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INTRODUCTION
EVERVOG M 3 TABLET is a combination of Metformin and Voglibose which belongs to the group of medicines called Antidiabetic agents. EVERVOG M 3 TABLET is indicated as a second-line therapy for the management of type II diabetes mellitus when diet, exercise and therapy with single agents does not result in adequate glycemic control.
Type II diabetes is a chronic medical condition in which the body does not make enough insulin, or the produced insulin does not work well. Symptoms include excessive urination, excessive thirst, hunger, fatigue and blurred vision.
Along management with EVERVOG M 3 TABLET, follow regular exercise and diet plan as advised by your doctor to achieve better results.
Prior and during therapy with EVERVOG M 3 TABLET, your doctor might access your kidney functions frequently to avoid the risk of side effects, especially if you are elderly with poor kidney functions. Avoid consumption of alcohol while taking EVERVOG M 3 TABLET as it could aggravate your existing disease condition and increase the risk of lactic acidosis.
EVERVOG M 3 TABLET is generally not recommended for use in pregnant or breastfeeding women and in children (aged less than 18 years) due to lack of safety and effectiveness. It should be used with caution in elderly patients (aged 65 years or above).
The most common side effects of taking EVERVOG M 3 TABLET are nausea, vomiting, diarrhea, stomach pain, headache and dizziness. Consult your doctor if any of the side effects worsen.
USES OF EVERVOG M 3 TABLET
- To manage type II diabetes mellitus (as second-line of therapy) when diet, exercise and therapy with single agents does not result in adequate glycemic control
HOW EVERVOG M 3 TABLET WORKS
[GBNKYWORD] helps to control blood sugar levels, where metformin works by reducing the amount of glucose released into the blood by the liver and voglibose acts by reversibly inhibiting the activity of various carbohydrate digestive enzymes (Ex. sucrose, maltose, zomaltase, etc.) in the gut, thus leading to delayed digestion and absorption of glucose into the blood stream.
DIRECTIONS FOR USE
Take EVERVOG M 3 TABLET as advised by your physician. Swallow EVERVOG M 3 TABLET with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF EVERVOG M 3 TABLET
COMMON
- nausea, vomiting, diarrhea, stomach pain or loss of appetite
- heart burn
- change in taste
- general weakness
- headache
- dizziness
RARE
- rash and itching
- anemia (decreased RBC count)
- signs of decreased platelet count in blood (easy bleeding or bruising)
- signs of decreased white blood cell (repeated fever and infections, mouth sores)
Stop taking EVERVOG M 3 TABLET and contact your doctor immediately if you experience any of the following side effects:
- symptoms of lactic acidosis (such as vomiting, stomach pain, decreased heartbeat, difficulty in breathing, muscle cramps, general weakness with severe tiredness or reduced body temperature)
- hepatitis (inflammation of liver with tiredness, loss of appetite, weight loss, with or without yellowing of skin or eyes)
- signs of low blood pressure (such as excessive hunger, headache, shaking, sweating, confusion, anxiety, fast heartbeat)
HOW TO MANAGE SIDE EFFECTS
Diarrhea
Drink lot of fluids such as water to keep yourself hydrated. Avoid taking any medicine on your own for treating diarrhea. Consult your doctor if the symptom did not improve.
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines while you are feeling dizzy. Do not consume too much of alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom did not improve.
Headache
Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the head if required. Do not consume too much of alcohol. Consult your doctor if the symptom did not improve.
Loss Of Appetite
Eat when you are hungry. Eat smaller meals more often than usual. Snack only when you're hungry. Always try to have a nutritious snack that is rich in calories and protein such as dried fruit and nuts. Consult your doctor if the symptom did not improve.
Nausea And Vomiting
Try to take EVERVOG M 3 TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom did not improve.
Stomach Pain
Rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. Do not self-treat on your own and consult your doctor if the symptom did not improve on its own.
WARNING & PRECAUTIONS
PREGNANCY
ContraindicatedEVERVOG M 3 TABLET is not recommended for use in pregnant women. Consult your doctor before taking EVERVOG M 3 TABLET.
BREASTFEEDING
ContraindicatedEVERVOG M 3 TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking EVERVOG M 3 TABLET.
DRIVING AND USING MACHINES
Use with CautionEVERVOG M 3 TABLET has no direct influence on the ability to drive and use machines, however it may cause hypoglycemia (low blood sugar levels). Patients should be warned about signs of hypoglycemia (such as weakness, dizziness, fast heartbeat, vision disorders or difficulty in concentration) before or while driving or using machines. Do not drive or use any machines if you start to feel these symptoms.
ALCOHOL
Consult your doctorAvoid consumption of alcohol while taking EVERVOG M 3 TABLET since it may increase the risk of lactic acidosis, dizziness or sleepiness. Consult your doctor before taking EVERVOG M 3 TABLET.
KIDNEY
ContraindicatedEVERVOG M 3 TABLET is not recommended for use in patients with severe kidney disease. Consult your doctor before taking EVERVOG M 3 TABLET.
LIVER
ContraindicatedEVERVOG M 3 TABLET is not recommended for use in patients with liver problems. Consult your doctor before taking EVERVOG M 3 TABLET.
ALLERGY
ContraindicatedDo not take EVERVOG M 3 TABLET if you are allergic to Metformin or Voglibose.
HEART DISEASE
ContraindicatedEVERVOG M 3 TABLET is not recommended for use in patients with heart problems (such as recent heart attack or failure, cardiogenic shock (problems in blood circulation) or abnormal breathing). Consult your doctor before taking EVERVOG M 3 TABLET.
USE IN PEDIATRICS
ContraindicatedEVERVOG M 3 TABLET is generally not recommended for use in children and adolescents (under 18 years) due to lack of safety and effectiveness. Consult your doctor before taking EVERVOG M 3 TABLET.
USE IN GERIATRICS
Use with CautionEVERVOG M 3 TABLET should be used with caution in elderly patients (aged 65 years or above). Management with EVERVOG M 3 TABLET will be usually initiated at the low effective dose depending on kidney, liver or heart function and your doctor may assess the kidney function more frequently. Consult your doctor before taking EVERVOG M 3 TABLET.
OTHERS
EVERVOG M 3 TABLET is not recommended for use if you:
- have lactic acidosis (lactic acid build up in the bloodstream) or ketoacidosis (ketone bodies accumulate in the blood)
- have ever had a diabetic pre-coma
- have severe dehydration (either due to vomiting, diarrhea or shock)
- have severe infection, before and after operation or with serious trauma
- have gastrointestinal obstruction (a block in intestines)
- are alcoholic
Before taking EVERVOG M 3 TABLET, inform your doctor if you:
- have an upcoming major surgery
- are scheduled for X-ray or scan using iodination contrast agents
- have a history of laparotomy or ileus (surgery in abdomen)
- have any chronic intestinal disease (accompanied by disturbed digestion and absorption)
- have aggravating symptoms due to increased generation of intestinal gas (stenosis, large intestine ulcer, severe hernia, roemheld syndrome)
- have vitamin B12 deficiency
- are malnourished
- have problems in pituitary or adrenal glands
INTERACTIONS
A. Drug-Drug interactions:
Before taking EVERVOG M 3 TABLET inform to your doctor, if you are taking any of these medicines:
- diuretics (medicines used to increase urine output) Ex. furosemide, chlorothiazide, hydrochlorothiazide
- other medicines used to treat diabetes (Ex. insulin, glipizide, glyburide, glimepiride)
- medicines used to control blood cholesterol levels such as fibric acid derivatives (Ex. fenofibrate, gemfibrozil)
- antipsychotics (used to treat mental illness) Ex. chlorpromazine, fluphenazine, mesoridazine, perphenazine, or prochlorperazine
- monoamine oxidase inhibitors (used to treat depression) Ex. fluoxetine, sertraline
- sympathomimetic agents (used to treat circulatory disorders) Ex. ephedrine, adrenaline, noradrenaline, isoprenaline, phenylephrine and phenylpropanolamine
- medicines used to treat certain cancer (Ex. vandetanib, crizotinib, olaparib)
- cimetidine (used to treat ulcers)
- ranolazine (used to treat chest pain)
- medicines used to treat infections (isavuconazole, dolutegravir, trimethoprim)
- medicines used to treat heart problems such as alpha-blockers (alfuzosin, prazosin), beta-blockers (Ex. propranolol, atenolol), calcium channel blockers (Ex. nifedipine, verapamil)
- medicines used to treat epilepsy (Ex. phenytoin, valproic acid)
- medicines used to treat pain and inflammation (such as ibuprofen and celecoxib)
- medicines used to treat high blood pressure (Ex. captopril, enalapril, losartan, valsartan)
- bronchodilators (used to treat asthma) Ex. salbutamol, terbutaline, salmeterol, formoterol, ipratropium
- carbonic anhydrase inhibitors (used to treat glaucoma) Ex. topiramate, zonisamide, acetazolamide or dichlorphenamide
- thyroid hormones (used to treat abnormal thyroid function) Ex. thyroxine, triiodothyronine
- hormonal replacement therapy (used to correct menstrual disorders) Ex. estradiol, ethinyl estradiol
- oral contraceptives (abortion pill) Ex. mifepristone
- nicotinic acid (used to treat or prevent niacin deficiency)
- corticosteroids (used to treat inflammation) Ex. dexamethasone, prednisolone
- isoniazid (used to treat tuberculosis)
- medicines containing alcohol (such as cough syrup)
- iodinated contrast agents (used during an X-ray or scan)
Overdosage:
If you or anyone else accidentally take too much of EVERVOG M 3 TABLET, consult your doctor immediately or go to a nearest hospital straight away as it could lead to a life-threatening condition called lactic acidosis and stomach discomfort or diarrhea may occur. Symptoms of lactic acidosis might include nausea, vomiting, stomach pain with muscle cramps, decreased heartbeat, general weakness with severe tiredness, difficulty in breathing or reduced body temperature.
SYNOPSIS
| Drug | : | Metformin, Voglibose |
| Pharmacological Category | : | Biguanides, Alpha-glucosidase inhibitor |
| Therapeutic Indication | : | Type II diabetes mellitus |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep EVERVOG M 3 TABLET out of reach of children
- Store at room temperature
FAQs ABOUT EVERVOG M 3 TABLET
Q: Can I consume alcohol while taking EVERVOG M 3 TABLET?
A: No, avoid consumption of alcohol while taking EVERVOG M 3 TABLET since it may increase the risk of lactic acidosis, dizziness or sleepiness. Consult your doctor before taking EVERVOG M 3 TABLET if you are alcoholic or having history of alcohol consumption.
Q: Can EVERVOG M 3 TABLET be used in pregnant women?
A: No, EVERVOG M 3 TABLET is not recommended for use in pregnant women. Consult your doctor for advice before taking EVERVOG M 3 TABLET if you are pregnant or planning to get pregnant.
Q: Is EVERVOG M 3 TABLET safe to use in elderly patients?
A: Yes, EVERVOG M 3 TABLET should be used with caution in elderly patients (aged 65 years or above). Consult your doctor before taking this medicine. Your doctor might check your kidney function frequently to avoid kidney damage and for dose adjustment.
Q: What is EVERVOG M 3 TABLET used for?
A: EVERVOG M 3 TABLET is indicated as a second-line therapy for the management of type II diabetes mellitus when diet, exercise and therapy with single agents does not result in adequate glycemic control.
Q: What to do if I forget to take a dose of EVERVOG M 3 TABLET?
A: You should take EVERVOG M 3 TABLET immediately when you remember. If it is time for your next dose of EVERVOG M 3 TABLET skip the dose and follow your regular dose schedule. Do not double the dose of this medicine to match up your missed dose.
REFERENCES
1. KD. Tripathi. Insulin, Oral Hypoglycemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 275-276 & 277.
2. Gerald G. Briggs and Roger K. Freeman. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 2451-2456.
3. Takeda. Voglibose Tablets 0.2 / OD Tablets 0.2 Special Drug Use Surveillance "Long-term Use in Patients with Impaired Glucose Tolerance". NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in December 2018]. [Accessed on 9th October 2021] https://clinicaltrials.gov/ct2/show/NCT01993927
4. Tae Jung Oh, Jae Myung Yu, Kyung Wan Min, Hyun Shik Son, Moon Kyu Lee, Kun Ho Yoon, Young Duk Song, Joong Yeol Park, In Kyung Jeong, Bong Soo Cha, Yong Seong Kim, Sei Hyun Baik, In Joo Kim, Doo Man Kim, Sung Rae Kim, Kwan Woo Lee, Jeong Hyung Park, In Kyu Lee, Tae Sun Park, Sung Hee Choi and Sung Woo Park. Efficacy and Safety of Voglibose Plus Metformin in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial. NCBI; PMC US National Library of Medicine, National Institute of Health. June 2019. [Accessed on 9th October 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581551/
5. Torrent Pharmaceuticals Ltd. Voglitor MF. Torrentian.com. [Revised in July 2020]. [Accessed on 9th October 2021] https://www.torrentian.com/pisheet/Upload/PI_Sheet/1720.pdf
6. Torrent Pharmaceuticals Ltd. Voglitor MF Forte. Torrentian.com. [Revised in July 2020]. [Accessed on 9th October 2021] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2851.pdf
USEFUL DIAGNOSTIC TESTS
- Glucose - Fasting Blood
- Glucose - Postprandial Blood
- Glycosylated Hemoglobin
AUTHOR DETAILS
Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 18 Oct 2023 | 05:01 PM(IST)
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