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ESPIN contains S-Amlodipine which belongs to the group of medicines called Antihypertensives. It is used to treat essential hypertension (abnormal high blood pressure which occurs mostly due to obesity, family history or unhealthy diet) and angina pectoris (type of chest pain due to reduced blood flow to the heart).
ESPIN is not recommended for use in patients with certain heart problems. ESPIN should be used with caution in patients having liver and kidney impairment. ESPIN should be used with caution in pregnant and breastfeeding women only if clearly advised by the doctor.
ESPIN should be used with caution in elderly patients so, consult your doctor before taking it. The most common side effects of taking ESPIN are headache, nausea, abdominal pain, diarrhoea, indigestion and visual disturbances, etc. Consult your doctor if any of the side effects worsen.
ESPIN reduces blood pressure by a direct relaxant effect on smooth muscle of blood vessels. In angina, it works by reducing the pressure against which the heart works, stabilizing the heart rate and thus reducing energy consumption and oxygen requirements by the heart muscle. It also probably dilatates the main coronary arteries and increases oxygen delivery by heart muscle in patients with coronary artery spasm.
Take ESPIN as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Correct dosage and duration of ESPIN will be prescribed to you by your doctor depending upon your age, body weight and disease condition.
Nausea and vomiting:
Take ESPIN with or just after meals. Stick to simple meals. Avoid eating oily, fried or spicy foods. Do not lie down or sleep immediately after eating. Consult your doctor if the symptom does not improve.
Drink lot of fluids such as water to keep yourself hydrated. Avoid eating high-fat or spicy foods. Do not take any medicine on your own to treat diarrhea without consulting your doctor.
Try to rest and relax. Eat and drink slowly or try to eat smaller meals more frequently. Keep a heat pad on your stomach. If you stomach still aches, consult your doctor.
Raise your head and shoulders up while sleeping as this can prevent stomach acid from coming up. Do not eat 3 to 4 hours before going to bed and avoid tea, coffee, cola, or alcohol. If indigestion does not improve, consult your doctor.
Eat plenty of fibre rich foods such as fresh fruits, vegetables, and cereals and drink plenty of water. Exercise more regularly. Consult your doctor if the symptom does not improve.
Apply hot or cold-water bag on your head. Try to take rest in a quiet and dark room. Drink tea or coffee. Massage the scalp or head with mild pressure. Consult your doctor if the symptom gets worse.
ESPIN should be used with caution in pregnant women only if considered clearly necessary. Consult your doctor before taking ESPIN.
ESPIN should be used with caution in breastfeeding women only if considered clearly necessary. Consult your doctor taking ESPIN.
Do not drive or operate any machines if you experience dizziness, headache, fatigue (extreme tiredness), impaired ability to react or nausea after taking ESPIN.
ESPIN should be used with caution in patients having kidney impairment. Consult your doctor before taking ESPIN.
ESPIN should be used with caution in patients having liver impairment. Consult your doctor before taking ESPIN.
Do not take if you are allergic or dihydropyridine derivatives (such as felodipine, nimodipine) or S-Amlodipine or any of the other ingredients of this medicine.
ESPIN is not recommended for use in patients with severe hypotension (low blood pressure), shock including cardiogenic shock (serious condition caused by the sudden drop in blood flow through the body, high grade aortic stenosis (obstruction of the outflow tract of the left ventricle), or haemodynamically unstable heart failure after heart attack. ESPIN should be used with caution in patients with congestive heart failure. Consult your doctor before taking ESPIN.
Use in pediatrics:
Safety and effectiveness of ESPIN is not established in children. Consult child’s doctor for advice.
Use in geriatrics:
ESPIN should be used with caution in elderly patients. Consult your doctor before taking it.
A. Drug-Drug interactions:
Before taking ESPIN inform your doctor if you are taking any of the following medicines:
B. Drug - Food interaction:
Avoid eating grapefruit or drinking grapefruit juice while taking ESPIN as it may drop your blood pressure further.
If you or anyone else accidentally take too much of ESPIN, consult your doctor immediately or visit the nearby hospital. The common symptoms of overdose are low blood pressure and fast heartbeat.
|Pharmacological Category||:||Calcium Channel Blockers|
|Therapeutic Indication||:|| |
Essential hypertension, Angina pectoris
|Dosage Forms||:|| |
What is ESPIN and why is it given?
ESPIN contains S-Amlodipine which is used in the treatment of essential hypertension (high blood pressure that is not caused by any other condition is called essential hypertension) and angina pectoris (chest pain).
Is ESPIN safe in pregnant women?
ESPIN is only recommended for use in pregnant women when there is no safer alternative and when the disease itself carries greater risk for the mother and the baby. If you are pregnant, think you may be pregnant or planning to get pregnant, consult your doctor before taking this medicine. Inform your doctor immediately if you become pregnant during treatment with ESPIN.
Can ESPIN be taken by patients with heart disease?
ESPIN is not recommended for use in patients with severe hypotension (low blood pressure), shock including cardiogenic shock (life threatening condition caused by the sudden drop in blood flow through the body), blood flow obstruction to left ventricle (Ex. high grade aortic stenosis), haemodynamically unstable heart failure after heart attack and it should be used with caution in patients with congestive heart failure. Consult your doctor for advice before taking ESPIN.
Does ESPIN cause skin rash?
Yes, ESPIN may cause skin rash in some people. Try to avoid hot showers because it may cause skin irritation. Avoid frequent contact and rubbing over the affected area. Use sunscreen and protective clothing when going outdoors. If this symptom does not get better, consult your doctor for advice.
What are the common side effects of ESPIN?
The common side effects of taking ESPIN are somnolence (over sleepiness), dizziness, headache, visual disturbance including double vision, palpitation, flushing, shortness of breath, stomach pain, nausea, indigestion, altered bowel habits (diarrhoea and constipation), muscle cramps, weakness, reduced muscle strength, fluid retention and ankle swelling.
Can I take other medicines with ESPIN?
Before taking ESPIN inform your doctor if you are taking, have taken, or might take any other medicine, including prescription, over the counter or any herbal medicine, as these might cause serious unusual effect by interacting with each other.
1. KD. Tripathi. Antianginal and Other Anti-Ischaemic Drugs. Essentials of medical pharmacology. Eighth edition. 2019. Page –595.
2. Thacker, Hemant P. S-amlodipine--the 2007 clinical review. Europe PMC. April 2007. [Accessed on 29th July 2022] https://europepmc.org/article/med/17822186
3. Selcuk Sen, Meral Demir, Zerrin Yigit, and Ali Yagiz Uresin. Efficacy and Safety of S-Amlodipine 2.5 and 5 mg/d in Hypertensive Patients Who Were Treatment-Naive or Previously Received Antihypertensive Monotherapy. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. July 2018. [Accessed on 29th July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974697/
4. Torrent Pharmaceuticals Ltd. Esam (S-Amlodipine Besylate Tablets). [Revised in January 2017]. [Accessed on 29th June 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/1626.pdf
5. Zuventus healthcare. Eslo Tablet (S (-) Amlodipine). [Accessed on 29th July 2022] http://www.zuventus.co.in/patient_wise_products_selected.aspx?Medi_Id=25
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