INTRODUCTION

FLUOXEE 60MG contains Fluoxetine which belongs to the group of medicines called selective serotonin reuptake inhibitors. It is used to treat major depressive episodes and obsessive-compulsive disorder (a mental disorder in which a person feels the need to perform certain routines repeatedly) in adults. It can also be used to treat moderate to severe major depressive disorder in children aged 8 years or over, in combination with other psychological medicine, if the depression does not respond after 4-6 sessions. It is also used in combination with other psychological medicine, to treat bulimia nervosa (an eating disorder) in adults.

Take this medicine as directed by your physician. This medicine can be taken with or without meals. The most common side effects are suicidal thoughts and sleep problems. If you have thoughts of killing or harming yourself, contact your doctor immediately. Do not drive or operate any machines if your ability is affected by this medicine. Do not take FLUOXEE 60MG along with monoamine oxidase inhibitors without consulting your doctor. Before taking this medicine, inform your doctor if you are pregnant or breastfeeding women.

USES OF FLUOXEE 60MG

• Treats major depressive episodes and obsessive-compulsive disorder in adults
• Treats bulimia nervosa in adults, in combination with other psychological medicine

HOW FLUOXEE 60MG WORKS

Fluoxetine acts by inhibiting the re-uptake of serotonin (5HT) at the post-synaptic nerve terminal of neuronal membrane, enhancing the actions of serotonin on 5HT1A receptors. As a result, it stabilizes your mood and state of well-being.

DIRECTIONS FOR USE

Take FLUOXEE 60MG as directed by your physician. It can be taken with or without food. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose for you depending upon your condition. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.

SIDE EFFECTS OF FLUOXEE 60MG

HOW TO MANAGE SIDE EFFECTS

Nausea or vomiting:

Try taking this medicine with, or just after meal. Stick to simple meals. Do not eat rich or spicy food.

Diarrhea:

Drink lots of fluids, such as water or juice, to avoid dehydration. Do not take any medicines without speaking to a doctor.

WARNING & PRECAUTIONS

INTERACTIONS

Talk to your doctor, if you are taking,

• other medicines used to treat depression such as monoamine oxidase inhibitors (e.g. nialamide, selegiline, iproniazid, moclobemide, phenelzine, tranylcypromine, isocarboxazid, toloxatone), tricyclic antidepressants (e.g. imipramine, desipramine and amitriptyline) lithium or St.John’s wort
• medicines used to treat migraine (e.g. sumatriptan)
• medicines used to treat mental illness (e.g. tryptophan, risperidone)
• medicines used to treat heart problems (e.g. flecainide, propafenone, nebivolol or encainide)
• medicines used to treat allergies (e.g. astemizole, mequitazine, mizolastine, cyproheptadine)
• medicines used to thin your blood (e.g. warfarin, aspirin, buprofen, diclofenac)
• antimicrobial agents (e.g. sparfloxacin, moxifloxacin, erythromycin IV, pentamidine)
• metoprolol (used to treat heart failure)
• tramadol (used to relieve pain)
• phenytoin (used to treat epilepsy)
• halofantrine (used to treat malaria)
• tamoxifen (used to treat breast cancer)
• diuretics (increases urine output) e.g. furosemide

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT FLUOXEE 60MG

Can FLUOXEE 60MG be used during breastfeeding?

No. It is not recommended for use during breastfeeding. Consult your doctor for advice.

Can you drink alcohol while taking FLUOXEE 60MG?

No. Avoid alcohol consumption while taking this medicine.

REFERENCES

1. KD. Tripathi. Drugs Used in Mental Illness: Antidepressant and Antianxiety Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 460-462.

2. James M. O’Donnell and Richard C. Shelton. Drug therapy for Depression and Anxiety disorders. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 405-411.

3. Gerald G. Briggs and Roger K. Freeman. F. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 1609-1627.

4. University of Pittsburgh. Pharmacological Intervention Project (Fluoxetine) (FIDAA). NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on July 2013] [Accessed 27th November 2020] https://clinicaltrials.gov/ct2/show/NCT00027378

5. Andrea Rossi, Alessandra Barraco, and Pietro Donda. Fluoxetine: a review on evidence-based medicine. NCBI; PMC US National Library of Medicine, National Institute of Health. February 2004. [Accessed 27th November 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC356924/#:~:text=in%20this%20review.-,Results,the%20first%20week%20of%20therapy.

6. Endo Ventures Ltd. Electronic Medicines Compendium (EMC); [Revised on July 2019] [Accessed 27th November 2020] https://www.medicines.org.uk/emc/files/pil.9338.pdf

7. Accord. Electronic Medicines Compendium (EMC); [Revised on September 2020] [Accessed 27th November 2020] https://www.medicines.org.uk/emc/files/pil.5787.pdf

8. Accord Healthcare Limited. Electronic Medicines Compendium (EMC); [Revised on October 2020] [Accessed 27th November 2020] https://www.medicines.org.uk/emc/files/pil.6013.pdf

9. APL Swift Services (Malta) Limited or Milpharm Limited. Electronic Medicines Compendium (EMC); [Revised on August 2020] [Accessed 27th November 2020] https://www.medicines.org.uk/emc/files/pil.7088.pdf

10. Dr. Reddy’s Laboratories (UK) Ltd. Electronic Medicines Compendium (EMC); [Revised on July 2019] [Accessed 27th November 2020] https://www.medicines.org.uk/emc/files/pil.3716.pdf

11. Eli Lilly and Company. Health Products Regulatory Authority (HPRA). [Revised on August 2017] [Accessed 27th November 2020] http://www.hpra.ie/img/uploaded/swedocuments/2195294.PPA1562_091_001.2d3c2f40-5ca6-406b-9e60-a5dca4edf180.000001Prozac%20PIL.170908.pdf