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INTRODUCTION
GABAPRIME M TABLET is a combination of Gabapentin and Methylcobalamin which belongs to the group of medicines called Anticonvulsants and Vitamin-B complex respectively. It is used to treat nerve pain (also known as neuropathic pain).
Take GABAPRIME M TABLET as directed by your physician. It can be taken with or without meals. Before taking GABAPRIME M TABLET inform your doctor if you have any lung, liver, kidney or heart problems. You must also inform your doctor if you have fits disorders, nerve problems, Vitamin B9/Vitamin B6 deficiency or a history of drug abuse as a precaution.
Do not take GABAPRIME M TABLET without consulting your doctor if you are pregnant or breastfeeding. The most common side effects of taking GABAPRIME M TABLET are increased infections, confusion, anxiety, hostility, emotional liability, abnormal thinking, sleepiness, dizziness, nausea, vomiting and tiredness. Consult your doctor if any of these side effects trouble you.
You must also inform your doctor immediately if you experience severe depressive symptoms along with suicidal thoughts or thoughts of harming or killing oneself after taking GABAPRIME M TABLET as a precaution.
USES OF GABAPRIME M TABLET
- Treats nerve pain
HOW GABAPRIME M TABLET WORKS
GABAPRIME M TABLET contains two medicines namely gabapentin and methylcobalamin. Gabapentin reduces pain sensation by interfering with the pain signals travelling between the damaged nerves and the brain.
Methylcobalamin is a vitamin. It repairs and rejuvenates the damaged nerve cells. It improves the production of a substance called myelin which forms a protective covering around the nerve fibres. This protects the nerve cells from getting damaged further. Collectively, this medicine effectively reduces nerve pain and protects the nerve cells from further damage.
DIRECTIONS FOR USE
Take GABAPRIME M TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. GABAPRIME M TABLET can be taken with or without food.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition. Do not stop taking GABAPRIME M TABLET abruptly without consulting your doctor.
SIDE EFFECTS OF GABAPRIME M TABLET
COMMON
- viral infections, fever, sore throat, cough
- dizziness, drowsiness, sleepiness or lack of sleep
- tiredness, weakness
- lack of coordination or balance, muscle pain, joint pain
- nausea, vomiting
- hostility (a strong sense of belief)
- confusion, emotional liability
- increased appetite or lack of appetite
- anger, anxiety, nervousness, depression, mood changes
- abnormal thinking, slurred speech, loss of memory
- headache
- numbness of body parts
- blurred vision or double vision
- flushing, high blood pressure
- dry nose, dry mouth, inflamed gums
- stomach pain, diarrhea, indigestion, constipation, bloating
- weight gain
- impotence (problems in erections)
- swelling of face, hands or legs
UNCOMMON
- agitation
- racing heartbeat
- liver problems
- increase in blood sugar levels
RARE
- low blood glucose levels
Stop taking this medicine and contact your doctor immediately if you experience any of the following side effects:
- muscle pain and/or weakness
- signs of inflammation in the pancreas (such as persistent stomach pain, nausea, vomiting)
- suicidal thoughts (thoughts of harming or killing themselves)
- signs of a severe allergic reaction (skin rash with blisters and peeling, swelling of the eye, throat or tongue which leads to difficulty in breathing)
- shortness of breath or shallow breaths
- severe skin reactions (such as skin rash, redness, itching and hair loss)
HOW TO MANAGE SIDE EFFECTS
Nausea and vomiting:
Try to take GABAPRIME M TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. If you experience severe nausea or vomiting along with severe stomach pain, contact your doctor immediately.
Diarrhea:
Drink lots of fluids, such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for treating diarrhea. Consult your doctor if the symptom worsens.
Headache:
Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the head if required. Do not consume too much of alcohol. Consult your doctor if the symptom worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines while you are feeling dizzy. Do not consume too much of alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom worsens.
Weight gain:
Weight gain caused due to GABAPRIME M TABLET is often dose dependent and it is predominantly seen among diabetic patients. Try to exercise more regularly and eat a healthy balanced diet as instructed by your doctor. Consult your doctor if the symptom worsens.
WARNING & PRECAUTIONS
PREGNANCY
GABAPRIME M TABLET is not recommended for use in pregnant women unless considered necessary by the physician. Therefore, consult your doctor before taking it. Women of childbearing potential should use a suitable contraceptive method to avoid pregnancy while taking this medicine.
BREASTFEEDING
GABAPRIME M TABLET is not recommended for use in breastfeeding women unless considered necessary by the physician. Therefore, consult your doctor before taking it.
DRIVING AND USING MACHINES
Do not drive or operate any heavy tools or machines if you experience dizziness or sleepiness after taking GABAPRIME M TABLET.
ALCOHOL
Avoid consumption of alcohol while taking this medicine, as it could make you feel sleepy.
KIDNEY
GABAPRIME M TABLET should be used with caution in patients with kidney diseases (including dialysis). Therefore, consult your doctor before taking it.
LIVER
GABAPRIME M TABLET should be used with caution in patients with liver diseases. Therefore, consult your doctor before taking it.
ALLERGY
Do not take GABAPRIME M TABLET if you are allergic to Gabapentin or to Methylcobalamin.
LUNGS
GABAPRIME M TABLET should be used with caution in patients with respiratory disorders. Therefore, consult your doctor before taking it.
HEART DISEASE
GABAPRIME M TABLET should be used with caution in patients with hypertension (high blood pressure) or any other heart problems. Therefore, consult your doctor before taking it.
OTHERS
Before taking GABAPRIME M TABLET, inform your physician if you:
- suffer from different types of seizures (such as absence, tonic-clonic, myoclonic)
- have any other nerve problems
- have a history of misuse or substance abuse
- work on places which requires handling mercury or mercury components
- have folate deficiency
- are going for a urine test
- have Vitamin B6 deficiency
Use in Pediatrics:
GABAPRIME M TABLET is not recommended for use in children aged below 6 years. You must consult your doctor before using this medicine in children aged above 6 years as a precaution.
Use in Geriatrics:
GABAPRIME M TABLET should be used with caution in elderly patients (aged 65 years or above). Therefore, consult your doctor before taking it. Proper dose adjustments and careful monitoring are required in such patients.
INTERACTIONS
A. Drug-Drug Interactions:
Before taking GABAPRIME M TABLET, inform your doctor if you are taking any of the following medicines such as:
- oral contraceptives (birth control pills) Ex. norethisterone and/or ethinyl estradiol
- nitrous oxide (an anesthetic)
- neuroleptic drugs (used to treat epilepsy) Ex. phenytoin, carbamazepine, valproic acid
- neomycin (used to treat bacterial infections)
- colchicine (used to treat and prevent gout)
- medicines used to treat depression (Ex. sertraline, isocarboxazid, phenelzine or tranylcypromine)
- medicines that can reduce anxiety and induce sleep (Ex. phenobarbital, clonazepam etc.)
- medicines used to treat psychiatric illness (such as chlorpromazine)
- opioids (used for pain relief) such as morphine
- antacids (used to neutralize stomach acid production) such as aluminium hydroxide, magnesium hydroxide
- tetracyclines (used to treat bacterial infections)
- medicines used to treat cancer (such as doxorubicin, cisplatin, carboplatin)
- para-amino salicylic acid (used to treat tuberculosis)
- medicines used to treat diabetes orally (such as metformin, phenformin)
- medicines used to treat stomach ulcers (such as ranitidine, cimetidine)
- potassium chloride (used to treat potassium deficiency)
- cholestyramine (a medicine used to control blood cholesterol levels)
B. Drug-Food interaction:
This medicine can be taken with or without food.
Overdosage:
If you or anyone else accidentally took much of this medicine, contact your doctor immediately or go to a hospital straight away. Symptoms of overdosage might include dizziness, drowsiness, tiredness, fainting, double vision, slurred speech and mild diarrhoea.
SYNOPSIS
| Drug | : | Gabapentin, Methylcobalamin |
| Pharmacological Category | : | Cyclic GABA analogs, Vitamin B complex |
| Therapeutic Indication | : | Nerve Pain |
| Dosage Forms | : | Tablet, Capsule |
MORE INFORMATION
- Keep GABAPRIME M TABLET out of reach of children
- Store GABAPRIME M TABLET at room temperature
- Protect from light and moisture
FAQs ABOUT GABAPRIME M TABLET
Q: How long will it take for GABAPRIME M TABLET to start acting?
A: GABAPRIME M TABLET may start to exert its analgesic effects from day 2 of administration. An initial benefit of pain relief can be seen in patients after 2-4 weeks of therapy. However, it may take few months to show effects in some individuals.
Q: How long will the effects of GABAPRIME M TABLET last long?
A: The effects of GABAPRIME M TABLET can last long between 12-24 hr. This time range may vary among individuals, depending upon the severity of the disease condition.
Q: Can GABAPRIME M TABLET treat diabetic neuropathy?
A: Yes. GABAPRIME M TABLET can be used to treat diabetic neuropathy. It provides symptomatic pain relief in patients who have nerve pain caused due to diabetes.
Q: What happens if I stop taking GABAPRIME M TABLET?
A: Do not stop taking GABAPRIME M TABLET unless your doctor tells you as it may lead to withdrawal symptoms such as difficulty in falling asleep, anxiety, nausea, pain and sweating. Therefore, continue to take GABAPRIME M TABLET as long as instructed by your doctor to achieve better results.
Q: Can GABAPRIME M TABLET reduce nerve damage?
A: Yes. GABAPRIME M TABLET can reduce further nerve damage. It repairs and rejuvenates the damaged nerve fibres. It improves myelin production in the body which repairs and rebuilds the protective covering around the nerve fibres which prevents it from further damage.
Q: Is taking GABAPRIME M TABLET safe?
A: The safety of GABAPRIME M TABLET varies with patient to patient. Your doctor will closely monitor your health condition while taking GABAPRIME M TABLET to avoid the risk of side effects.
Q: Is GABAPRIME M TABLET addictive?
A: Research has shown that GABAPRIME M TABLET can cause drug abuse or dependence. Therefore, it is better to inform your doctor before taking this medicine, if you already have a previous history of substance abuse as a precaution.
Q: Can GABAPRIME M TABLET cause weight gain? If so, how can I manage my weight?
A: GABAPRIME M TABLET may increase your body weight. It increases your hunger (appetite) which makes you eat more and eventually leads to increase in body weight. Weight can be managed by doing regular exercise and by eating a healthy balanced diet. Avoid calorie-rich foods such as soft drinks, chips, cakes, biscuits and sweets. Research says that patients with diabetes tend to put on weight easily while taking GABAPRIME M TABLET. Dose adjustments for antidiabetic medicines can help in such situations. If the symptom bothers you, consult your doctor for advice.
Q: Can GABAPRIME M TABLET cause sleepiness or drowsiness?
A: Yes. GABAPRIME M TABLET may cause sleepiness and drowsiness. Rest and relax while feeling sleepy. Avoid consumption of alcohol while taking GABAPRIME M TABLET as it can make you feel drowsier. Do not drive or operate any tools or machines while you are feeling sleepy. Consult your doctor if the symptom bothers you.
Q: Will the use of GABAPRIME M TABLET affect my sex life?
A: Yes. GABAPRIME M TABLET can affect sexual life of both men and women. It decreases sexual desire in men and women and can cause difficulty in erection or delayed ejaculation in men. The exact mechanism behind these effects is not known. If you experience any such problems, contact your doctor immediately.
Q: Can I take GABAPRIME M TABLET along with alcohol?
A: No. Avoid consumption of alcohol while taking GABAPRIME M TABLET as it may make you feel drowsier. Moreover, GABAPRIME M TABLET is not recommended for use in patients having alcohol abuse unless considered necessary. Therefore, consult your doctor before taking it.
Q: Can I take a higher dose of GABAPRIME M TABLET to increase pain relieving effects?
A: No. Do not take a higher dose of GABAPRIME M TABLET than recommended by your doctor. Taking a higher dose of GABAPRIME M TABLET without consulting a doctor can increase the risk of toxicity and can lead to side effects. If the prescribed dose is not effective for you, consult your doctor for a suitable higher dose. Never consume a higher dose GABAPRIME M TABLET without proper medical supervision.
Q: What to do if I forgot to take GABAPRIME M TABLET?
A: Take GABAPRIME M TABLET as soon as you remember until it’s time for the next one. If you missed a dose, skip the missed one and take the next dose at time normally you would take. Do not take a double dose to make up the missed one, as it may lead to overdosage. If you are not sure, consult your doctor. Your doctor may instruct you about the next steps.
Q: What are the precautions that I need to follow while taking GABAPRIME M TABLET?
A: Before taking GABAPRIME M TABLET, inform your doctor about your pre-existing disease conditions as precaution. GABAPRIME M TABLET should not be used if you are planning to become pregnant without consulting your doctor. GABAPRIME M TABLET can cause extreme sleepiness and dizziness and therefore avoid taking other medicines or alcohol that can make you feel drowsier ever more. It can also impair memory, attention and thinking ability in few individuals and so avoid travelling or driving on your own for a while. If case of any queries, consult your doctor for advice.
REFERENCES
1. KD. Tripathi. Antiepileptic Drugs & Hematinics and Erythropoietin. Essentials of medical pharmacology. Seventh edition. 2013. Page – 419 & 608.
2. Ming Zhang, Wenjuan Han, Sanjue Hu and Hui Xu. Methylcobalamin: A Potential Vitamin of Pain Killer. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. December 2013. [Accessed on 11th January 2023]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888748/
3. Aisha Hasan, Muhammad Haroon Khilan, Aizaz Khan, Mohammad Haroon Hassan, Anab Rehan Taseer, Sajid Iqbal, Mahnoor Amir and Muhammad Ashraf Chaudhary. Comparison of Gabapentin Monotherapy vs. Combination Therapy of Methyl Cobalamin and Gabapentin in Treating Diabetic Neuropathic Pain. Journal of Biology and Today’s World. 2020. [Accessed on 11th January 2023]. https://www.iomcworld.org/articles/comparison-of-gabapentin-monotherapy-vs-combination-therapy-of-methyl-cobalamin-and-gabapentin-in-treating-diabetic-neuropathic-pa-55830.html
4. Milpharm Limited. Gabapentin Milpharm 100/300/400 mg capsules, hard. Electronic Medicines Compendium. [Revised in December 2022]. [Accessed on 11th January 2023]. https://www.medicines.org.uk/emc/files/pil.4121.pdf
5. Torrent Pharmaceuticals Ltd. Gabator M. [Revised in August 2022]. [Accessed on 11th January 2023]. https://www.torrentian.com/pisheet/Upload/PI_Sheet/3108.pdf
6. LaRenon Healthcare Pvt Ltd. Laregab-M. June 2005. [Accessed on 11th January 2023]. https://www.larenon.com/wp-content/uploads/2022/03/LAREGAB-M-LBL.pdf
7. Central Drugs Standard Control Organization. Methylcobalamin 1500 mcg + Gabapentin SR 600 mg film coated tablets (additional strength). November 2009. FDC of Gabapentin (300mg) + Methylcobalamin (500mcg) Tablet. May 2005. Gabapentin 100mg + methylcobalamin 500mcg tablets (Additional Strength). January 2008. [Accessed on 11th January 2023]. https://cdsco.gov.in/opencms/resources/UploadCDSCOWeb/2018/UploadApprovalNewDrugs/dciApprovedfdc.pdf
AUTHOR DETAILS
Written By Srilekha. R, B.Pharm
Last updated on 12 Jan 2023 | 03:34 PM(IST)
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