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INTRODUCTION

EZICAS AZ NASAL SPRAY is a combination of Azelastine and Fluticasone which belongs to the group of medicines called Antihistamines and Corticosteroids respectively. It is used to relieve the symptoms of moderate to severe seasonal and perennial allergic rhinitis in which use of either intranasal antihistamine or corticosteroid alone is not considered insufficient. It is used to relieve the symptoms of allergies such as runny nose, post nasal drip, sneezing and itchy or blocked nose.

Seasonal and perennial allergic rhinitis is an allergic reaction to substances called as pollen (hay fever), house mites, moulds, dust or pets.

Avoid consumption of alcohol while using this medicine, because it further decreases alertness and impairment of CNS performance may occur.

Before using this medicine, inform your doctor if you have tuberculosis, asthma, liver or kidney disease.

EZICAS AZ NASAL SPRAY is generally not recommended for use in pregnant women unless clearly necessary. Contact your doctor before using.

EZICAS AZ NASAL SPRAY should be used with caution in breastfeeding women because it may pass through the breast milk. Contact your doctor before using.

EZICAS AZ NASAL SPRAY is not recommended for use in children and adolescents. Contact your doctor before using.

EZICAS AZ NASAL SPRAY should be used with caution in elderly patients aged 65 years or above. Contact your doctor before using.

The most common side effects of using this medicine are nosebleed, headache, bitter taste in mouth and unpleasant smell. Contact your doctor, if any of the side effects worsen or persist for a long duration.

USES OF EZICAS AZ NASAL SPRAY

It is used to relieve the symptoms of:

  • moderate to severe seasonal and perennial allergic rhinitis (in adults and children)
  • allergies such as runny nose, postnasal drip, sneezing and itchy or blocked nose

HOW EZICAS AZ NASAL SPRAY WORKS

EZICAS AZ NASAL SPRAY is a combination of Azelastine and Fluticasone where Azelastine is an antihistamine which prevents the effects of substances called histamine that is responsible for the allergic reaction in the body. Fluticasone is a corticosteroid that reduces inflammation and symptoms of allergic rhinitis.

DIRECTIONS FOR USE

Use EZICAS AZ NASAL SPRAY as advised by your physician. It is for intranasal use only. Check the label for directions before use. Shake the bottle gently before each use.

SIDE EFFECTS OF EZICAS AZ NASAL SPRAY

COMMON

  • headache
  • bitter taste in the mouth
  • unpleasant smell
  • nosebleed

UNCOMMON

  • slight irritation inside the nose (cause mild stinging, itching, or sneezing)
  • nasal dryness
  • cough, dry throat or throat irritation

RARE

  • dry mouth

Stop using EZICAS AZ NASAL SPRAY and contact your doctor immediately if you experience any of the following side effects:

  • sleepiness or drowsiness
  • nasal problems symptoms such as crusting in the nose, nosebleeds, runny nose, nasal septal perforation, sore in your nose, surgery on nose, nose injury
  • redness or white colored patches in nose or mouth
  • eye problems (glaucoma or cataract)
  • immune system problems and increased risk of infections symptoms such as fever, aches or pains, chills, feeling tired
  • tiredness, weakness, nausea, vomiting, low blood pressure
  • slowed or delayed growth (in children)

HOW TO MANAGE SIDE EFFECTS

Headache:

Rest and relax. Drink plenty of fluids such as water or electrolytes and apply a pain-relieving balm on the head if necessary. Do not consume alcohol. Contact your doctor if the symptom did not improve.

WARNING & PRECAUTIONS

PREGNANCY

EZICAS AZ NASAL SPRAY should be used with caution in pregnant women. Contact your doctor before using.

BREASTFEEDING

EZICAS AZ NASAL SPRAY should be used with caution in breastfeeding women because it may pass through the breast milk. Contact your doctor before using.

DRIVING AND USING MACHINES

Do not drive or operate any machines, if you experience dizziness, drowsiness, sleepiness, somnolence, and fatigue after using EZICAS AZ NASAL SPRAY.

ALCOHOL

Avoid consumption of alcohol while using this medicine, because it may decrease alertness and impairment of CNS performance.

KIDNEY

EZICAS AZ NASAL SPRAY should be used with caution in patients with kidney disease. Contact your doctor before using.

LIVER

EZICAS AZ NASAL SPRAY should be used with caution in patients with severe liver disease. Consult your doctor before using.

ALLERGY

Do not use EZICAS AZ NASAL SPRAY if you are allergic to Azelastine or Fluticasone or any other ingredients of this medicine.

LUNGS

EZICAS AZ NASAL SPRAY should be used with caution in patients with asthma, tuberculosis. Contact your doctor before using.

OTHERS

Before using EZICAS AZ NASAL SPRAY, inform your doctor if you:

  • had recent surgery in the nose, nasal trauma, nasal ulcers,
  • have an infection in the nose
  • have glaucoma and cataract
  • have impaired adrenal function
  • blurred vision or other visual disturbances
  • have ocular herpes simplex infection, chicken pox and measles
  • have untreated infections like fungal, bacterial, viral, or parasitic infections
  • have any other medical conditions

Use in pediatrics:

Your doctor will prescribe the right dose depending on your child’s age, body weight and disease condition. Consult your doctor before using EZICAS AZ NASAL SPRAY. 

Use in geriatrics:

EZICAS AZ NASAL SPRAY should be used with caution in elderly patients (above 65 years of age). Contact your doctor before using.

INTERACTIONS

A. Drug-Drug interactions:

Inform your physician, if you are using,

  • medicines used to treat viral infections such as HIV (Ex. atazanavir, darunavir, ritonavir, cobicistat)
  • medicines used for fungal infections (Ex. ketoconazole, itraconazole, voriconazole)
  • medicines used for bacterial infections (Ex. erythromycin, clarithromycin)
  • medicines used to treat stomach ulcers (Ex. cimetidine and ranitidine)
  • medicines used for asthma (Ex. theophylline)
  • nefazodone (used for depression)
  • medicines used to treat inflammation (Ex. dexamethasone, methylprednisolone and prednisone)

Overdosage:

If you or anyone else accidentally uses too much of EZICAS AZ NASAL SPRAY, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are increased somnolence, hypercorticism and adrenal suppression conditions such as weight loss, fatigue, muscle weakness, low blood sugar, salt cravings, joint pains, depression and darkening of the skin.

SYNOPSIS

Drug :   Azelastine, Fluticasone
Pharmacological Category :   Antihistamines, Corticosteroids
Therapeutic Indication :   Allergic Rhinitis
Dosage Forms :   Nasal spray, Nasal drops

MORE INFORMATION

  • Keep out of reach of children
  • Store below 30°C

FAQs ABOUT EZICAS AZ NASAL SPRAY

Does [GBNKEYWORDD] cause sleepiness?

Yes. EZICAS AZ NASAL SPRAY may cause sleepiness. Avoid driving or operating any machinery if you feel sleepiness, dizziness, drowsiness and fatigue after using EZICAS AZ NASAL SPRAY.

Does EZICAS AZ NASAL SPRAY affects growth in children?

Yes. Using EZICAS AZ NASAL SPRAY for a long time may cause children to grow more slowly. Contact your doctor before using this medicine.

Can EZICAS AZ NASAL SPRAY cause adrenal suppression?

Yes. EZICAS AZ NASAL SPRAY may cause adrenal suppression (a condition in which adrenal gland does not produce enough steroid hormone and symptoms include weight loss, fatigue, muscle weakness, low blood pressure, salt cravings, joint pains, depression and darkening of the skin). Contact your doctor before using.

Does EZICAS AZ NASAL SPRAY cause glaucoma and cataracts?

Yes. EZICAS AZ NASAL SPRAY may result in the development of glaucoma or cataracts. Contact your doctor if you experience blurred vision or change in vision.

Can EZICAS AZ NASAL SPRAY decrease immunity?

Yes. EZICAS AZ NASAL SPRAY may decrease immunity and increase the risk of infections. Contact your doctor if you experience symptoms of infections such as fever, chills, body aches, and fatigue.

Can I use EZICAS AZ NASAL SPRAY in children?

No. EZICAS AZ NASAL SPRAY is not recommended for use in children and adolescents. Contact your doctor before using.

REFERENCES

1. K.D. Tripathi. Histamine and Antihistaminics & Drugs for Cough and Bronchial Asthma Essentials of medical pharmacology. Seventh edition. 2013. Page- 167, 231.

2. Robert. J. Kizior, Keith j. Hodgson. Rhinitis preparation. Saunders Nursing Drug Handbook 2021. 28th edition. 2021. Page-36.

3. Teva Pharmaceuticals USA. A Double-Blind, Randomized, Placebo-Controlled, Parallel-Group, Multi-Site Study to Evaluate the Therapeutic Equivalence of Azelastine Hydrochloride and Fluticasone Propionate, 137/50 mcg Nasal Spray, to Dymista™ Nasal Spray.  NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in February 2015] [Accessed on 2nd June 2022] https://clinicaltrials.gov/ct2/show/NCT02249663

4. Chennakeshavaraju N, Narayana S, M Mohiyuddin AS. Comparative study of the efficacy and safety of intranasal azelastine hydrochloride and fluticasone furoate in the treatment of allergic rhinitis. Journal of Family Community Medicine. January 2021. [Accessed on 14th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927963/

5. Peter M. Debbaneh, Anna K. Bareiss, Sarah K. Wise,  Edward D. McCoul. Intranasal Azelastine and Fluticasone as Combination Therapy for Allergic Rhinitis: Systematic Review and Meta-analysis. Sage journals. April 2019. [Accessed on 14th June 2022] https://journals.sagepub.com/doi/abs/10.1177/0194599819841883

6. Frank C. Hampel, Paul H. Ratner, Julius Van Bavel, N. J. Amar, Pramila Daftary, William Wheeler, Harry Sacks. Uses of Azelastine and Fluticasone spray. Elsevier Journals. March 2009. [Accessed on 2nd June 2022] https://www.sciencedirect.com/science/article/abs/pii/S1081120610006058

7. Meda Pharma GMBH & Co KG. Electronic Medicines Compendium (EMC). [Revised on February 2022] [Accessed on 19th May 2022] https://www.medicines.org.uk/emc/files/pil.9450.pdf

8. Meda Pharmaceuticals Inc. U.S. Food & Drug Administration. [Revised on February 2015] [Accessed on 19th May 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/202236s008lbl.pdf

9. MEDA Pharma GmbH & Co. KG. Health Products Regulatory Authority (HPRA). [Revised on October 2020] [Accessed on 19th May 2022] http://www.hpra.ie/img/uploaded/swedocuments/612fdc1b-9662-4c24-b6bd d362ba1e258f.pdf

10. MEDA Pharma GmbH & Co. KG. Health Products Regulatory Authority (HPRA). [Revised on January 2022] [Accessed on 19th May 2022] http://www.hpra.ie/img/uploaded/swedocuments/9622571d-2fcd-4eda-b94a-bd3c922bde51.pdf

11. Meda Pharmaceuticals. Azelastine and Fluticasone. [Revised on April 2021] [Accessed on 19th May 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4c557ec4-c4cf-11df-851a-0800200c9a66

12. Cipla Ltd. Duonase- nasal spray (Azelastine and Fluticasone). Ciplamed. [Revised on January 2017] [Accessed on 19th May 2022] https://www.ciplamed.com/content/duonase-nasal-spray

AUTHOR DETAILS

Written By Dr. Janet.C, Pharm.D
Last updated on 10 Dec 2022 | 11:09 PM(IST)

PRODUCT DETAILS

    Net Qty
    1 N
    Ingredient
    AZELASTINE 140MCG+FLUTICASONE 50MCG
    Hsn Code
    30049099
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The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

Ezicas AZ Nasal Spray 7ml

Ezicas AZ Nasal Spray 7ml Mkt: Intas Pharmaceuticals Ltd

₹ 349.32 MRP ₹ 426.00