INTRODUCTION

EVEROTAS 10MG contains Everolimus is an antineoplastic chemotherapy drug. This medication is classified as an mTOR kinase inhibitor. It reduces the blood supply to the tumour and slows down the growth and spread of cancer cells. This medicine is used to treat people with advanced kidney cancer and subependymal giant cell astrocytoma (SEGA) by slowing the growth and spread of tumour cells. It is also used as Prophylaxis of organ rejection in kidney and liver transplant.

Everolimus is a targeted therapy which works by targeting specific to the cancer cells, thereby decreasing side effects caused by unwanted damage to the healthy cells. It is a kinase inhibitor that inhibits mTor kinase. mTor kinase is an enzyme required for cell growth and survival and by blocking this enzyme, the medication prevents cell division and, in turn, tumor growth. The medication can also interrupt the development of blood vessels (angiogenesis) that supply with nutrients, which tumor need to grow.

Always take this medicine as instructed by your doctor.Avoid grapefruit juice while taking this medicine. Swallow this medicine whole and do not chew or crush it. EVEROTAS 10MG can develop mouth ulcers and sores. Your doctor might prescribe with a mouthwash, gel or other products. Before taking this medicine, consult your doctor if you have any ongoing medication for any underlying disease. Do not drive or handle any machines while taking this medicine may cause tiredness. It is not to be used in children or adolescents below 18 years of age. The most common side effects are chills (signs of infection), fever, coughing and wheezing, excessive thirst, high or low urine output, increased appetite with weight loss, tiredness and bleeding.

USES OF EVEROTAS 10MG

• Breast cancer
• Neuroendocrine tumors (NET)
• Renal cell carcinoma (RCC)

HOW EVEROTAS 10MG WORKS

EVEROTAS 10MG works by inhibiting mTor kinase, an enzyme required for cell growth and survival. By blocking this enzyme, it prevents cell division and, in turn, tumor growth. This medicine can also interrupt the development of blood vessels (angiogenesis) that supply with nutrients, which tumor need to grow.

DIRECTIONS FOR USE

Always take EVEROTAS 10MG exactly as your doctor has directed you. Avoid grapefruit juice while taking this medicine. Swallow this medicine whole and do not chew or crush it.

SIDE EFFECTS OF EVEROTAS 10MG

HOW TO MANAGE SIDE EFFECTS

Cough:

Drink sufficient quantity of fluids which helps to thin the mucus in your throat. Suck on cough drops or hard candies.

WARNING & PRECAUTIONS

INTERACTIONS

Tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or the following:

• ketoconazole, itraconazole, voriconazole or fluconazole (used to treat fungal infections)
• clarithromycin, telithromycin and erythromycin (used to treat bacterial infections)
• ritonavir, efavirenz and nevirapine (used to treat HIV infection/AIDS)
• verapamil or diltiazem (used to treat heart conditions or high blood pressure)
• dronedarone (used to regulate heartbeat)
• ciclosporin
• imatinib (inhibits the growth of abnormal cells)
• ramipril
• rifampicin (used to treat tuberculosis)
• dexamethasone
• phenytoin, carbamazepine or phenobarbital

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT EVEROTAS 10MG

What should I avoid while taking EVEROTAS 10MG?

Avoid grapefruit or grapefruit juice while taking this medicine. 

How long can you take EVEROTAS 10MG?

There is no definite duration of treatment with this medicine. It is continued till clinical benefit is seen or unacceptable toxicity or side effects occur.

How is EVEROTAS 10MG administered?

It is taken once or twice daily. The medicine should always either be taken with food or always be taken without food. It should be swallowed whole with water and should not be crushed or chewed.

REFERENCES

1. KD Tripathi MD. Miscellaneous drugs. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page - 882.

2. Krensky AM, Bennett WM, Vincenti F. Immunosuppressants, Tolerogens, and Immunostimulants. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. Page - 1013.

3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 526.

4. Novartis Pharmaceuticals UK Ltd. Electronic Medicines Compendium (EMC); [Revised Feb 2020] [Accessed Oct 7, 2020] https://www.medicines.org.uk/emc/files/pil.7732.pdf

5. Novartis Pharmaceuticals Corporation. 2009; U.S. Food & Drug Administration; [Revised Oct 2010] [Accessed Oct 7, 2020] https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022334s6lbl.pdf

USEFUL DIAGNOSTIC TESTS

• Breast Cancer (CA 15.3/ ER/ PR)
• Carcino Embryonic Antigen
• Complete Blood Count