INTRODUCTION

FLUCOL 650MG TABLET is a combination of Caffeine, Chlorpheniramine, Paracetamol and Phenylephrine, which belongs to the group of medicines called Central nervous system stimulants, Antihistamines, Analgesics and nasal decongestants respectively. It is used in the treatment of the common cold and flu to provide relief from fever, nasal congestion, headache, pain and symptoms of the nose or throat due to upper respiratory tract allergies. It is also used in bacterial infections such as sinusitis, tonsillitis and otitis media, along with other medicines.

While taking FLUCOL 650MG TABLET, avoid alcohol, coffee, strong tea and other tonic drinks. FLUCOL 650MG TABLET is not recommended for use in patients with asthma, severely impaired liver or kidney function, severe hypertension, heart diseases, closed-angle glaucoma, an adrenal gland tumour (Pheochromocytoma), hyperthyroidism, diabetes, porphyria, peptic ulcer or hyperplasia of the prostate gland.

FLUCOL 650MG TABLET is also not recommended for use in pregnant women, breastfeeding women or children below 12 years of age. In elderly patients, FLUCOL 650MG TABLET should be used with caution. The common side effects of FLUCOL 650MG TABLET are nausea and vomiting, drowsiness, insomnia, dizziness, headache and nervousness. If any of these become worse, contact your doctor.

USES OF FLUCOL 650MG TABLET

Treats the following conditions in adults and children (6 to12 years of age):

• Common cold and flu to provide relief from fever, nasal congestion, headache and pain
• Allergic symptoms of the nose or throat due to upper respiratory tract allergies
• Bacterial infections such as sinusitis, tonsillitis and otitis media along with other medicines

HOW FLUCOL 650MG TABLET WORKS

[GBNKWEYORD] is a combination of medicines, where Paracetamol works by elevating the pain threshold and acting on the heat-regulating centre in the brain to reduce pain and fever; Phenylephrine works by reducing swelling of the blood vessels in the nasal passages; Chlorpheniramine reduces the effects of the natural chemical histamine in the body and Caffeine enhances the activity of Paracetamol and reduces drowsiness due to Chlorpheniramine. This collective collection provides relief from fever, nasal congestion, runny nose, sneezing, headache and pain.

DIRECTIONS FOR USE

Take FLUCOL 650MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. The correct dose and duration for you will be decided by your doctor, depending on your age, body weight and disease condition. Do not stop taking FLUCOL 650MG TABLET unless your doctor advises you to stop.

SIDE EFFECTS OF FLUCOL 650MG TABLET

HOW TO MANAGE SIDE EFFECTS

Nausea or vomiting:

Take FLUCOL 650MG TABLET with or just after meals, along with your medication. Stick to simple meals and avoid eating oily or spicy foods. If there is no improvement, contact your doctor for advice.

Headache:

Try to relax and rest yourself. Apply pain balm to the head to ease the pain. Sip on some hot water or ginger tea. If there is no improvement, contact your doctor for advice.

Dizziness:

Sit down or lie down slowly when you are feeling dizzy. Take some time to rest and drink plenty of water. Avoid coffee and other carbonated drinks. If there is no improvement, contact your doctor for advice.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:  

Before taking FLUCOL 650MG TABLET, inform your doctor if you are taking any of the following medicine:

• medicines used in depression treatment [ex. isocarboxazid, phenelzine, amitriptyline]
• brompheniramine, benzphetamine, ephedrine (other medicines used for nasal congestion, allergic shock and heart failure)
• digoxin (a medicine used in the treatment of heart diseases)
• phenytoin (a medicine used in epilepsy treatment)
• zolpidem, flurazepam, suvorexant, butabarbital and triazolam (medicines used for sleep disorders)
• ergotamine and methysergide (medicines used to treat severe, throbbing headaches, such as migraine and cluster headaches)
• medicines used to control blood pressure (ex. reserpine, methyldopa, debrisoquine, atenolol and propranolol)
• warfarin and dicumarol sodium (medicines used to prevent blood clotting)

B. Drug - Food interaction:

Avoid taking coffee, strong tea and other tonic drinks while taking FLUCOL 650MG TABLET.

Overdosage:

If you or anyone else accidentally take too much of FLUCOL 650MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are pallor, nausea, vomiting, anorexia, abdominal pain, vomiting, excessive urination, tachycardia, insomnia, restlessness, excitement, agitation, jitteriness, tremors and convulsions.

SYNOPSIS

MORE INFORMATION

• Keep FLUCOL 650MG TABLET out of reach from children
• Store at room temperature

FAQs ABOUT FLUCOL 650MG TABLET

Q: What is FLUCOL 650MG TABLET used for?

A: FLUCOL 650MG TABLET temporarily treats symptoms caused by the common cold, flu, allergies or other breathing illnesses (such as sinusitis and bronchitis). It also helps relieve stuffy nose, sinus and ear congestion symptoms.

Q: Is FLUCOL 650MG TABLET suitable for cold weather?

A: FLUCOL 650MG TABLET contains medicines that treat headache, fever, body aches, a runny or stuffy nose, sneezing, itching, watery eyes and sinus congestion caused by allergies, the common cold or the flu. Always take the medicine after consulting a doctor.

Q: Can FLUCOL 650MG TABLET cause high BP?

A: FLUCOL 650MG TABLET can cause severe hypertensive episodes leading to intracranial haemorrhage in the case of overdosage. Always inform patients about the dangers of exceeding the recommended dose and the increased risk of serious adverse effects such as hypertensive crises.

Q: Does FLUCOL 650MG TABLET affect the kidney?

A: FLUCOL 650MG TABLET can cause irreversible kidney damage if used for a prolonged period. Thus, it is not recommended for use in patients with severely impaired kidney function. You should always consult a doctor before taking the medicine.

Q: Can we take FLUCOL 650MG TABLET and cetirizine together?

A: Using FLUCOL 650MG TABLET together with Cetirizine may increase side effects such as dizziness, drowsiness and difficulty concentrating. Some people, especially the elderly, may also experience impaired thinking, confusion and problems in motor coordination.

REFERENCES

1. KD Tripathi. Drugs acting on the Autonomic nervous system, Autacoids and related drugs, Essentials of medical pharmacology. Eighth edition. 2019. Page – 245, 179, 153, 223.

2. Abdulbari, M. M. and M. S. Ihsan. Simultaneous determination and validation of chlorpheniramine maleate, acetaminophen, phenylpropanolamine hydrochloride and caffeine in tablet dosage form by using reverse-phase high-performance liquid chromatography. [Revised in July 2013] [Accessed on 20th June 2022] https://asset-pdf.scinapse.io/prod/2186195757/2186195757.pdf

3. Saga Laboratories. COL-COL. https://www.nafdac.gov.ng/wp-content/uploads/Files/SMPC/Jan_2022/COL-COL-Tablet-SmPC.pdf

4. Centaurpharma.Sinarest Tablet. https://www.centaurpharma.com/downloads/Sinarest%20Tab.pdf

USEFUL DIAGNOSTIC TESTS

• Liver function tests
• Fasting blood sugar level
• Random blood sugar level