ETOPA 100mg Injection 5ml

INTRODUCTION

ETOPA 100MG INJECTION contains Etoposide which belongs to the group of medicines called Anticancer agents. It is used to treat various types of cancer such as lung cancer, blood cancer, lymph cancer, ovarian cancer and testicular cancer.

ETOPA 100MG INJECTION should be used under careful medical supervision. During treatment with ETOPA 100MG INJECTION, your doctor will periodically monitor your heart, liver, kidney functions as a precaution.

Before receiving ETOPA 100MG INJECTION, inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have any serious infections, low albumin levels in blood or recently received any vaccine or radiotherapy or chemotherapy as a precaution.

Do not receive ETOPA 100MG INJECTION without consulting your doctor if you are pregnant or breastfeeding. Both men and women undergoing therapy with this medicine, must use a suitable contraceptive to prevent pregnancy during and until 6 months after stopping the therapy.

The most common side effects of receiving ETOPA 100MG INJECTION are blood disorders, loss of appetite, constipation, pigmentation on the skin, temporary hair loss, weakness, tiredness and sore lips, mouth or throat ulcers. Consult your doctor if any of these side effects worsen.

USES OF ETOPA 100MG INJECTION

It is used to treat various types of cancer such as:

• Small cell lung cancer
• Blood cancer (Ex. acute myeloid leukaemia)
• Lymph cancer (Ex. Hodgkin’s lymphoma, non-Hodgkin’s lymphoma)
• Ovarian cancer
• Testicular cancer

HOW ETOPA 100MG INJECTION WORKS

ETOPA 100MG INJECTION is an anticancer agent. It works by blocking the abnormal actions of certain cellular proteins (topoisomerase 2) that triggers cancer cell formation. As a result, it reduces cancer formation and prevents its further growth within the body.

DIRECTIONS FOR USE

ETOPA 100MG INJECTION will be given to you only by a doctor or a nurse into the vein (intravenously).  Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF ETOPA 100MG INJECTION

HOW TO MANAGE SIDE EFFECTS

Dizziness Or Drowsiness

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Consult your doctor if your dizziness worsens.

Nausea And Vomiting

Stick to simple meals and avoid oil rich or spicy foods. Consult your doctor if nausea worsens.

Skin Rash Or Itching

Avoid hot showers because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. Consult your doctor if your skin rash worsens.

WARNING & PRECAUTIONS

PREGNANCY

Contraindicated

ETOPA 100MG INJECTION is not recommended for use in pregnant women. Therefore, consult your doctor for advice before receiving it. Women of childbearing potential must use a suitable contraceptive method to prevent pregnancy while receiving ETOPA 100MG INJECTION and until 6 months after stopping the therapy.

BREASTFEEDING

Contraindicated

ETOPA 100MG INJECTION may pass through breast milk. Therefore, it is not recommended for use in breast-feeding women. Kindly consult your doctor before receiving it.

DRIVING AND USING MACHINES

Use with Caution

Do not drive or operate any machines if your ability is affected by ETOPA 100MG INJECTION.

ALCOHOL

Consult your doctor

Avoid consumption of alcohol while receiving ETOPA 100MG INJECTION to avoid unwanted reactions.

KIDNEY

Use with Caution

ETOPA 100MG INJECTION should be used with caution in patients with kidney diseases. Therefore, consult your doctor before receiving it.

LIVER

Use with Caution

ETOPA 100MG INJECTION should be used with caution in patients with liver diseases. Therefore, consult your doctor before receiving it.

ALLERGY

Consult your doctor

Talk to your doctor before receiving ETOPA 100MG INJECTION if you are allergic to Etoposide.

USE IN PEDIATRICS

Monitoring required

ETOPA 100MG INJECTION should be used in children and adolescents (aged below 18 years) only is prescribed by a physician. Therefore, consult your doctor before receiving it.

USE IN GERIATRICS

Use with Caution

ETOPA 100MG INJECTION should be used with caution in elderly patients (aged 65 years or older). Therefore, consult your doctor before receiving it.

INTERACTIONS

A. Drug - Drug interactions:

Before receiving ETOPA 100MG INJECTION inform your doctor if you are taking any of the following medicines such as:

• live vaccines (including yellow fever vaccine)
• ciclosporin (a medicine used to suppress immune function and to prevent graft rejection)
• cisplatin (another medicine used to treat cancer)
• medicines used to treat epilepsy (such as phenytoin, carbamazepine)
• warfarin (a medicine used to prevent blood clot formation)
• medicines used for pain relief (such as phenylbutazone, sodium salicylate, or aspirin)
• other medicines used for cancer such as anthracyclines (Ex. doxorubicin, epirubicin, daunorubicin)

Overdosage:

ETOPA 100MG INJECTION will be given to you only by a doctor or nurse in a hospital, and so it is unlikely to receive an overdose. However, contact your doctor if you experience any unusual side effects.

SYNOPSIS

MORE INFORMATION

• Keep ETOPA 100MG INJECTION out of reach of children
• Store ETOPA 100MG INJECTION in a refrigerator between 2-8°C

FAQs ABOUT ETOPA 100MG INJECTION

Q: How does ETOPA 100MG INJECTION works?

A: ETOPA 100MG INJECTION is an anticancer agent. It works by blocking the abnormal actions of certain cellular proteins (topoisomerase 2) that triggers cancer cell formation. As a result, it reduces cancer formation and prevents its further growth within the body.

Q: Can I receive ETOPA 100MG INJECTION during breastfeeding?

A: No. ETOPA 100MG INJECTION is not recommended for use in breast-feeding women. Therefore, consult your doctor before receiving.

Q: Can ETOPA 100MG INJECTION increase the risk of infections?

A: ETOPA 100MG INJECTION may cause a drop in the number of white blood cells in the body and may weaken your immune system. As a result, you may be at a greater risk of getting infected while receiving ETOPA 100MG INJECTION. To avoid this, your doctor will regular monitor your blood counts as a precaution. However, inform your doctor if you experience any signs of infection such as fever.

Q: Can the use of ETOPA 100MG INJECTION make me feel tired?

A: Yes. ETOPA 100MG INJECTION may make you feel tired easily. This is because, it reduces the levels of red blood cells in your blood and may make you anaemic. Consult your doctor if you experience tiredness after receiving ETOPA 100MG INJECTION. Tiredness can also occur if you have any pre-existing disease conditions such as liver or kidney impairment while receiving this medicine.

Q: Can I drive a car after receiving ETOPA 100MG INJECTION?

A: ETOPA 100MG INJECTION may make you feel tired or dizzy. Therefore, do not drive or operate any heavy tools or machines if your ability is affected by ETOPA 100MG INJECTION.

Q: How ETOPA 100MG INJECTION is administered?

A: ETOPA 100MG INJECTION will be given to you only by a doctor or a nurse into the vein (intravenously).

Q: How to control nausea caused due to ETOPA 100MG INJECTION?

A: Generally, anticancer medicines are associated with uncontrollable nausea and vomiting. To avoid this, your doctor would prescribe a suitable medicine to control them along with ETOPA 100MG INJECTION. If not, consult your doctor for a suitable anti-emetic medicine. Do not self-treat nausea.

REFERENCES

1. KD. Tripathi. Anticancer Drugs. Essentials of Medical Pharmacology. 7th Edition. 2013. Page – 866.

2. Gizem Reyhanoglu; Prasanna Tadi. Etoposide. StatPearls. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. July 2022. [Accessed on 11th February 2023]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3336826/

3. Neon Healthcare Limited. ETOPOPHOS™ 100 mg Powder for Solution for Injection Etoposide (as phosphate). Electronics Medicines Compendium. [Revised in February 2022]. [Accessed on 11th February 2023]. https://www.medicines.org.uk/emc/files/pil.10514.pdf

4. Central Drugs Standard Control Organization. Etoposide Capsule and Injection. March 1988. [Accessed on 11th February 2023]. https://cdscoonline.gov.in/CDSCO/Drugs

USEFUL DIAGNOSTIC TESTS

• Beta Human Chorionic Gonadotropin, Tumour marker

AUTHOR DETAILS

Written By Srilekha. R, B.Pharm
Last updated on 14 Feb 2023 | 07:11 PM(IST)