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INTRODUCTION
EUCLIDE XR 60 TABLET contains Gliclazide which belongs to the group of medicines called Antidiabetic agents. It is used in adults to treat Type II diabetes mellitus when diet, exercise and lifestyle changes alone does not result in adequate response.
Type II diabetes mellitus is a chronic disease associated with abnormally high levels of glucose in the blood. It is caused either due to inadequate production of a hormone called insulin (produced by pancreas to metabolize glucose) or due to inadequate sensitivity of body cells to the actions of insulin.
During therapy with EUCLIDE XR 60 TABLET, your doctor might ask you to make certain lifestyle changes such as following a healthy diet, regular physical exercise and quitting alcohol consumption.
Before taking EUCLIDE XR 60 TABLET, inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have any hormonal problems, genetic disorders (such as G6PD deficiency) or if you are malnourished, starved, on an irregular diet.
EUCLIDE XR 60 TABLET is not suitable for use in patients with type I diabetes mellitus. Consult your doctor before taking EUCLIDE XR 60 TABLET if you are pregnant or planning to become pregnant or breastfeeding.
One of the most common side effects of taking EUCLIDE XR 60 TABLET is hypoglycemia (low blood sugar levels) which can be identified through symptoms such as increased hunger, sweating, shakiness, weakness or an irregular heartbeat. To avoid this, your doctor will periodically monitor your blood sugar levels and adjust the dose of EUCLIDE XR 60 TABLET accordingly.
You can also carry a sugary snack (such as biscuits, glucose drinks or sweet candies) along with you as a precaution and have them immediately if you experience any signs of hypoglycemia. However, consult your doctor if there is no improvement in your condition. Other common side effects of taking EUCLIDE XR 60 TABLET are headache, dizziness and constipation.
USES OF EUCLIDE XR 60 TABLET
- Treats Type II diabetes mellitus in adults
HOW EUCLIDE XR 60 TABLET WORKS
EUCLIDE XR 60 TABLET effectively controls blood sugar levels, where gliclazide makes the pancreas secrete more insulin to digest the circulating sugars (glucose) in the blood. It also makes the body more sensitive to insulin which helps in utilizing the circulating blood glucose (sugars) leading to decrease in blood glucose levels.
DIRECTIONS FOR USE
Take EUCLIDE XR 60 TABLET before meals or as advised by your physician. Swallow the medicine with a glass of water. Do not cursh or chew the medicine.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Continue to take EUCLIDE XR 60 TABLET for the duration recommended by your doctor to achieve better control over blood sugar levels.
SIDE EFFECTS OF EUCLIDE XR 60 TABLET
COMMON
- hypoglycemia (low blood sugar levels)
- dizziness
- headache
UNCOMMON
- stomach pain
- nausea or vomiting
- indigestion, diarrhea or constipation
RARE
- low RBC and platelet count (causing pale skin, tiredness, headache, prolonged bleeding or bruising, shortness of breath or dizziness)
- skin rash and itching
- changes in vision
Stop taking EUCLIDE XR 60 TABLET and contact your doctor immediately if you experience any of the following side effects:
- severe allergic reaction (such as skin rash, swelling of the face, eyelids, lips, tongue or throat which causes difficulty in breathing or swallowing)
- severe skin reactions (such as DRESS characterized by fever or flu-like symptoms along with skin rashes with widespread blistering or peeling of skin)
- signs of liver problems (such as fever, yellowing of skin and whites of the eyes, weakness, fatigue, weight loss and loss of appetite)
- signs of severe decrease in blood sugar level (such as confusion, headache, excessive sweating, clammy skin, trembling, weakness, double vision, excessive hunger, nausea, vomiting, problems in sleeping, feeling agitated, unable to concentrate, drowsiness, loss of consciousness, slowed reactions, depression, trouble seeing or speaking, paralysis, numbness, dizziness, hallucinations, difficulty in breathing, slowed or faster heartbeat with chest pain)
HOW TO MANAGE SIDE EFFECTS
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Diarrhea:
Hydrate yourself by drinking plenty of fluids, such as water or fruit juices. Consuming ORS can also be beneficial. Do not self-treat diarrhea on your own. Consult your doctor if your diarrhea becomes uncontrollable.
Constipation:
Eat plenty of fiber rich foods such as fresh fruits, vegetables and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.
Low blood sugar:
Have foods rich in sugars such as fruit juices, glucose drinks, candies, honey or biscuits. Check your blood sugar after 10 minutes. If not gained optimum level, take another sugary snack or a drink and check the blood sugar again. consult your doctor if there is no improvement in your condition.
WARNING & PRECAUTIONS
PREGNANCY
EUCLIDE XR 60 TABLET is generally not recommended for use in pregnant women. Therefore, consult your doctor before taking it.
BREASTFEEDING
EUCLIDE XR 60 TABLET is generally not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you feel dizzy or experience blurred vision after taking EUCLIDE XR 60 TABLET.
ALCOHOL
Avoid alcohol consumption while taking EUCLIDE XR 60 TABLET as it could aggravate your exisiting condition.
KIDNEY
EUCLIDE XR 60 TABLET is not recommended for use in patients with severe kidney disease. It should be used with caution in patients with decreased kidney functions. Therefore, consult your doctor before taking it.
LIVER
EUCLIDE XR 60 TABLET is not recommended for use in patients with severe liver disease. It should be used with caution in patients with decreased liver functions. Therefore, consult your doctor before taking it.
ALLERGY
Do not take EUCLIDE XR 60 TABLET if you are allergic to Gliclazide or to any other medicines that belongs to sulphonylureas (such as glibenclamide, glipizide).
OTHERS
EUCLIDE XR 60 TABLET is not recommended for use if you have:
- type I diabetes (or insulin-dependent diabetes)
- diabetic ketoacidosis (increased levels of sugar and ketone bodies in the blood)
- diabetic coma or pre-coma
- serious traumatic injury
- G6PD deficiency (an inherited blood disorder)
- prophyria (an inherited blood disorder)
Before taking EUCLIDE XR 60 TABLET inform your doctor if you:
- are malnourished, starved, on an irregular diet or feeling weak
- perform extreme physical exercises
- have hormonal problems (Ex. disorders of pituitary gland, adrenal cortex or thyroid gland)
Use in pediatrics:
EUCLIDE XR 60 TABLET is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before administration.
Use in geriatrics:
EUCLIDE XR 60 TABLET should be used with caution in elderly patients especially in those who take medicines such as CNS depressants or beta-blockers. Therefore, consult your doctor before taking it.
INTERACTIONS
A. Drug-Drug interactions :
Before taking EUCLIDE XR 60 TABLET, inform your doctor if you are taking any of the following medicines such as:
- other antidiabetic medications such as metformin, insulin, glipizide, glibenclamide, dapaglifozin, teneligliptin etc.
- antifungal medicines (used to treat fungal infections) such as miconazole or fluconazole
- St. John’s Wort (a herbal preparations used to treat depression)
- antibiotics (used to treat bacterial infections) such as fluorquinolones (Ex. ciprofloxacin, moxifloxacin), clarithromycin, co-trimoxazole, rifampicin, chlormaphenicol, tetracyclines or sulphonamides (Ex. sulphasalazine)
- medicines used to treat high blood pressure or heart failure such as beta blockers (Ex. atenolo, propranolol), ACE-inhibitors (Ex. captopril or enalapril)
- medicines used to treat stomach ulcers such as ranitidine, famotidine
- medicines used to treat depression (such as moclobemide, isocarboxazid, phenelzine and tranylcypromine)
- medicines used for pain relief (Ex. aspirin, phenylbutazone, ibuprofen, phenylbutazone, azapropazone)
- medicines containing alcohol such as cough preparations
- medicines to treat mental illness (such as chlorpromazine, prochlorperazine, lithium)
- corticosteroids (used to treat pain and inflammation) Ex. prednisolone, cotisone, betamethasone
- medicines used to treat asthma (Ex. salbutamol, terbutaline)
- ritodrine (a medicine used to stop pre-mature labour)
- danazol (a medicine used to treat breast disorders, heavy menstrual bleeding and endometriosis)
- medicines used for blood thinning (Ex. warfarin).
- diuretics (used to increase urine ouptut and to reduce edema) such as bendroflumethiazide, hydrochlorothiazide, furosemide
- oral contraceptives (birth control pills) Ex. drospirenone, ethinylestradiol
- sulfinpyrazone (a medicine used to treat gout)
- aminoglutethimide (a medicine used to treat breast cancer or prostate cancer)
- thyroid hormones such as thyroxine (used to treat thyroid deficiency)
- octreotide (a medicine used to treat bleeding in the gut)
- testosterone (a hormonal medicine used to treat delayed puberty in men)
- cimetidine (a medicine used to treat stomach ulcers)
- clofibrate (a medicine used to treat high blood cholesterol levels)
- disopyramide (a medicine used for irregular heartbeats)
- laxatives (used to treat constipation) Ex. lactulose, ispagula
Overdosage:
If you or anyone else accidentally took more of EUCLIDE XR 60 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose might include signs of low blood glucose levels such as weakness, sweating, trembling, fast heartbeat, confusion and double vision.
SYNOPSIS
| Drug | : | Gliclazide |
| Pharmacological Category | : | Sulfonylureas |
| Therapeutic Indication | : | Type II Diabetes Mellitus |
| Dosage Forms | : | Tablet, Capsule |
MORE INFORMATION
- Keep EUCLIDE XR 60 TABLET out of reach of children
- Store EUCLIDE XR 60 TABLET at room temperature
FAQs ABOUT EUCLIDE XR 60 TABLET
What is EUCLIDE XR 60 TABLET used for?
EUCLIDE XR 60 TABLET is an antidiabetic medicine used to treat Type II diabetes mellitus when diet, exercise and lifestyle changes alone does not result in adequate response.
How and when to take EUCLIDE XR 60 TABLET?
Take EUCLIDE XR 60 TABLET before meals or as advised by your physician. Swallow the medicine with a glass of water. Do not cursh or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
How long should I take EUCLIDE XR 60 TABLET?
You need to take EUCLIDE XR 60 TABLET as long as your doctor or physician prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition
Can I stop taking EUCLIDE XR 60 TABLET without consulting your doctor?
No. You should not stop taking EUCLIDE XR 60 TABLET without consulting your doctor because it may lead to reversal of symptoms. If you feel better after using EUCLIDE XR 60 TABLET, consult your doctor for advice. Your doctor might would reduce the dose gradually before discontinuation of therapy.
Will taking a higher dose of EUCLIDE XR 60 TABLET be more effective?
No, taking a higher dose of EUCLIDE XR 60 TABLET will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
What to do if I forget to take a dose of EUCLIDE XR 60 TABLET?
If you forget to take a dose of EUCLIDE XR 60 TABLET, take it as soon as you remember. However, if it is time to take the next dose, skip the missed dose and take the next one at regular times. Do not take a double dose of EUCLIDE XR 60 TABLET to compensate a missed dose, as it could lead to toxicity.
What precautions do I need to follow while taking EUCLIDE XR 60 TABLET?
Before taking EUCLIDE XR 60 TABLET, inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have hormonal problems, genetic problems (surgery in the gut) or if you are malnourished. EUCLIDE XR 60 TABLET is not suitable for use in patients with type I diabetes mellitus. Consult your doctor before taking EUCLIDE XR 60 TABLET if you are pregnant or planning to become pregnant. During therapy with EUCLIDE XR 60 TABLET, follow the diet and lifestyle changes instructed by your doctor. Always carry a sugary snack (such as biscuits, glucose drinks or sweet candies) along with you as a precaution and have them immediately if you experience any signs of hypoglycemia.
Can I take medication for high blood pressure along with EUCLIDE XR 60 TABLET?
No. It is not advisable to take medicines to control blood pressure while taking EUCLIDE XR 60 TABLET without consulting your doctor. Therefore, consult your doctor before taking any antihypertensive such as beta blockers (Ex. atenolol, propranolol) along with EUCLIDE XR 60 TABLET as they have known interactions with EUCLIDE XR 60 TABLET.
What should I do if I experience low blood sugar after taking EUCLIDE XR 60 TABLET?
Low blood sugar is a common side effect of taking EUCLIDE XR 60 TABLET. Try to have sugar rich food items such as fruit juice, glucose tablets or gel, soft drinks, honey, or sugary candy. Check your blood sugar after 10 minutes. If not gained optimum level, take another sugary snack, or drink, and check the blood sugar again. In case of persistent low blood sugar levels, consult your doctor immediately.
Can EUCLIDE XR 60 TABLET cause dizziness?
Yes. Dizziness is a common side effect of using EUCLIDE XR 60 TABLET. In case you experience dizziness, lie down until it passes, then get up slowly and carefully. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, and alcohol. Do not drive or use machinery to avoid accidents. Consult your doctor if you experience dizziness continuously for a long time after taking EUCLIDE XR 60 TABLET.
Can EUCLIDE XR 60 TABLET be taken with insulin?
Co-administration of EUCLIDE XR 60 TABLET with insulin is considered risky as they are increased chances of hypoglycemia (decreased blood sugar levels). Consult your doctor before taking it.
Can EUCLIDE XR 60 TABLET be used in pregnant women?
No. EUCLIDE XR 60 TABLET is not recommended for use in pregnant women. Therefore, consult your doctor for advice before taking.
REFERENCES
1.K. D. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 270-27
2. Shinnya Miwa, Hirotaka Watada, Ohmura chie and Yasushi Tanaka. Efficacy and Safety of Once Daily Gliclazide (20 mg/day) Compared with Nateglinide. ScienceDirect.com. August 2004. [Accessed on 2nd September 2022] https://www.researchgate.net/publication/8361650_Efficacy_and_Safety_of_Once_Daily_Gliclazide_20_mgday_Compared_with_Nateglinide
3. Les Laboratoires Servier. Electronic Medicines Compendium (EMC). [Revised in July 2022] [Accessed on 2nd September 2022] https://www.medicines.org.uk/emc/files/pil.1321.pdf
4. Accord. Electronic Medicines Compendium (EMC). [Revised in March 2021] [Accessed on 2nd September 2022] https://www.medicines.org.uk/emc/product/5883/pil#gref
5. Accord. Electronic Medicines Compendium (EMC). [Revised in March 2021] [Accessed on 2nd September 2022] https://www.medicines.org.uk/emc/files/pil.2044.pdf
6. Balkanpharma-Dupnitsa AD. Electronic Medicines Compendium (EMC). [Revised in January 2021] [Accessed on 2nd September 2022] https://www.medicines.org.uk/emc/files/pil.4991.pdf
7. Zentiva Pharma UK Limited. Electronic Medicines Compendium (EMC). [Revised in June 2021] [Accessed on 2nd September 2022] https://www.medicines.org.uk/emc/files/pil.13829.pdf
USEFUL DIAGNOSTIC TESTS
- Glucose - Fasting Blood
- Glucose - Postprandial Blood
- Glycosylated Haemoglobin
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