugary snack and check the blood sugar again. consult your doctor if there is no improvement in your condition.

WARNING & PRECAUTIONS

PREGNANCY

Contraindicated

GLIBETIC 5MG TABLET is generally not recommended for use in pregnant women. Therefore, consult your doctor before taking it.

BREASTFEEDING

Contraindicated

GLIBETIC 5MG TABLET is generally not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.

DRIVING AND USING MACHINES

Use with Caution

GLIBETIC 5MG TABLET does not affect your ability to drive or operate any tools or machines. However, avoid driving or handling heavy tools or machines if your ability is affected by GLIBETIC 5MG TABLET.

ALCOHOL

Consult your doctor

Avoid alcohol consumption while taking GLIBETIC 5MG TABLET as it could aggravate your exisiting condition.

KIDNEY

Contraindicated

GLIBETIC 5MG TABLET is not recommended for use in patients with kidney problems. Therefore, consult your doctor before taking it.

LIVER

Contraindicated

GLIBETIC 5MG TABLET is not recommended for use in patients with liver problems. Therefore, consult your doctor before taking it.

ALLERGY

Contraindicated

Do not take GLIBETIC 5MG TABLET if you are allergic to Glipizide or to any other medicines that belongs to sulphonylureas (such as glibenclamide, gliclazide).

USE IN PEDIATRICS

Contraindicated

GLIBETIC 5MG TABLET is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before administration.

USE IN GERIATRICS

Use with Caution

GLIBETIC 5MG TABLET should be used with caution in elderly patients. Therefore, consult your doctor before taking it.

INTERACTIONS

A. Drug-Drug interactions:

Before taking GLIBETIC 5MG TABLET, inform your doctor if you are taking any of the following medicines such as:

• antifungal medicines (used to treat fungal infections) such as miconazole or fluconazole
• antibiotics (used to treat bacterial infections) such as fluorquinolones (Ex. ciprofloxacin, moxifloxacin), clarithromycin, co-trimoxazole, rifampicin, chlormaphenicol, tetracyclines or sulphonamides (Ex. sulphasalazine)
• medicines used to treat high blood pressure or heart failure such as beta blockers (Ex. atenolo, propranolol), ACE-inhibitors (Ex. captopril or enalapril)
• medicines used to treat stomach ulcers such as ranitidine, famotidine, cimetidine
• medicines used to treat depression (such as moclobemide, isocarboxazid, phenelzine and tranylcypromine)
• medicines used for pain relief (Ex. aspirin, phenylbutazone, ibuprofen, phenylbutazone, azapropazone)
• medicines to treat mental illness (such as chlorpromazine, prochlorperazine, lithium)
• corticosteroids (used to treat pain and inflammation) Ex. prednisolone, cotisone, betamethasone
• medicines used to treat asthma (Ex. salbutamol, terbutaline)
• danazol (a medicine used to treat breast disorders, heavy menstrual bleeding and endometriosis)
• medicines used for blood thinning (Ex. warfarin)
• diuretics (used to increase urine ouptut and to reduce edema) such as bendroflumethiazide, hydrochlorothiazide, furosemide
• oral contraceptives (birth control pills) Ex. drospirenone, ethinylestradiol
• sulfinpyrazone, probenecid (medicines used to treat gout)
• thyroid hormones such as thyroxine (used to treat thyroid deficiency)
• phenytoin (a medicine used to treat epilepsy)
• clofibrate, nicotinic acid (medicines used to treat high blood cholesterol levels)
• isoniazid (a medicine used to treat tuberculosis)

B. Drug-Food Interactions:

Food may delay the absorption of GLIBETIC 5MG TABLET in the body. Therefore, take GLIBETIC 5MG TABLET 30 minutes before meal.

Overdosage:

If you or anyone else accidentally took more GLIBETIC 5MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose might include signs of low blood glucose levels such as weakness, sweating, trembling, fast heartbeat, confusion, and double vision.

SYNOPSIS

MORE INFORMATION

• Keep GLIBETIC 5MG TABLET out of reach of children
• Store GLIBETIC 5MG TABLET at room temperature

FAQs ABOUT GLIBETIC 5MG TABLET

Q: What is GLIBETIC 5MG TABLET used for?

A: GLIBETIC 5MG TABLET is an antidiabetic medicine used in the management of type II diabetes mellitus when diet, exercise and lifestyle changes alone does not result in adequate response.

Q: How and when to take GLIBETIC 5MG TABLET?

A: Take GLIBETIC 5MG TABLET before meals or as advised by your physician. Swallow the medicine with a glass of water. Do not cursh or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

Q: How long should I take GLIBETIC 5MG TABLET?

A: You need to take GLIBETIC 5MG TABLET as long as your doctor or physician prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

Q: Can I stop taking GLIBETIC 5MG TABLET without consulting your doctor?

A: No. You should not stop taking GLIBETIC 5MG TABLET without consulting your doctor because it may lead to reversal of symptoms. If you feel better after using GLIBETIC 5MG TABLET, consult your doctor for advice. Your doctor might would reduce the dose gradually before discontinuation of therapy.

Q: Will taking a higher dose of GLIBETIC 5MG TABLET be more effective?

A: No, taking a higher dose of GLIBETIC 5MG TABLET will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.

Q: What to do if I forget to take a dose of GLIBETIC 5MG TABLET?

A: If you forget to take a dose of GLIBETIC 5MG TABLET, take it as soon as you remember. However, if it is time to take the next dose, skip the missed dose and take the next one at regular times. Do not take a double dose of GLIBETIC 5MG TABLET to compensate a missed dose, as it could lead to toxicity.

Q: What precautions do I need to follow while taking GLIBETIC 5MG TABLET?

A: Before taking GLIBETIC 5MG TABLET, inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you are pregnant or breastfeeding. Always carry a sugary snack (such as biscuits, glucose drinks or sweet candies) along with you as a precaution and have them immediately if you experience any signs of hypoglycemia.

Q: Can I take medication for high blood pressure along with GLIBETIC 5MG TABLET?

A: No. It is not advisable to take medicines to control blood pressure while taking GLIBETIC 5MG TABLET without consulting your doctor. Therefore, consult your doctor before taking any antihypertensive such as beta blockers (Ex. atenolol, propranolol) along with GLIBETIC 5MG TABLET as they have known interactions with GLIBETIC 5MG TABLET.

Q: What should I do if I experience low blood sugar after taking GLIBETIC 5MG TABLET?

A: Low blood sugar is a common side effect of taking GLIBETIC 5MG TABLET. Try to have sugar rich food items such as fruit juice, glucose tablets or gel, soft drinks, honey, or sugary candy. Check your blood sugar after 10 minutes. If not gained optimum level, take another sugary snack and check the blood sugar again. In case of persistent low blood sugar levels, consult your doctor immediately.

Q: Can GLIBETIC 5MG TABLET cause dizziness?

A: Yes. Dizziness is a common side effect of using GLIBETIC 5MG TABLET. In case you experience dizziness, lie down until it passes, then get up slowly and carefully. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, and alcohol. Do not drive or use machinery to avoid accidents. Consult your doctor if you experience dizziness continuously for a long time after taking GLIBETIC 5MG TABLET.

Q: Can GLIBETIC 5MG TABLET be taken with insulin?

A: Co-administration of GLIBETIC 5MG TABLET with insulin is considered risky as they are increased chances of hypoglycemia (decreased blood sugar levels). Consult your doctor before taking it.

Q: Can GLIBETIC 5MG TABLET be used in pregnant women?

A: No. GLIBETIC 5MG TABLET is not recommended for use in pregnant women. Therefore, consult your doctor for advice before taking.

REFERENCES

1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 270-272.

2. Ricardo Correa; Bryan S. Quintanilla Rodriguez; Thomas M. Nappe. Glipizide. State Pearls. NIH. National Library of Medicine. National Center for Biotechnology Information. July 2022. [Accessed on 18th November 2022] https://www.ncbi.nlm.nih.gov/books/NBK459177/

3. E Wåhlin-Boll, L Groop, S Karhumaa, P H Groop, K J Tötterman, A Melander. Therapeutic equivalence of once- and thrice-daily glipizide. NIH. National Library of Medicine. National Center for Biotechnology Information. Pubmed.gov. 1986. [Accessed on 18th November 2022] https://pubmed.ncbi.nlm.nih.gov/3536529/

4. Pharmacia Italia S.p.a., Ascoli Piceno Plant. Electronic Medicines Compendium (EMC). [Revised in February 2018] [Accessed on 18th November 2022] https://www.medicines.org.uk/emc/files/pil.1687.pdf

5. Pfizer Ltd. U.S. Food & Drug Administration. [Revised in October 2015] [Accessed on 18th November 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020329s029lbl.pdf

USEFUL DIAGNOSTIC TESTS

• Glucose-Fasting Blood
• Glucose-Postprandial Blood
• Glycosylated Haemoglobin

AUTHOR DETAILS

Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 18 Oct 2023 | 05:01 PM(IST)