FOLITRAX 25MG contains methotrexate which belongs to a group of medicine called anti-metabolites. It works by stopping or slowing the growth of cancer cells. It can also be used as an immunosuppressant, which reduces the activity of the immune system. In larger doses, it can be used to treat various forms of cancer. In smaller doses, it can be used to treat severe form of psoriasis (a skin disease with thickened patches of inflamed red skin, often covered by silvery scales) and rheumatoid arthritis, when it has not responded to other treatments.
Methotrexate kills the rapidly multiplying cells of the skin in psoriasis. In rheumatoid arthritis, it reduces inflammation in joints by altering body's defence mechanism in immune system. In cancer, methotrexate inhibits the enzymes responsible for nucleotide synthesis and prevents cell division. FOLITRAX 25MG must not be given to pregnant or breastfeeding women. Consult your doctor before taking. Before taking this medicine, inform your doctor if you have kidney or liver problems, anemia or weak immune system.
Methotrexate inhibits the enzymes responsible for nucleotide synthesis including dihydrofolate reductase, thymidylate synthase, aminoimidazole caboxamide ribonucleotide transformylase (AICART) and amido phosphoribosyl transferase which prevents cell division and leads to anti-inflammatory actions.
Since cellular proliferation in malignant tissues (cancerous tissue) are greater than in most normal tissues, methotrexate may impair malignant growth without causing any irreversible damage to normal tissues. Methotrexate has an immunosuppressive effect, resulting in the inhibition of lymphocyte multiplication. In psoriasis, it kills the rapidly multiplying skin cells.
This medicine should be only given by a doctor or a nurse into a vein (intravenously), muscle (intramuscularly) or into an artery (intraarterially). It may also be given by an infusion (drip) into a vein. Your doctor will decide the correct dose for you and how often it must be given.
Feeling sick or being sick:
Try taking this medicine with, or just after, a meal and stick to simple meals. Do not eat rich or spicy food.
Stomach pain:
Try to rest and relax. You can eat and drink slowly or have smaller and frequent meals. Keeping a heat pad on your stomach may also help. If still pain persists, speak to your doctor.
FOLITRAX 25MG should be used with caution if you are pregnant, or if you are trying to become pregnant. Consult your doctor for advice.
FOLITRAX 25MG should be used with caution if you are breastfeeding. Consult your doctor for advice.
Do not drive or operate any machines if your ability is affected by this medicine.
Do not drink alcohol while being treated with FOLITRAX 25MG, as alcohol increases the risk of liver damage.
FOLITRAX 25MG should be taken with caution in patients with severe kidney disease. Consult your doctor for advice.
FOLITRAX 25MG should be taken with caution in patients with severe liver disease. Consult your doctor for advice.
Do not take this medicine if you are allergic (hypersensitive) to methotrexate.
If you have a medical condition which causes a build-up of fluid in the lining of your lungs or in your abdomen, you may be more sensitive to the effects of FOLITRAX 25MG. Your doctor will prescribe the right dose for you.
Do not take FOLITRAX 25MG, if you have:
Talk to your doctor, if you are taking,
Drug | : | Methotrexate |
Pharmacological Category | : | Antimetabolite, Antirheumatic, Immunosuppressant Agent |
Therapeutic Indication | : | Psoriasis, Rheumatoid arthritis, Cancer |
Dosage Forms | : | Tablet, Injection, Gel |
Store below 20-25°C and keep out of reach of children.
Can FOLITRAX 25MG be given to pregnant women?
No. This medicine can cause birth defects, harm the unborn child or cause miscarriage. So, it should not be given to pregnant women unless necessary.
Can FOLITRAX 25MG be given to children?
Yes. This medicine should be used with caution in children. Special care is required.
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