INTRODUCTION

ESTRAGEST 2 contains Estradiol which belongs to Estrogen derivative. It is a Hormone replacement therapy (HRT). As age progresses, ovaries make less hormones and will no longer produce it after you have been through the menopause. It can be used in peri- and postmenopausal women. During the menopause, the amount of the oestrogen produced by a woman’s body drops. This can cause symptoms such as hot face, neck and chest ("hot flushes"). This medicine helps in relieving these symptoms after menopause. After the menopause some women may develop fragile bones (osteoporosis). If you are at an increased risk of fractures due to osteoporosis and other medicines are not suitable for you, you can use It is used to prevent osteoporosis after menopause.

Take ESTRAGEST 2 according to the dose and frequency as advised by your doctor. Swallow the medicine whole, do not crush or chew. It can be taken with or without food. This medicine is used to relieve the symptoms occuring after menopause and prevents osteoporosis. It is for use in postmenopausal women only. The common side effects are swollen breast, headache and nausea. Before using, tell your doctor if you have liver, kidney or heart problems. It is not recommended for use in adolescents or children.

USES OF ESTRAGEST 2

• Relieve the symptoms occuring after menopause and prevents osteoporosis

HOW ESTRAGEST 2 WORKS

ESTRAGEST 2 acts on the on the estrogen receptors to relieve vasomotor systems (such as hot flashes) and urogenital symptoms. It also prevents osteoporosis. 

DIRECTIONS FOR USE

Take ESTRAGEST 2 according to the dose and frequency as advised by your doctor. Swallow the medicine whole, do not crush or chew. It can be taken with or without food.

SIDE EFFECTS OF ESTRAGEST 2

HOW TO MANAGE SIDE EFFECTS

Nausea:

Stick to simple normal meals and do not eat rich or spicy foods.

Stomach pain:

Place a warm bottle or heated bag on your abdomen. Soak in a warm bath. Drink plenty of clear fluids and water. Soak in a warm bath. Drink plenty of clear fluids and water.

Vomiting:

Drink clear or ice-cold drinks. Eat light, bland foods and avoid fried, greasy, or sweet foods.

WARNING & PRECAUTIONS

INTERACTIONS

Inform your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or the following,

• barbiturates, phenytoin, primidone, carbamazepine and oxcarbazepine, topiramate and felbamate (used for epilepsy)
• rifampicin, rifabutin (used to treat tuberculosis)
• nevirapine, efavirenz, ritonavir and nelfinavir (used to treat HIV infection)
• St John’s Wort (herbal medicine)
• griseofulvin, fluconazole, itraconazole, ketoconazole and voriconazole (used to treat fungal infection)
• clarithromycin and erythromycin (treats bacterial infections)
• verapamil and diltiazem (used to treat heart diseases)

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT ESTRAGEST 2

Can use ESTRAGEST 2 during pregnancy?

This medicine is not recommended during pregnancy, or if you are planning to get pregnant.

What should I avoid while taking ESTRAGEST 2?

Avoid grapefruit juice while taking this medicine.

REFERENCES

1. KD Tripathi MD. Hormones and related drugs: Estrogens, progestins and contraceptives. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page – 308.

2. Levin ER and Hammes SR. Estrogens and Progestins. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. Page 1173-1175.

3. Masters SB. Hypothalmic & Pituitary Hormones. Basic and Clinical Pharmacology. 11th ed. New Delhi; 2009. Page - 701-702.

4. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page: 500-501.

5. Victor W. Henderson, Howard N. Hodis, Carol A. McCleary, Frank Z. Stanczyk, Donna Shoupe, Naoko Kono, Laurie Dustin, Hooman Allayee, Wendy J. Mack. Cognitive effects of estradiol after menopause: A randomized trial of the timing hypothesis. [August 16, 2016] [Accessed Nov 13 2020] https://n.neurology.org/content/87/7/699

6. Bayer plc, Electronic Medicines Compendium (EMC); [Revised July 2020] [Accessed Nov 13 2020] https://www.medicines.org.uk/emc/files/pil.1417.pdf

7. Mylan Pharmaceuticals Inc, [Revised Aug 2018] [Accessed Nov 13 2020] https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=144db6ad-c4cf-45ea-b27c-a76a319dba38