INTRODUCTION

GAMAPOSE LOTION contains Cetrimide and Gamma benzene hexachloride which belong to the group of medicines called Antiseptics and Antiparasitic drugs respectively. It is used for the treatment of Scabies (skin infection with itchy skin rashes caused by mites), Pediculosis (infestation of scalp caused by eggs, larvae, or adults of lice) and Lice.

It is advised to avoid person to person contact and sharing of clothes and utensils with infected persons to avoid the risk of spreading of scabies and lice. It is not recommended to use GAMAPOSE LOTION if you have fits, allergy to any of its ingredients, open, broken, or cranky skin. Before using GAMAPOSE LOTION inform your doctor if you have HIV or AIDS, had a history of fits or conditions like head injury, tumor in your brain or spinal cord, cirrhosis of the liver, or heavy alcohol drinking.

GAMAPOSE LOTION is not recommended to be used during pregnancy and breastfeeding unless it is clearly necessary. Do not use GAMAPOSE LOTION to treat a premature infant or young baby and elderly patients. Most common side effects of using GAMAPOSE LOTION include tingling, itching, burning in skin, and skin rashes. Consult a doctor if any of these symptoms worsens.

USES OF GAMAPOSE LOTION

It is used to treat:

• scabies (skin infection with itchy skin rashes caused by mites)
• pediculosis (infestation of scalp caused by eggs, larvae, or adults of lice)
• lice

HOW GAMAPOSE LOTION WORKS

GAMAPOSE LOTION contains Cetrimide and Gamma benzene hexachloride. Cetrimide is an antiseptic agent that kills disease causing bacteria. Gamma benzene hexachloride is an insecticide that kills insects by damaging the brain of mites.

DIRECTIONS FOR USE

Apply GAMAPOSE LOTION as advised by your physician. It is for external use only. Shake well before use. Wash your hands before applying GAMAPOSE LOTION. Take adequate amounts of medicine and apply on affected areas (apply on the entire body in cases of scabies). Wash off completely with warm water after 8-12 hours.

Read the instructions within the label before using the medicine. Avoid contact with your eyes, nose, and mouth. Avoid making your skin too oily by applying creams while using GAMAPOSE LOTION. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF GAMAPOSE LOTION

HOW TO MANAGE SIDE EFFECTS

Skin Rash Or Itching

Apply a cool compress or wet cloth over the burned area. Apply moisturizers if required. Contact the doctor if it is not subsiding.

WARNING & PRECAUTIONS

PREGNANCY

Contraindicated

GAMAPOSE LOTION is not recommended to use if you are pregnant or planning to get pregnant unless it is considered clearly necessary due to the lack of safety data. Consult your doctor before using GAMAPOSE LOTION.

BREASTFEEDING

Contraindicated

GAMAPOSE LOTION is not recommended for use in breastfeeding women as it may pass through the breast milk. If you use GAMAPOSE LOTION, pump your breast milk and throw away the milk for at least 24 hours after using the medicine.

During this time, feed your baby formula or breast milk you stored before you used this medicine. Consult a doctor before using it.

LIVER

Use with Caution

GAMAPOSE LOTION should be used with caution if you have cirrhosis of the liver. Consult your doctor before using.

ALLERGY

Contraindicated

Do not use GAMAPOSE LOTION if you are allergic to Cetrimide, Gamma benzene hexachloride or any other constituents of this medicine. Consult your doctor before using GAMAPOSE LOTION.

OTHERS

It is not recommended to use GAMAPOSE LOTION if you have:

• open, broken, or cranky skin
• fits

Before using GAMAPOSE LOTION inform your doctor if you have:

• HIV or AIDS
• history of fits or conditions like head injury, tumour in your brain or spinal cord
• heavy alcohol drinking habit
• a sexual partner

Use in paediatrics:

GAMAPOSE LOTION should be used with extreme caution in premature infants and young children. Consult a doctor before using it for children.

Use in geriatrics

GAMAPOSE LOTION is not recommended in elderly patients due to the lack of safety data. Consult a doctor before using it.

INTERACTIONS

A. Drug – drug interactions:

Before using GAMAPOSE LOTION inform your doctor if you are taking any of the following medicines:

• antipsychotics (medicines used to treat mental disorders. Ex. chlorpromazine, haloperidol)
• antidepressants (medicines used to treat depression. Ex. Citalopram, escitalopram)
• theophylline (medicine used to treat wheezing, shortness of breath)
• cyclosporin, mycophenolate mofetil, tacrolimus capsules (medicines used to prevent transplant rejection)
• penicillin, imipenem, quinolone antibiotics (medicines used to treat bacterial infection)
• chloroquine sulfate (medicine used to treat malaria)
• pyrimethamine (medicine used to treat parasitic infection called toxoplasmosis)
• isoniazid (medicine used to treat tuberculosis)
• meperidine (medicine used to relieve moderate to severe pain)
• methocarbamol (medicine used to relieve Musculo-skeletal pain)
• centrally active anticholinesterases (Ex. rivastigmine, donepezil)
• radiographic contrast agents (Ex. iodine, barium sulfate)

Overdosage:

If you or anyone else accidentally apply too much GAMAPOSE LOTION, consult your doctor immediately.

SYNOPSIS

MORE INFORMATION

• Keep GAMAPOSE LOTION out of reach of children
• Store GAMAPOSE LOTION at room temperature

FAQs ABOUT GAMAPOSE LOTION

Q: What is GAMAPOSE LOTION used for?

A: GAMAPOSE LOTION is used for the treatment of Scabies (skin infection with itchy skin rashes caused by mites), Pediculosis (infestation of scalp caused by eggs, larvae, or adults of lice) and Lice. Consult a doctor before using it.

Q: How GAMAPOSE LOTION works?

A: GAMAPOSE LOTION contains Cetrimide and Gamma benzene hexachloride. Cetrimide is an antiseptic agent that kills disease causing bacteria. Gamma benzene hexachloride is an insecticide that kills insects by damaging the brain of mites.

Q: Can I apply moisturizing lotion while using GAMAPOSE LOTION?

A: No. It is better to avoid use of moisturizing lotions or creams that makes your skin oily while using GAMAPOSE LOTION as oily skin increases the chances of faster absorption of medicine and may lead to neurotoxicity (fits) in individuals.

Q: Does GAMAPOSE LOTION cause any side effects?

A: It may cause stinging, burning, redness, itching and tingling in the skin along with skin rashes in some individuals. Consult a doctor if you experience any unusual symptoms while using this medicine.

Q: Is it safe to use GAMAPOSE LOTION during pregnancy?

A: GAMAPOSE LOTION is not recommended to use if you are pregnant or planning to get pregnant unless it is clearly necessary due to the lack of safety data. Consult your doctor before using it.

REFERENCES

1. KD Tripathi. Antiseptics. Disinfectants and Ectoparasiticides. Essentials of Medical pharmacology eighth edition (2019), page number- 962

2. James G.H. Dinulos MD. Lindane. Science direct. Habif's Clinical Dermatology, 2021[Accessed on 30th January 2023] https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/lindane

3. L M Solomon, L Fahrner, D P West. Gamma benzene hexachloride toxicity: a review. NIH, National library of medicine, national center for biotechnology information. Pubmed.gov. March 1977.[Accessed on 30th January 2023] Gamma benzene hexachloride toxicity: a review - PubMed (nih.gov)

4. Lindane Lotion. United States Food and Drug Administration (USFDA) [Accessed on 30th January 2023] https://www.accessdata.fda.gov/drugsatfda_docs/label/2003/006309lotionlbl.pdf

5. Cetrimide + Gamma Benzene Hexachloride. Leeford pharma [Accessed on 30th January 2023] https://www.leeford.in/product/1286/neoscab-lotion

6. Cetrimide + Gamma Benzene Hexachloride. Ikon remedies [Accessed on 30th January 2023] https://www.ikonremedies.com/product/gamabion-lotion/

7. Cetrimide + Gamma Benzene Hexachloride. Orion Life science [Accessed on 30th January 2023] http://www.orionlifeindia.com/gamma-benzene-hexachloride-cetrimide-emulsion-5043668.html

8. Cetrimide + Gamma Benzene Hexachloride. Alpha drugs[Accessed on 30th January 2023] https://www.alphadrug.in/product/scabnyl-lotion/

9. Cetrimide + Gamma Benzene Hexachloride. Talent India pharmaceuticals [Accessed on 30th January 2023] https://talentindia.com/html/dermatology-and-cosmetology/