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INTRODUCTION
ETOWIN PG TABLET is a combination of Etoricoxib and Pregabalin which belongs to the group of medicines called Nonsteroidal Anti-inflammatory drugs (NSAIDs) and Anticonvulsants respectively. It is used for the treatment of neuropathic pains associated with spinal cord injury, diabetic peripheral neuropathy (nerve damages with numbness, loss of sensation, and sometimes pain in your feet, legs, or hand due to high sugar levels), fibromyalgia (pain in soft tissues and muscles all over the body) and post herpetic neuralgias (burning pain in nerves mainly after shingles infection).
It is not recommended to take ETOWIN PG TABLET if you have serious liver diseases, kidney diseases, inflammatory bowel diseases, gastrointestinal bleeding, congestive heart failure, increased blood pressure and inflammatory bowel diseases. ETOWIN PG TABLET is not recommended during pregnancy and lactation unless it is clearly necessary. Do not give ETOWIN PG TABLET to children and adolescents below 16 years of age. Consult your doctor for before taking.
ETOWIN PG TABLET should be taken only under medical supervision as there is a chance of developing addiction, dependence and withdrawal reactions. The most common side effects of taking ETOWIN PG TABLET includes dizziness, sleepiness, difficulty in concentrating, dry mouth, blurred vision, weight gain, swelling of hands or feet, cold and flu symptoms, and irregular heartbeat. Consult your doctor if any of these symptoms gets worsened for you while taking ETOWIN PG TABLET.
USES OF ETOWIN PG TABLET
It is used to treat neuropathic pain associated with:
- spinal cord injury
- diabetic peripheral neuropathy
- fibromyalgia
- post herpetic neuralgia
HOW ETOWIN PG TABLET WORKS
ETOWIN PG TABLET is a combination of Etoricoxib and Pregabalin. Etoricoxib is a selective Cox 2 inhibitors that relieves pain by blocking the effects of cox 2 (cyclooxygenase 2) enzymes that are responsible for the production of prostaglandins (pain and inflammation). Pregabalin relieves pain by reducing the release of neurotransmitters by decreasing calcium influx at nerve endings.
DIRECTIONS FOR USE
Take ETOWIN PG TABLET as advised by your doctor. Swallow ETOWIN PG TABLET with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose, duration of treatment based on your age, body weight and severity of conditions.
SIDE EFFECTS OF ETOWIN PG TABLET
COMMON
- dizziness
- sleepiness
- difficulty in concentration
- dry mouth
- blurring of vision
- weight gain
- swelling of hands or feet
- cold and flu symptoms
- irregular heartbeat
- increased appetite
- confusion, irritability
- low sexual desire
- headache
- sedation
- balance problems
- altered memory
- nausea, vomiting
- flatulence
- constipation
- diarrhoea
- muscle pain
- swelling in body
- fatigue
- breathing disturbances
UNCOMMON
- decreased neutrophils count
- anorexia (abnormal loss of food appetite)
- low blood sugar levels
- hallucination, restlessness, agitations, depression, mood changes
- mental impairment
- abnormal vision, eye irritations
- sound sensitivity
- increased heart rate, heart block, abnormal blood pressure
- hot flushing
- cough, nasal dryness, snoring, runny nose
- saliva secretion
- gastric disturbances
- skin rashes
- muscle and joint pain
- abnormal urination
- breast pain, abnormal periods
- stomach pain, peptic ulcers, and bleeding
- facial puffiness
RARE
- throat tightness
- swelling in lungs
- pancreatitis
- swelling in tongue
- loss of hunger
- fluid collection in abdomen
- cold sweat
- breast enlargement and discharge
- abnormal periods
- decreased sodium and WBC count
Stop taking ETOWIN PG TABLET and contact your doctor if you experience:
- swelling of face, lips, and throat with difficulty in breathing and talking (symptoms of angioedema)
- suicidal thoughts or depression
- memory loss, hallucinations, dependence, depression, stress, restlessness, agitation, irritability, aggression, delusion, nightmares
- changes in salivation, increased liver enzyme levels, changes in the way you walk and muscle weakness
- allergic reactions (Steven Johnson’s syndrome)
- fits/seizures
- urinary retention
- vision disturbances
- jaundice
- low blood pressure, increased heart rate, loss of consciousness (symptoms of anaphylactic shock)
HOW TO MANAGE SIDE EFFECTS
Bloating
Stick to simple meals. Drink enough fluids. Avoid eating oily, fried, or spicy foods. Take adequate rest. Consult doctor before taking any medication.
Constipation
Drink adequate amount of water. Include plenty of fruits and vegetables in your daily diet. Avoid smoking and alcohol consumption. Eat a well-balanced diet. Do exercises regularly. Consult your doctor before taking any medicines.
Nausea And Vomiting
Drink lots of water and fruit juices. Eat simple and light meals throughout the day. Stay away from oil rich and spicy foods. Consult your doctor if the symptoms are worsening.
Dry Mouth
Drink plenty of water and fruit juices and consume soft foods with higher water and fibre content.
Headache
Rest and relax. Drink plenty of fluids such as water. Apply a pain balm on your forehead and massage if needed. Consult doctor before taking any medication.
Indigestion
Eat a balanced diet. Avoid consumption of alcohol. Reduce the intake of spicy food. Drink plenty of water and other fluids to stay hydrated.
WARNING & PRECAUTIONS
PREGNANCY
Monitoring requiredETOWIN PG TABLET is not recommended to take during pregnancy unless it is clearly necessary due to the lack of safety data. Consult your doctor before taking ETOWIN PG TABLET.
BREASTFEEDING
ContraindicatedETOWIN PG TABLET is not recommended to take during breastfeeding. Consult your doctor before taking it.
DRIVING AND USING MACHINES
Use with CautionDo not drive or operate any machines if you feel dizziness, sedation, reduction in mental alertness, blurring of vision, somnolence after taking ETOWIN PG TABLET.
ALCOHOL
ContraindicatedConsumption of alcohol is not recommended while taking ETOWIN PG TABLET as it may increase the risk of side effects.
KIDNEY
ContraindicatedETOWIN PG TABLET is not recommended to be taken in patients with severe kidney diseases. Consult your doctor before taking it.
LIVER
Consult your doctorETOWIN PG TABLET is not recommended for use if you have severe liver diseases. ETOWIN PG TABLET should be taken with caution in patients diagnosed with liver diseases. Consult your doctor before taking ETOWIN PG TABLET.
ALLERGY
ContraindicatedDo not take ETOWIN PG TABLET if you are allergic to Etoricoxib, Pregabalin or any other ingredients of this medicine.
HEART DISEASE
ContraindicatedETOWIN PG TABLET is not recommended to be taken in patients with increased blood pressure, congestive heart failure or any other heart diseases. Consult your doctor before taking ETOWIN PG TABLET.
USE IN PEDIATRICS
ContraindicatedETOWIN PG TABLET is not recommended for children and adolescents below 16 years of age due to the lack of safety data. Consult your doctor before taking.
USE IN GERIATRICS
Use with CautionETOWIN PG TABLET should be used with caution to elderly people as they are at a higher risk of developing side effects such as dizziness, somnolence, reduced mental alertness, confusion. Consult your doctor before giving ETOWIN PG TABLET to elderly people.
OTHERS
ETOWIN PG TABLET is not recommended for use if you have:
- peptic ulcerations
- irritable bowel syndrome
- gastrointestinal bleeding
INTERACTIONS
A. Drug-Drug interactions:
Before taking ETOWIN PG TABLET, inform your doctor if you are taking any of the following medicines:
- phenytoin, carbamazepine, lamotrigine, valproic acid (medicine used to treat fits)
- lorazepam (medicine used to treat anxiety)
- oxycodone (medicine used to treat pain)
- ethanol (medicine used to treat infections)
- diuretics (Ex. chlorothiazide, chlorthalidone)
- angiotensin II antagonists (Ex. telmisartan, losartan)
- acetyl salicylic acid (medicine used to relieve minor pain)
- cyclosporin, tacrolimus (medicine used to prevent body from rejecting transplanted organ)
- methotrexate (medicine used to calm immune system)
- lithium (medicine used to treat mania)
- estradiol, norethindrone (medicine used to prevent unwanted pregnancy)
- minoxidil (medicine used to treat hair fall)
- salbutamol (medicine used to treat cough)
- rifampicin (medicine used to treat tuberculosis)
Overdosage:
If you or anyone else accidentally took too much of ETOWIN PG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage includes somnolence, confusions, agitation, restlessness, fits.
SYNOPSIS
| Drug | : | Etoricoxib, Pregabalin |
| Pharmacological Category | : | Selective Cox 2 inhibitors, Anticonvulsants |
| Therapeutic Indication | : | Treats Neuropathic pain |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep ETOWIN PG TABLET out of sight and reach of children
- Store ETOWIN PG TABLET at room temperature
FAQs ABOUT ETOWIN PG TABLET
Q: What is ETOWIN PG TABLET used for?
A: ETOWIN PG TABLET is used for the treatment of neuropathic pains associated with spinal cord injury, diabetic peripheral neuropathy (nerve damages with numbness, loss of sensation, and sometimes pain in your feet, legs, or hand due to high sugar levels), fibromyalgia (pain in soft tissues and muscles all over the body) and post herpetic neuralgias (burning pain in nerves mainly after shingles infection).
Q: Can I drive while taking ETOWIN PG TABLET?
A: Do not drive or operate any machines if you feel dizziness, sedation, reduction in mental alertness, blurring of vision, somnolence after taking ETOWIN PG TABLET.
Q: Is it safe to take ETOWIN PG TABLET during pregnancy?
A: It is not recommended to take ETOWIN PG TABLET during pregnancy unless it is clearly necessary due to the lack of safety data. Consult your doctor before taking ETOWIN PG TABLET.
Q: what are the common side effects of taking ETOWIN PG TABLET?
A: The most common side effects of taking ETOWIN PG TABLET includes dizziness, sleepiness, difficulty in concentrating, dry mouth, blurring of vision, weight gain, swelling of hands or feet, cold and flu symptoms, and irregular heartbeat. Consult your doctor before taking ETOWIN PG TABLET.
Q: How ETOWIN PG TABLET works?
A: Etoricoxib is a selective Cox 2 inhibitors that relieves pain by blocking the effects of cox 2 (cyclooxygenase 2) enzymes that are responsible for the production of prostaglandins that are responsible for pain and inflammation. Pregabalin relieves pain by reducing the release of neurotransmitters by decreasing calcium influx at nerve endings.
REFERENCES
1. KD Tripathi. NSAIDS and antipyretic -Analgesics. Essentials of Medical pharmacology eighth edition (2019), page number – 222.
2. KD Tripathi. Antiepileptic drugs. Essentials of Medical pharmacology eighth edition (2019), page number – 446.
3. Alan. K Matsumoto, Paul F. Etoricoxib. National Library of medicine. National centre for Biotechnology information. PubMed (2004). [Accessed on 8th March 2023] https://pubmed.ncbi.nlm.nih.gov/15319795/#:~:text=It%20is%20a%20member%20of,nonsteroidal%20antiinflammatory%20drugs%20(NSAIDs)
4. Torrent pharma. Pregabalin. [Revised in May 2017] [Accessed on 8th March 2023] https://www.torrentian.com/pisheet/Upload/PI_Sheet/1505.pdf
5. Torrent Pharma. Etoricoxib. [Revised in September 2016] [Accessed on 8th March 2023] https://www.torrentian.com/pisheet/Upload/PI_Sheet/1960.pdf
6. Etoricoxib + Pregabalin. Leeford Pharma. [Accessed on 8th March 2023] https://www.leeford.in/product/780/pregabanyl-et
7. Etoricoxib + Pregabalin. Lareon pharma. [Accessed on 8th March 2023] https://www.larenon.com/wp-content/uploads/2021/08/PBREN-ET_-LBL.pdf
8. Etoricoxib + Pregabalin. Osian biotech. [Accessed on 8th March 2023] https://osiantebiotech.com/product/etoricoxib-60mg-pregabalin-75mg/
9. Etoricoxib + Pregabalin. Numera life sciences. [Accessed on 8th March 2023] https://www.numeralifesciences.com/etoricoxib-60mg-pregabalin-75-mg
10. Pregabalin. Drug bank. [Revised in March 2023] [Accessed on 8th March 2023] https://go.drugbank.com/drugs/DB00230
11. Etoricoxib. Drug bank. [Revised in May 2021] [Accessed on 8th March 2022] https://go.drugbank.com/drugs/DB01628
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