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FEMOSTON 2/10 Tablet 28's
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INTRODUCTION
FEMOSTON 2/10 is a combination of Dydrogesterone and Estradiol which belongs to the group of medicines called Hormone Replacement Therapy. It is used among postmenopausal women to relive menopausal symptoms such as hot flushes, sleep problems, irritability, or depression.
It can also be used to prevent osteoporosis (bone loss and fragility) among postmenopausal women who are at risk of developing fractures easily. FEMOSTON 2/10 should be used only in women who do not have their period at least for the past 6 months.
Estradiol and dydrogesterone are synthetic derivative of female sex hormones (oestrogen and progesterone). They supplement our body with sufficient levels of female sex hormones which improves postmenopausal symptoms.
FEMOSTON 2/10 is not a contraceptive (birth control pill), therefore it cannot prevent you from becoming pregnant. Your doctor will instruct you to have periodic blood tests and regular physical examination (breast examination) to avoid the risk of unwanted side effects.
Do not take FEMOSTON 2/10 if you have or previously had breast cancer, uterine cancer, unexplained vaginal bleeding, heart problems or blood clots. Before taking FEMOSTON 2/10 inform your doctor if you have any liver or kidney problems, diabetes, asthma, or epilepsy.
FEMOSTON 2/10 is not intended for use in pregnant and breastfeeding women. It should be used with caution in women aged above 65 years. The most common side effects of taking FEMOSTON 2/10 are stomach pain, back pain, breast pain or tenderness, headache, vaginal infection, or vaginal discharge. Consult your doctor if any of these side effect worsens. Also, inform your doctor if you experience any changes in your breast such as breast pain, tenderness, discharge from the nipple, or lump growth in the breasts.
USES OF FEMOSTON 2/10
It is used in postmenopausal women to:
- relieve menopausal symptoms
- prevent osteoporosis
HOW FEMOSTON 2/10 WORKS
FEMOSTON 2/10 supplements our body with sufficient levels of female sex hormones (estrogen and progesterone). This helps in treating problems associated with hormonal deficiency states such as menopause. As a result, it provides relief from postmenopausal symptoms such as hot flushes, sleep problems, irritability, depression and bone loss.
DIRECTIONS FOR USE
Take FEMOSTON 2/10 strictly as advised by your physician. Swallow FEMOSTON 2/10 with a glass of water. Do not crush or chew the medicine. Try to take FEMOSTON 2/10 at the same time each day.
Do not miss any dose of FEMOSTON 2/10 in between the therapy, as it may reduce its effectiveness. In case if you have missed a dose of FEMOSTON 2/10 take it as soon as you remember. Avoid taking a double dose of FEMOSTON 2/10 to compensate the missed dose it may lead to bleeding or spotting. Your doctor will decide the correct dose and duration of FEMOSTON 2/10 for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF FEMOSTON 2/10
COMMON
- stomach pain, back pain
- breast pain or tenderness
- vaginal thrush (a vaginal infection)
- depression, nervousness
- headache, dizziness
- nausea, vomiting
- flatulence
- pelvic pain, vaginal discharge
- feeling unwell, weakness or tiredness
- swelling of the ankles, feet, or fingers
- weight gain
UNCOMMON
- cystitis symptoms like (increased urination, burning sensation, blood in urine)
- changes in libido
- varicose vein
- indigestion
- gallbladder disease
- breast swelling
- pre-menstrual syndrome (PMS)
- weight loss
RARE
- ovarian cancer
- anaemia (symptoms such as weakness, tiredness, shortness of breath and headache)
- memory problems, inability to think, reasoning, changes in mood and behaviour
- muscle twitches
- worsening of fits (epilepsy)
- eye problems
- blood clots in the arteries (arterial thromboembolism)
- inflammation of the pancreas (pancreatitis)
- leg cramps
- uterine cervical ulceration
- increased thyroid activity
Stop taking FEMOSTON 2/10 and contact your doctor immediately if you experience any of the following side effects:
- allergic reactions (such as skin rash, itching, swelling of the skin around the face and neck, difficulty to breath or swallow)
- heart attack
- tumours that interact the levels of progestogens (Ex. meningioma)
- heavy, abnormal, painful vaginal bleeding, irregular or prolonged bleeding (for more than 6 months)
- sings of liver disease such as yellowing of your skin or the whites of your eyes (jaundice)
- rise in blood pressure (symptoms include headache, tiredness, dizziness)
- migraine or severe headache
- blood clot (symptoms include painful swelling, redness of the legs, sudden chest pain, difficulty in breathing)
- signs of breast cancer (such as breast pain or discharge, skin dimpling, changes in the nipple, or formation of lump in breast)
- skin disorders like chloasma (discolouration of skin in the face and neck), erythema nodosum (painful reddish patches on skin), erythema multiforme (skin rash with reddish colour and sores)
HOW TO MANAGE SIDE EFFECTS
Nausea or vomiting:
Drink clear or ice-cold drinks. Eat light, bland foods. Avoid fried, greasy, or sweet foods. Eat slowly and eat smaller, more frequent meals, drinking gradually larger amounts of clear liquids, avoid solid food until the vomiting episode has passed, take rest. Consult your doctor if nausea worsen.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
WARNING & PRECAUTIONS
PREGNANCY
FEMOSTON 2/10 is not intended for use in pregnant women. Consult your doctor before taking.
BREASTFEEDING
FEMOSTON 2/10 is not intended for use in breastfeeding women. Consult your doctor before taking.
DRIVING AND USING MACHINES
Do not drive or handle heavy machines if you experience dizziness, drowsiness, tiredness, or blurred vision after taking FEMOSTON 2/10.
ALCOHOL
Avoid consumption of alcohol while taking FEMOSTON 2/10.
KIDNEY
FEMOSTON 2/10 should be used with caution in patients with kidney diseases. Therefore, consult your doctor before taking it.
LIVER
FEMOSTON 2/10 is not recommended for use in patients who have or ever had liver diseases. It should be used with caution in patients with gall stones or benign liver tumour. Therefore, consult your doctor before taking it.
ALLERGY
Do not take FEMOSTON 2/10 if you are allergic to estradiol or dydrogesterone.
LUNGS
FEMOSTON 2/10 should be used with caution in patients with asthma. Therefore, consult your doctor before taking it.
HEART DISEASE
FEMOSTON 2/10 is not recommended for use in patients with heart diseases (such as heart attack, stroke or angina). Therefore, consult your doctor before taking it.
OTHERS
FEMOSTON 2/10 is not recommended if you have:
- or previously had breast cancer
- cancer in the uterus lining (endometrium), or if you are suspected of having it
- unexplained vaginal bleeding
- untreated endometrial hyperplasia (excessive thickening of the layer of uterus)
- or had blood clot in a vein (thrombosis, deep venous thrombosis, pulmonary embolism)
- blood clotting disorder (such as Protein C, Protein S, antithrombin deficiency)
- porphyria (inherited disorder affecting RBC)
- meningioma (brain tumour affected by the levels of progestogens
Before taking FEMOSTON 2/10 inform your doctor if you have:
- fibroids (tumours growth in uterus)
- endometriosis (a condition where inner lining of the uterus grows outside the uterus)
- or had family history of breast cancer
- diabetes
- migraine or severe headaches (a neurological disease with symptoms of severe headache)
- or ever had systemic lupus erythematosus (a serious disease in which immune system attacks its own body)
- or ever had epilepsy
- fluid retention
- premature menopause
- any blood tests to be done
- or ever had hereditary and acquired angioedema
- or ever had otosclerosis (disease affecting the eardrum and hearing)
- any upcoming surgery
Use in paediatrics:
FEMOSTON 2/10 is generally not recommended for use in children and adolescents (aged below 18 years of age). Therefore, consult your doctor before taking it.
Use in geriatrics:
FEMOSTON 2/10 should be used with caution in elderly patients. Therefore, consult your doctor before taking it.
INTERACTIONS
A. Drug - Drug interactions:
Before taking FEMOSTON 2/10, inform your doctor if you are taking any of the following medicines such as:
- medicines used to treat epilepsy (Ex. phenobarbital, phenytoin, and carbamazepine)
- medicines used to treat tuberculosis (Ex. rifampicin and rifabutin)
- medicines used to treat HIV infection (Ex. nevirapine, efavirenz, ritonavir and nelfinavir)
- St John’s Wort (an herbal medicine used to treat mental illness)
- medicines used to treat Hepatitis C viral infection (Ex. ombitasvir, paritaprevir, ritonavir, dasabuvir, glecaprevir/pibrentasvir)
- tacrolimus and cyclosporin (a medicine used to suppress immune function and to prevent graft rejection)
- fentanyl (a medicine used for pain relief)
- theophylline (a medicine used for asthma and other breathing problems)
Overdosage:
If you or anyone else accidentally took more FEMOSTON 2/10, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose might include nausea, vomiting, breast tenderness, dizziness, stomach pain, drowsiness, or menstrual bleeding.
SYNOPSIS
| Drug | : | Dydrogesterone, Estradiol |
| Pharmacological Category | : | Hormonal Replacement Therapy |
| Therapeutic Indication | : | Menopausal symptoms |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep FEMOSTON 2/10 out of reach of children
- Store FEMOSTON 2/10 at room temperature
FAQs ABOUT FEMOSTON 2/10
What is the use of FEMOSTON 2/10?
FEMOSTON 2/10 is used to treat relive menopausal symptoms (such as hot flushes, sleep problems, irritability, or depression) and to prevent osteoporosis among postmenopausal women.
Can I stop taking FEMOSTON 2/10 once my symptoms subside?
No. Do not stop taking FEMOSTON 2/10 unless your doctor advises you to stop, because sudden termination of FEMOSTON 2/10 will not provide an expected result. Continue to take FEMOSTON 2/10 as advised by the doctor.
Can FEMOSTON 2/10 be used to prevent osteoporosis in postmenopausal women?
No. FEMOSTON 2/10 is not used to prevent osteoporosis in healthy women. If you are at an increased risk of fractures due to osteoporosis and if other medicines are not suitable for you, then FEMOSTON 2/10 can be used to prevent osteoporosis after menopause.
What are the side effects of FEMOSTON 2/10?
FEMOSTON 2/10 may cause few side effects like stomach pain, back pain, breast pain or tenderness, headache, vaginal infection, or vaginal discharge. Consult your doctor if any of these side effect worsens. Also, inform your doctor if you experience any changes in your breast such as breast pain, tenderness, discharge from the nipple, or lump growth in the breasts, heavy menstrual bleeding, pain, swelling, redness of the legs, sudden chest pain, difficulty in breathing.
What precautions need to be followed while taking FEMOSTON 2/10?
Before taking FEMOSTON 2/10 inform your doctor if you have or previously had breast cancer, uterine cancer, unexplained vaginal bleeding, heart problems, blood clots, diabetes, or asthma. Take FEMOSTON 2/10 regularly as instructed by the physician without fail. Do not miss a dose of FEMOSTON 2/10 to achieve maximum benefits. Periodically undergo blood tests and breast examination as advised by your doctor without fail. Women aged below 50 years must use suitable contraceptive method to avoid pregnancy while taking FEMOSTON 2/10.
Can FEMOSTON 2/10 be used as a contraceptive?
No. FEMOSTON 2/10 is not a contraceptive (birth control pill) and therefore necessary safety measures must be followed to avoid pregnancy. If it is less than 12 months since your last menstrual period and you are under 50 years of age, you may still need to use additional contraception to prevent pregnancy. In case if you become pregnant while taking FEMOSTON 2/10 stop taking the medicine and consult your doctor immediately.
Can FEMOSTON 2/10 be used to induce periods?
No. FEMOSTON 2/10 is not used to induce periods. It is intended for use in postmenopausal women to treat menopausal symptoms. It works by supplementing your body with sufficient female sex hormones.
Can FEMOSTON 2/10 be used in pregnant women?
No. FEMOSTON 2/10 not intended for use in pregnant women. It is used only in postmenopausal women to treat menopausal symptoms. Women taking FEMOSTON 2/10 must follow a suitable contraceptive method to avoid pregnancy. In case if you found to be pregnant stop taking the medicine and consult your doctor immediately.
Can FEMOSTON 2/10 cause cancer?
Yes. Research has that shown that prolonged use of FEMOSTON 2/10 may lead to breast cancer. To avoid this, your doctor will constantly monitor your health condition using periodic blood tests and ultrasounds (breast examination). However, inform your doctor immediately if you experience any unusual symptoms such as severe breast pain or tenderness, purplish discoloration of breasts or discharge from nipples.
How long do we bleed while taking FEMOSTON 2/10?
Nearly 75-90% of women experience bleeding up to 5 days while undergoing therapy with FEMOSTON 2/10. Bleeding usually starts at the last day of the monthly course or may happen in between the cycle as well. However, consult your doctor if you’re bleeding or spotting appears after some time on therapy, or continue to happen even after stop taking FEMOSTON 2/10.
Can FEMOSTON 2/10 cause memory loss?
Yes. FEMOSTON 2/10 may cause memory loss in elderly women (above 60 years). Consult your doctor if you are experiencing forgetfulness or memory problems.
Who should not take FEMOSTON 2/10?
FEMOSTON 2/10 is not recommended for use in patients who have or ever had breast cancer, or endometrial cancer (uterus cancer). It is also not recommended for use in patients having unexplained vaginal bleeding, increased thickening of uterus, or blood clot problems. Therefore, consult your doctor before taking it.
How to take FEMOSTON 2/10?
Take FEMOSTON 2/10 strictly as advised by your physician. Swallow FEMOSTON 2/10 with a glass of water. Do not crush or chew the medicine. Try to take FEMOSTON 2/10 at the same time each day. Do not miss any dose of FEMOSTON 2/10 in between the therapy, as it may reduce its effectiveness. In case if you have missed a dose of FEMOSTON 2/10 take it as soon as you remember. Avoid taking a double dose of FEMOSTON 2/10 to compensate the missed dose it may lead to bleeding or spotting.
REFERENCES
1. K.D. Tripathi. Estrogens, Progestins and Contraceptives. Essentials of Pharmacology. Seventh Edition. 2013. Page: 306, 316, 318.
2. Foster, R.H., Balfour, J.A. Estradiol and Dydrogesterone, A Review of Their Combined Use as Hormone Replacement Therapy in Postmenopausal Women. Springer link. October 2012. [Accessed on 3rd May 2022] https://link.springer.com/article/10.2165/00002512-199711040-00006#citeas
3. Abbott Biologicals B.V. Electronic Medicines Compendium (EMC) [Revised in February 2022] [Accessed on 3rd May 2022] https://www.medicines.org.uk/emc/files/pil.5523.pdf
4. Abbott Biologicals B.V [Revised in August 2020] [Accessed on 3rd May 2022] http://www.hpra.ie/img/uploaded/swedocuments/12ac7504-07a3-478a-8d5b-9d64d0fd154f.pdf
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