INTRODUCTION

EXEL M CREAM is a combination of Clobetasol and Miconazole which belongs to the group of medicines called Corticosteroids and Antifungals. It is used to treat resistant dermatoses (skin infections) with secondary fungal infections like psoriasis (except widespread plaque psoriasis) and recalcitrant dermatoses.

EXEL M CREAM is not recommended for use in patients with rosacea, acne vulgaris, perioral dermatitis, pruritus without inflammation, perianal and genital pruritus. EXEL M CREAM should be used with caution in patients with liver or kidney disease and psoriasis. Contact your doctor before applying.

Use of EXEL M CREAM during pregnancy should only be considered if the expected benefit to the mother outweighs the risk to the foetus. Contact your doctor before applying. Use of EXEL M CREAM during lactation should only be considered if the expected benefit to the mother outweighs the risk to the infant. Contact your doctor before applying.

EXEL M CREAM is not recommended for use in children under 1 year of age and should be used with caution in children above 1 year of age. Contact your doctor before applying. EXEL M CREAM should be used with caution in elderly patients. Contact your doctor before applying. The most common side effects of this medicine are pruritus, skin burning or skin pain. Contact your physician if any of the symptoms worsen.

USES OF EXEL M CREAM

It is used to treat:

• resistant dermatoses (skin infections) with secondary fungal infection Ex. psoriasis (except widespread plaque psoriasis)
• recalcitrant dermatoses

HOW EXEL M CREAM WORKS

EXEL M CREAM helps to treat infection, where Clobetasol belongs to Corticosteroids which blocks the production of certain chemical messengers (prostaglandins) that make the skin red, swollen, and itchy and Miconazole is an antifungal which inhibits the fungal growth.  

DIRECTIONS FOR USE

Apply EXEL M CREAM as directed by your physician. It is for external use only. Apply a thin layer of the medicine to the affected area of the skin and rub it gently. Avoid contact with eyes.

SIDE EFFECTS OF EXEL M CREAM

WARNING & PRECAUTIONS

PREGNANCY

Consult your doctor

Use of EXEL M CREAM during pregnancy should only be considered if the expected benefit to the mother outweighs the risk to the foetus. Contact your doctor before applying.

BREASTFEEDING

Consult your doctor

Use of EXEL M CREAM during lactation should only be considered if the expected benefit to the mother outweighs the risk to the infant. Contact your doctor before applying.

KIDNEY

Use with Caution

EXEL M CREAM should be used with caution in patients with kidney disease. Contact your doctor before applying.

LIVER

Use with Caution

EXEL M CREAM should be used with caution in patients with liver disease. Contact your doctor before applying.

ALLERGY

Contraindicated

Do not use EXEL M CREAM if you are allergic to Clobetasol, Miconazole or to any other ingredients of this medicine.

USE IN PEDIATRICS

Consult your doctor

EXEL M CREAM is not recommended for use in children under 1 year of age and should be used with caution in children above 1 year of age. Contact your doctor before applying.

USE IN GERIATRICS

Use with Caution

EXEL M CREAM should be used with caution in elderly patients. Contact your doctor before applying.

INTERACTIONS

A. Drug-Drug interactions:

Before using EXEL M CREAM inform your doctor if you are taking the following medicine:

• ritonavir (medicines used for HIV infections)
• itraconazole (medicines used for fungal infections)
• warfarin (medicines used to treat or prevent blood clots)

Overdosage:

If you or anyone else accidentally uses too much of EXEL M CREAM, consult your doctor immediately or visit the nearby hospital.

SYNOPSIS

MORE INFORMATION

• Keep out of reach of children
• Store EXEL M CREAM below 25°C

FAQs ABOUT EXEL M CREAM

Q: What are the possible side effects of applying EXEL M CREAM?

A: The most common side effects of this medicine are pruritis, skin burning sensation or skin pain. Contact your physician if any of the symptoms worsen.

Q: Can I stop applying EXEL M CREAM?

A: Do not stop applying EXEL M CREAM suddenly without consulting your doctor, as it leads to adrenal insufficiency. Therefore, it is important to apply EXEL M CREAM until your doctor advice you to stop.

Q: Can I use EXEL M CREAM for long time?

A: No. Do not apply EXEL M CREAM for more than four weeks without medical supervision. If the condition worsens or does not improve within four weeks, Contact your doctor.

Q: Can I use EXEL M CREAM in psoriasis?

A: EXEL M CREAM should be used with caution in patients with psoriasis due to risk of rebound relapses, generalised pustular psoriasis, development of tolerance, local or systemic toxicity due to impaired skin barrier. Contact your doctor before applying.

Q: Can I use EXEL M CREAM in children?

A: Yes. EXEL M CREAM should be used with caution in children above 1 year of age. Contact your doctor before applying.

REFERENCES

1. K.D. Tripathi. Drugs acting on the skin and mucous membrane & Antifungal drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 895, 792.

2. Bethesda (MD). Clobetasol. National Institute of Health. NLM. National Centre for Biotechnology Information. PubChem Compound Summary. 2004. [Accessed on 17th June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/5311051

3. Bethesda (MD). Miconazole. National Institute of Health. NLM. National Centre for Biotechnology Information. PubChem Compound Summary. 2004. [Accessed on 17th June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/4189

4. GlaxoSmithKline Pharmaceuticals Limited. Clobetasol propionate and miconazole nitrate.  [Revised on May 2021] [Accessed on 24th June 2022] https://india-pharma.gsk.com/media/6416/tenovate-m.pdf