INTRODUCTION
FRAGMIN 10000IU contains Dalteparin which belongs to a group of medicines called anti-thrombotic, which helps in the prevention of blood clots formation by thinning the blood. This medicine is used to prevent blood clots (venous thromboembolism).
The development of blood clots in the legs (deep vein thrombosis) or lungs (pulmonary embolism), e.g. after surgery, prolonged bed rest or in patients with certain types of cancer is called venous thromboembolism. FRAGMIN 10000IU is a sterile, low molecular weight heparin with antithrombotic properties which works by decreasing the clotting ability of the blood.
FRAGMIN 10000IU will be administered by a doctor or nurse. Before receiving this medicine, tell your doctor if you have liver, kidney or heart problem, pregnant women and breastfeeding mothers. Your doctor will administer the right dose depends on your child’s age and body weight. The common side effects are bleeding or pain at the injection site.
USES OF FRAGMIN 10000IU
Used to prevent and treats,
- blood clots (venous thromboembolism) forming before and after an operation or if you are bedridden due to illness and prevents their recurrence
- deep vein thrombosis in patients bedridden due to a medical condition but not limited to heart failure and respiratory failure
- solid tumours in patients suffering from low platelet counts
HOW FRAGMIN 10000IU WORKS
FRAGMIN 10000IU is a sterile, low molecular weight heparin with antithrombotic properties which works by decreasing the clotting ability of the blood.
DIRECTIONS FOR USE
FRAGMIN 10000IU usually injected into a skin fold in your abdomen (stomach), or the outer aspects of thigh by a doctor or nurse. It should not be injected into your muscles.
SIDE EFFECTS OF FRAGMIN 10000IU
SERIOUS
- breathing difficulty
- swelling of the lips, mouth, throat or eyes
COMMON
- reversible decrease in the number platelets in blood
- bleeding
- pain and reactions at the injection site
- haematoma (clotting of blood under the skin)
RARE
- a severe decrease in the number of clotting cells in blood (Type II thrombocytopenia)
- alopecia (hair loss)
- painful skin lesions
WARNING & PRECAUTIONS
PREGNANCY
FRAGMIN 10000IU is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.
BREASTFEEDING
FRAGMIN 10000IU should be used with caution during breastfeeding. Discuss the risks and benefits with your doctor.
DRIVING AND USING MACHINES
FRAGMIN 10000IU does not affect the ability to drive and handle machines.
KIDNEY
FRAGMIN 10000IU should be used with caution in patients suffering from active kidney diseases. Consult your doctor for advice.
LIVER
FRAGMIN 10000IU is not recommended in patients with active liver diseases or liver failure. Before taking, discuss the risks and benefits with your doctor.
ALLERGY
Tell your doctor if you are allergic (hypersensitive) to Dalteparin.
OTHERS
Inform your doctor if you have or had,
- stomach and duodenum ulcer (small intestine)
- brain haemorrhage (bleeding in brain) or brain tumour
- haemophilia
- decrease in number of platelets (heparin-induced thrombocytopenia)
- stroke caused by a bleed
- eye disease caused by blood pressure or diabetes
- uncontrolled high blood pressure
INTERACTIONS
Inform your physician if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or the following,
- aspirin, dipyridamole, glycoprotein receptor antagonists and warfarin (used to thin blood)
- indometacin (used to reduce pain and inflammation)
- sulfinpyrazone and probenecid (used for gout)
- etacrynic acid (used for water retention)
- dextrans (increase the blood volume)
- cytostatics (used for cancer)
- TPA-tissue plasminogen activator
- Antihistamines (for allergy and hay fever )
- digoxin or digitoxin (used for heart or circulation problems )
- tetracyclines, penicillin (used to treat bacterial infections)
- Vitamin C
- intravenous nitroglycerine (used to treat angina)
- quinine (used to treat malaria)
SYNOPSIS
| Drug | : | Dalteparin |
| Pharmacological Category | : | Anticoagulant |
| Therapeutic Indication | : | Venous thromboembolism |
| Dosage Forms | : | Injection |
MORE INFORMATION
Store below 20-25°C and keep out of reach of children.
FAQs ABOUT FRAGMIN 10000IU
Can FRAGMIN 10000IU be injected into muscles?
It should be injected into a muscle, usually in bottom by a doctor or nurse.
Can FRAGMIN 10000IU use during pregnant?
It is not recommended for use during pregnant unless necessary. Consult your doctor for advice.
Can the use of FRAGMIN 10000IU increase the risk of bleeding?
Yes, it may increase the risk of bleeding. Inform your doctor if you notice any abnormal bruising or bleeding.
REFERENCES
1. KD Tripathi MD. Drugs affecting coagulation, bleeding and thrombosis. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page – 619.
2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 350-351.
3. Fox KA, White HD, Gersh BJ, et al. Antithrombotic Agents: Platelet Inhibitors, Acute Anticoagulants, Fibrinolytics and Chronic Anticoagulants. Drugs for the Heart. 8th ed. Philadelphia, Pennsylvania: Elsevier Saunders; 2013. Page - 70.
4. Klas norrby1 and Arvid nordenhem. Dalteparin, a low-molecular-weight heparin, promotes angiogenesis mediated by heparin-binding VEGF-A in vivo. Dec, 2010; [Accessed Jan 7, 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003896/
5. Pfizer Limited. Oct, 2020. Electronic Medicines Compendium (EMC); [Revised Oct, 2020] [Accessed Jan 7, 2021] https://www.medicines.org.uk/emc/files/pil.4246.pdf
6. Pfizer Inc. Eisai Inc. 1994, U.S. Food & Drug Administration; [Revised Oct, 2020] [Accessed Jan 7, 2021] https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020287s050lbl.pdf
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