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INTRODUCTION
ESOZ 40MG contain esomeprazole which belongs to a group of medicine called proton pump inhibitors. It is used to treat gastroesophageal reflux disease (GERD) in both adults and adolescents, stomach ulcers caused by pain killers such as NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) in adults. It also helps in preventing rebleeding followed by therapeutic endoscopy done for acute bleeding gastric or duodenal ulcers.
Gastroesophageal reflux disease is a condition where the acid in the stomach acid frequently flows back into the oesophagus (a tube connecting your mouth and stomach). This acid reflux can irritate the lining of your oesophagus. It works by reducing the amount of acid in the stomach which helps in relief of acid related indigestion and heartburn.
ESOZ 40MG can be given to children and adolescents aged 1-18 years and adults, including the elderly. It will be administered by a doctor or nurse. Inform your doctor before taking this medicine, if you have ever had kidney, heart or liver disease. Pregnant and breastfeeding women should consult their doctor before taking this medicine.
USES OF ESOZ 40MG
- Treat Gastroesophageal reflux disease (GERD)
- Treat stomach ulcers caused by pain killers
- Prevent rebleeding in adults following therapeutic endoscopy
HOW ESOZ 40MG WORKS
ESOZ 40MG works by reducing the amount of acid in the stomach which helps in relief of acid related indigestion and heartburn.
DIRECTIONS FOR USE
ESOZ 40MG will be administered by a doctor or nurse.
SIDE EFFECTS OF ESOZ 40MG
SERIOUS
- severe allergic reaction (such as sudden wheezing, swelling of your lips, tongue and throat or body, rash, fainting or difficulties in swallowing)
- reddening of the skin with blister or peeling. There may also be severe blisters and bleeding in the lips, eyes, mouth, nose, and genitals (Stevens-Johnson syndrome or toxic epidermal necrolysis)
- liver problems (such as yellow skin, dark urine, and tiredness)
COMMON
- headache
- diarrhoea
- stomach pain
- constipation
- wind (flatulence)
- nausea, vomiting
- injection site reaction
- benign polyps in the stomach
RARE
- blood problem such as reduced number of white cell or platelet
- low levels of sodium in the blood
- feeling agitated, confused, or depressed
- taste changes
- eyesight problems such as blurred vision
- suddenly feeling wheezy or short of breath
- inflammation of the inside of the mouth
- thrush infection
- hair loss (alopecia)
- skin rash on exposure to sunshine
- joint pains (arthralgia) or muscle pains (myalgia)
- generally feeling unwell and lacking energy
- increased sweating
HOW TO MANAGE SIDE EFFECTS
Headache:
Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.
Diarrhoea:
Drink lot of fluid such as water or juice, to avoid dehydration. Do not take any medicines without speaking to a doctor.
Stomach pain:
Try to rest and relax. eat and drink slowly and smaller and frequent meals. Applying a heat pad or covered hot water bottle on your stomach may also help. If still pain persists, speak to your doctor.
Constipation:
Take fibre rich foods such as fresh fruit, vegetables and cereals, and drink plenty of water. Exercise more regularly.
Nausea and vomiting:
Keep try taking this medicine with, or just after, a meal or snack and stick to simple meals and do not eat rich or spicy food.
WARNING & PRECAUTIONS
PREGNANCY
ESOZ 40MG should be used with caution in pregnant women. Consult your doctor before taking this medicine.
BREASTFEEDING
ESOZ 40MG is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.
DRIVING AND USING MACHINES
Do not drive or operate machinery while taking this medicine, since it may cause dizziness and blurred vision.
ALCOHOL
Consumption of alcohol is not recommended during treatment with ESOZ 40MG.
KIDNEY
ESOZ 40MG should be used with caution in patients suffering from active kidney diseases. Consult your doctor for advice.
LIVER
ESOZ 40MG should be used with caution in patients suffering from liver function impairment or active liver diseases. Consult your doctor for advice.
ALLERGY
Do not take ESOZ 40MG if you are allergic (hypersensitive) to esomeprazole or any other ingredients in this medicine.
OTHERS
Tell your doctor if you have or had a condition such as,
- skin reaction
- osteoporosis
INTERACTIONS
Talk to your doctor if you are taking,
- nelfinavir, atazanavir (used to treat HIV infection)
- clopidogrel (used to prevent blood clots)
- ketoconazole, itraconazole or voriconazole (used to treat fungal infection)
- erlotinib, methotrexate (used to treat cancer)
- citalopram, imipramine, clomipramine (used to treat depression)
- diazepam (used to treat anxiety, relax muscles)
- phenytoin (used to treat epilepsy)
- warfarin (used for thin blood)
- cilostazol (used to treat intermittent claudication)
- cisapride (used to treat indigestion and heartburn)
- digoxin (used to treat heart problems)
- tacrolimus (used for organ transplantation)
- rifampicin (used to treat tuberculosis)
- St. John’s wort (Hypericum perforatum) (used to treat depression)
SYNOPSIS
| Drug | : | Esomeprazole |
| Pharmacological Category | : | Proton Pump Inhibitor |
| Therapeutic Indication | : | Gastroesophageal reflux disease, stomach ulcers or intestinal ulcer, Zollinger-Ellison syndrome, rebleeding of ulcers |
| Dosage Forms | : | Tablet, Injection |
MORE INFORMATION
Store below 20-25°C and keep out of reach of children.
FAQs ABOUT ESOZ 40MG
Can I take ESOZ 40MG during kidney disease?
It should be used with caution in patients suffering from active kidney diseases.
Can I take ESOZ 40MG during pregnancy?
It should be used with caution in pregnant women. Consult your doctor before taking this medicine.
Can I take ESOZ 40MG during breast feeding?
It is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.
REFERENCES
1. KD Tripathi. Drugs for Peptic Ulcer and Gastroesophageal Reflux Disease. Essentials of Medical Pharmacology. seventh edition.2013. Page - 653.
2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page -1428-1432.
3. Evangelos Kalaitzakis 1, Einar Björnsson. A review of esomeprazole in the treatment of gastroesophageal reflux disease (GERD). NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. Aug 2007. [Accessed 07 Nov 2020] https://pubmed.ncbi.nlm.nih.gov/18472988/
4. AstraZeneca UK Limited; Electronic Medicines Compendium (EMC); [Revised on Feb 2020] [Accessed 07 Nov 2020] https://www.medicines.org.uk/emc/files/pil.43.pdf
5. Sun Pharmaceutical Industries Europe B.V; Electronic Medicines Compendium (EMC); [Revised on Jun 2018] [Accessed 07 Nov 2020] https://www.medicines.org.uk/emc/files/pil.4095.pdf
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