FOLITRAX 20mg Tablet 4's

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Methotrexate 20mg
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Drug Information for FOLITRAX 20mg Tablet 4's


  • FOLITRAX contains methotrexate which is an anti-metabolite medicine (medicine which affects how the body’s cells grow) and immunosuppressant (medicine which reduces the activity of the immune system)







What FOLITRAX is used for?

FOLITRAX is used to treat:

  • severe psoriasis (a skin disease with thickened patches of inflamed red skin, often covered by silvery scales) when other treatments are not effective
  • severe arthritis due to psoriasis
  • rheumatoid arthritis
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Talk to your Doctor before taking this medicine, if you:

  • are allergic to methotrexate or any of the other ingredients of FOLITRAX
  • have significant kidney or liver problems
  • have been told you have (or think you have) a blood disorder such as low levels of white blood cells, red blood cells (anaemia) or platelets
  • have any infection
  • your immune system is not working as well as it should
  • have a stomach ulcer or ulcerative colitis (inflammation and ulceration of the gut)
  • have a medical condition which causes a buildup of fluid in the lining of your lungs or in your abdomen
  • have radiotherapy (risk of tissue and bone damage may be increased)
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  • Tell your doctor if you are pregnant, trying to become pregnant or breast-feeding before this medicine is used
  • This medicine must not be used during pregnancy
  • Mothers should not breast-feed while treatment with FOLITRAX. Due to the risk of birth defects, conception should be avoided during FOLITRAX treatment and for at least 6 months after treatment is stopped
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  • This medicine can be used to treat children with severe psoriasis, but should not be used in those under 3 years of age
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  • Do not drive or use machines if you experience any side effect (e.g. dizziness, drowsiness or blurred vision) which may lessen your ability to do so
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Special care is needed if you are taking/using other medicines as some could interact with methotrexate, for example:

  • non-steroidal anti-inflammatory medicines e.g. ibuprofen (medicines taken for pain relief)
  • aspirin or similar medicines (known as salicylates)
  • omeprazole, esomeprazole and pantoprazole (medicines used to reduce the production of stomach acid)
  • diuretics (water tablets)
  • medicines taken for diabetes (including insulin and tablets)
  • antibiotics such as penicillins, sulphonamides, co-trimoxazole, trimethoprim, tetracycline, chloramphenicol and para-aminobenzoic acid
  • phenytoin (medicine often used to treat epilepsy)
  • vitamin supplements containing folic acid
  • probenecid (medicine used to treat gout)
  • nitrous oxide (used for general anaesthesia and pain relief)
  • live virus vaccines
  • mercaptopurine (medicine used in the treatment of blood cell cancer)
  • theophylline (medicine used in the treatment of asthma)
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  • Always take these tablets exactly as your doctor has told you
  • The tablets should be swallowed whole with a drink of water while sitting upright or standing

Recommended Dose

  • Rheumatoid arthritis: Take methotrexate tablets once a week. The dose usually starts at 7.5 to 15 mg per week but may rise to 20 mg per week. The dose may be given all at once, or it can be split into 3 doses at 12 hourly intervals over 24 hours
  • Psoriasis: Take methotrexate tablets once a week. The dose is usually between 5 to 25 mg per week. The dose may be given all at once, or it can be split into 3 doses at 12 hourly intervals over 24 hours

If you are given too much FOLITRAX

  • If you take more than your prescribed dose or if you take an overdose of FOLITRAX, call your doctor or go to the nearest hospital emergency room right away

If you forget to use FOLITRAX 

  • Take it as soon as possible
  • Do not double the dose

If you stop using FOLITRAX

  • Do not stop taking this medicine without your doctor’s advice
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Like all medicines, this medicine can cause side effects althoygh not everybody gets them.


  • severe allergic reaction - you may experience a sudden itchy rash (hives), swelling of the hands, feet, ankles, face, lips, mouth or throat (which may cause difficulty in swallowing or breathing), and you may feel you are going to faint
  • inflammation of the lung with breathlessness
  • symptoms of an infection e.g. fever, chills, achiness, sore throat.
  • unexpected bleeding e.g. bleeding gums, blood in the urine or in vomit, or the appearance of unexpected bruises or broken blood vessels (broken veins)
  • black tarry stools
  • skin rashes or blistering to the surfaces of the eyes, nose, vagina or anus (back passage)
  • diarrhea
  • weakness in the legs that spreads to the upper limbs and the face, which may result in paralysis
  • abdominal pain, fatty stools, vomiting
  • chest pain (which may be due to heart or lung problems)
  • low blood pressure (you may feel faint)
  • fits
  • blurred vision, dizziness
  • difficulty/inability to talk, muscle weakness
  • abnormally easily broken bones (osteoporosis)
  • pain or redness of the blood vessels (vasculitis)
  • itching or the appearance of lightened patches on the skin, bruises, boils
  • increased sensitivity to sunlight
  • acne
  • yellowing of the skin and whites of the eyes (jaundice)
  • pain in the stomach, loins or abdomen
  • you may need to pass urine more often than normal, which may be painful (cystitis)
  • headaches, drowsiness
  • reduced appetite, feeling or being sick
  • irregular periods in women (periods may stop completely)
  • hair loss
  • effects on learning and memory
  • ringing in the ears
  • joint and muscle pain
  • blood clot which causes pain, swelling or redness (cerebral, deep vein, retinal vein or arterial vein)
  • mood alterations
  • inflammation of the lungs, which causes breathlessness, cough and raised temperature, pneumonia
  • shingles (Herpes Zoster)
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  • Keep out of the reach and sight of children
  • This medicine must not be used after the expiry date
  • Store at room temperature (15-25°C)
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The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment.  Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

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